Clinical and Experimental Metastasis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Cancer cell metabolic plasticity in migration and metastasis
AbstractMetabolic reprogramming is a hallmark of cancer metastasis in which cancer cells manipulate their metabolic profile to meet the dynamic energetic requirements of the tumor microenvironment. Though cancer cell proliferation and migration through the extracellular matrix are key steps of cancer progression, they are not necessarily fueled by the same metabolites and energy production pathways. The two main metabolic pathways cancer cells use to derive energy from glucose, glycolysis and oxidative phosphorylation, are preferentially and plastically utilized by cancer cells depending on both their intrinsic metabolic p...
Source: Clinical and Experimental Metastasis - June 2, 2021 Category: Cancer & Oncology Source Type: research

Novel approach involving stereotactic body radiotherapy followed by intramedullary nail placement for long bone metastases: a case report
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - May 30, 2021 Category: Cancer & Oncology Source Type: research

Myeloid derived suppressor cells and the release of micro-metastases from dormancy
AbstractMetastasis is the primary cause of cancer mortality and an improved understanding of its pathology is critical to the development of novel therapeutic approaches. Mechanism-based therapeutic strategies require insight into the timing of tumor cell dissemination, seeding of distant organs, formation of occult lesions and critically, their release from dormancy. Due to imaging limitations, primary tumors can only be detected when they reach a relatively large size (e.g.  >  1 cm3), which, based on our understanding of tumor evolution, occurs approximately 10  years and about 30 doubling times following tumo...
Source: Clinical and Experimental Metastasis - May 20, 2021 Category: Cancer & Oncology Source Type: research

In-transit metastatic cutaneous melanoma: current management and future directions
AbstractManagement of in-transit melanoma encompasses a variety of possible treatment pathways and modalities. Depending on the location of disease, number of lesions, burden of disease and patient preference and characteristics, some treatments may be more beneficial than others. After full body radiographic staging is performed to rule out metastatic disease, curative therapy may be performed through surgical excision, intraarterial regional perfusion and infusion therapies, intralesional injections, systemic therapies or various combinations of any of these. While wide excision is limited in indication to superficial le...
Source: Clinical and Experimental Metastasis - May 17, 2021 Category: Cancer & Oncology Source Type: research

Cancer heterogeneity and metastasis: life at the edge
AbstractThere is abundant evidence that the phenotype of cells the tumor at the stromal interface is distinct from the tumor cells that are within the core. Molecular phenotyping of cells at the edge show that they express higher levels of proteins associated with elevated glycolytic metabolism, including GLUT-1, HIF-1, and CA-IX. An end product of glycolysis is the production of acid, and acidosis of tumors is strongly associated with increased metastatic potential across a wide variety of tumor types. The molecular machinery promoting this export of acid is being defined, with close collaboration between carbonic anhydra...
Source: Clinical and Experimental Metastasis - May 17, 2021 Category: Cancer & Oncology Source Type: research

Cancer microenvironment and genomics: evolution in process
AbstractCancer heterogeneity is a result of genetic mutations within the cancer cells. Their proliferation is not only driven by autocrine functions but also under the influence of cancer microenvironment, which consists of normal stromal cells such as infiltrating immune cells, cancer-associated fibroblasts, endothelial cells, pericytes, vascular and lymphatic channels. The relationship between cancer cells and cancer microenvironment is a critical one and we are just on the verge to understand it on a molecular level. Cancer microenvironment may serve as a selective force to modulate cancer cells to allow them to evolve ...
Source: Clinical and Experimental Metastasis - May 10, 2021 Category: Cancer & Oncology Source Type: research

Detection of cancer metastasis: past, present and future
This article attempts to address some of the resultant questions that were the subject of the session “Novel Frontiers in the Diagnosis of Cancer” at the 8th International Congress on Cancer Metastases, held in San Francisco, CA in October 2019. Some of these questions addressed include the significance of sentinel node metastasis in melanoma, and the optimal method for their pathologic analysis. The finding of circulating tumor cells in the blood may potentially supplant surgical techniques for detection of metastatic disease, and we are beginning to perfect techniques for their detection, understand how to apply the ...
Source: Clinical and Experimental Metastasis - May 7, 2021 Category: Cancer & Oncology Source Type: research

Current management of melanoma patients with nodal metastases
AbstractThe management of melanoma patients with nodal metastases has undergone dramatic changes over the last decade. In the past, the standard of care for patients with a positive sentinel lymph node biopsy (SLNB) was a completion lymph node dissection (CLND), while patients with palpable macroscopic nodal disease underwent a therapeutic lymphadenectomy in cases with no evidence of systemic spread. However, studies have shown that SLN metastases present as a spectrum of disease, with certain SLN-based factors being prognostic of and correlated with outcomes. Furthermore, the results of key clinical trials demonstrate tha...
Source: Clinical and Experimental Metastasis - May 7, 2021 Category: Cancer & Oncology Source Type: research

Secondary lymphedema from cancer therapy
AbstractThis manuscript is a summary of findings focusing on various aspects of secondary lymphedema specifically as a sequelae of treatment for cancer. The topic was addressed at a session held during the 8th International Congress on Cancer Metastasis that was unique a for the inclusion of patients with lymphedema and therapists joining physicians, healthcare professionals, and researchers in an effort to give an overview of secondary lymphedema following cancer therapy as well as highlighting the unknowns in the field. Lymphedema is defined and both diagnosis and incidence of cancer-related lymphedema are explored. Furt...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Cancer neoantigens as potential targets for immunotherapy
AbstractImmune checkpoint inhibitors (ICIs) targeting the cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) and programed cell death protein 1 (PD-1) or its ligand PD-L1 have increased the survival and cure rates for patients with many cancer types in various disease settings. However, only 10 –40% of cancer patients benefited from these ICIs, of whom ~ 20% have treatment interruption or discontinuation due to immune-related adverse events that can be severe and even fatal. Current efforts in precision immunotherapy are focused on improving biomarker-based patient selection for curr ently available ICIs and explor...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Emerging photoacoustic and thermoacoustic imaging technologies for detecting primary and metastatic cancer and guiding therapy
AbstractIn recent years, there has been a progressive trend towards less invasive technologies for detecting metastatic cancer and guiding therapy with the goal of lower morbidity, better outcomes, and superior cosmetic appearance than traditional methods. This mini-review examines three emerging noninvasive hybrid technologies for detecting primary cancer, metastasis and guiding thermal therapy. Real-time thermoacoustic imaging and thermometry potentially provides valuable and critical feedback for guiding focused microwave ablation therapy. Label-free photoacoustic monitoring of cancer cells is a promising clinical diagn...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Mechanisms of breast cancer metastasis
AbstractInvasive breast cancer tends to metastasize to lymph nodes and systemic sites. The management of metastasis has evolved by focusing on controlling the growth of the disease in the breast/chest wall, and at metastatic sites, initially by surgery alone, then by a combination of surgery with radiation, and later by adding systemic treatments in the form of chemotherapy, hormone manipulation, targeted therapy, immunotherapy and other treatments aimed at inhibiting the proliferation of cancer cells. It would be valuable for us to know how breast cancer metastasizes; such knowledge would likely encourage the development ...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Precision oncology for breast cancer through clinical trials
AbstractPrecision treatment for breast cancers has made several notable advances in recent decades, but challenges of tumor heterogeneity, drug resistance, and aggressive recurrence and metastases remain. To meet and overcome these challenges, we must refine our understanding of breast subtypes and treatment biomarkers according to the knowledge afforded across the spectrum of ‘omics assays. A critical aspect of harnessing this knowledge into actionable biomarkers for treatment decision relies on our ability to integrate knowledge across data types and leverage our insight in evidence-based clinical trials. We review rec...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Current status of gastrointestinal tract cancer brain metastasis and the use of blood-based cancer biomarker biopsy
AbstractBrain metastasis (BM) frequently occurs in patients with cutaneous melanoma, lung, and breast cancer; although, BM rarely arises from cancers of the gastrointestinal tract (GIT). The reported incidence of GIT cancer BM is less than 4%. In the last few years, effective systemic therapy has prolonged the survival of GIT patients and consequently, the incidence of developing BM is rising. Therefore, the epidemiology and biology of BM arising from GIT cancer requires a more comprehensive understanding. In spite of the development of new therapeutic agents for patients with metastatic GIT cancers, survival for patients ...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Breast cancer disparities in outcomes; unmasking biological determinants associated with racial and genetic diversity
AbstractBreast cancer (BC) remains a leading cause of death among women today, and mortality among African American women in the US remains 40% higher than that of their White counterparts, despite reporting a similar incidence of disease over recent years. Previous meta-analyses and studies of BC mortality highlight that tumor characteristics, rather than socio-economic factors, drive excess mortality among African American women with BC. This is further complicated by the heterogeneity of BC, where BC can more appropriately be defined as a collection of diseases rather than a single disease. Molecular phenotyping and gen...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research