Clinical and serological characterization of acute pleuropericarditis suggests an autoinflammatory pathogenesis and highlights risk factors for recurrent attacks
CONCLUSION: This study highlights that most cases of PP are idiopathic and PP cases with various triggers have an identical clinical phenotype. Our data suggest that the clinical, epidemiological and serological characteristics of idiopathic PP considerably differ from patients with PP caused by autoimmune disease like SLE. We further demonstrate that PP has a high risk of recurrence and identify factors associated with this risk, allowing for a targeted secondary prophylaxis.PMID:38358415 | DOI:10.1007/s00392-024-02390-w (Source: Clin Med Res)
Source: Clin Med Res - February 15, 2024 Category: Research Authors: Dorothee Kaudewitz Lukas John Jan Meis Norbert Frey Hanns-Martin Lorenz Florian Leuschner Norbert Blank Source Type: research
Clinical and serological characterization of acute pleuropericarditis suggests an autoinflammatory pathogenesis and highlights risk factors for recurrent attacks
CONCLUSION: This study highlights that most cases of PP are idiopathic and PP cases with various triggers have an identical clinical phenotype. Our data suggest that the clinical, epidemiological and serological characteristics of idiopathic PP considerably differ from patients with PP caused by autoimmune disease like SLE. We further demonstrate that PP has a high risk of recurrence and identify factors associated with this risk, allowing for a targeted secondary prophylaxis.PMID:38358415 | DOI:10.1007/s00392-024-02390-w (Source: Clin Med Res)
Source: Clin Med Res - February 15, 2024 Category: Research Authors: Dorothee Kaudewitz Lukas John Jan Meis Norbert Frey Hanns-Martin Lorenz Florian Leuschner Norbert Blank Source Type: research
Clinical and serological characterization of acute pleuropericarditis suggests an autoinflammatory pathogenesis and highlights risk factors for recurrent attacks
CONCLUSION: This study highlights that most cases of PP are idiopathic and PP cases with various triggers have an identical clinical phenotype. Our data suggest that the clinical, epidemiological and serological characteristics of idiopathic PP considerably differ from patients with PP caused by autoimmune disease like SLE. We further demonstrate that PP has a high risk of recurrence and identify factors associated with this risk, allowing for a targeted secondary prophylaxis.PMID:38358415 | DOI:10.1007/s00392-024-02390-w (Source: Clin Med Res)
Source: Clin Med Res - February 15, 2024 Category: Research Authors: Dorothee Kaudewitz Lukas John Jan Meis Norbert Frey Hanns-Martin Lorenz Florian Leuschner Norbert Blank Source Type: research
Practical approaches for clinicians in chronic pain management: Strategies and solutions
Best Pract Res Clin Rheumatol. 2024 Feb 9:101934. doi: 10.1016/j.berh.2024.101934. Online ahead of print.ABSTRACTEffective management of chronic pain necessitates multidisciplinary approaches including medical treatment, physical therapy, lifestyle interventions, and behavioral or mental health therapy. Medical providers regularly report high levels of stress and challenge when treating patients with chronic pain, which recur in part due to improper education on contributors to pain and misalignment in patient and provider goals and expectations for treatment. The current paper reviews common challenges and misconceptions ...
Source: Clin Med Res - February 10, 2024 Category: Research Authors: John A Sturgeon Corinne Cooley Deeba Minhas Source Type: research
Investigator-Initiated vs. Investigator-Sponsored Research: Definitions Matter
J Clin Med Res. 2024 Jan;16(1):31-32. doi: 10.14740/jocmr5090. Epub 2024 Jan 31.NO ABSTRACTPMID:38327388 | PMC:PMC10846485 | DOI:10.14740/jocmr5090 (Source: Clin Med Res)
Source: Clin Med Res - February 8, 2024 Category: Research Authors: Elli Gourna Paleoudis Cheryl Pinto Source Type: research
Cold Agglutinin Disease and COVID-19: A Scoping Review of Treatments and Outcomes
CONCLUSIONS: This review found no increased risk of severe outcomes in CAD and COVID-19 patients treated with rituximab.PMID:38327389 | PMC:PMC10846489 | DOI:10.14740/jocmr5102 (Source: Clin Med Res)
Source: Clin Med Res - February 8, 2024 Category: Research Authors: Jackson S Musuuza Silpa Kumar Dheeraj Kumar Posa Aakash Hans Sankett Nayyar Leslie Christensen Gilbert-Roy Kamoga Source Type: research
Intubation Time, Lung Mechanics and Outcome in COVID-19 Patients Suffering Acute Respiratory Distress Syndrome: A Single-Center Study
CONCLUSIONS: Among COVID-19 intubated patients, age, late intubation, high SOFA scores, low PaO2/FiO2 ratio, and low lung compliance are associated with higher intensive care unit (ICU) mortality.PMID:38327390 | PMC:PMC10846488 | DOI:10.14740/jocmr4984 (Source: Clin Med Res)
Source: Clin Med Res - February 8, 2024 Category: Research Authors: Diamanto Aretha Sotiria Kefala Alexandra Nikolopoulou Vasilios Karamouzos Maria Valta Virginia Mplani Alexandra Georgakopoulou Chrysavgi Papamichail Christina Sklavou Fotini Fligou Source Type: research
RAM Cannula Versus Bi-Nasal Prongs as Respiratory Device Interfaces in Neonates of Thirty-Two or More Weeks of Gestation With Respiratory Distress: The First "ProRAM" Randomized Trial Report
CONCLUSIONS: The use of RAM cannula in delivering noninvasive ventilation to newborns ≥ 32 weeks of age did not affect the noninvasive ventilation failure rate or incidence of air leak. The use was associated with a shorter duration of respiratory support and a reduced risk of nasal septal injury.PMID:38327391 | PMC:PMC10846486 | DOI:10.14740/jocmr5077 (Source: Clin Med Res)
Source: Clin Med Res - February 8, 2024 Category: Research Authors: Manar Al-Lawama Bayan Alaraj Mahmoud Abu Zahra Ibtehal AlHasanat Heba Habash AbdelKareem Alhyari Leen Alshajrawi Sallam Jaafreh Source Type: research
Use of a Novel Buffered Hypertonic Saline Solution for Fluid Replacement and Resuscitation During Spinal Surgery in Adolescents
CONCLUSION: Use of a novel 2% buffered hypertonic saline solution for intraoperative resuscitation during major orthopedic procedures decreases the need for 5% albumin while avoiding the development of hyperchloremic metabolic acidosis which may occur with standard sodium chloride solutions.PMID:38327392 | PMC:PMC10846487 | DOI:10.14740/jocmr5059 (Source: Clin Med Res)
Source: Clin Med Res - February 8, 2024 Category: Research Authors: Maria Lysandrou Julie Rice-Weimer Sibelle Aurelie Yemele Kitio Islam Elmitwalli Allen Kadado Walter Samora Marco Corridore Joseph D Tobias Source Type: research
Gene expression, micro-CT and histomorphometrical analysis of sinus floor augmentation with biphasic calcium phosphate and deproteinized bovine bone mineral: A randomized controlled clinical trial
CONCLUSIONS: The BCP, HA/β-TCP ratio of 70/30 presented similar histological and micro-CT outcomes in terms of new bone formation and residual graft particles with DBBM. The gene expression analysis revealed different gene expression patterns between augmented and native bone, but showed no significant difference between the two biomaterials.PMID:38317374 | DOI:10.1111/cid.13303 (Source: Clin Med Res)
Source: Clin Med Res - February 6, 2024 Category: Research Authors: Sirida Arunjaroensuk Katanchalee Nampuksa Naruporn Monmaturapoj Pasutha Thunyakitpisal Thantrira Porntaveetus Nikos Mattheos Atiphan Pimkhaokham Source Type: research
Identifying novel chemical-related susceptibility genes for five psychiatric disorders through integrating genome-wide association study and tissue-specific 3'aQTL annotation datasets
In this study, we aim to search novel susceptibility genes, pathways, and related chemicals of five psychiatric disorders via GWAS and 3'aQTLs datasets. The GWAS datasets of five psychiatric disorders were collected from the open platform of Psychiatric Genomics Consortium (PGC, https://www.med.unc.edu/pgc/ ) and iPSYCH ( https://ipsych.dk/ ) (Demontis et al. in Nat Genet 51(1):63-75, 2019; Grove et al. in Nat Genet 51:431-444, 2019; Genomic Dissection of Bipolar Disorder and Schizophrenia in Cell 173: 1705-1715.e1716, 2018; Mullins et al. in Nat Genet 53: 817-829; Howard et al. in Nat Neurosci 22: 343-352, 2019). The 3'un...
Source: Clin Med Res - February 2, 2024 Category: Research Authors: Sirong Shi Huijie Zhang Xiaoge Chu Qingqing Cai Dan He Xiaoyue Qin Wenming Wei Na Zhang Yijing Zhao Yumeng Jia Feng Zhang Yan Wen Source Type: research
Perinatal Prognosis of Pregnancies with Single Umbilical Artery in a Romanian Third-Level Unit
Conclusions: Perinatal prognosis regarding SUA is significantly poorer than in cases without this pathology. One-third of fetuses with SUA were associated with fetal anomalies. The most common pathologies associated with SUA were cardiovascular, limb, urogenital, and digestive system malformations. Our data are similar to those described in other studies; therefore, we conclude, we can implement the general recommendations in our region regarding counselling patients.PMID:38296637 | DOI:10.3121/cmr.2023.1775 (Source: Clin Med Res)
Source: Clin Med Res - January 31, 2024 Category: Research Authors: J ános Levente Turos Emmanuel Ladanyi Tam ás Szabó B éla Szabó Source Type: research
"Dialogue Between Franklin and the Gout" Reexamined
Clin Med Res. 2023 Dec;21(4):196-200. doi: 10.3121/cmr.2023.1833.ABSTRACTBenjamin Franklin, one of the founding fathers of the United States, was not just a politician and a political philosopher but an inventor with a scientific temperament. He was overweight and likely suffered from the consequences of metabolic syndrome including gout. He woke up with a gout attack on October 22, 1780 and wrote the "Dialogue Between Franklin and the Gout." His observations on the risk factors for gout are re-examined in the modern context 243 years later.PMID:38296638 | DOI:10.3121/cmr.2023.1833 (Source: Clin Med Res)
Source: Clin Med Res - January 31, 2024 Category: Research Authors: Mary Mikhael Chokkalingam Siva Source Type: research
Meningitis in the Guise of Dementia: Lyme-Induced Normal Pressure Hydrocephalus
Clin Med Res. 2023 Dec;21(4):226-229. doi: 10.3121/cmr.2023.1829.ABSTRACTWhile the cause of altered mentation in the elderly may be multifactorial, infectious etiologies may be missed. This case report aims to detail an account of a patient with dementia, found to have Lyme meningitis in the setting of a normal pressure hydrocephalus (NPH). The patient smelled of urine and presented with ambulatory dysfunction, fitting the "wet, wacky, and wobbly" triad of NPH while also having subjective chills and leukocytosis. Non-contrast brain CT scan showed dilated ventricles. Cerebrospinal fluid (CSF) studies suggested aseptic menin...
Source: Clin Med Res - January 31, 2024 Category: Research Authors: Ryan Liu Matheus Polly Robert P Lennon Alexis Reedy-Cooper Source Type: research
A Systematic Review of Interleukin-17 in Oral Lichen Planus: From Etiopathogenesis to Treatment
Clin Med Res. 2023 Dec;21(4):201-215. doi: 10.3121/cmr.2023.1822.ABSTRACTLichen planus (LP) is a chronic autoimmune disease of skin and mucous membranes. World Health Organization has announced oral lichen planus (OLP) as a premalignant lesion. The exact etiology of OLP remains unknown; however, different mechanisms may be involved in its immunopathogenesis. The upregulation of cytokines, chemokines, and adhesion molecules is consistent with a persistent and erratic immunological response to OLP-mediated antigens generated by oral keratinocytes and innate immune cells. These molecules attract T cells, and mast cells to the...
Source: Clin Med Res - January 31, 2024 Category: Research Authors: Farzaneh Agha-Hosseini Mahdieh-Sadat Moosavi Hosna Bahrami Source Type: research
