Retrospective Study of IDegLira, a New Fixed-Ratio Combination, in Japanese Patients With Type 2 Diabetes Mellitus: Analysis of Background Factors Affecting Effectiveness After 6 Months of Treatment
CONCLUSION: In this study, initiation of IDegLira in a real-world clinical setting was beneficial in lowering HbA1c in Japanese T2DM patients with inadequate glycemic control with existing therapy.PMID:37822852 | PMC:PMC10563818 | DOI:10.14740/jocmr4995 (Source: Clin Med Res)
Source: Clin Med Res - October 12, 2023 Category: Research Authors: Hodaka Yamada Jun Morimoto Shunsuke Funazaki Shiori Tonezawa Asuka Takahashi Masashi Yoshida Shuichi Nagashima Kazuo Hara Source Type: research
Computer-Aided Pulmonary Fibrosis Detection Leveraging an Advanced Artificial Intelligence Triage and Notification Software
CONCLUSIONS: ScreenDx-LungFibrosis™ accurately and reliably identified PF with a rapid per-case processing time, underscoring its potential for transformative improvement in PF outcomes when routinely applied to chest CTs.PMID:37822853 | PMC:PMC10563821 | DOI:10.14740/jocmr5020 (Source: Clin Med Res)
Source: Clin Med Res - October 12, 2023 Category: Research Authors: Kavitha C Selvan Angad Kalra Joshua Reicher Michael Muelly Ayodeji Adegunsoye Source Type: research
Hypernatremia: Epidemiology and Predictive Role in Emerging and Established Acute Kidney Injury
In conclusion, hypernatremic individuals are at higher risk of death during in-hospital therapy. Also, the electrolyte disorder potentially qualifies as a future biomarker for AKI onset and AKI-associated mortality.PMID:37822854 | PMC:PMC10563820 | DOI:10.14740/jocmr4990 (Source: Clin Med Res)
Source: Clin Med Res - October 12, 2023 Category: Research Authors: Clara Jansch Igor Matyukhin Marahrens Marahrens Rebecca Lehmann Baschar Khader Oliver Ritter Susann Patschan Daniel Patschan Source Type: research
Comparative analysis of diagnostic ultrasound and histopathology for detecting cervical lymph node metastases in head and neck cancer
CONCLUSION: Our LN mapping and meticulous 1:1 node-by-node comparison reveals the usefulness of US for detecting metastatic involvement of neck LNs in head and neck carcinomas as compared to histopathology. The predictive ability for small tumor deposits less than 8 mm in size remains weak and urgently needs improvement.PMID:37823935 | DOI:10.1007/s00432-023-05439-x (Source: Clin Med Res)
Source: Clin Med Res - October 12, 2023 Category: Research Authors: Karl Christoph Sproll Iryna Hermes Gerd Felder Nikolas H Stoecklein Maximilian Seidl Peter Kaiser Wolfgang Kaisers Source Type: research
Opioid Free Total Intravenous Anesthesia With Dexmedetomidine-Esketamine-Lidocaine for Patients Undergoing Lumpectomy
CONCLUSION: For patients undergoing lumpectomy, OFA technique with dexmedetomidine-esketamine-lidocaine showed a better postoperative analgesic efficacy, a more stable hemodynamics, and a lower incidence of PONV. However, such advantage of OFA technique should be weighed against a longer awakening time and recovery time of orientation in clinical practice.PMID:37822850 | PMC:PMC10563822 | DOI:10.14740/jocmr5000 (Source: Clin Med Res)
Source: Clin Med Res - October 12, 2023 Category: Research Authors: Xia Li Qian Ping Li Ya Jie Chen Shi Qin Xu Xian Wang Shan Wu Feng Source Type: research
Beyond Human Limits: Harnessing Artificial Intelligence to Optimize Immunosuppression in Kidney Transplantation
J Clin Med Res. 2023 Sep;15(8-9):391-398. doi: 10.14740/jocmr5012. Epub 2023 Sep 30.ABSTRACTThe field of kidney transplantation is being revolutionized by the integration of artificial intelligence (AI) and machine learning (ML) techniques. AI equips machines with human-like cognitive abilities, while ML enables computers to learn from data. Challenges in transplantation, such as organ allocation and prediction of allograft function or rejection, can be addressed through AI-powered algorithms. These algorithms can optimize immunosuppression protocols and improve patient care. This comprehensive literature review provides a...
Source: Clin Med Res - October 12, 2023 Category: Research Authors: Debargha Basuli Sasmit Roy Source Type: research
Retrospective Study of IDegLira, a New Fixed-Ratio Combination, in Japanese Patients With Type 2 Diabetes Mellitus: Analysis of Background Factors Affecting Effectiveness After 6 Months of Treatment
CONCLUSION: In this study, initiation of IDegLira in a real-world clinical setting was beneficial in lowering HbA1c in Japanese T2DM patients with inadequate glycemic control with existing therapy.PMID:37822852 | PMC:PMC10563818 | DOI:10.14740/jocmr4995 (Source: Clin Med Res)
Source: Clin Med Res - October 12, 2023 Category: Research Authors: Hodaka Yamada Jun Morimoto Shunsuke Funazaki Shiori Tonezawa Asuka Takahashi Masashi Yoshida Shuichi Nagashima Kazuo Hara Source Type: research
Computer-Aided Pulmonary Fibrosis Detection Leveraging an Advanced Artificial Intelligence Triage and Notification Software
CONCLUSIONS: ScreenDx-LungFibrosis™ accurately and reliably identified PF with a rapid per-case processing time, underscoring its potential for transformative improvement in PF outcomes when routinely applied to chest CTs.PMID:37822853 | PMC:PMC10563821 | DOI:10.14740/jocmr5020 (Source: Clin Med Res)
Source: Clin Med Res - October 12, 2023 Category: Research Authors: Kavitha C Selvan Angad Kalra Joshua Reicher Michael Muelly Ayodeji Adegunsoye Source Type: research
Hypernatremia: Epidemiology and Predictive Role in Emerging and Established Acute Kidney Injury
In conclusion, hypernatremic individuals are at higher risk of death during in-hospital therapy. Also, the electrolyte disorder potentially qualifies as a future biomarker for AKI onset and AKI-associated mortality.PMID:37822854 | PMC:PMC10563820 | DOI:10.14740/jocmr4990 (Source: Clin Med Res)
Source: Clin Med Res - October 12, 2023 Category: Research Authors: Clara Jansch Igor Matyukhin Marahrens Marahrens Rebecca Lehmann Baschar Khader Oliver Ritter Susann Patschan Daniel Patschan Source Type: research
Comparative analysis of diagnostic ultrasound and histopathology for detecting cervical lymph node metastases in head and neck cancer
CONCLUSION: Our LN mapping and meticulous 1:1 node-by-node comparison reveals the usefulness of US for detecting metastatic involvement of neck LNs in head and neck carcinomas as compared to histopathology. The predictive ability for small tumor deposits less than 8 mm in size remains weak and urgently needs improvement.PMID:37823935 | DOI:10.1007/s00432-023-05439-x (Source: Clin Med Res)
Source: Clin Med Res - October 12, 2023 Category: Research Authors: Karl Christoph Sproll Iryna Hermes Gerd Felder Nikolas H Stoecklein Maximilian Seidl Peter Kaiser Wolfgang Kaisers Source Type: research
Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity
CONCLUSIONS: IL-1b-mediated Regnase-1 downregulation induces MDSCs and promotes pancreatic cancer through the evasion of anticancer immunity.PMID:37814340 | PMC:PMC10561497 | DOI:10.1186/s13046-023-02831-w (Source: Clin Med Res)
Source: Clin Med Res - October 9, 2023 Category: Research Authors: Junya Okabe Takahiro Kodama Yu Sato Satoshi Shigeno Takayuki Matsumae Kazuma Daiku Katsuhiko Sato Teppei Yoshioka Minoru Shigekawa Masaya Higashiguchi Shogo Kobayashi Hayato Hikita Tomohide Tatsumi Toru Okamoto Takashi Satoh Hidetoshi Eguchi Shizuo Akira Source Type: research
Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity
CONCLUSIONS: IL-1b-mediated Regnase-1 downregulation induces MDSCs and promotes pancreatic cancer through the evasion of anticancer immunity.PMID:37814340 | PMC:PMC10561497 | DOI:10.1186/s13046-023-02831-w (Source: Clin Med Res)
Source: Clin Med Res - October 9, 2023 Category: Research Authors: Junya Okabe Takahiro Kodama Yu Sato Satoshi Shigeno Takayuki Matsumae Kazuma Daiku Katsuhiko Sato Teppei Yoshioka Minoru Shigekawa Masaya Higashiguchi Shogo Kobayashi Hayato Hikita Tomohide Tatsumi Toru Okamoto Takashi Satoh Hidetoshi Eguchi Shizuo Akira Source Type: research
Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity
CONCLUSIONS: IL-1b-mediated Regnase-1 downregulation induces MDSCs and promotes pancreatic cancer through the evasion of anticancer immunity.PMID:37814340 | DOI:10.1186/s13046-023-02831-w (Source: Clin Med Res)
Source: Clin Med Res - October 9, 2023 Category: Research Authors: Junya Okabe Takahiro Kodama Yu Sato Satoshi Shigeno Takayuki Matsumae Kazuma Daiku Katsuhiko Sato Teppei Yoshioka Minoru Shigekawa Masaya Higashiguchi Shogo Kobayashi Hayato Hikita Tomohide Tatsumi Toru Okamoto Takashi Satoh Hidetoshi Eguchi Shizuo Akira Source Type: research
Rationale and design of a randomised phase III registration trial investigating finerenone in participants with type 1 diabetes and chronic kidney disease: The FINE-ONE trial
CONCLUSIONS: FINE-ONE will evaluate the efficacy and safety of finerenone in T1D and CKD. Finerenone could become the first registered treatment for CKD associated with T1D in almost 30 years.TRIAL REGISTRATION: ClinicalTrials.gov NCT05901831.PMID:37805000 | DOI:10.1016/j.diabres.2023.110908 (Source: Clin Med Res)
Source: Clin Med Res - October 7, 2023 Category: Research Authors: Hiddo J L Heerspink Andreas L Birkenfeld David Z I Cherney Helen M Colhoun Linong Ji Chantal Mathieu Per-Henrik Groop Richard E Pratley Sylvia E Rosas Peter Rossing Jay S Skyler Katherine R Tuttle Robert Lawatscheck Charlie Scott Robert Edfors Markus F Sc Source Type: research
Rationale and design of a randomised phase III registration trial investigating finerenone in participants with type 1 diabetes and chronic kidney disease: The FINE-ONE trial
CONCLUSIONS: FINE-ONE will evaluate the efficacy and safety of finerenone in T1D and CKD. Finerenone could become the first registered treatment for CKD associated with T1D in almost 30 years.TRIAL REGISTRATION: ClinicalTrials.gov NCT05901831.PMID:37805000 | DOI:10.1016/j.diabres.2023.110908 (Source: Clin Med Res)
Source: Clin Med Res - October 7, 2023 Category: Research Authors: Hiddo J L Heerspink Andreas L Birkenfeld David Z I Cherney Helen M Colhoun Linong Ji Chantal Mathieu Per-Henrik Groop Richard E Pratley Sylvia E Rosas Peter Rossing Jay S Skyler Katherine R Tuttle Robert Lawatscheck Charlie Scott Robert Edfors Markus F Sc Source Type: research
