Mutant CYP3A4/5 Correlated with Clinical Outcomes by Affecting Rivaroxaban Pharmacokinetics and Pharmacodynamics in Patients with Atrial Fibrillation
ConclusionTheCYP3A4 polymorphisms (rs2242480, rs2246709, and rs3735451) andCYP3A5 rs776746 were associated with variations in rivaroxaban PK/PD. The minor allele (C) carriers on rs3735451 and the minor allele (A) carriers on rs2246709 were correlated with clinical outcomes. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - August 5, 2023 Category: Cardiology Source Type: research
P2Y12 Inhibitors in STEMI Patients — One Size Does Not Fit All
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - August 2, 2023 Category: Cardiology Source Type: research
The Effect of Hydroxychloroquine on Cardiovascular Disease in Patients with Rheumatoid Arthritis
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - August 1, 2023 Category: Cardiology Source Type: research
Surgical or Percutaneous Coronary Revascularization for Heart Failure: a Focus on Symptoms and Stenosis
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - August 1, 2023 Category: Cardiology Source Type: research
The Effect of Hydroxychloroquine on Cardiovascular Disease in Patients with Rheumatoid Arthritis
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - August 1, 2023 Category: Cardiology Source Type: research
Advances in MicroRNA Therapy for Heart Failure: Clinical Trials, Preclinical Studies, and Controversies
AbstractHeart failure (HF) is a rapidly growing public health issue with more than 37.7 million patients worldwide and an annual healthcare cost of $108 billion. However, HF-related drugs have not changed significantly for decades, and it is essential to find biological drugs to provide better treatment for HF patients. MicroRNAs (miRNAs) are non-coding RNAs (ncRNAs) with a length of approximately 21 nucleotides and play an important role in the onset and progression of cardiovascular diseases. Increasing studies have shown that miRNAs are widely involved in the pathophysiology of HF, and the regulation of miRNAs has promi...
Source: Cardiovascular Drugs and Therapy - July 28, 2023 Category: Cardiology Source Type: research
Preliminary Study on Retrograde Recanalization of Radial Artery Occlusion Through Distal Radial Artery Access: a Single-Center Experience
ConclusionsDTRA is a safe and feasible approach for retrograded recanalization of RAO, with a high procedure success rate and few complications. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - July 27, 2023 Category: Cardiology Source Type: research
Who Should Be the Corresponding Author, What Are Their Responsibilities, and What Email Address Should They Provide?
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - July 14, 2023 Category: Cardiology Source Type: research
Netrin-1 and RGMa: Novel Regulators of Atherosclerosis-Related Diseases
AbstractBackgroundsNeuronal guidance proteins (NGPs) have been demonstrated to guide the elongation of neuronal axonal growth cones in the developing central nervous system. Non-neuronal functions of NGPs have also been described, especially in relation to atherosclerosis.FindingsNetrin-1 and repulsive guidance molecule a (RGMa) are NGPs that have been shown to regulate endothelial cell adhesion and angiogenesis, macrophage migration and apoptosis, smooth muscle cells (SMCs) phenotypic dedifferentiation and mobility, chemokine activities, and inflammatory responses during atherosclerosis initiation and progression.Purpo...
Source: Cardiovascular Drugs and Therapy - July 13, 2023 Category: Cardiology Source Type: research
Poking and Prodding So They Take Their Pills
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - July 11, 2023 Category: Cardiology Source Type: research
