Circ_0026218 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell dysfunction by regulating miR-188-3p/TLR4/NF- κB pathway
ConclusionCirc_0026218 knockdown attenuated ox-LDL-induced dysfunction in HUVECs via regulating miR-188-3p/TLR4/NF- κB pathway. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 31, 2022 Category: Cardiology Source Type: research

Efficacy and Safety of Inclisiran in Patients with Polyvascular Disease: Pooled, Post Hoc Analysis of the ORION-9, ORION-10, and ORION-11 Phase 3 Randomized Controlled Trials
ConclusionTwice-yearly inclisiran dosing (after the initial and 3-month doses) was well tolerated and provided effective and sustained lipid-lowering in patients, irrespective of PVD status. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 23, 2022 Category: Cardiology Source Type: research

Considerations for Left Atrial Appendage Occlusion During Cardiac Surgery
AbstractAtrial fibrillation is associated with an increased risk of stroke secondary to thrombus formation in the left atrial appendage. Left atrial appendage occlusion (LAAO) is an effective method of reducing the risk of stroke in patients with atrial fibrillation. Although LAAO does not remove the requirement for anticoagulation, it reduces the risk of stroke when compared to anticoagulation alone. We critically analyze the data on LAAO in cardiac surgery. We also discuss the methods of LAAO, the risks of LAAO, and patient populations that could benefit from LAAO. We discuss high-level evidence that LAAO at the time of ...
Source: Cardiovascular Drugs and Therapy - December 23, 2022 Category: Cardiology Source Type: research

Left Ventricular Thrombus Management After Acute Myocardial Infarction in Clinical Practice: Results from LEVITATION Survey and Narrative Review
ConclusionThe survey has depicted for the first time the current real-world management of this neglected topic and has highlighted several grey zones that are still present and not supported by evidence. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 20, 2022 Category: Cardiology Source Type: research

PrevAleNce and Associated factors of inappropriaTe dosing of direct Oral anticoaguLants In pAtients with Atrial Fibrillation: the ANATOLIA-AF Study
ConclusionThe study demonstrated that the prevalence of inappropriate direct oral anticoagulant dosing according to the European Heart Rhythm Association recommendations was 24.9% in patients with atrial fibrillation. Several demographic and clinical factors were associated with the inappropriate prescription of direct oral anticoagulants. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 17, 2022 Category: Cardiology Source Type: research

Oxidative Stress-Mediated Programmed Cell Death: a Potential Therapy Target for Atherosclerosis
AbstractNowadays, as a type of orderly and active death determined by genes, programmed cell death (PCD), including apoptosis, pyroptosis, ferroptosis, and necroptosis, has attracted much attention owing to its participation in numerous chronic cardiovascular diseases, especially atherosclerosis (AS), a canonical chronic inflammatory disease featured by lipid metabolism disturbance. Abundant researches have reported that PCD under distinct internal conditions fulfills different roles of atherosclerotic pathological processes, including lipid core expansion, leukocyte adhesion, and infiltration. Noteworthy, emerging evidenc...
Source: Cardiovascular Drugs and Therapy - December 16, 2022 Category: Cardiology Source Type: research

METTL3: a Potential New Target in the Treatment Strategy of Atherosclerosis?
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 5, 2022 Category: Cardiology Source Type: research

Left Bundle Branch Area Pacing versus Biventricular Pacing for Cardiac Resynchronization Therapy on Morbidity and Mortality
ConclusionLBBAP was associated with a comparable effect on morbidity and mortality relative to BVP in patients with indications for CRT. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 2, 2022 Category: Cardiology Source Type: research

Flavocoxid Ameliorates Aortic Calcification Induced by Hypervitaminosis D3 and Nicotine in Rats Via Targeting TNF- α, IL-1β, iNOS, and Osteogenic Runx2
ConclusionThese findings demonstrate FCX ability to attenuate VDN-induced aortic calcinosis in rats, suggesting its potential for preventing arteiocalcinosis in diabetic patients and those with chronic kidney disease. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 11, 2022 Category: Cardiology Source Type: research

Proton Pump Inhibitor and Clopidogrel Use After Percutaneous Coronary Intervention and Risk of Major Cardiovascular Events
ConclusionsIn patients who receive clopidogrel after PCI, concomitant use of PPI seems to increase the risk of major cardiovascular events. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 11, 2022 Category: Cardiology Source Type: research

Calsyntenin-1 Promotes Doxorubicin-induced Dilated Cardiomyopathy in Rats
ConclusionOur findings demonstrated that CLSTN1 promotes the pathogenesis of doxorubicin-induced DCM. CLSTN1 could be a therapeutic target to prevent the development of doxorubicin-induced DCM. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 9, 2022 Category: Cardiology Source Type: research

Intracoronary Thrombolysis in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention: an Updated Meta-analysis of Randomized Controlled Trials
ConclusionsThe present meta-analysis suggests that ICT was associated with improved MACE and myocardial microcirculation in STEMI patients undergoing PPCI, without significant increase in major bleeding. However, these findings necessitate confirmation in a contemporary large RCT. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 8, 2022 Category: Cardiology Source Type: research

Effect of Sodium-Glucose Co-transporter-2 Inhibitors on Ventricular Repolarization Markers in Heart Failure with Reduced Ejection Fraction
ConclusionsThe addition of SGLT2 inhibitors to optimal medical therapy in HFrEF patients positively changes VRM (QT, QTc, QTd, Tp-e, and Tp-e/QTc). (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 7, 2022 Category: Cardiology Source Type: research

Association Between Platelet Glycoprotein IIb/IIIa Inhibition and In-Hospital Outcomes in ST-Elevation Myocardial Infarction Patients Treated with Coronary Thrombus Aspiration: Findings from the CCC-ACS Project
ConclusionIn a nationwide registry, routine use of GPI following thrombus aspiration was not associated with reduced in-hospital ischemic events and mortality but at the cost of increased major bleeding. However, for patients aged  <  60 years, there may be a potential net benefit. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 7, 2022 Category: Cardiology Source Type: research

The Effect of Colchicine in Acute Myocardial Infarction
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - November 2, 2022 Category: Cardiology Source Type: research