Pain mechanisms for the practicing rheumatologist
Best Pract Res Clin Rheumatol. 2024 Mar 22:101942. doi: 10.1016/j.berh.2024.101942. Online ahead of print.ABSTRACTPain in rheumatic diseases transcends the traditional nociceptive paradigm, incorporating complex interactions between nociceptive, neuropathic, and nociplastic mechanisms, as well as significant psychosocial factors. Advances in understanding chronic pain highlight the role of peripheral and central sensitization, and the emergence of nociplastic pain-a result of altered central nervous system processing. This modern perspective acknowledges the influence of mood disorders, environmental stressors, and cogniti...
Source: Clin Med Res - March 23, 2024 Category: Research Authors: Deeba Minhas Source Type: research
Suicidal ideation in patients with diabetes and childhood abuse - The mediating role of personality functioning: Results of a German representative population-based study
CONCLUSIONS: Diabetes patients experience increased SID prevalences, especially those with emotional or sexual abuse. In individuals with a history of emotional abuse, impaired personality functioning partly explained SID and should therefore be considered and addressed in this patient group.PMID:38521129 | DOI:10.1016/j.diabres.2024.111635 (Source: Clin Med Res)
Source: Clin Med Res - March 23, 2024 Category: Research Authors: Sandra Zara Johannes Kruse Elmar Br ähler Cedric Sachser J örg M Fegert Karl-Heinz Ladwig Mareike Ernst Hanna Kampling Source Type: research
Pain mechanisms for the practicing rheumatologist
Best Pract Res Clin Rheumatol. 2024 Mar 22:101942. doi: 10.1016/j.berh.2024.101942. Online ahead of print.ABSTRACTPain in rheumatic diseases transcends the traditional nociceptive paradigm, incorporating complex interactions between nociceptive, neuropathic, and nociplastic mechanisms, as well as significant psychosocial factors. Advances in understanding chronic pain highlight the role of peripheral and central sensitization, and the emergence of nociplastic pain-a result of altered central nervous system processing. This modern perspective acknowledges the influence of mood disorders, environmental stressors, and cogniti...
Source: Clin Med Res - March 23, 2024 Category: Research Authors: Deeba Minhas Source Type: research
Suicidal ideation in patients with diabetes and childhood abuse - The mediating role of personality functioning: Results of a German representative population-based study
CONCLUSIONS: Diabetes patients experience increased SID prevalences, especially those with emotional or sexual abuse. In individuals with a history of emotional abuse, impaired personality functioning partly explained SID and should therefore be considered and addressed in this patient group.PMID:38521129 | DOI:10.1016/j.diabres.2024.111635 (Source: Clin Med Res)
Source: Clin Med Res - March 23, 2024 Category: Research Authors: Sandra Zara Johannes Kruse Elmar Br ähler Cedric Sachser J örg M Fegert Karl-Heinz Ladwig Mareike Ernst Hanna Kampling Source Type: research
Pain mechanisms for the practicing rheumatologist
Best Pract Res Clin Rheumatol. 2024 Mar 22:101942. doi: 10.1016/j.berh.2024.101942. Online ahead of print.ABSTRACTPain in rheumatic diseases transcends the traditional nociceptive paradigm, incorporating complex interactions between nociceptive, neuropathic, and nociplastic mechanisms, as well as significant psychosocial factors. Advances in understanding chronic pain highlight the role of peripheral and central sensitization, and the emergence of nociplastic pain-a result of altered central nervous system processing. This modern perspective acknowledges the influence of mood disorders, environmental stressors, and cogniti...
Source: Clin Med Res - March 23, 2024 Category: Research Authors: Deeba Minhas Source Type: research
Large language models as decision aids in neuro-oncology: a review of shared decision-making applications
J Cancer Res Clin Oncol. 2024 Mar 19;150(3):139. doi: 10.1007/s00432-024-05673-x.ABSTRACTShared decision-making (SDM) is crucial in neuro-oncology, fostering collaborations between patients and healthcare professionals to navigate treatment options. However, the complexity of neuro-oncological conditions and the cognitive and emotional burdens on patients present significant barriers to achieving effective SDM. This discussion explores the potential of large language models (LLMs) such as OpenAI's ChatGPT and Google's Bard to overcome these barriers, offering a means to enhance patient understanding and engagement in their...
Source: Clin Med Res - March 20, 2024 Category: Research Authors: Aaron Lawson McLean Yonghui Wu Anna C Lawson McLean Vagelis Hristidis Source Type: research
Large language models as decision aids in neuro-oncology: a review of shared decision-making applications
J Cancer Res Clin Oncol. 2024 Mar 19;150(3):139. doi: 10.1007/s00432-024-05673-x.ABSTRACTShared decision-making (SDM) is crucial in neuro-oncology, fostering collaborations between patients and healthcare professionals to navigate treatment options. However, the complexity of neuro-oncological conditions and the cognitive and emotional burdens on patients present significant barriers to achieving effective SDM. This discussion explores the potential of large language models (LLMs) such as OpenAI's ChatGPT and Google's Bard to overcome these barriers, offering a means to enhance patient understanding and engagement in their...
Source: Clin Med Res - March 20, 2024 Category: Research Authors: Aaron Lawson McLean Yonghui Wu Anna C Lawson McLean Vagelis Hristidis Source Type: research
Large language models as decision aids in neuro-oncology: a review of shared decision-making applications
J Cancer Res Clin Oncol. 2024 Mar 19;150(3):139. doi: 10.1007/s00432-024-05673-x.ABSTRACTShared decision-making (SDM) is crucial in neuro-oncology, fostering collaborations between patients and healthcare professionals to navigate treatment options. However, the complexity of neuro-oncological conditions and the cognitive and emotional burdens on patients present significant barriers to achieving effective SDM. This discussion explores the potential of large language models (LLMs) such as OpenAI's ChatGPT and Google's Bard to overcome these barriers, offering a means to enhance patient understanding and engagement in their...
Source: Clin Med Res - March 20, 2024 Category: Research Authors: Aaron Lawson McLean Yonghui Wu Anna C Lawson McLean Vagelis Hristidis Source Type: research
Large language models as decision aids in neuro-oncology: a review of shared decision-making applications
J Cancer Res Clin Oncol. 2024 Mar 19;150(3):139. doi: 10.1007/s00432-024-05673-x.ABSTRACTShared decision-making (SDM) is crucial in neuro-oncology, fostering collaborations between patients and healthcare professionals to navigate treatment options. However, the complexity of neuro-oncological conditions and the cognitive and emotional burdens on patients present significant barriers to achieving effective SDM. This discussion explores the potential of large language models (LLMs) such as OpenAI's ChatGPT and Google's Bard to overcome these barriers, offering a means to enhance patient understanding and engagement in their...
Source: Clin Med Res - March 20, 2024 Category: Research Authors: Aaron Lawson McLean Yonghui Wu Anna C Lawson McLean Vagelis Hristidis Source Type: research
Major Adverse Events in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH and TODAY Studies
CONCLUSIONS: In youth-onset diabetes, end-organ events were infrequent but did occur before 15 years diabetes duration. Rates were higher and had different risk factors in T2D versus T1D.PMID:38493952 | DOI:10.1016/j.diabres.2024.111606 (Source: Clin Med Res)
Source: Clin Med Res - March 17, 2024 Category: Research Authors: Amy K Mottl Jeanie B Tryggestad Scott Isom Rose A Gubitosi-Klug Leora Henkin Neil H White Ralph D'Agostino Kara S Hughan Lawrence M Dolan Kimberly L Drews SEARCH for Diabetes in Youth Study Group TODAY Study Group Source Type: research
Major Adverse Events in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH and TODAY Studies
CONCLUSIONS: In youth-onset diabetes, end-organ events were infrequent but did occur before 15 years diabetes duration. Rates were higher and had different risk factors in T2D versus T1D.PMID:38493952 | DOI:10.1016/j.diabres.2024.111606 (Source: Clin Med Res)
Source: Clin Med Res - March 17, 2024 Category: Research Authors: Amy K Mottl Jeanie B Tryggestad Scott Isom Rose A Gubitosi-Klug Leora Henkin Neil H White Ralph D'Agostino Kara S Hughan Lawrence M Dolan Kimberly L Drews SEARCH for Diabetes in Youth Study Group TODAY Study Group Source Type: research
Major Adverse Events in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH and TODAY Studies
CONCLUSIONS: In youth-onset diabetes, end-organ events were infrequent but did occur before 15 years diabetes duration. Rates were higher and had different risk factors in T2D versus T1D.PMID:38493952 | DOI:10.1016/j.diabres.2024.111606 (Source: Clin Med Res)
Source: Clin Med Res - March 17, 2024 Category: Research Authors: Amy K Mottl Jeanie B Tryggestad Scott Isom Rose A Gubitosi-Klug Leora Henkin Neil H White Ralph D'Agostino Kara S Hughan Lawrence M Dolan Kimberly L Drews SEARCH for Diabetes in Youth Study Group TODAY Study Group Source Type: research
Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers' cohort study
CONCLUSIONS: Overweight/obesity was associated with the risk of CVD and its subtypes. About 30% of the risk was explained by hypertension, hyper-LDL-cholesterolemia, and diabetes, of which hypertension accounted for approximately the half of the explained risk. However, overweight/obesity increased the risk of CVD even in those without hypertension. These findings highlight the importance of controlling and preventing overweight/obesity regardless of chronic disease status.PMID:38480065 | DOI:10.1016/j.orcp.2024.02.006 (Source: Clin Med Res)
Source: Clin Med Res - March 13, 2024 Category: Research Authors: Abubakr Ahmed Abdullah Al-Shoaibi Yuanying Li Zean Song Young Jae Hong Chifa Chiang Yoshihisa Nakano Yoshihisa Hirakawa Masaaki Matsunaga Atsuhiko Ota Koji Tamakoshi Hiroshi Yatsuya Source Type: research
Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers' cohort study
CONCLUSIONS: Overweight/obesity was associated with the risk of CVD and its subtypes. About 30% of the risk was explained by hypertension, hyper-LDL-cholesterolemia, and diabetes, of which hypertension accounted for approximately the half of the explained risk. However, overweight/obesity increased the risk of CVD even in those without hypertension. These findings highlight the importance of controlling and preventing overweight/obesity regardless of chronic disease status.PMID:38480065 | DOI:10.1016/j.orcp.2024.02.006 (Source: Clin Med Res)
Source: Clin Med Res - March 13, 2024 Category: Research Authors: Abubakr Ahmed Abdullah Al-Shoaibi Yuanying Li Zean Song Young Jae Hong Chifa Chiang Yoshihisa Nakano Yoshihisa Hirakawa Masaaki Matsunaga Atsuhiko Ota Koji Tamakoshi Hiroshi Yatsuya Source Type: research
Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers' cohort study
CONCLUSIONS: Overweight/obesity was associated with the risk of CVD and its subtypes. About 30% of the risk was explained by hypertension, hyper-LDL-cholesterolemia, and diabetes, of which hypertension accounted for approximately the half of the explained risk. However, overweight/obesity increased the risk of CVD even in those without hypertension. These findings highlight the importance of controlling and preventing overweight/obesity regardless of chronic disease status.PMID:38480065 | DOI:10.1016/j.orcp.2024.02.006 (Source: Clin Med Res)
Source: Clin Med Res - March 13, 2024 Category: Research Authors: Abubakr Ahmed Abdullah Al-Shoaibi Yuanying Li Zean Song Young Jae Hong Chifa Chiang Yoshihisa Nakano Yoshihisa Hirakawa Masaaki Matsunaga Atsuhiko Ota Koji Tamakoshi Hiroshi Yatsuya Source Type: research
