Mutant CYP3A4/5 Correlated with Clinical Outcomes by Affecting Rivaroxaban Pharmacokinetics and Pharmacodynamics in Patients with Atrial Fibrillation

ConclusionTheCYP3A4 polymorphisms (rs2242480, rs2246709, and rs3735451) andCYP3A5 rs776746 were associated with variations in rivaroxaban PK/PD. The minor allele (C) carriers on rs3735451 and the minor allele (A) carriers on rs2246709 were correlated with clinical outcomes.
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research