Radiotherapy Reduces Microhardness and Mineral and Organic Composition, and Changes the Morphology of Primary Teeth: An in vitro Study
Conclusion: We concluded that radiotherapy caused a reduction in surface hardness, changed mineral and organic composition, and promoted morphological changes on the enamel and dentin of primary teeth.Caries Res 2019;53:296 –304 (Source: Caries Research)
Source: Caries Research - October 12, 2018 Category: Dentistry Source Type: research
A Comparison of Simple Analytical Methods for Determination of Fluoride in Microlitre-Volume Plasma Samples
In conclusion, the known-addition technique could be a suitab le alternative for the measurement of fluoride in plasma with microlitre-volume samples.Caries Res 2019;53:275 –283 (Source: Caries Research)
Source: Caries Research - October 8, 2018 Category: Dentistry Source Type: research
State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management
The principles of minimally invasive dentistry clearly dictate the need for clinically effective measures to remineralize early enamel caries lesions. While fluoride-mediated remineralization is the cornerstone of current caries management philosophies, a number of new remineralization strategies have been commercialized or are under development that claim to promote deeper remineralization of lesions, reduce the potential risks associated with high-fluoride oral care products, and facilitate caries control over a lifetime. These non-fluoride remineralizing systems can be broadly categorized into biomimetic enamel regenera...
Source: Caries Research - October 8, 2018 Category: Dentistry Source Type: research
Radiotherapy Activates and Protease Inhibitors Inactivate Matrix Metalloproteinases in the Dentinoenamel Junction of Permanent Teeth
In conclusion, irradiation increased gelatinase activity in all regions of the DEJ. Treatment with 0.12% CHX, 0.05% NaF, and 400 μM polyphenol EGCG postradiotherapy inactivated enzyme activity.Caries Res 2019;53:253 –259 (Source: Caries Research)
Source: Caries Research - October 4, 2018 Category: Dentistry Source Type: research
Effect of Fluoride Toothpaste Containing Nano-Sized Sodium Hexametaphosphate on Enamel Remineralization: An in situ Study
Conclusion: The addition of 0.5% HMPnano to a conventional fluoride toothpaste was able to promote an additional remineralizing effect of artificial caries lesions.Caries Res 2019;53:260 –267 (Source: Caries Research)
Source: Caries Research - October 4, 2018 Category: Dentistry Source Type: research
Association of Environmental Tobacco Smoke with the Risk of Severe Early Childhood Caries among 3-Year-Old Japanese Children
This study suggests that there is a significant association between ETS from family members and S-ECC.Caries Res 2019;53:268 –274 (Source: Caries Research)
Source: Caries Research - October 4, 2018 Category: Dentistry Source Type: research
Dental Caries in European Adults and Senior Citizens 1996 –2016: ORCA Saturday Afternoon Symposium in Greifswald, Germany – Part II
In conclusion, in the last two decades, a decline in caries was observed among European adults, and to a lesser extent among senior citizens. It is expected that the decline in caries will contribute to better oral health of individuals.Caries Res 2019;53:242 –252 (Source: Caries Research)
Source: Caries Research - September 18, 2018 Category: Dentistry Source Type: research
Are mTOR and Endoplasmic Reticulum Stress Pathway Genes Associated with Oral and Bone Diseases?
The purpose of this cohort study was to identify associations between combined oral and bone disease phenotypes and genes present in cell regulatory pathways. The studied pathways play important roles in cellular growth, proliferation, differentiation, and homeostasis. DNA samples extracted from whole saliva of 3,912 individuals were genotyped and these data analyzed according to dental caries experience, periapical lesions, periodontitis, osteoporosis, or temporomandibular joint discomfort. Samples were obtained from the Dental Registry and DNA Repository project at the University of Pittsburgh. Twenty-seven polymorphisms...
Source: Caries Research - September 11, 2018 Category: Dentistry Source Type: research
Analysis of Polymorphisms in Genes Differentially Expressed in the Enamel of Mice with Different Genetic Susceptibilities to Dental Fluorosis
In conclusion, polymorphisms inAmbn, Col14a1, andMmp20 are associated with the susceptibility to DF.Caries Res 2019;53:228 –233 (Source: Caries Research)
Source: Caries Research - August 27, 2018 Category: Dentistry Source Type: research
Genes Regulating Immune Response and Amelogenesis Interact in Increasing the Susceptibility to Molar-Incisor Hypomineralization
Ameloblasts are sensitive cells whose metabolism and function may be affected by inflammatory stimuli. The aim of this study was to evaluate the possible association between polymorphisms in immune response-related genes and molar-incisor hypomineralization (MIH), and their interaction with polymorphisms in amelogenesis-related genes. DNA samples were obtained from 101 nuclear families that had at least 1 MIH-affected child. Eleven single-nucleotide polymorphisms (SNPs) were investigated in immune response genes using TaqMan ® technology allele-specific probes. A transmission disequilibrium test was performed to verify ov...
Source: Caries Research - August 21, 2018 Category: Dentistry Source Type: research
A Membrane-Targeted Peptide Inhibiting PtxA of Phosphotransferase System Blocks < b > < i > Streptococcus mutans < /i > < /b >
In conclusion, C10-K KWW has been developed; it acts through interaction with the bacterial membrane and interferes with L-ascorbate translocation to inhibitS. mutans growth and eradicate its biofilm. C10-KKWW may be especially effective at optimal oral ascorbate levels. A combination of C10-KKWW with sodium L-ascorbate might also be a novel strategy for dental caries treatment.Caries Res 2019;53:176 –193 (Source: Caries Research)
Source: Caries Research - August 14, 2018 Category: Dentistry Source Type: research
< b > < i > Streptococcus mutans < /i > < /b > and < b > < i > Streptococcus sanguinis < /i > < /b > Expression of Competition-Related Genes, Under Sucrose
Streptococcus mutans synthesizes 3 glucosyltransferases (Gtfs) associated with cariogenic biofilms, while commensalStreptococcus sanguinis produces only one;gtfP and hydrogen peroxide (H2O2) by SpxB. The aim was to test the hypothesis that under a sucrose-induced cariogenic challenge, the expression of competition-related genes is differentially regulated depending on whetherS. sanguinis orS. mutans primarily colonize enamel. Dual-species biofilms ofS. sanguinis andS. mutans were formed under different colonization sequences on enamel slabs and exposed to 10% sucrose for 5 min, 3×/day for 5 days. Biofilms were analyzed ...
Source: Caries Research - August 14, 2018 Category: Dentistry Source Type: research
Minimally Invasive Intervention for Primary Caries Lesions: Are Dentists Implementing This Concept?
Contemporary minimally invasive treatment concepts for restorative treatment of primary caries lesions include both delayed intervention and smaller-sized preparations restricted to removal of carious tissue. The aim of this study was to investigate whether these concepts have resulted in a trend towards a more conservative choice made by dentists regarding treatment thresholds and restorative techniques. The results from previously conducted, precoded questionnaires developed by Espelid and Tveit, as well as from a recent Dutch questionnaire, were collected and analysed. A worldwide trend towards more minimally invasive s...
Source: Caries Research - August 14, 2018 Category: Dentistry Source Type: research
Pediatric Adapted Liking Survey: A Novel, Feasible and Reliable Dietary Screening in Clinical Practice
Conclusion: The PALS appears to be a fast, feasible and reliable dietary screener in a clinical setting to assist in forming tailored diet-related messages for dental caries and obesity prevention.Caries Res 2019;53:153 –159 (Source: Caries Research)
Source: Caries Research - August 8, 2018 Category: Dentistry Source Type: research
Association between a New Sugar Index and Caries Experience: Results of a Cross-Sectional Field Study
Conclusion: The results of our study show that not only the correlation between the sugar index and caries experience was stronger for 4th-graders than for 6th-graders, but also more distinctly visible differences were observed when comparing extreme groups. This indicates that protective factors, such as fluoridation and the preventive sealing of fissures, help level out the differences in caries occurrence in older children when compared to younger children.Caries Res 2019;53:160 –167 (Source: Caries Research)
Source: Caries Research - August 8, 2018 Category: Dentistry Source Type: research
