Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore
ConclusionOur findings suggest that concomitant use of simvastatin with rivaroxaban may be associated with bleeding events in an Asian cohort. Further studies using physiologically based pharmacokinetic modelling are required to investigate the drug-drug interactions between these drugs. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - October 1, 2023 Category: Cardiology Source Type: research
Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts
ConclusionThis study suggests that treatment with TERI leads to more negative outcomes following cardiac ischemia reperfusion, and administration of TERI to at-risk populations should receive special considerations. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - October 1, 2023 Category: Cardiology Source Type: research
Mesenchymal Stem Cell –Originated Exosomal Lnc A2M-AS1 Alleviates Hypoxia/Reperfusion-Induced Apoptosis and Oxidative Stress in Cardiomyocytes
ConclusionLnc A2M-AS1 delivery via MSC-derived exosomes ameliorated H/R-induced cardiomyocyte apoptosis and oxidative stress via regulating miR-556-5p/XIAP, opening a new window into the pathogenesis of myocardial I/R injury. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - October 1, 2023 Category: Cardiology Source Type: research
Reply to the Letter to the Editor Titled “The Effects of Dexamethasone on Cardiovascular Disease: Friend or Foe?” by Han et al
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - October 1, 2023 Category: Cardiology Source Type: research
The Effects of Dexamethasone on Cardiovascular Disease: Friend or Foe?
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - October 1, 2023 Category: Cardiology Source Type: research
Long-term Dexamethasone Treatment Increases Cardiac Galectin-3 Levels
ConclusionThe finding of the current study is the first to show that dexamethasone causes an increase in gal-3 levels in myocardium. Our study provides an important step in the development of possible therapeutics by determining that dexamethasone causes an increase in gal-3 levels in the myocardium and raises awareness about the follow-up of patients receiving long-term glucocorticoid therapy. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - October 1, 2023 Category: Cardiology Source Type: research
Targeted Mobilisation of Endogenous Endothelial Progenitor Cells — an Alternate Approach to Allogeneic Therapy for Ischaemic Cardiovasular Disease?
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - October 1, 2023 Category: Cardiology Source Type: research
Platelet-Mediated Transfer of Cardioprotection by Remote Ischemic Conditioning and Its Abrogation by Aspirin But Not by Ticagrelor
ConclusionPlatelets serve as carriers for RIC ’s cardioprotective signal through an aspirin-sensitive and thus cyclooxygenase-dependent mechanism. The P2Y12 inhibitor ticagrelor per se induces a humoral cardioprotective signal.Graphical abstract (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research
The Impact of Trimetazidine on Cardiac Fibrosis, Inflammation, and Function in Ischemic Cardiomyopathy Patients
ConclusionAdjunctive TMZ therapy for ICM effectively improved vascular endothelial function and reduced inflammation. Furthermore, our exploratory findings may be used to provide new information on the potential effects of TMZ on myocardial fibrosis by downregulating CTGF. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research
Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore
ConclusionOur findings suggest that concomitant use of simvastatin with rivaroxaban may be associated with bleeding events in an Asian cohort. Further studies using physiologically based pharmacokinetic modelling are required to investigate the drug-drug interactions between these drugs. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research
Mesenchymal Stem Cell –Originated Exosomal Lnc A2M-AS1 Alleviates Hypoxia/Reperfusion-Induced Apoptosis and Oxidative Stress in Cardiomyocytes
ConclusionLnc A2M-AS1 delivery via MSC-derived exosomes ameliorated H/R-induced cardiomyocyte apoptosis and oxidative stress via regulating miR-556-5p/XIAP, opening a new window into the pathogenesis of myocardial I/R injury. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research
Long-term Dexamethasone Treatment Increases Cardiac Galectin-3 Levels
ConclusionThe finding of the current study is the first to show that dexamethasone causes an increase in gal-3 levels in myocardium. Our study provides an important step in the development of possible therapeutics by determining that dexamethasone causes an increase in gal-3 levels in the myocardium and raises awareness about the follow-up of patients receiving long-term glucocorticoid therapy. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research
Minimal Adherence Threshold to Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation to Reduce the Risk of Thromboembolism and Death: A Nationwide Cohort Study
ConclusionPoor adherence to NOACs is associated with increased risks of thromboembolism and all-cause mortality. The minimal adherence threshold should be ≥ 90%, preferably even ≥ 95%. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 14, 2023 Category: Cardiology Source Type: research
Long Non-coding RNA Involved in the Pathophysiology of Atrial Fibrillation
ConclusionIn conclusion, targeting AF-related lncRNAs holds substantial promise for future investigations and represents a potential therapeutic avenue for managing AF. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 13, 2023 Category: Cardiology Source Type: research
Trimetazidine to Reduce Myocardial Fibrosis —Competing Interests with SGLT2 Inhibitors?
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 13, 2023 Category: Cardiology Source Type: research
