Clinical and Experimental Metastasis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The role of epigenetic modifications in Colorectal Cancer Metastasis
AbstractDistant metastasis is the major contributor to the high mortality rate of colorectal cancer (CRC). To overcome the poor prognosis caused by distant metastasis, the mechanisms of CRC metastasis should be further explored. Epigenetic events are the main mediators of gene regulation and further affect tumor progression. Recent studies have found that some epigenetic enzymes are often dysregulated or mutated in multiple tumor types, which prompted us to study the roles of these enzymes in CRC metastasis. In this review, we summarized the alteration of enzymes related to various modifications, including histone modifica...
Source: Clinical and Experimental Metastasis - April 16, 2022 Category: Cancer & Oncology Source Type: research

Less contrast-enhanced areas within lymph nodes in the delayed phase of contrast-enhanced MRI: a suspicious finding for lymph node metastases
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - April 11, 2022 Category: Cancer & Oncology Source Type: research

ADC textural features in patients with single brain metastases improve clinical risk models
ConclusionsTextural analysis of ADC maps in patients with single brain metastases improved established clinical risk models. These findings may aid to better understand the pathogenesis of BM and may allow selection of patients for new treatment options. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - April 8, 2022 Category: Cancer & Oncology Source Type: research

Metastasis prevention: targeting causes and roots
In conclusion, we highlight the importance of clinical evaluation of the agents showing antimetastatic effectsin vivo, especially in patients with early-stage cancers, the identification of metastatic seeds, and the development of therapeutics for their eradication. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - March 26, 2022 Category: Cancer & Oncology Source Type: research

PSMA-guided metastases directed therapy for bone castration sensitive oligometastatic prostate cancer: a multi-institutional study
AbstractTo assess the outcomes of a cohort of bone oligometastatic prostate cancer patients treated with PSMA-PET guided stereotactic body radiotherapy (SBRT). From April 2017 to January 2021, 40 patients with oligorecurrent prostate cancer detected by PSMA-PET were treated with SBRT for bone oligometastases. Concurrent androgen deprivation therapy was an exclusion criterion. A total of 56 prostate cancer bone oligometastases were included in the present analysis. In 28 patients (70%), oligometastatic disease presented as a single lesion, two lesions in 22.5%, three lesions in 5%, four lesions in 2.5%. 30.3% were spine-met...
Source: Clinical and Experimental Metastasis - March 9, 2022 Category: Cancer & Oncology Source Type: research

Dedication to late Dale Han, MD
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - March 7, 2022 Category: Cancer & Oncology Source Type: research

Development and characterization of a rat brain metastatic tumor model by multiparametric magnetic resonance imaging and histomorphology
AbstractTo facilitate the development of new brain metastasis (BM) treatment, an easy-to-use and clinically relevant animal model with imaging platform is needed. Rhabdomyosarcoma BM was induced in WAG/Rij rats. Post-implantation surveillance and characterizations were systematically performed with multiparametric MRI including 3D T1 and T2 weighted imaging, diffusion-weighted imaging (DWI), T1 and T2 mapping, and perfusion-weighted imaging (PWI), which were validated by postmortem digital radiography (DR), µCT angiography and histopathology. The translational potential was exemplified by the application of a vascular dis...
Source: Clinical and Experimental Metastasis - February 26, 2022 Category: Cancer & Oncology Source Type: research

Fluid shear stress influences invasiveness of HeLa cells through the induction of autophagy
In this study, we report the role of hemodynamic shear stresses in fostering the release of pro-extravasation factors through the mediation of autophagy in cervical cancer HeLa cells. HeLa cells were exposed to physiological shear stress through the microfluidic approach adapted in our previous study on the role of hemodynamic shear stresses in survival of HeLa cells. Herein, an optimum number of passes through a cylindrical microchannel was chosen such that the viability of cells was unaffected by shear. Shear-exposed cells were then probed for their invasive and migratory potential through in vitro migration and invasion...
Source: Clinical and Experimental Metastasis - February 25, 2022 Category: Cancer & Oncology Source Type: research

Detection of sentinel lymph nodes by tilmanocept in oral squamous cell carcinoma
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 22, 2022 Category: Cancer & Oncology Source Type: research

Introduction: Novel Frontiers in Cancer Metastasis
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 22, 2022 Category: Cancer & Oncology Source Type: research

Oligoprogressive castration-resistant prostate cancer treated with metastases-directed stereotactic body radiation therapy: predictive factors for patients ’ selection
In conclusion, we confirmed the efficacy of SBRT for oligoprogression from PC, with the potential to prolong t he on-going systemic therapy and interrupt the metastatic cascade. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 21, 2022 Category: Cancer & Oncology Source Type: research

Future perspectives: Novel Frontiers in Cancer Metastasis
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 12, 2022 Category: Cancer & Oncology Source Type: research

Editorial: Novel Frontiers in Cancer Metastasis
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 12, 2022 Category: Cancer & Oncology Source Type: research

Histopathological growth patterns of resected non-colorectal, non-neuroendocrine liver metastases: a retrospective multicenter studyss
ConclusionsThis study demonstrates that HGPs apply to liver metastases across a wide variety of primary tumour origins. They hold a prognostic value in these cases, suggesting that HGPs could represent a pan-cancer biomarker for survival after surgical resection of liver metastases. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 6, 2022 Category: Cancer & Oncology Source Type: research

Perfusion defects in non-enlarged metastatic lymph nodes using vessel wall magnetic resonance imaging: Detection performance and diagnostic value
AbstractA perfusion defect (PD) in non-enlarged lymph nodes (LNs) of oral squamous cell carcinoma (OSCC) is the most reliable radiological criterion for the diagnosis of metastasis. However, conventional contrast-enhanced (CE) T1 weighted images using turbo spin echo (TSE) sequence is limited in detecting PD in non-enlarged LNs due to flow artifacts from cervical blood vessels. Vessel wall (VW) MR imaging with blood vessel flow suppression and high spatial resolution may provide new insights into the detection of PD. However, there are no reports in the literature on the usefulness of VW MR imaging for the diagnosis of LN ...
Source: Clinical and Experimental Metastasis - February 4, 2022 Category: Cancer & Oncology Source Type: research