Clinical and Experimental Pharmacology and Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Exploring the modulatory effects of sotagliflozin on dyslipidemia in mice: The role of glucagon, fibroblast growth factor 21 and glucagon-like peptide 1
In conclusion, sotagliflozin was found to have an effect on GLP-1 and also stimulate the release of glucagon and FGF21, which are important for regulating fat metabolism. Therefore, sotagliflozin might represent a potential therapeutic approach for the treatment of diabetic dyslipidemia and steatohepatitis.PMID:38527859 | DOI:10.1111/1440-1681.13854 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - March 25, 2024 Category: Drugs & Pharmacology Authors: Nitin J Deshmukh M S Kalshetti Mohan Patil Pankaj Autade Ganesh V Sangle Source Type: research

Epidemiology and risk factors of bloodstream infections among adolescents and young adults with acute lymphoblastic leukaemia: An 11-year retrospective cohort study
In this study, we analysed these aspects in AYAs patients and compared similarities and differences with children (<15 years old) and older adults (>39 years old). We analysed the pathogenic epidemiology, antibiotic resistance and BSI risk factors of 73 children, 180 AYAs, and 110 older adults with ALL in three comprehensive hospitals from January 2010 to August 2021. The data on BSIs in AYAs were compared to that of the other two groups. In this study, the epidemiology of BSIs in AYAs was similar to that of older adult patients. Concerning clinical characteristics, most AYAs and older adults with BSIs were in a rela...
Source: Clinical and Experimental Pharmacology and Physiology - March 7, 2024 Category: Drugs & Pharmacology Authors: Longlong Xue Yishu Tang Liwen Wang Cong Xu Qian Cheng Xin Li Source Type: research

Differential responses of cerebral and renal oxygenation to altered perfusion conditions during experimental cardiopulmonary bypass in sheep
Clin Exp Pharmacol Physiol. 2024 Apr;51(4):e13852. doi: 10.1111/1440-1681.13852.ABSTRACTWe tested whether the brain and kidney respond differently to cardiopulmonary bypass (CPB) and to changes in perfusion conditions during CPB. Therefore, in ovine CPB, we assessed regional cerebral oxygen saturation (rSO2 ) by near-infrared spectroscopy and renal cortical and medullary tissue oxygen tension (PO2 ), and, in some protocols, brain tissue PO2 , by phosphorescence lifetime oximetry. During CPB, rSO2 correlated with mixed venous SO2 (r = 0.78) and brain tissue PO2 (r = 0.49) when arterial PO2 was varied. During the first 30 mi...
Source: Clinical and Experimental Pharmacology and Physiology - March 7, 2024 Category: Drugs & Pharmacology Authors: Roger G Evans Andrew D Cochrane Sally G Hood Bruno Marino Naoya Iguchi Rinaldo Bellomo Peter R McCall Nobuki Okazaki Alemayehu H Jufar Lachlan F Miles Taku Furukawa Connie P C Ow Jaishankar Raman Clive N May Yugeesh R Lankadeva Source Type: research

A 2-week treatment with 5-azacytidine improved the hypercontractility state in prostate from obese mice: Role of the nitric oxide-cyclic guanosine monophosphate signalling pathway
In conclusion, our study paves the way to develop or repurpose therapies that recover the expression of eNOS and sGC and, hence, to improve prostate function in BPH.PMID:38452757 | DOI:10.1111/1440-1681.13851 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - March 7, 2024 Category: Drugs & Pharmacology Authors: Ana Carolina Ghezzi Gabriela Reolon Passos Mariana Gon çalves de Oliveira Akila Lara Oliveira Guilherme Rossi Assis-Mendon ça Glaucia Coelho de Mello Edson Antunes Fabiola Zakia Monica Source Type: research