Taxes to Unhealthy Food and Beverages and Oral Health in Mexico: An Observational Study
In January 2014, taxes on sugar-sweetened beverages and nonessential energy-dense food were implemented in Mexico to discourage the consumption of these products. Published evaluations have shown reductions in purchases of taxed food and beverages associated with the implementation of this fiscal policy. Although there are some studies on the impact on health based on simulation studies, no evaluations with empirical data on changes in oral health have been published. We used administrative records and data from an epidemiological surveillance system to estimate changes in (1) outpatient visits related to dental caries; (2...
Source: Caries Research - April 14, 2021 Category: Dentistry Source Type: research

JNK Signaling Pathway Mediates Fluoride-Induced Upregulation of CK1 α during Enamel Formation
This study aimed to investigate the effects of fluoride on CK1α expression and to assess the regulation of molecular signaling involving fluoride a nd CK1α during enamel development. Kunming mice were randomly divided into the control and F groups with induced clinical features of fluorosis. The F group mice, including mothers and newborns, were treated with 50 ppm fluoridated water. Immunohistochemical staining of the sections of the embryoni c mandible regions was performed at the bell stage. Protein expression and signaling pathways in a mouse-derived ameloblast-like cell line (LS8) exposed to fluoride or a ...
Source: Caries Research - April 7, 2021 Category: Dentistry Source Type: research

The Impact of Early Childhood Factors on Dental Caries Incidence in First Permanent Molars: A 7-Year Follow-Up Study
In conclusion, individual and cont extual determinants showed an important role in the incidence of caries in first permanent molars.Caries Res (Source: Caries Research)
Source: Caries Research - March 31, 2021 Category: Dentistry Source Type: research

Fluoride Binding to < b > < i > Streptococcus mutans < /i > < /b > Pellets Rich in Extracellular Polysaccharides
In conclusion, the data suggest that a matrix of dental biofilm rich in EPS does not affect fluoride retention in the biofilm.Caries Res (Source: Caries Research)
Source: Caries Research - March 29, 2021 Category: Dentistry Source Type: research

Monitoring of Erosive Tooth Wear with Intraoral Scanners In vitro
Intraoral scanners (IOS) have been used to quantify tooth wear, but so far they have not been systematically validated for monitoring of tissue loss. The aim of this in vitro study was to investigate whether progression of tissue loss can be detected with an IOS and whether IOS values agree with those obtained with noncontacting profilometry (PRO) serving as a standard method. Model jaws were mounted in a phantom head positioned in a dental chair. Flattened areas were prepared on the non-load-bearing cusps of the first molars (model teeth;n = 16) in order to fix flat enamel samples with an experimental area and a reference...
Source: Caries Research - March 22, 2021 Category: Dentistry Source Type: research

Reply to Letter: Comment on the Paper: How to Intervene in the Caries Process: Early Childhood Caries – A Systematic Review
Caries Res (Source: Caries Research)
Source: Caries Research - March 19, 2021 Category: Dentistry Source Type: research

Amylase Alpha 1 Gene ( < b > < i > AMY1 < /i > < /b > ) Copy Number Variation and Dental Caries Experience: A Pilot Study among Adults in Lithuania
Conclusions: Our study demonstrated an association betweenAMY1 CNV and high smooth-surface caries experience. Studies with larger sample sizes are needed to validate this association.Caries Res (Source: Caries Research)
Source: Caries Research - March 18, 2021 Category: Dentistry Source Type: research

Reply to Letter to the Editor regarding our Paper: How to Intervene in the Caries Process: Early Childhood Caries – A Systematic Review
Caries Res (Source: Caries Research)
Source: Caries Research - March 16, 2021 Category: Dentistry Source Type: research

Association of Oral Health Literacy and School Factors with Untreated Dental Caries among 12-Year-Olds: A Multilevel Approach
This study evaluated the association between oral health literacy (OHL), school factors, and untreated dental caries in 12-year-old Brazilian adolescents using a multilevel approach. A population-based cross-sectional study was carried out with 740 adolescents randomly selected from private and public schools in Campina Grande, Brazil. Two dentists were trained and calibrated to diagnose dental caries using the Nyvad index and OHL using the Brazilian Rapid Estimate of Literacy in Dentistry (BREALD-30). The caregivers of the adolescents reported demographic data (sex, skin color, and socioeconomic status). Data of school fa...
Source: Caries Research - March 15, 2021 Category: Dentistry Source Type: research

Breastfeeding and Childhood Dental Caries: Results from a Socially Diverse Birth Cohort Study
This study was part of the Generation R Study, a prospective multiethnic cohort study conducted in Rotterdam, The Netherlands. In total, 4,146 children were included in the analyses. Information about feeding practices was derived from delivery reports and questionnaires during infancy. Caries was measured via intraoral photographs at the age of 6 years and defined as decayed, missing, and filled teeth (dmft). Negative binomial hurdle regression analyses were used to study the associations between several infant feeding practices and childhood caries. The prevalence of dental caries at the age of 6 years was 27.9% (n = 1,1...
Source: Caries Research - March 11, 2021 Category: Dentistry Source Type: research

Clinical Effect of Two Fluoride Varnishes in Caries-Active Preschool Children: A Randomized Controlled Trial
In conclusion, the 2 fluoride varnishes demonstrated an equal capacity to reduce the incidence of caries in caries-active preschool children over a 12-month period in comparison with a control group.Caries Res (Source: Caries Research)
Source: Caries Research - March 11, 2021 Category: Dentistry Source Type: research

Comment on the Paper: How to Intervene in the Caries Process: Early Childhood Caries – A Systematic Review by Schmoeckel et al.
Caries Res (Source: Caries Research)
Source: Caries Research - March 5, 2021 Category: Dentistry Source Type: research

Letter to the Editor with Reference to “How to Intervene in the Caries Process: Early Childhood Caries – A Systematic Review”
Caries Res (Source: Caries Research)
Source: Caries Research - March 2, 2021 Category: Dentistry Source Type: research

NOCTP and NRCT Are Not Complete without Tailored Motivational Communication
Caries Res (Source: Caries Research)
Source: Caries Research - February 25, 2021 Category: Dentistry Source Type: research

Reply to Letter “NOCTP and NRCT Are Not Complete without Tailored Motivational Communication”
Caries Res (Source: Caries Research)
Source: Caries Research - February 23, 2021 Category: Dentistry Source Type: research

Examining the Relationship between Social and School Environment and Children ’s Caries Experience Using Primary and Secondary Data: A Cluster Analysis
Dental caries is still prevalent worldwide, even with advances in preventive and curative measures. The aim was to examine clustering patterns of socioeconomic and environmental characteristics of schools and their associations with caries experience of schoolchildren. An epidemiological survey with cross-sectional design was conducted in 2014/2015 and included 5,213 students (aged 2 –11 years) from 38 public schools of Carapicuíba (SP, Brazil). Primary data consisted of dental examinations performed at schools by 6 calibrated examiners to evaluate caries experience (dmf/DMFT index). Secondary data were extrac...
Source: Caries Research - February 18, 2021 Category: Dentistry Source Type: research

In vitro Study of the Role of Human Neutrophil Enzymes on Root Caries Progression
The role of the host immune system in caries progression is mainly speculative, and it is believed that it entails the enzymatic degradation of the dentin organic matrix. The aim of this study was to evaluate the proteolytic effect of human neutrophil enzymes on root caries progression. For this, specimens of bovine root dentin were divided into 4 groups (n = 30): caries (C), caries + neutrophils (C + N), no caries (Control), and no caries + neutrophils (Control + N).Streptococcus mutans biofilm (105 CFU/mL) was grown on the root surface to artificially induce root carious lesions (C and C + N groups). Specimens were then ...
Source: Caries Research - February 12, 2021 Category: Dentistry Source Type: research

Is the Erosion-Protective Effect Still Maintained when Tin Concentrations Are Reduced in Mouth Rinse Solutions?
Conclusion: Sn2+ concentrations in mouth rinses may be lowered to 200 ppm without compromising the anti-erosive properties of the solution.Caries Res (Source: Caries Research)
Source: Caries Research - February 8, 2021 Category: Dentistry Source Type: research

Association of Dietary Fluoride Intake and Diet Variables with Dental Caries in Adolescents from the ELEMENT Cohort Study
To examine the association of dietary fluoride intake, total carbohydrate consumption and other key dietary variables with dental caries experience among adolescents, a cross-sectional analysis was conducted in a sample of 402 participants from the Early Life Exposures in Mexico to Environmental Toxicants cohort. The presence and severity of dental caries were assessed using the International Caries Detection and Assessment System (ICDAS) to calculate the number of decayed, missing, and filled teeth or surfaces (D1MFT/D4MFT). The dietary intake of fluoride, energy, carbohydrates, and food groups was estimated using a valid...
Source: Caries Research - February 3, 2021 Category: Dentistry Source Type: research

Acceleration of Enamel Subsurface Lesion Remineralisation by Intralesion pH Modulation
Remineralisation of demineralised enamel subsurface lesions can be enhanced by pretreatment of the lesions with base (NaOH). The aim of this study was to test the effect of intralesion pH modulation on remineralisation of demineralised enamel subsurface lesions by casein phosphopeptide-stabilised amorphous calcium fluoride phosphate (CPP-ACFP) in vitro. Two remineralisation models were utilised, the first involving 60-min cyclic pH modulation for 105 h and the second involved short-term cyclic pH modulation (12-min cycle, 240 min total duration) compared with the equivalent time of continuous treatment (200 min total durat...
Source: Caries Research - February 1, 2021 Category: Dentistry Source Type: research

Does the Trimester of Smoking Matter in the Association between Prenatal Smoking and the Risk of Early Childhood Caries?
Conclusions: Within the limitations of covariates adjusted for, with the caveat that residual confounding and bias from unmeasured covariates are likely present, our findings suggest that smoking during pregnancy may be harmful to the oral health of the offspring irrespective of the trimester during which the smoking occurred. Nevertheless, these results should be interpreted cautiously because the findings might not generalize broadly.Caries Res (Source: Caries Research)
Source: Caries Research - January 28, 2021 Category: Dentistry Source Type: research

Protective Effect of Solutions Containing Polymers Associated with Fluoride and Stannous Chloride on Hydroxyapatite Dissolution
This study investigated the protective effect of experimental solutions containing 4 polymers (polyoxirane, hydroxypropylmethylcellulose [HPMC], pectin, and an amino methacrylate copolymer [AMC]) in 2 concentrations (low and high) associated or not with sodium fluoride (F; 225 ppm F–) or sodium fluoride plus stannous chloride (FS; 800 ppm Sn2+) on the dissolution of hydroxyapatite crystals (HA). Deionized water was the control. The pretreated HA was added to a 0.3% citric acid solution (pH 3.8). An automatic titrant machine added aliquots of 0.1 N HCl at a rate of 28 μL/min, in a total reaction time of 5 min. Grou...
Source: Caries Research - January 27, 2021 Category: Dentistry Source Type: research

Epidemiology of Erosive Tooth Wear, Dental Fluorosis and Molar Incisor Hypomineralization in the American Continent
Non-carious dental lesions such as developmental defects of enamel (DDE) and erosive tooth wear (ETW) are the subject of intensive research. This paper aims to give perspectives on both DDE, including dental fluorosis and molar incisor hypomineralization (MIH), and ETW, presenting epidemiological data from the Americas and associated diagnostic aspects. Besides, it is important to present evidence to guide the clinical assessment process, supporting the clinicians ’ management decisions towards better oral health of their patients. The overall increase in the worldwide prevalence of non-carious lesions discussed in t...
Source: Caries Research - January 13, 2021 Category: Dentistry Source Type: research

ORCA Has Lost One of Its Pioneers
Caries Res (Source: Caries Research)
Source: Caries Research - January 11, 2021 Category: Dentistry Source Type: research

Thomas Marthaler: Scientist, Musician, Friend
Caries Res (Source: Caries Research)
Source: Caries Research - January 6, 2021 Category: Dentistry Source Type: research

Experiencing Financial Strain and Clinically Assessed Caries Experience in Dentate Adults Aged 25 –44 Years: An Exploration of Potential Pathways
Large socioeconomic inequalities still exist in oral health. It is already known that oral health-related behaviour may contribute to these inequalities, but why people with a lower socioeconomic position behave less healthily is not easily understood. A possible explanation that integrates insights on health behaviour, stress, and financial resources is the pathway of behavioural responses to financial strain. The aim of this study was to assess to what extent financial strain is associated with clinically assessed caries experience in a population-based study of dentate adults, independently of other socioeconomic indica...
Source: Caries Research - December 22, 2020 Category: Dentistry Source Type: research

The Top 100 Most-Cited Papers in Cariology: A Bibliometric Analysis
This study aimed to quali-quantitatively analyze the 100 most-cited papers in Cariology. A search strategy was first determined using specific keywords related to the field. A comprehensive search was then conducted in the Thompson Reuters Web of Science citation indexing database up to April 2019. Papers focused on any aspect of Cariology were included. A panel of 4 researchers conducted the selection of papers and extracted data on the number of citations, title, authors, country, year, journals, study design, and topic of interest. Scopus and Google Scholar were also searched to compare the number of citations. The VOSv...
Source: Caries Research - December 18, 2020 Category: Dentistry Source Type: research

The pH-Responsive Property of Antimicrobial Peptide GH12 Enhances Its Anticaries Effects at Acidic pH
In conclusion, acidic pH enhanced the antibacterial and antibiofilm activities of GH12, and GH12 is a potential smart anticaries agent targeting the cariogenic acidic microenvironment.Caries Res (Source: Caries Research)
Source: Caries Research - December 18, 2020 Category: Dentistry Source Type: research

Pulp Vitality and Longevity of Adhesive Restorations Are Not Affected by Selective Carious Removal: A Multicenter Clinical Trial
The aim of this multicenter randomized clinical trial was to evaluate the pulp vitality and survival rate of adhesive restorations performed on posterior deciduous teeth after non-selective (NSCR) or selective (SCR) carious tissue removal over 33 months. One hundred and seven children (average age 4 –8 years, SD 1.4) with at least two active moderate cavitated lesions in dentin were included. Teeth were randomized and submitted to NSCR or SCR before composite resin restoration. Restorations were clinically and radiographically assessed at baseline, 6, 12, 18, 24, and 33 months by a blinded, t rained, and calibrated o...
Source: Caries Research - December 16, 2020 Category: Dentistry Source Type: research

Atraumatic Restorative Treatment-Sealed versus Nonsealed First Permanent Molars: A 3-Year Split-Mouth Clinical Trial
In conclusion, the application of ART sealants was not more efficacious than nonsealing in reducing the development of dentine cavitated lesions in first permanent molars.Caries Res (Source: Caries Research)
Source: Caries Research - December 16, 2020 Category: Dentistry Source Type: research

Contents Vol. 54, 2020
Caries Res 2020;54:I –VI (Source: Caries Research)
Source: Caries Research - December 15, 2020 Category: Dentistry Source Type: research

Acknowledgement to Reviewers
Caries Res 2020;54:525 –526 (Source: Caries Research)
Source: Caries Research - December 15, 2020 Category: Dentistry Source Type: research

Acknowledgement of Financial Support
Caries Res 2020;54:524 (Source: Caries Research)
Source: Caries Research - December 15, 2020 Category: Dentistry Source Type: research

68th Annual ORCA Congress 2021
Caries Res (Source: Caries Research)
Source: Caries Research - December 11, 2020 Category: Dentistry Source Type: research

How to Intervene in the Caries Process in Older Adults: A Joint ORCA and EFCD Expert Delphi Consensus Statement
Aim: To provide recommendations for dental clinicians for the management of dental caries in older adults with special emphasis on root caries lesions.Methods: A consensus workshop followed by a Delphi consensus process were conducted with an expert panel nominated by ORCA, EFCD, and DGZ boards. Based on a systematic review of the literature, as well as non-systematic literature search, recommendations for clinicians were developed and consented in a two-stage Delphi process.Results: Demographic and epidemiologic changes will significantly increase the need of management of older adults and root caries in the future. Agein...
Source: Caries Research - December 8, 2020 Category: Dentistry Source Type: research

Demineralization Inhibitory Effects of Highly Concentrated Fluoride Dentifrice and Fluoride Gels/Solutions on Sound Dentin and Artificial Dentin Caries Lesions in vitro
Objectives: The aim of this in vitro study was to compare the demineralization inhibitory effect of gels/solutions used in combination with either standard or highly fluoridated dentifrices on sound dentin as well as on artificial dentin caries-like lesions.Methods: Bovine dentin specimens (n = 240) with two different surfaces each (sound [ST] and artificial caries lesion [DT]) were prepared and randomly allocated to twelve groups. Weekly interventions during pH-cycling (28 days, 6 × 120 min demineralization/day) were: the application of gels/solutions containing amine fluoride/sodium fluoride (12,500 ppm F [ppm]; pH...
Source: Caries Research - December 7, 2020 Category: Dentistry Source Type: research

67th ORCA Congress
Caries Res (Source: Caries Research)
Source: Caries Research - November 26, 2020 Category: Dentistry Source Type: research

Efficacy of Probiotic Milk for Caries Regression in Preschool Children: A Multicenter Randomized Controlled Trial
In conclusion, probiotic milk consumption either daily or tri weekly can modestly prevent new caries, but considerably reverse carious lesions, suggesting that a daily or triweekly dose interval is sufficient to reverse carious lesions.Caries Res (Source: Caries Research)
Source: Caries Research - November 23, 2020 Category: Dentistry Source Type: research

The Addition of Propylene Glycol Alginate to a Fluoride Solution to Control Enamel Wear: An in situ Study
In conclusion, PGA was not able to improve the protective e ffect of NaF against erosive enamel wear.Caries Res (Source: Caries Research)
Source: Caries Research - November 11, 2020 Category: Dentistry Source Type: research

Susceptibility of Dental Enamel of Different Ages to Caries-Like Lesion Development
This study investigated the impact of estimated age, anatomical location, and the presence of wear facets on the susceptibility of enamel to develop caries-like lesions. Extracted human premolars (n = 261) had their age estimated between 10 and 93 years old, using established forensic methods. Specimens of enamel (4 × 4 mm) were prepared from the middle of the buccal surfaces, preserving the outer surface layer. The central area of the block (4 × 1 mm) was protected with nail polish and used as an internal control. The specimens were demineralized for 8 days (with 0.1 M acetic acid, 1.28 mM Ca, 0.74 mM Pi, an d...
Source: Caries Research - November 11, 2020 Category: Dentistry Source Type: research

Salivary Hemoglobin Protects against Erosive Tooth Wear in Gastric Reflux Patients
Conclusions: Our results indicate that many proteins, with special emphasis on Hb, may be involved in the resistance of GERD patients to the occurrence of ETW. These proteins may be candidates for inclusion in dental products to protect against ETW.Caries Res (Source: Caries Research)
Source: Caries Research - November 10, 2020 Category: Dentistry Source Type: research

Sealing Proximal Non- and Micro-Cavitated Carious Lesions Using a One-Session Separator Technique: A 2-Year Randomised Clinical Study
The presence of initial caries accounts for the majority of approximal carious lesions in many countries. The aim of this clustered, split-mouth, randomised, controlled clinical trial was to use a metal separator to widen the approximal space in a one-visit session before sealing and to evaluate patient acceptance, together with the efficacy of the proximal sealing in arresting incipient carious lesions after 2 years. A total of 48 patients with a mean age of 41.9 years were selected. They had at least one pair of proximal initial carious lesions, including the distal surface of the canines to the mesial surface of the thi...
Source: Caries Research - November 4, 2020 Category: Dentistry Source Type: research

Pellicle Modification with Casein and Mucin Does Not Affect Surface Loss from Erosion and Abrasion
Conclusion: The observed differences in SMH suggest that a different abrasion protocol could lead to differences in surface loss, and further investigation of whether and under which conditions pellicle modification leads to increased resistance to abrasion remains worthwhile.Caries Res (Source: Caries Research)
Source: Caries Research - October 28, 2020 Category: Dentistry Source Type: research

Dose-Response Effect of Fluoride Dentifrices on De-/Remineralization of Root Dentine in situ
In conclusion, a dose-response F effect was observed, and the high-fluoride dentifrice was effective in enhancing root dentine remineralization in this short-term in situ study.Caries Res (Source: Caries Research)
Source: Caries Research - October 19, 2020 Category: Dentistry Source Type: research

Development of a Fluorescence-Based Caries Scoring System for an Intraoral Scanner: An in vitro Study
Conclusion: A fluorescence-based caries scoring system was developed for the intraoral scanner showing promising performance compared to state-of-the-art caries detection methods. The intraoral scanner accompanied by an automated caries scoring system may improve objective caries detection and increase the efficiency and effectiveness of oral examinations. Furthermore, this device has the potential to support reliable monitoring of early caries lesions.Caries Res (Source: Caries Research)
Source: Caries Research - October 14, 2020 Category: Dentistry Source Type: research

Long-Term Survival of Enamel-Defect-Affected Teeth
There has been considerable research focussed on the occurrence and aetiology of developmental defects of enamel, but less is known about the extent to which enamel-defect-affected teeth may be at greater risk for dental caries. The Dunedin Multidisciplinary Health and Development Study is a prospective cohort study of 1,037 children born in Dunedin, New Zealand, between April 1, 1972, and March 31, 1973. Participants were examined for the presence of developmental defects of enamel at the age of 9 years and then repeatedly for the occurrence of dental caries through to the age of 45 years. After controlling for confoundin...
Source: Caries Research - October 13, 2020 Category: Dentistry Source Type: research

Effect of Different Toothbrushing Routines on Interproximal Fluoride Concentration
This study aimed to evaluate the effect of different toothbrushing routines and different kinds of toothpaste on the interproximal fluoride concentration after toothbrushing and its clinical relevance to the recommendations given to patients regarding the process of toothbrushing. Eight adults participated a total of 8 times in order to test different toothbrushing routines with different amounts of toothpaste (1 or 2 cm), durations (1 or 2 min) and amounts of water after toothbrushing (10 or 20 mL). An additional 8 adults participated 6 times in total to test different forms of toothpaste administration (paste, gel and fo...
Source: Caries Research - October 7, 2020 Category: Dentistry Source Type: research

Effects of Additional Use of Bioactive Glasses or a Hydroxyapatite Toothpaste on Remineralization of Artificial Lesions in vitro
Conclusion: Under remineralizing in vitro conditions, brushing with 1,400 ppm FTP induced significantly more remineralization compared to storage in artificial saliva. The additional administration of both bioactive glasses as well as the substitutional brushing with an HTP resulted in significantly less remineralization compared to brushing with 1,400 ppm FTP.Caries Res (Source: Caries Research)
Source: Caries Research - September 30, 2020 Category: Dentistry Source Type: research

Effects of Sodium Trimetaphosphate, Associated or Not with Fluoride, on the Composition and pH of Mixed Biofilms, before and after Exposure to Sucrose
The aim of the present study was to evaluate the influence of sodium trimetaphosphate (TMP), associated or not with fluoride (F), on the concentrations of F, calcium (Ca), and phosphorus (P) and on the pH of mixed biofilms ofStreptococcus mutans andCandida albicans, before and after exposure to sucrose. The biofilms received three treatments (72, 78, and 96 h after the beginning of their formation), at three TMP concentrations (0.25, 0.5, or 1%), with or without F at 500 ppm. Solutions containing 500 and 1,100 ppm F as well as artificial saliva were also tested as controls. Biofilm pH was measured and the concentrations of...
Source: Caries Research - September 30, 2020 Category: Dentistry Source Type: research

G öran Frostell: A Grand Old Man in Swedish Preventive Odontology
Caries Res (Source: Caries Research)
Source: Caries Research - September 18, 2020 Category: Dentistry Source Type: research