Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TRK-0315)
CONCLUSIONS: Our data reveal that a considerable proportion of patients with mNSCLC are not eligible to participate in a clinical trial and were found to have worse outcomes than potentially trial-eligible patients, whose outcomes were comparable with those obtained from pivotal clinical trials. This is of substantial clinical relevance for physicians discussing outcomes to be expected with their patients and stresses the need for real-world effectiveness analyses.PMID:38586301 | PMC:PMC10995980 | DOI:10.1016/j.jtocrr.2023.100626 (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Frank Griesinger Martin Sebastian Wolfgang M Brueckl Horst-Dieter Hummel Bastian Jaeschke Jens Kern Claas Wesseler Martina J änicke Annette Fleitz Stefan Zacharias Annette Hipper Annika Groth Wilko Weichert Steffen D örfel Volker Petersen Jan Schr öder Source Type: research
The role of coronary artery disease in lung transplantation: a propensity-matched analysis
CONCLUSION: In this cohort, relevant CAD was not associated with worse outcomes and should therefore not be considered a contraindication for LuTx. Nonetheless, cardiovascular events in CAD patients highlight the necessity of control of cardiovascular risk factors and a structured cardiac follow-up.PMID:38587564 | DOI:10.1007/s00392-024-02445-y (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Enzo L üsebrink Nils Gade Paula Seifert Felix Ceelen Tobias Veit Fabian Fohrer Sabine Hoffmann Julia H öpler Leonhard Binzenh öfer Daniel Roden Inas Saleh Hugo Lanz Sebastian Michel Christian Schneider Michael Irlbeck Roland Tomasi Rudolf Hatz J örg H Source Type: research
Mortality risk relationship using standard categorized BMI or knee-height based BMI - does the overweight/lower mortality paradox hold true?
CONCLUSION: Regardless of classic BMI or KH-BMI estimation, overweight men and women aged ≥ 80 years had a lower mortality risk compared to normal/underweight men and women ≥ 80 years.PMID:38587702 | DOI:10.1007/s40520-024-02742-6 (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Nivetha Natarajan Gavriilidou Mats Pihlsg ård S ölve Elmståhl Henrik Ekstr öm Source Type: research
Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TRK-0315)
CONCLUSIONS: Our data reveal that a considerable proportion of patients with mNSCLC are not eligible to participate in a clinical trial and were found to have worse outcomes than potentially trial-eligible patients, whose outcomes were comparable with those obtained from pivotal clinical trials. This is of substantial clinical relevance for physicians discussing outcomes to be expected with their patients and stresses the need for real-world effectiveness analyses.PMID:38586301 | PMC:PMC10995980 | DOI:10.1016/j.jtocrr.2023.100626 (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Frank Griesinger Martin Sebastian Wolfgang M Brueckl Horst-Dieter Hummel Bastian Jaeschke Jens Kern Claas Wesseler Martina J änicke Annette Fleitz Stefan Zacharias Annette Hipper Annika Groth Wilko Weichert Steffen D örfel Volker Petersen Jan Schr öder Source Type: research
The role of coronary artery disease in lung transplantation: a propensity-matched analysis
CONCLUSION: In this cohort, relevant CAD was not associated with worse outcomes and should therefore not be considered a contraindication for LuTx. Nonetheless, cardiovascular events in CAD patients highlight the necessity of control of cardiovascular risk factors and a structured cardiac follow-up.PMID:38587564 | DOI:10.1007/s00392-024-02445-y (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Enzo L üsebrink Nils Gade Paula Seifert Felix Ceelen Tobias Veit Fabian Fohrer Sabine Hoffmann Julia H öpler Leonhard Binzenh öfer Daniel Roden Inas Saleh Hugo Lanz Sebastian Michel Christian Schneider Michael Irlbeck Roland Tomasi Rudolf Hatz J örg H Source Type: research
Mortality risk relationship using standard categorized BMI or knee-height based BMI - does the overweight/lower mortality paradox hold true?
CONCLUSION: Regardless of classic BMI or KH-BMI estimation, overweight men and women aged ≥ 80 years had a lower mortality risk compared to normal/underweight men and women ≥ 80 years.PMID:38587702 | DOI:10.1007/s40520-024-02742-6 (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Nivetha Natarajan Gavriilidou Mats Pihlsg ård S ölve Elmståhl Henrik Ekstr öm Source Type: research
Prognostic utility and characteristics of MIB-1 labeling index as a proliferative activity marker in childhood low-grade glioma: a retrospective observational study
CONCLUSION: These data confirm a correlation of MIB-1 LI and radiologically detectable TGV in PLGG for the first time. Compared with preoperative TGV, a crucially decreasing correlation of MIB-1 LI and TGV after surgery may result in limited prognostic capability of MIB-1 LI in PLGG.PMID:38580878 | PMC:PMC10997709 | DOI:10.1007/s00432-024-05701-w (Source: Clin Med Res)
Source: Clin Med Res - April 5, 2024 Category: Research Authors: David Gorodezki Julian Zipfel Andrea Bevot Thomas N ägele Martin Ebinger Martin U Schuhmann Jens Schittenhelm Source Type: research
Prognostic utility and characteristics of MIB-1 labeling index as a proliferative activity marker in childhood low-grade glioma: a retrospective observational study
CONCLUSION: These data confirm a correlation of MIB-1 LI and radiologically detectable TGV in PLGG for the first time. Compared with preoperative TGV, a crucially decreasing correlation of MIB-1 LI and TGV after surgery may result in limited prognostic capability of MIB-1 LI in PLGG.PMID:38580878 | DOI:10.1007/s00432-024-05701-w (Source: Clin Med Res)
Source: Clin Med Res - April 5, 2024 Category: Research Authors: David Gorodezki Julian Zipfel Andrea Bevot Thomas N ägele Martin Ebinger Martin U Schuhmann Jens Schittenhelm Source Type: research
Prognostic impact of metabolic syndrome in patients with primary endometrial cancer: a retrospective bicentric study
CONCLUSION: In our analysis, MetS in patients with EC was not associated with impaired oncological outcome. However, our findings show that obesity itself is an important comorbidity associated with significantly reduced PFS.PMID:38570343 | PMC:PMC10991018 | DOI:10.1007/s00432-024-05699-1 (Source: Clin Med Res)
Source: Clin Med Res - April 3, 2024 Category: Research Authors: Ina Shehaj Slavomir Krajnak Morva Tahmasbi Rad Bahar Gasimli Annette Hasenburg Thomas Karn Marcus Schmidt Volker M üller Sven Becker Khayal Gasimli Source Type: research
Prognostic impact of metabolic syndrome in patients with primary endometrial cancer: a retrospective bicentric study
CONCLUSION: In our analysis, MetS in patients with EC was not associated with impaired oncological outcome. However, our findings show that obesity itself is an important comorbidity associated with significantly reduced PFS.PMID:38570343 | PMC:PMC10991018 | DOI:10.1007/s00432-024-05699-1 (Source: Clin Med Res)
Source: Clin Med Res - April 3, 2024 Category: Research Authors: Ina Shehaj Slavomir Krajnak Morva Tahmasbi Rad Bahar Gasimli Annette Hasenburg Thomas Karn Marcus Schmidt Volker M üller Sven Becker Khayal Gasimli Source Type: research
Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas
CONCLUSIONS: Our study has identified CSMD1 as a tumor suppressor in gliomas and elucidated its role in TNF-induced neuroinflammation, contributing to a deeper understanding of glioma pathogenesis.PMID:38561856 | PMC:PMC10986120 | DOI:10.1186/s13046-024-03019-6 (Source: Clin Med Res)
Source: Clin Med Res - April 2, 2024 Category: Research Authors: Emre Can Tuysuz Eleni Mourati Rebecca Rosberg Aleksandra Moskal Chrysostomi Gialeli Elinn Johansson Valeria Governa Mattias Belting Alexander Pietras Anna M Blom Source Type: research
Impact of pulmonary hypertension on outcomes after TEER in patients suffering from mitral regurgitation
CONCLUSION: PAWP at baseline was significantly and independently associated with HFH and might serve as a valuable parameter for identifying patients at high risk for HFH after M-TEER. ACM and procedural success were not affected by pulmonary arterial pressure before M-TEER. We suggest that the post-capillary component of PH serves as the driving force behind the risk of HFH.PMID:38565712 | DOI:10.1007/s00392-024-02442-1 (Source: Clin Med Res)
Source: Clin Med Res - April 2, 2024 Category: Research Authors: Philippa Jaeger Ioannis Toskas Jessica-Kristin Henes Serhii Shcherbyna Frederic Schwarz Miriam Euper Peter Seizer Harald Langer Andreas E May Tobias Geisler Meinrad Gawaz J ürgen Schreieck Dominik Rath Source Type: research
Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas
CONCLUSIONS: Our study has identified CSMD1 as a tumor suppressor in gliomas and elucidated its role in TNF-induced neuroinflammation, contributing to a deeper understanding of glioma pathogenesis.PMID:38561856 | PMC:PMC10986120 | DOI:10.1186/s13046-024-03019-6 (Source: Clin Med Res)
Source: Clin Med Res - April 2, 2024 Category: Research Authors: Emre Can Tuysuz Eleni Mourati Rebecca Rosberg Aleksandra Moskal Chrysostomi Gialeli Elinn Johansson Valeria Governa Mattias Belting Alexander Pietras Anna M Blom Source Type: research
Impact of pulmonary hypertension on outcomes after TEER in patients suffering from mitral regurgitation
CONCLUSION: PAWP at baseline was significantly and independently associated with HFH and might serve as a valuable parameter for identifying patients at high risk for HFH after M-TEER. ACM and procedural success were not affected by pulmonary arterial pressure before M-TEER. We suggest that the post-capillary component of PH serves as the driving force behind the risk of HFH.PMID:38565712 | DOI:10.1007/s00392-024-02442-1 (Source: Clin Med Res)
Source: Clin Med Res - April 2, 2024 Category: Research Authors: Philippa Jaeger Ioannis Toskas Jessica-Kristin Henes Serhii Shcherbyna Frederic Schwarz Miriam Euper Peter Seizer Harald Langer Andreas E May Tobias Geisler Meinrad Gawaz J ürgen Schreieck Dominik Rath Source Type: research
Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas
CONCLUSIONS: Our study has identified CSMD1 as a tumor suppressor in gliomas and elucidated its role in TNF-induced neuroinflammation, contributing to a deeper understanding of glioma pathogenesis.PMID:38561856 | DOI:10.1186/s13046-024-03019-6 (Source: Clin Med Res)
Source: Clin Med Res - April 2, 2024 Category: Research Authors: Emre Can Tuysuz Eleni Mourati Rebecca Rosberg Aleksandra Moskal Chrysostomi Gialeli Elinn Johansson Valeria Governa Mattias Belting Alexander Pietras Anna M Blom Source Type: research
