Compliance of Prone Positioning in Non-Intubated COVID-19 Patients
Clin Med Res. 2023 Dec;21(4):171-176. doi: 10.3121/cmr.2023.1830.NO ABSTRACTPMID:38296641 | DOI:10.3121/cmr.2023.1830 (Source: Clin Med Res)
Source: Clin Med Res - January 31, 2024 Category: Research Authors: Christopher G Bargoud Tingyu Jih Danika Baskar Lindsay Volk Sheraz Siddiqui Mafudia Suaray Rory Ulloque Sara Khalil Rachel L Choron Source Type: research
Investigating the Effect of Temperature Therapy on the Severity of Restless Legs Syndrome: Systematic Review and Meta-Analysis
Conclusion: The present study findings suggested temperature therapy could mildly reduce the severity of RLS symptoms. It was also found that the highest efficacy of this intervention could be achieved when the higher temperature was used in fewer treatment sessions in hemodialysis patients. Based on our findings, this intervention can be included in the care plan of patients with RLS considering the settings described to achieve the highest efficacy.PMID:38296642 | DOI:10.3121/cmr.2023.1824 (Source: Clin Med Res)
Source: Clin Med Res - January 31, 2024 Category: Research Authors: Mohammad Mehdi Mohammadi Ali Akbar Vaisi Raygani Source Type: research
Distance Matters: Investigating No-Shows in a Large Rural Provider Network
Conclusion: Our analysis showed patients who lived <5 miles and >20 miles from the clinic had higher no-show rates. The odds of a no-show were comparable between patients who showed up and those who did not. Male patients, Spanish-speaking patients, patients with a history of no-shows, and Medicaid beneficiaries were more likely to miss their appointments. Understanding the impact of these variables on no-show rates can assist healthcare providers in developing strategies to improve patient access and reduce no-show rates. These findings imply that rural patients may face a variety of barriers when seeking healthcare...
Source: Clin Med Res - January 31, 2024 Category: Research Authors: Abdul Shour Adedayo A Onitilo Source Type: research
Association between iron deficiency anemia and subsequent stomach and colorectal cancer diagnosis in Germany
CONCLUSION: These findings add to the literature and suggest an association between IDA and GI cancers. The extent to which this association is due to GI bleeding or other pathophysiological processes that may be caused by IDA requires further investigation, particularly experimental studies.PMID:38289465 | PMC:PMC10827837 | DOI:10.1007/s00432-023-05534-z (Source: Clin Med Res)
Source: Clin Med Res - January 30, 2024 Category: Research Authors: Sarah Krieg Sven Loosen Andreas Krieg Tom Luedde Christoph Roderburg Karel Kostev Source Type: research
Short-term serial circulating tumor DNA assessment predicts therapeutic efficacy for patients with advanced pancreatic cancer
CONCLUSION: This short-term ctDNA kinetics assessment may provide predictive information to reflect real-time therapeutic response and lead to effective refinement of regimen in patients with advanced pancreatic cancer undergoing systemic chemotherapy.PMID:38277079 | PMC:PMC10817839 | DOI:10.1007/s00432-023-05594-1 (Source: Clin Med Res)
Source: Clin Med Res - January 26, 2024 Category: Research Authors: Hideki Motobayashi Yuji Kitahata Ken-Ichi Okada Motoki Miyazawa Masaki Ueno Shinya Hayami Atsushi Miyamoto Atsushi Shimizu Masatoshi Sato Tomohiro Yoshimura Yuki Nakamura Norio Takemoto Tomoki Nakai Takahiko Hyo Kyohei Matsumoto Hiroki Yamaue Manabu Kawai Source Type: research
Augmenting MEK inhibitor efficacy in BRAF wild-type melanoma: synergistic effects of disulfiram combination therapy
CONCLUSIONS: Disulfiram and its metabolite represent an attractive pharmaceutical approach to induce ER stress in melanoma cells that potentiates the antitumor effect of MEK inhibition and may be an interesting candidate for combination therapy of BRAF WT melanoma.PMID:38263136 | PMC:PMC10804659 | DOI:10.1186/s13046-023-02941-5 (Source: Clin Med Res)
Source: Clin Med Res - January 23, 2024 Category: Research Authors: Francisco Meraz-Torres Heike Niessner Sarah Pl öger Simon Riel Barbara Sch örg Nicolas Casadei Manfred Kneilling Martin Schaller Lukas Flatz Boris Macek Thomas Eigentler Olaf Rie ß Claus Garbe Teresa Amaral Tobias Sinnberg Source Type: research
Quality of life of persons with painful diabetic neuropathy: How can we improve it?
Diabetes Res Clin Pract. 2023 Dec;206 Suppl 1:110756. doi: 10.1016/j.diabres.2023.110756.ABSTRACTPainful diabetic neuropathy (PDN) is difficult to treat, with pharmacological treatments providing only partial pain relief that is limited by medication side effects. This necessitates a holistic approach to pain control,with pharmacological treatments supplemented by the management of psychosocial aspects of pain experience. Pain catastrophising and psychological flexibility are among the psychological constructs impacting persons' adaptation to PDN. While the former increases disability and reduces quality of life (QoL), the...
Source: Clin Med Res - January 20, 2024 Category: Research Authors: Loretta Vileikyte Source Type: research
Autonomic diabetic neuropathies: A brief overview
This article summarizes the latest epidemiology of diabetic autonomic neuropathy (DAN), and provides a brief overview on epidemiology, current outcomes measures for screening and diagnosis in research and clinical settings, the latest evidence on effective management, and novel perspectives on the impacts of social determinants of health in development and management of DAN. Among the various forms of diabetic neuropathy, distal symmetric polyneuropathy and diabetic autonomic neuropathies, particularly cardiovascular autonomic neuropathy, are by far the most studied. However, emerging data highlight the impact of other for...
Source: Clin Med Res - January 20, 2024 Category: Research Authors: Rodica Pop-Busui Source Type: research
Where does spinal cord stimulation fit into the international guidelines for refractory painful diabetic neuropathy? a consensus statement
CONCLUSION: Globally, the use of opioids should rarely be recommended for refractory, severe PDN. Based on increasing clinical evidence, SCS, especially HF-SCS, should be considered as a treatment for PDN that is not responsive to first- or second-line monotherapy/dual therapy.PMID:38245326 | DOI:10.1016/j.diabres.2023.110763 (Source: Clin Med Res)
Source: Clin Med Res - January 20, 2024 Category: Research Authors: A J M Boulton T S Jensen T Luecke E A Petersen R Pop-Busui R S Taylor S Tesfaye L Vileikyte D Ziegler Source Type: research
A brief overview of the diabetic neuropathies
Diabetes Res Clin Pract. 2023 Dec;206 Suppl 1:110758. doi: 10.1016/j.diabres.2023.110758.ABSTRACTThe diabetic neuropathies represent the commonest long-term complications of diabetes, and may be the presenting feature of Type 2 diabetes. In clinical practice, distal symmetrical polyneuropathy (DSPN) and the autonomic neuropathies are the most frequently seen forms of diabetic neuropathy. The 2017 American Diabetes Association classification system for the neuropathies of diabetes are in general use. Treatment challenges remain and the need for revised recommendations and further discussion of management of severely painful...
Source: Clin Med Res - January 20, 2024 Category: Research Authors: Andrew J M Boulton Source Type: research
Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function
CONCLUSION: In patients with low-flow severe aortic stenosis, low transaortic gradient and cardiac output are not primarily due to LV dysfunction or global changes in gene expression, but may be attributed to other additional cardiac pathologies like mitral regurgitation, atrial fibrillation or right ventricular dysfunction. These factors should also be considered during planning of aortic valve replacement.PMID:38236417 | DOI:10.1007/s00392-023-02372-4 (Source: Clin Med Res)
Source: Clin Med Res - January 18, 2024 Category: Research Authors: Svante Gersch Torben Lange Bo Eric Beuthner Manar Elkenani Niels Paul Moritz Schnelle Elisabeth Zeisberg Miriam Puls Gerd Hasenfu ß Andreas Schuster Karl Toischer Source Type: research
Long-term survival of stage IV melanoma patients: evaluation on 640 melanoma patients entering stage IV between 2014 and 2017
CONCLUSION: This dataset comprises the largest available cohort of long-term surviving stage IV melanoma patients. Since 90% of patients in our cohort are still alive today, we expect an increasing number of long-term survivors in the future. Our data indicate the need for specific follow-up programs addressing the needs of long-term survivors.PMID:38238578 | PMC:PMC10796594 | DOI:10.1007/s00432-023-05533-0 (Source: Clin Med Res)
Source: Clin Med Res - January 18, 2024 Category: Research Authors: Markus Reitmajer Ulrike Leiter Lena Nanz Teresa Amaral Lukas Flatz Claus Garbe Andrea Forschner Source Type: research
Analysis of laboratory parameters before the occurrence of hepatic sinusoidal obstruction syndrome in children, adolescents, and young adults after hematopoietic stem cell transplantation
CONCLUSION: In summary, the laboratory parameters INR, aPTT, protein C, and ferritin were very useful to predict the occurrence of SOS. In addition, this is the first report on a significant association between SOS and high values of INR and aPTT after HSCT before SOS.PMID:38206490 | PMC:PMC10784366 | DOI:10.1007/s00432-023-05561-w (Source: Clin Med Res)
Source: Clin Med Res - January 11, 2024 Category: Research Authors: Lorena Johann Bernd Gruhn Source Type: research
Disparities in Palliative Care Among Critically Ill Patients With and Without COVID-19 at the End of Life: A Population-Based Analysis
CONCLUSIONS: PC was markedly less common among critically ill septic patients with COVID-19 during terminal hospitalization, compared to those without COVID-19. Further studies are needed to determine the factors underlying these findings in order to reduce disparities in use of PC.PMID:38189035 | PMC:PMC10769605 | DOI:10.14740/jocmr5027 (Source: Clin Med Res)
Source: Clin Med Res - January 8, 2024 Category: Research Authors: Lavi Oud Source Type: research
Cardiac Amyloidosis Patient With Cardiac Conduction Disturbances
J Clin Med Res. 2023 Dec;15(10-11):456-460. doi: 10.14740/jocmr5051. Epub 2023 Dec 9.ABSTRACTTransthyretin cardiac amyloidosis (ATTR-CA) has recently been diagnosed more because of advances in diagnostic techniques, such as 99mTc-labeled pyrophosphate (99mTc-PYP) scintigraphy. ATTR-CA remains poorly diagnosed by many physicians, except for cardiologists and neurologists, and by patients. In this manuscript, we present a patient who was recommended to undergo a close examination but developed cardiac conduction disturbances and defects due to delays in the examination and treatment initiation. The patient was a 72-year-old ...
Source: Clin Med Res - January 8, 2024 Category: Research Authors: Keisuke Hosono Shunsuke Kiuchi Takanori Ikeda Source Type: research
