Clinical and Experimental Metastasis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancer
We report for the first time that the molecular gene signatures are specific to the different types of breast cancer metastasis. Several genes, including CHPF, ARC, ANGPTL4, NR2E1, SH2D1A, CTSW, POLR2J4, SPTLC1, ILK, ALDH3B1, PDE6A, SCTR, ADM, HEY1, KCNF1, and UVRAG, were found to be predictors of the risk for site-specific metastasis of breast cancer. Expression of POLR2JA, SPTLC1, ILK, ALDH3B1, and the estrogen receptor was significantly associated with breast cancer bone metastasis. Expression of PDE6A and NR2E1 was causally linked to breast cancer brain metastasis. Expression of HEY1, KCNF1, UVRAG, and the estrogen and...
Source: Clinical and Experimental Metastasis - October 20, 2020 Category: Cancer & Oncology Source Type: research

Percutaneous isolated hepatic perfusion (chemosaturation) with melphalan following right hemihepatectomy in patients with cholangiocarcinoma and metastatic uveal melanoma: peri- and post-interventional adverse events and therapy response compared to a matched group without prior liver surgery
AbstractTo evaluate feasibility, frequency and severity of peri-procedural complications and post-procedural adverse events (AEs) in patients with advanced cholangiocarcinoma or liver metastasis of uveal melanoma and prior hemihepatectomy undergoing chemosaturation percutaneous hepatic perfusion (CS-PHP) and to analyze therapy response and overall survival compared to a matched group without prior surgery. CS-PHP performed between 10/2014 and 02/2018 were retrospectively assessed. To determine peri-procedural safety and post-procedural adverse events, hospital records and hematological, hepatic and biliary function were ca...
Source: Clinical and Experimental Metastasis - October 9, 2020 Category: Cancer & Oncology Source Type: research

Is repeated pulmonary metastasectomy justified?
In conclusion, our results suggest that RPM offers favorable survival rates without increasing post-operative morbidity. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - September 12, 2020 Category: Cancer & Oncology Source Type: research

Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells
AbstractBrain metastases (BM) are an ever-increasing challenge in oncology, threatening quality of life and survival of many cancer patients. The majority of BM originate from lung adenocarcinoma, and stage III patients have a risk of 40 –50% to develop BM in the first years of disease onset. As therapeutic options are limited, prevention of their occurrence is an attractive concept. Here we investigated whether Nintedanib (BIBF 1120), a tyrosine kinase inhibitor (TKI) targeting the VEGF pathway approved for lung adenocarcinoma, a nd the dual anti-VEGF-A/Ang2 nanobody BI836880 have the potential to prevent BM formation. ...
Source: Clinical and Experimental Metastasis - September 11, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Mass spectrometry-based proteomic capture of proteins bound to the MACC1 promoter in colon cancer
In the original publication of the article, Acknowledgements section was published incorrectly. The correct Acknowledgements is given in this Correction. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - September 3, 2020 Category: Cancer & Oncology Source Type: research

Cancer stem cell generation during epithelial-mesenchymal transition is temporally gated by intrinsic circadian clocks
AbstractEpithelial-mesenchymal transition (EMT) is a key event preceding tumor cell metastasis that increases cell invasiveness and cancer stem cell (CSC)  populations. Studies suggest that genes used in generating circadian rhythms also serve in regulating EMT. To test the role of circadian clocks in cellular EMT events two cancer cell lines were compared, one that has a well-established circadian clock, C6 from rat glioma, and one that does not, MC F-7 from human breast tumor. MCF-7 tumorsphere cultures were tested for evidence of circadian rhythms because of previously reported circadian rhythm enhancement in C6 tumors...
Source: Clinical and Experimental Metastasis - August 19, 2020 Category: Cancer & Oncology Source Type: research

Prediction of pathological fracture in patients with lower limb bone metastasis using computed tomography imaging
In conclusion, MCI and CCI examined by CT images were the risk factors for pathological fracture. CCI ≥ 50% is a widely known risk factor, but in addition, it may be better to consider surgery if MCI in the proximal femur is observed in metastasis with 25–50% CCI. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - July 30, 2020 Category: Cancer & Oncology Source Type: research

Adrenal SBRT: a multi-institutional review of treatment outcomes and toxicity
We report the outcomes of a multi-institutional cohort of patients treated with definitive radiotherapy for adrenal metastases, primarily using 10 fraction regimens. Retrospective review of institutional databases revealed 29 lesions in 27 patients were treated from 2005 to 2018 at two institutions. Outcome data, including local control, disease-free, and overall survival were abstracted from the medical record system. Toxicity was graded using CTCAE v5.0. Detailed radiotherapy data was abstracted from the treatment planning systems. The median dose was 50  Gy in 10 fractions. Actuarial 1 and 2 year local control was 86%...
Source: Clinical and Experimental Metastasis - July 21, 2020 Category: Cancer & Oncology Source Type: research

Histopathological growth patterns as biomarker for adjuvant systemic chemotherapy in patients with resected colorectal liver metastases
This study evaluates whether HGPs can predict the effectiveness of adjuvant CTx in patients with resected CRLM. Two main types of HGPs can be distinguished; the desmoplastic type and the non-desmoplastic type. Uni- and multivariable analyses for overall survival (OS) and disease-free survival (DFS) were performed, in both patients treated with and without preoperative chemotherapy. A total of 1236 patients from two tertiary centers (Memorial Sloan Kettering Cancer Center, New York, USA; Erasmus MC Cancer Institute, Rotterdam, The Netherlands) were included (period 2000 –2016). A total of 656 patients (53.1%) patients rec...
Source: Clinical and Experimental Metastasis - July 19, 2020 Category: Cancer & Oncology Source Type: research

CT based quantitative measures of the stability of fractured metastatically involved vertebrae treated with spine stereotactic body radiotherapy
This study quantified computed tomography (CT) based stability measures in metastatic vertebrae with VCF treated with spine SBRT. It was hypothesized that semi-automated quantification of VCF based on CT metrics would be related to clinical outcomes. 128 SBRT treated spinal metastases patients were identified from a prospective database. Of these, 18 vertebral segments were identified with a VCF post-SBRT. A semi-automated system for quantifying VCF was developed based on CT imaging before and after SBRT. The system identified and segmented SBRT treated vertebral bodies, calculated stability metrics at single time points a...
Source: Clinical and Experimental Metastasis - July 7, 2020 Category: Cancer & Oncology Source Type: research

Sociocultural incentives for cancer care implementation
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - July 6, 2020 Category: Cancer & Oncology Source Type: research

Mass spectrometry-based proteomic capture of proteins bound to the MACC1 promoter in colon cancer
AbstractMACC1 (metastasis associated in colon cancer 1) is a key driver that induces metastasis in colon cancer. However, the mechanisms by which MACC1 expression is transcriptionally regulated and the factors enriched at the MACC1 promoter remain largely unknown. The binding of proteins to specific DNA sites in the genome is a major determinant of genomic maintenance and the regulation of specific genes. The study herein utilized two methods to study the binding proteins of the MACC1 promoter region in colon cancer. Specifically, we adopted CRISPR-based chromatin affinity purification with mass spectrometry (CRISPR-ChAP-M...
Source: Clinical and Experimental Metastasis - June 30, 2020 Category: Cancer & Oncology Source Type: research

Assessment of incentivizing effects for cancer care frameworks
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - June 16, 2020 Category: Cancer & Oncology Source Type: research

Phase II trial of high dose stereotactic body radiation therapy for lymph node oligometastases
AbstractLymph nodes are common sites of oligometastases for several primaries. Stereotactic body radiation therapy (SBRT) represents an effective treatment but no consensus exists regarding dose and fractionation. Aim of this trial was to evaluate safety and efficacy of high-dose SBRT. We included patients with 1 to 3 lymph node metastases. Primary end-point was safety, while secondary end-points were in-field local control (LC), out-field lymph nodal progression free survival (LPFS), distant metastasis free survival (DMFS), progression free survival (PFS) and overall survival (OS). 64 lesions in 52 patients were treated f...
Source: Clinical and Experimental Metastasis - June 14, 2020 Category: Cancer & Oncology Source Type: research

Comparing the fate of brain metastatic breast cancer cells in different immune compromised mice with cellular magnetic resonance imaging
AbstractMetastasis is the leading cause of mortality in breast cancer patients, with brain metastases becoming increasingly prevalent. Studying this disease is challenging due to the limited experimental models and methods available. Here, we used iron-based cellular MRI to track the fate of a mammary carcinoma cell line (MDA-MB-231-BR) in vivo to characterize the growth of brain metastases in the nude and severely immune-compromised NOD/SCID/ILIIrg −/− (NSG) mouse. Nude and NSG mice received injections of iron-labeled MDA-MB-231-BR cells. Images were acquired with a 3T MR system and assessed for signal voids and metas...
Source: Clinical and Experimental Metastasis - June 11, 2020 Category: Cancer & Oncology Source Type: research