Clinical and Experimental Metastasis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling
AbstractApproximately 90% of cancer-related deaths result from cancer metastasis. In prostate and breast cancers, bone is the most common site of cancer cell dissemination. Key steps in the metastatic cascade are promoted through upregulation of critical cell signaling pathways in neoplastic cells. The present study assessed the role of the receptor tyrosine kinase Axl in prostate and breast cancer cell metastasis to bones using (i) Axl knockdown neoplastic cells and osteoclast progenitor cellsin vitro, (ii) intracardiac injection of Axl knockdown tumor cellsin vivo, and (iii) selective Axl inhibitor BGB324. Axl inhibition...
Source: Clinical and Experimental Metastasis - March 31, 2021 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: Upfront citorreduction and hyperthermic intraperitoneal chemotherapy with paclitaxel in patients with stage III-C serous epithelial ovarian cancer
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - March 23, 2021 Category: Cancer & Oncology Source Type: research

Protective measures for patients with advanced cancer during the Sars-CoV-2 pandemic: Quo vadis?
AbstractCancer patients represent a vulnerable cohort during the Sars-CoV-2 pandemic. Oncological societies have generated a plethora of recommendations, but precise instructions about routine oncological procedures remain scarce. Here, we report on local COVID-19 protection measures established in an interdisciplinary approach at a tertiary care center during the first wave of the pandemia in Germany. Following these measures, no additional morbidity or mortality during oncological procedures was observed, and no nosocomial infections were registered. However, Validation of our measures is outstanding and regional SARS-Co...
Source: Clinical and Experimental Metastasis - March 23, 2021 Category: Cancer & Oncology Source Type: research

Synchronous peritoneal metastases from lung cancer: incidence, associated factors, treatment and survival: a Dutch population-based study
AbstractPeritoneal metastases (PM) from lung cancer are rare and it is unknown how they affect the prognosis of patients with lung cancer. This population-based study aimed to assess the incidence, associated factors, treatment and prognosis of PM from lung cancer. Data from the Netherlands Cancer Registry were used. All patients diagnosed with lung cancer between 2008 and 2018 were included. Logistic regression analysis was performed to identify factors associated with the presence of PM. Cox regression analysis was performed to identify factors associated with the overall survival (OS) of patients with PM. Between 2008 a...
Source: Clinical and Experimental Metastasis - March 18, 2021 Category: Cancer & Oncology Source Type: research

Single ‐fraction versus hypofractionated gamma knife radiosurgery for small metastatic brain tumors
AbstractStereotactic radiosurgery (SRS) has become a standard of care for the treatment of metastatic brain tumors (METs). Although a better balance of tumor control and toxicity of hypofractionated SRS (hfSRS) compared with single-fraction SRS (sfSRS) was demonstrated in large METs, there is no data comparing two approaches for small METs (<  4 cm3). It was aimed to compare clinical outcomes between sfSRS versus hfSRS Gamma Knife radiosurgery (GKRS) in a series of patients with unresected, small METs. Patients (n  = 208) treated with sfGKRS or hfGKRS between June 2017 and May 2020 were retrospectively examined in...
Source: Clinical and Experimental Metastasis - March 17, 2021 Category: Cancer & Oncology Source Type: research

Breast cancer liver metastasis: current and future treatment approaches
AbstractNearly all fatalities arising from breast tumors are attributable to distant metastases. Breast cancer liver metastasis (BCLM) is associated with poor prognoses, with the median survival time being 2 to 3  years. Tumor intrinsic subtype directs preferential metastasis to specific organs, with HER2-enriched tumors demonstrating the highest rates of metastasis to the liver, though all subtypes can grow in the liver. There is no singular established standard-of-care for BCLM; therapeutic selection is d riven by histologic and molecular hallmarks of the primary tumor or biopsied metastasis samples. Given the poor prog...
Source: Clinical and Experimental Metastasis - March 6, 2021 Category: Cancer & Oncology Source Type: research

Type IV collagen as a potential biomarker of metastatic breast cancer
AbstractNo reliable, non-invasive biomarker of metastatic breast cancer (mBC) exists: circulating CA15-3 (cCA15-3) is the marker mostly used to monitor mBC. Circulating collagen IV (cCOLIV) has been evaluated in other metastatic cancers and has been found to be a promising biomarker. The overarching aim of this study was to evaluate cCOLIV as a potential biomarker in patients with mBC. The first aim was to determine the levels of cCOL IV and cCA15-3 in patients with healthy controls, primary breast cancer (pBC) and mBC. The second aim was to compare levels of cCOLIV and cCA15-3 in patients with different metastatic sites o...
Source: Clinical and Experimental Metastasis - March 3, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Intraperitoneal mitomycin C improves survival compared to cytoreductive surgery alone in an experimental model of highgrade pseudomyxoma peritonei
A correction to this paper has been published: https://doi.org/10.1007/s10585-021-10084-0 (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - March 2, 2021 Category: Cancer & Oncology Source Type: research

Longitudinal CTCs gene expression analysis on metastatic castration-resistant prostate cancer patients treated with docetaxel reveals new potential prognosis markers
AbstractCTCs have extensively been used for the monitoring and characterization of metastatic prostate cancer, but their application in the clinic is still very scarce. Besides, the resistance mechanisms linked to prostate cancer treatment remain unclear. Liquid biopsies represent the most promising alternative due to the complexity of biopsying bone metastasis and the duration of the disease. We performed a prospective longitudinal study in CTCs from 20 castration-resistant prostate cancer patients treated with docetaxel. For that, we used CellSearch ® technology and a custom gene expression panel with qRT-PCR using a CT...
Source: Clinical and Experimental Metastasis - February 26, 2021 Category: Cancer & Oncology Source Type: research

Wnt/ β-catenin/Slug pathway contributes to tumor invasion and lymph node metastasis in head and neck squamous cell carcinoma
In conclusion, the canonical Wnt/β-catenin/Slug signaling axis significantly contributes to cancer cell invasion and LNM. Its blockade may be a treatment strategy for LNM and tumor recurrence in HNSCC. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 25, 2021 Category: Cancer & Oncology Source Type: research

Impact of the COVID-19 pandemic on quality of life and emotional wellbeing in patients with bone metastases treated with radiotherapy: a prospective cohort study
This study has shown a strong increase in the experience of isolation and a decrease of emotional functioning and general quality of life during the COVID-19 lockdown in cancer patients with bone metastases. Due to the nature of the treatment of this patient pop ulation, efforts should be made to minimize these changes during future lockdowns. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 25, 2021 Category: Cancer & Oncology Source Type: research

Electron beam intraoperative radiotherapy for metastatic epidural spinal cord compression: a prospective observational study
This study’s findings suggest that decompression surgery and IORT followed by EBRT are effective in achieving local control and maintaining ambulation in patients with MESCC. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 24, 2021 Category: Cancer & Oncology Source Type: research

Molecular insights into the interplay between adiposity, breast cancer and bone metastasis
AbstractCancer is a complex disease, with various pre-existing health ailments enhancing its pathology. In cancer, the extracellular environment contains various intrinsic physiological factors whose levels are altered with aging and pre-existing conditions. In obesity, the tumor microenvironment and metastases are enriched with factors that are both derived locally, and from other physiological compartments. Similarly, in obesity, the cancer cell environment both at the site of origin and at the secondary site i.e., metastatic niche, contains significantly more phenotypically-altered adipocytes than that of un-obese cance...
Source: Clinical and Experimental Metastasis - February 16, 2021 Category: Cancer & Oncology Source Type: research

TGF β signaling networks in ovarian cancer progression and plasticity
AbstractEpithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women. Late-stage diagnosis with significant tumor burden, accompanied by recurrence and chemotherapy resistance, contributes to this poor prognosis. These morbidities are known to be tied to events associated with epithelial-mesenchymal transition (EMT) in cancer. During EMT, localized tumor cells alter their polarity, cell –cell junctions, cell–matrix interactions, acquire motility and invasiveness and an exaggerated potential for metastatic spread. Key triggers for EMT include the Transforming Growth Factor-β (TGFβ) family of gro...
Source: Clinical and Experimental Metastasis - February 15, 2021 Category: Cancer & Oncology Source Type: research

Better pain control with 8-gray single fraction palliative radiotherapy for skeletal metastases: a Bayesian network meta-analysis
AbstractExternal Beam Radiotherapy (EBRT) allows remarkable pain control in patients with skeletal metastases. We performed a Bayesian network meta-analysis comparing the most commonly used radiotherapy regimens for palliative management in patients with skeletal metastases. The main online databases were accessed in October 2020. All randomized clinical trials evaluating the irradiation of painful bone metastases were considered. The following irradiation patterns were analysed and included in the present network meta-analysis: 8 Gy- and 10 Gy/single fraction, 20 Gy/5 fractions, 30 Gy/10 fractions. The Bayesian hierarchic...
Source: Clinical and Experimental Metastasis - February 9, 2021 Category: Cancer & Oncology Source Type: research