When Less is More: Drug-Coated Balloons Threaten a Paradigm Revolution
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 19, 2023 Category: Cardiology Source Type: research
Oral Anticoagulation for Atrial Fibrillation in Octogenarians Across the Renal Function Spectrum
ConclusionDOACs seem to be safe and effective in octogenarians with chronic kidney disease at stage ≥ G3b. As compared with VKA administration, the use of DOACs was associated with lower mortality rates among AF octogenarians with renal dysfunction. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 18, 2023 Category: Cardiology Source Type: research
ROS-Activated TRPM2 Channel: Calcium Homeostasis in Cardiovascular/renal System and Speculation in Cardiorenal Syndrome
AbstractThe transient receptor potential melastatin 2 (TRPM2) channel is a nonselective calcium channel that is sensitive to oxidative stress (OS), and is widely expressed in multiple organs, such as the heart, kidney, and brain, which is inextricably related to calcium dyshomeostasis and downstream pathological events. Due to the increasing global burden of kidney or cardiovascular diseases (CVDs), safe and efficient drugs specific to novel targets are imperatively needed. Notably, investigation of the possibility to regard the TRPM2 channel as a new therapeutic target in ROS-related CVDs or renal diseases is urgently req...
Source: Cardiovascular Drugs and Therapy - December 18, 2023 Category: Cardiology Source Type: research
Establishment and Validation of the Nomogram Model and the Probability of Silent Cerebral Infarction After Ablation Atrial Fibrillation
ConclusionWe developed an easy-to-use nomogram model to predict the probability of silent cerebral infarction following radiofrequency ablation of atrial fibrillation. This model can provide a valid assessment of the probability of postoperative silent cerebral infarction in patients undergoing radiofrequency ablation of atrial fibrillation. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 16, 2023 Category: Cardiology Source Type: research
Cost-Effectiveness of Dapagliflozin in Heart Failure with Preserved or Mildly Reduced Ejection Fraction: the DELIVER Trial
ConclusionsDapagliflozin adjunctive therapy was cost-effective in patients with HFpEF or HFmrEF from the perspective of Chinese national insurance. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 14, 2023 Category: Cardiology Source Type: research
Use of Antihypertensive Drugs and Arterial Stiffness in the Longitudinal Study of Adult Health (ELSA-Brasil)
ConclusionBP control, regardless of the class of antihypertensive used is associated with a better AS trajectory, as assessed by PWV and PP. Among participants with controlled BP, the use of BCC, compared to not using this class, seems to be worse for the trajectory of PWV in individuals with arterial hypertension without cardiovascular disease. Further studies are needed to assess whether this effect results in a better prognosis for patients with arterial hypertension. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 12, 2023 Category: Cardiology Source Type: research
Colchicine Attenuates Microvascular Obstruction after Myocardial Ischemia-Reperfusion Injury by Inhibiting the Proliferation of Neutrophil in Bone Marrow
ConclusionsColchicine attenuated MVO after myocardial I/R injury by inhibiting the proliferation of neutrophils in BM through the neutrophil-derived S100A8/A9 inflammatory signaling pathway. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 8, 2023 Category: Cardiology Source Type: research
Beyond Hepatoprotection —The Cardioprotective Effects of Bicyclol in Diabetes
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 6, 2023 Category: Cardiology Source Type: research
Impact of CYP2C19 Genotype on Efficacy and Safety of Clopidogrel-based Antiplatelet Therapy in Stroke or Transient Ischemic Attack Patients: An Updated Systematic Review and Meta-analysis of Non-East Asian Studies
ConclusionThe present updated meta-analysis provides moderate quality evidence of association between CYP2C19 LOF alleles and an increased risk of stroke in non-East Asian patients with stroke/TIA after receiving clopidogrel therapy. Further large pharmacogenetic studies are still warranted to corroborate these findings. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 1, 2023 Category: Cardiology Source Type: research
MicroRNA-92a in Cardiovascular Disease: An Insufficiently Explored and Controversial Research Area
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 1, 2023 Category: Cardiology Source Type: research
Comment on “Comparison of Sodium-Glucose Cotransporter-2 Inhibitor and Dipeptidyl Peptidase-4 Inhibitor on the Risks of New-Onset Atrial Fibrillation, Stroke and Mortality in Diabetic Patients”
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 27, 2023 Category: Cardiology Source Type: research
Nicotinamide Riboside Supplementation Restores Myocardial Nicotinamide Adenine Dinucleotide Levels, Improves Survival, and Promotes Protective Environment Post Myocardial Infarction
ConclusionOur data show that nicotinamide riboside could be useful for MI management. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 24, 2023 Category: Cardiology Source Type: research
Comparison of Efficacy and Safety Between Drug-Coated Balloons Versus Drug-Eluting Stents in the Treatment of De Novo Coronary Lesions in Large Vessels: A Study-Level Meta-Analysis of Randomized Control Trials
ConclusionUse of DCB was associated with less LLL at 6 –12 months than DES and was not associated with any increase in adverse clinical events. This data suggests DCB are as effective in treating de novo coronary lesions in large vessels as DES. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 24, 2023 Category: Cardiology Source Type: research
Intervention of Tanshinone IIA on the PGK1-PDHK1 Pathway to Reprogram Macrophage Phenotype After Myocardial Infarction
ConclusionTan IIA regulates the energy metabolism of macrophages and changes its phenotype through the PGK1-PDHK1 signaling pathway, thus playing a role in improving MI. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 22, 2023 Category: Cardiology Source Type: research
Agathis dammara Extract and its Monomer Araucarone Attenuate Abdominal Aortic Aneurysm in Mice
ConclusionsThrough suppressing NF- κB/NLRP3 pathway activation, AD effectively mitigates the inflammatory response in VSMCs, mitigates inflammation in aortas, prevents extracellular matrix degradation, and consequently impedes the progression of AAA. AO emerges as one of the active compounds in AD responsible for inhibiting VSMC inf lammation and inhibiting AAA development. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 18, 2023 Category: Cardiology Source Type: research
