Clinical and Experimental Metastasis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study
AbstractBreast cancer in young patients is known to exhibit more aggressive biological behavior and is associated with a less favorable prognosis than the same disease in older patients, owing in part to an increased incidence of brain metastases. The mechanistic explanations behind these findings remain poorly understood. We recently reported that young mice, in comparison to older mice, developed significantly greater brain metastases in four mouse models of triple-negative and luminal B breast cancer. Here we have performed a quantitative mass spectrometry-based proteomic analysis to identify proteins potentially contri...
Source: Clinical and Experimental Metastasis - November 2, 2023 Category: Cancer & Oncology Source Type: research

Congratulations to Prof. em. Garth L. Nicolson – co-founder of Clinical & amp; Experimental Metastasis
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - October 21, 2023 Category: Cancer & Oncology Source Type: research

Cutting-edge innovations in breast cancer diagnosis- the potential of HDMI biomarkers
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - October 17, 2023 Category: Cancer & Oncology Source Type: research

Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver
AbstractPatients with cutaneous melanoma can develop in-transit metastases (ITM), most often localized to limbs. For patients with uveal melanoma that develop metastatic disease, the overall majority develop isolated liver metastases. For these types of metastases, regional cancer therapies have evolved as effective treatments. Isolated limb perfusion (ILP), isolated limb infusion (ILI), isolated hepatic perfusion (IHP) and percutaneous hepatic perfusion (PHP) achieve a high local concentration of chemotherapy with minimal systemic exposure. This review discusses the mechanism and available literature on locoregional treat...
Source: Clinical and Experimental Metastasis - October 16, 2023 Category: Cancer & Oncology Source Type: research

Development and adaptations of the Graded Prognostic Assessment (GPA) scale: a systematic review
AbstractThe Graded Prognostic Assessment (GPA) score has the best accuracy among prognostic scales for patients with brain metastases (BM). A wide range of GPA-derived scales have been established to different types of primary tumor BM. However, there is a high variability between them, and their characteristics have not been described altogether yet. We aim to summarize the features of the existent GPA-derived scales and to compare their predictor factors and their uses in clinical setting. Medline was searched from inception until January 2023 to identify studies related to the development, update, or validation of GPA. ...
Source: Clinical and Experimental Metastasis - October 11, 2023 Category: Cancer & Oncology Source Type: research

High sensitivity flow cytometry immunophenotyping increases the diagnostic yield of malignant pleural effusions
AbstractDiagnosing malignant pleural effusions (MPE) is challenging when patients lack a history of cancer and cytopathology does not detect malignant cells in pleural effusions (PE). We investigated whether a systematic analysis of PE by flow cytometry immunophenotyping (FCI) had any impact on the diagnostic yield of MPE. Over 7 years, 570 samples from patients with clinical suspicion of MPE were submitted for the FCI study. To screen for epithelial malignancies, a 3-color FCI high sensitivity assay was used. The FCI results, qualified as “malignant” (FCI+) or “non-malignant” (FCI-), were compared to integrated de...
Source: Clinical and Experimental Metastasis - October 9, 2023 Category: Cancer & Oncology Source Type: research

CT-based deep learning model: a novel approach to the preoperative staging in patients with peritoneal metastasis
AbstractPeritoneal metastasis (PM) is a frequent manifestation of advanced abdominal malignancies. Accurately assessing the extent of PM before surgery is essential for patients to receive optimal treatment. Therefore, we propose to construct a deep learning (DL) model based on enhanced computed tomography (CT) images to stage PM preoperatively in patients. All 168 patients with PM underwent contrast-enhanced abdominal CT before either open surgery or laparoscopic exploration, and peritoneal cancer index (PCI) was used to evaluate patients during the surgical procedure. DL features were extracted from portal venous-phase a...
Source: Clinical and Experimental Metastasis - October 5, 2023 Category: Cancer & Oncology Source Type: research

Etiology and treatment of cancer-related secondary lymphedema
AbstractLymphedema and specifically cancer-related lymphedema is not the main focus for both patients and physicians dealing with cancer. Its etiology is an unfortunate complication of cancer treatment. Although lymphedema treatments have gained an appreciable consensus, many practitioners have developed and prefer their own specific protocols and this is especially true for conventional (manual) versus surgical treatments. This collection of presentations explores the incidence and genetics of cancer-related lymphedema, early detection and monitoring techniques, both conventional and operative treatment options, and the i...
Source: Clinical and Experimental Metastasis - September 30, 2023 Category: Cancer & Oncology Source Type: research

Associations amongst genes, molecules, cells, and organs in breast cancer metastasis
AbstractThis paper is a cross fertilization of ideas about the importance of molecular aspects of breast cancer metastasis by basic scientists, a pathologist, and clinical oncologists at the Henry Ford Health symposium. We address four major topics: (i) the complex roles of lymphatic endothelial cells and the molecules that stimulate them to enhance lymph node and systemic metastasis and influence the anti-tumor immunity that might inhibit metastasis; (ii) the interaction of molecules and cells when breast cancer spreads to bone, and how bone metastases may themselves spread to internal viscera; (iii) how molecular express...
Source: Clinical and Experimental Metastasis - September 9, 2023 Category: Cancer & Oncology Source Type: research

PET/CT in assessment of colorectal liver metastases: a comprehensive review with emphasis on 18F-FDG
AbstractApproximately 25% of those who are diagnosed with colorectal cancer will develop colorectal liver metastases (CRLM) as their illness advances. Despite major improvements in both diagnostic and treatment methods, the prognosis for patients with CRLM is still poor, with low survival rates. Accurate employment of imaging methods is critical in identifying the most effective treatment approach for CRLM. Different imaging modalities are used to evaluate CRLM, including positron emission tomography (PET)/computed tomography (CT). Among the PET radiotracers, fluoro-18-deoxyglucose (18F-FDG), a glucose analog, is commonly ...
Source: Clinical and Experimental Metastasis - September 8, 2023 Category: Cancer & Oncology Source Type: research

Lymphatic trafficking of immune cells and insights for cancer metastasis
AbstractMost cancers and in particular carcinomas metastasise via the lymphatics to draining lymph nodes from where they can potentially achieve systemic dissemination by invasion of high endothelial blood venules (HEVs) in the paracortex [1,2]. Currently however, the mechanisms by which tumours invade and migrate within the lymphatics are incompletely understood, although it seems likely they exploit at least some of the normal physiological mechanisms used by immune cells to access lymphatic capillaries and traffic to draining lymph nodes in the course of immune surveillance, immune modulation and the resolution of infla...
Source: Clinical and Experimental Metastasis - August 22, 2023 Category: Cancer & Oncology Source Type: research

Efficacy and safety of thoracic radiotherapy for extensive stage small cell lung cancer after immunotherapy in real world
In this study, patients with ES-SCLC who received immunotherapy were assigned to receive either TRT or no TRT. TRT significantly improved progression-free survival (PFS), local recurrence-free survival (LRFS) and OS with well tolerated toxicity. Further sub-cohort analysis, TRT significantly improved LRFS in patients with oligo-metastasis and without liver metastasis. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - August 16, 2023 Category: Cancer & Oncology Source Type: research

Oncolytic intralesional therapy for metastatic melanoma
AbstractIn-transit metastasis (ITM) develop in approximately 1 in 10 patients with melanoma and the disease course can vary widely. Surgical resection is the gold-standard treatment; however, ITM are often surgically unresectable due to size, distribution, and/or anatomic involvement. Oncolytic viral therapies are one category of non-surgical treatment options available for ITM. They induce tumor cell lysis and systemic anti-tumor activity through selective infection of tumor cells by naturally occurring or genetically modified factors. While there are numerous oncolytic viral therapies in various stages of development for...
Source: Clinical and Experimental Metastasis - August 9, 2023 Category: Cancer & Oncology Source Type: research

Correction: Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - August 3, 2023 Category: Cancer & Oncology Source Type: research

Revealing the concealed: A tribute to Donald L. Morton, MD
AbstractDonald L. Morton, MD, epitomized one of America ’s dream scenarios: a person evolving from the humblest of origins to become an international celebrity in his profession, leading the world in the discipline of surgical oncology. His pioneering accomplishments in various roles have been well documented. Scientists, clinicians, students, and pati ents benefited from his contributions to the management of malignant diseases, particularly melanoma. His many attributes in pursuing the goal to cure malignant diseases are well known. Browsing the scientific literature reveals an almost unmatched publication record and c...
Source: Clinical and Experimental Metastasis - July 31, 2023 Category: Cancer & Oncology Source Type: research