Clinical and Experimental Metastasis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Indwelling pleural catheter versus talc pleurodesis for malignant pleural effusion: a meta-analysis
In conclusion, both TP and IPC are equally effective in treating patients with MPE. The number of hospitalizat ion days was significantly lower for patients who were treated with IPC, but the magnitude of the difference is of uncertain clinical importance. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - June 9, 2020 Category: Cancer & Oncology Source Type: research

The clinical efficacy of PSMA PET/MRI in biochemically recurrent prostate cancer compared with standard of care imaging modalities and confirmatory histopathology: results of a single-centre, prospective clinical trial
AbstractProspective evidence for the clinical role and efficacy of prostate specific membrane antigen (PSMA) positron emission tomography (PET)/magnetic resonance imaging (MRI) combining MRI characterization and localization of lesions with PET avidity in comparison to conventional imaging is limited. In a prospective clinical trial, we aimed to evaluate the diagnostic yield and therapeutic impact of PSMA PET/MRI in men with biochemical recurrence (BCR) following curative therapy. A single-centre, prospective clinical trial at the Princess Alexandra Hospital recruited 30 patients with BCR. Patients underwent PSMA PET/MRI a...
Source: Clinical and Experimental Metastasis - June 8, 2020 Category: Cancer & Oncology Source Type: research

Growth differentiation factor 15 (GDF15) in cancer cell metastasis: from the cells to the patients
AbstractGrowth differentiation factor 15 (GDF15), a member of the transforming growth factor β superfamily, has been postulated to be implicated in cancer cell metastasis although its role has not been fully elucidated yet. The purpose of this review is to clarify the role of GDF-15 in cancer cell metastasis based on current advances in the field. The studies were divided into those involv ing evaluation of GDF15 expression in the serum or tissue of cancer patients, and those involving in vitro experiments in cancer cell lines or in vivo experiments in animal models. GDF15 was shown to be elevated in the serum or tissues ...
Source: Clinical and Experimental Metastasis - June 4, 2020 Category: Cancer & Oncology Source Type: research

Predictors of prognosis of synchronous brain metastases in small-cell lung cancer patients
This study identifies risk factors for SBM among patients with SCLC, as well as indicators of prognosis among this patient population. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - June 3, 2020 Category: Cancer & Oncology Source Type: research

Stereobody radiotherapy for nodal recurrences in oligometastatic patients: a pooled analysis from two phase I clinical trials
AbstractStereotactic body radiotherapy (SBRT) has been shown to achieve high local control rates in limited metastatic burden of disease. Few papers reported on the efficacy of SBRT in nodal oligometastases. The primary aim of the present paper was to analyze the treatment outcome in this setting. Data from DESTROY-1 and SRS-DESTROY-2 phase I clinical trials were reviewed and analyzed. These trials were based on a 5 fractions and a single fraction regimens, respectively. End-points of this analysis were toxicity rates, overall response rate (ORR), and local control (LC). Patients treated between December 2003 and January 2...
Source: Clinical and Experimental Metastasis - June 2, 2020 Category: Cancer & Oncology Source Type: research

Prognostic influence of the treatment approach for pulmonary metastasis in patients with soft tissue sarcoma
In conclusion, pulmonary metastasectomy was the most important prognostic factor for post-metastasis survival in patients with metastatic STS. In addition, chemotherapy could prolong survival in patients who were not eligible for pulmonary resection. Although we should carefully weigh th e risks and benefits, appropriate treatment for pulmonary metastases could contribute to long-time survival. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - May 19, 2020 Category: Cancer & Oncology Source Type: research

Cumulative intracranial tumour volume prognostic assessment: a new predicting score index for patients with brain metastases treated by stereotactic radiosurgery
AbstractBrain metastases (BM) represent the most common intracranial malignancy in adults. Limitations of existing prognostic models reduce their predictivity and clinical applicability. The aim of this study is to validate the cumulative intracranial tumour volume prognostic assessment (CITVPA) as a new prognostic score system for patients with BM treated by Stereotactic Radiosurgery (SRS). Between January 2001 and December 2015, 1894 patients underwent Gamma Knife SRS treatment. The CITVPA model was implemented and validated as follows: the CITV cut-offs were identified thanks to a receiver-operating characteristic (ROC)...
Source: Clinical and Experimental Metastasis - May 18, 2020 Category: Cancer & Oncology Source Type: research

Development of 131 I-ixolaris as a theranostic agent: metastatic melanoma preclinical studies
AbstractTissue factor (TF), a blood coagulation protein, plays an important role in tumor growth, invasion, and metastasis. Ixolaris, a tick-derived non-immunogenic molecule that binds to TF, has demonstrated in vivo inhibitory effect on murine models of melanoma, including primary growth and metastasis. This work aimed to: I) develop an efficient and stable labeling technique of ixolaris with Iodine-131(131I); II) compare the biodistribution of131I and131I-ixolaris in tumor-free and melanoma-bearing mice; III) evaluate whether131I-ixolaris could serve as an antimetastatic agent. Ixolaris radioiodination was performed usin...
Source: Clinical and Experimental Metastasis - May 10, 2020 Category: Cancer & Oncology Source Type: research

Laser interstitial thermal therapy for in-field recurrence of brain metastasis after stereotactic radiosurgery: does treatment with LITT prevent a neurologic death?
In this study, we investigate the causes of death among patients with BM who undergo LITT for IFR after SRS. We conducted a  single institution retrospective case series of patients with BM who underwent LITT for IFR after SRS. Clinical and demographic data were collected via chart review. The primary endpoint was cause of death. Between 2010 and 2018, 70 patients with BM underwent LITT for IFR after SRS. Median follow- up after LITT was 12.0 months. At analysis, 49 patients died; a cause was determined in 44. Death was neurologic in 20 patients and non-neurologic in 24. The 24-month cumulative incidence of neurologic an...
Source: Clinical and Experimental Metastasis - May 5, 2020 Category: Cancer & Oncology Source Type: research

Tako-tsubo syndrome after intraperitoneal hyperthermic chemotherapy (HIPEC) with cisplatin: an unusual complication of cytoreductive surgery plus HIPEC
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - May 4, 2020 Category: Cancer & Oncology Source Type: research

A study on different therapies and prognosis-related factors for brain metastases in lung adenocarcinoma patients with driver mutation
AbstractBrain metastases (BMs) are frequently occurred in lung adenocarcinoma with driver mutation. There is a need to explore multi-discipline treatments and prognostic factors in those patients with most frequent driver mutations:EGFR mutation andALK fusion. In the retrospective study, different therapies and prognostic factors were compared betweenEGFR andALK-driven lung adenocarcinoma with BMs. 516 patients withEGFR mutation and 76 withALK fusion were screened for this study, 303 (58.7%) and 34 (44.7%) had BM respectively. In multivariate analyses, the pretreatment factors including delayed BMs and asymptomatic BMs, tr...
Source: Clinical and Experimental Metastasis - April 29, 2020 Category: Cancer & Oncology Source Type: research

Tumor shedding and metastatic progression after tumor excision in patient-derived orthotopic xenograft models of triple-negative breast cancer
This study assembles a timeline of PDOX tumor shedding and metastatic tumor progression before and after tumor excision surgery. We report the ability to use tumorectomies to increase the lifespan of TNBC PDOX models with the potential to obtain larger metastases. CTC clusters and CTCs expressing a mesenchymal marker (vimentin) were associated with metastatic burden in lung and liver. The data collected through these experiments will guide the further use of PDOX models in studying metastatic TNBC. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - April 24, 2020 Category: Cancer & Oncology Source Type: research

Astrocytic IGFBP2 and CHI3L1 in cerebrospinal fluid drive cortical metastasis of HER2+breast cancer
AbstractThe brain is often reported as the first site of recurrence among breast cancer patients overexpressing human epidermal growth factor receptor 2 (HER2). Although most HER2+tumors metastasize to the subcortical region of the brain, a subset develops in the cortical region. We hypothesize that factors in cerebrospinal fluid (CSF) play a critical role in the adaptation, proliferation, and establishment of cortical metastases. We established novel cell lines using patient biopsies to model breast cancer cortical and subcortical metastases. We assessed the localization and growth of these cells in vivo and proliferation...
Source: Clinical and Experimental Metastasis - April 10, 2020 Category: Cancer & Oncology Source Type: research

Single-fraction radiosurgery versus fractionated stereotactic radiotherapy in patients with brain metastases: a comparative study
AbstractTo compare the local control and brain radionecrosis in patients with brain metastasis primarily treated by single-fraction radiosurgery (SRS) or hypofractionated stereotactic radiotherapy (HFSRT). Between January 2012 and December 2017, 179 patients with only 1 –3 brain metastases (total: 287) primarily treated by SRS (14 Gy) or HFSRT (23.1 Gy in 3 fractions of 7.7 Gy, every other day) were retrospectively analyzed in a single center. Follow-up imaging data were available in 152 patients with 246 lesions. The corresponding Biological Effective Dose (B ED) were 33.6 Gy and 40.9 Gy respectively for SRS and HF...
Source: Clinical and Experimental Metastasis - March 16, 2020 Category: Cancer & Oncology Source Type: research

Curative-intent pancreas resection for pancreatic metastases: surgical and oncological results
ConclusionDespite malignant disease, overall survival of patients after metastasectomy for pancreatic metastasis is acceptable. Better survival appears to be associated with the primary tumor entity. Further research should focus on molecular markers to elucidate the mechanisms of pancreatic metastasis to choose the suitable therapeutic approach for the individual patient. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 23, 2020 Category: Cancer & Oncology Source Type: research