Clinical and Experimental Metastasis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Harnessing the versatile role of OPG in bone oncology: counterbalancing RANKL and TRAIL signaling and beyond
AbstractMore than 2 decades ago, the discovery of osteoprotegerin (OPG) as inhibitor of the receptor of activator of nuclear factor Kb (RANK) ligand (RANKL) revolutionized our understanding of bone biology and oncology. Besides acting as decoy receptor for RANKL, OPG acts as decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). OPG, RANKL, and TRAIL are ubiquitously expressed, stimulating per se pivotal signaling cascades implicated in cancer. In the context of cancer cell –bone cell interactions, cancer cells skew the OPG/RANKL/RANK (RANKL cognate receptor) balance towards bone destruction ...
Source: Clinical and Experimental Metastasis - September 30, 2019 Category: Cancer & Oncology Source Type: research

Retrospective analysis by site of primary tumor of patients with unresectable locally-advanced or metastatic pancreatic adenocarcinoma receiving chemotherapy
AbstractThe primary tumor site of pancreatic cancer has been suggested as a recommended variable in future studies of treatments of patients with unresectable or metastatic pancreatic adenocarcinoma (mPDAC). The aim of the current study is to analyze the differences between mPDAC of the head and mPDAC of the body-tail, both in prognostic and predictive terms in patients with mPDAC receiving palliative chemotherapy. Data of patients with a diagnosis of mPDAC and receiving chemotherapy (CHT), registered in the database of the division of Medical Oncology of the Ospedale Civile di Sanremo, were analyzed. Thirty-two variables ...
Source: Clinical and Experimental Metastasis - September 30, 2019 Category: Cancer & Oncology Source Type: research

PTEN loss activates a functional AKT/CXCR4 signaling axis to potentiate tumor growth and lung metastasis in human osteosarcoma cells
AbstractOsteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Loss of the tumor suppressor PTEN or activation of chemokine receptor CXCR4 has been demonstrated to associate with OS respectively. However, the signaling mechanism underlying PTEN-mediated antitumor effect remains largely unknown, and the crosstalk between PTEN and CXCR4 in OS has not been investigated. Here, we uncover a PTEN/AKT/CXCR4 pathway nexus in highly tumorigenic and metastatic human 143B OS cells. Loss of PTEN activates AKT/CXCR4 signaling axis and regulates a series of tumor cell behaviors. Notably, ERK is in...
Source: Clinical and Experimental Metastasis - September 29, 2019 Category: Cancer & Oncology Source Type: research

Identification of inflammatory mediators associated with metastasis of oral squamous cell carcinoma in experimental and clinical studies: systematic review
AbstractMetastasis, whether regional or distant, remains the main cause of morbidity and recurrence in oral cancer. The accumulating evidence suggests that inflammatory mediators are strong drivers for cancer progression and spread. However, the precise role of these inflammatory mediators in mediating specific metastatic stage is poorly understood  due to lack of integration/validation of experimental research data and the clinical trials, i.e., the data produced from research is not translated to clinical therapeutic targets. This, in turn, results in the lack of developing reliable biomarker that can be used for accura...
Source: Clinical and Experimental Metastasis - September 25, 2019 Category: Cancer & Oncology Source Type: research

Gene expression signatures of site-specificity in cancer metastases
AbstractWe have previously shown that metastases are generally characterized by a core program of gene expression that induces the oxidative energy metabolism, activates vascularization/tissue remodeling, silences extracellular matrix interactions, and alters ion homeostasis. This core program distinguishes metastases from their originating primary tumors as well as from their target host tissues. We hypothesized that organ preference is reflected in additional, site-selective components within the metastatic gene expression programs. Expanding our prior analysis of 653 human gene expression profiles plus data from a murin...
Source: Clinical and Experimental Metastasis - September 24, 2019 Category: Cancer & Oncology Source Type: research