Left Bundle Branch Pacing for Bradycardia in Non-obstructive Hypertrophic Cardiomyopathy Patients: Feasibility, Safety, and Effect
ConclusionLBBP might be feasible and safe for NOHCM patients with conventional bradycardia pacing indication, and there is no deterioration in cardiac function and LVOTG of patients with NOHCM. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - February 27, 2023 Category: Cardiology Source Type: research
When Is It Appropriate to Publish a Meta-Analysis in Cardiovascular Drugs and Therapy?
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - February 27, 2023 Category: Cardiology Source Type: research
Clinical Implications of Fractional Flow Reserve Measured Immediately After Percutaneous Coronary Intervention
ConclusionLAD location is a predictor of a lower post-PCI FFR. Post-PCI FFR is an independent predictor of TVF as well as of the composite of CD and MI. No uniform target post-PCI FFR value exists; different cut-off values may have to be applied in LAD as opposed to non-LAD vessels. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - February 23, 2023 Category: Cardiology Source Type: research
Dexamethasone-Induced Arterial Stiffening Is Attenuated by Training due to a Better Balance Between Aortic Collagen and Elastin Levels
ConclusionAs DEX is widely used in several situations, the clinical relevance of this study is that the maintenance of good physical capacity throughout life can be crucial to alleviate some of its side effects, such as arterial stiffness. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - February 16, 2023 Category: Cardiology Source Type: research
Acute Biomechanical Effects of Empagliflozin on Living Isolated Human Heart Failure Myocardium
ConclusionThe addition of empagliflozin to LMS from end-stage heart failure patients cultured in a biomimetic system improves contraction and relaxation kinetics by increasing total contraction duration without diminishing maximum force production. Therefore, we present convincing evidence that SGLT2i can directly act on the myocardium in absence of systemic influences from other organ systems. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - February 13, 2023 Category: Cardiology Source Type: research
Surgical or Percutaneous Coronary Revascularization for Heart Failure: a Focus on Symptoms and Stenosis
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - February 13, 2023 Category: Cardiology Source Type: research
Comparison of His –Purkinje Conduction System Pacing with Atrial–Ventricular Node Ablation and Pharmacotherapy in HFpEF Patients with Recurrent Persistent Atrial Fibrillation (HPP-AF study)
ConclusionsThe study aims to determine whether His –Purkinje conduction system pacing with atrioventricular node ablation can better improve patients' symptoms and quality of life, postpone the progression of heart failure, and reduce the rate of rehospitalization and mortality of patients with heart failure.Clinical trial registration number: ChiCTR1900027723, URL:http://www.chictr.org.cn/edit.aspx?pid=46128&htm=4 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - February 7, 2023 Category: Cardiology Source Type: research
Sitagliptin Ameliorates Creb5/lncRNA ENSMUST00000213271-Mediated Vascular Endothelial Dysfunction in Obese Mice
ConclusionCreb5/lncRNA ENSMUST00000213271 mediated vascular endothelial dysfunction through inhibiting AMPK/eNOS cascade in obesity. Elevation of GLP-1 by sitagliptin possibly improved endothelial function by suppressingCreb5/lncRNA ENSMUST00000213271 and subsequently restoring AMPK/eNOS activation in obese mice. This study will provide new evidence for the benefits of GLP-1 against vasculopathy in obesity. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - February 4, 2023 Category: Cardiology Source Type: research
The Function and Regulation of Platelet P2Y12 Receptor
AbstractIn addition to the key role in hemostasis and thrombosis, platelets have also been wildly acknowledged as immune regulatory cells and involving in the pathogenesis of inflammation-related diseases. Since purine receptor P2Y12 plays a crucial role in platelet activation, P2Y12 antagonists such as clopidogrel, prasugrel, and ticagrelor have been widely used in cardiovascular diseases worldwide in recent decades due to their potent antiplatelet and antithrombotic effects. Meanwhile, the role of P2Y12 in inflammatory diseases has also been extensively studied. Relatively, there are few studies on the regulation of P2Y1...
Source: Cardiovascular Drugs and Therapy - January 11, 2023 Category: Cardiology Source Type: research
Spontaneous Reperfusion in Patients with Transient ST-Elevation Myocardial Infarction —Prevalence, Importance and Approaches to Management
AbstractPatients with transient ST-elevation myocardial infarction (STEMI) or spontaneous resolution (SpR) of the ST-segment elevation on electrocardiogram could potentially represent a unique group of patients posing a therapeutic management dilemma. In this review, we discuss the potential mechanisms underlying SpR, its relation to clinical outcomes and the proposed management options for patients with transient STEMI with a focus on immediate versus early percutaneous coronary intervention. We performed a structured literature search of PubMed and Cochrane Library databases from inception to December 2020. Studies focus...
Source: Cardiovascular Drugs and Therapy - January 11, 2023 Category: Cardiology Source Type: research
The Function and Therapeutic Potential of Circular RNA in Cardiovascular Diseases
AbstractCircular RNA (circRNA) has a closed-loop structure, and its 3 ’ and 5’ ends are directly covalently connected by reverse splicing, which is more stable than linear RNA. CircRNAs usually possess microRNA (miRNA) binding sites, which can bind miRNAs and inhibit miRNA function. Many studies have shown that circRNAs are involved in the processes of cell senesc ence, proliferation and apoptosis and a series of signalling pathways, playing an important role in the prevention and treatment of diseases. CircRNAs are potential biological diagnostic markers and therapeutic targets for cardiovascular diseases (CVDs). To i...
Source: Cardiovascular Drugs and Therapy - January 11, 2023 Category: Cardiology Source Type: research
Bioresorbable Vascular Scaffolds: a Dissolving Dream?
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - January 11, 2023 Category: Cardiology Source Type: research
The Association of Proton Pump Inhibitors and QT Interval Prolongation in Critically Ill Patients
ConclusionIn ICU patients, the association between PPI prescription and increased risk of QT interval prolongation was independent of known QT-prolonging factors; pantoprazole and lansoprazole had a higher risk compared with omeprazole. The combination of PPIs and other QT-prolonging drugs should be avoided. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - January 10, 2023 Category: Cardiology Source Type: research
Sacubitril/valsartan improves all-cause mortality in heart failure patients with reduced ejection fraction and chronic kidney disease
ConclusionsSacubitril/valsartan had a lower all-cause mortality compared to ACEI/ARB in symptomatic HFrEF patients with CKD. Further prospective randomized studies are warranted to confirm our findings. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - January 7, 2023 Category: Cardiology Source Type: research
Canagliflozin Pretreatment Attenuates Myocardial Dysfunction and Improves Postcardiac Arrest Outcomes After Cardiac Arrest and Cardiopulmonary Resuscitation in Mice
ConclusionsCanagliflozin offered a strong cardioprotective effect against cardiac arrest and resuscitation-induced cardiac dysfunction. This canagliflozin-induced cardioprotection is mediated by the STAT-3-dependent cell-survival signaling pathway. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - January 7, 2023 Category: Cardiology Source Type: research
