Edaravone dexborneol attenuates cognitive impairment in a rat model of vascular dementia by inhibiting hippocampal oxidative stress and inflammatory responses and modulating the NMDA receptor signaling pathway
Brain Res. 2024 Apr 4:148917. doi: 10.1016/j.brainres.2024.148917. Online ahead of print.ABSTRACTExploring the intricate pathogenesis of Vascular Dementia (VD), there is a noted absence of potent treatments available in the current medical landscape. A new brain-protective medication developed in China, Edaravone dexboeol (EDB), has shown promise due to its antioxidant and anti-inflammatory properties, albeit with a need for additional research to elucidate its role and mechanisms in VD contexts. In a research setup, a VD model was established utilizing Sprague-Dawley (SD) rats, subjected to permanent bilateral typical car...
Source: Brain Research - April 6, 2024 Category: Neurology Authors: Hui Guo Haodong Li Zhisheng Jia Shuyu Ma Jin Zhang Source Type: research
Temporal expression of brainstem neurotrophic proteins following mild traumatic brain injury
Brain Res. 2024 Apr 4:148908. doi: 10.1016/j.brainres.2024.148908. Online ahead of print.ABSTRACTBDNF, a neurotrophic factor, and its receptors have been implicated in the pathophysiology of mild traumatic brain injury (mTBI). The brainstem houses many vital functions, that are also associated with signs and symptoms of mTBI, but has been understudied in mTBI animal models. We determined the extent to which neurotrophic protein and associated receptor expression is affected within the brainstem of adult rats following mTBI. Their behavioral function was assessed and temporal expression of the 'negative' regulators of neuro...
Source: Brain Research - April 6, 2024 Category: Neurology Authors: Jacob I McPherson Vijaya Prakash Krishnan Muthaiah Kathiravan Kaliyappan John J Leddy Kirkwood E Personius Source Type: research
Neurobehavioral and molecular changes in a rodent model of ACTH-induced HPA axis dysfunction
In conclusion, ACTH administration resulted in a sex-specific onset of depressive-like symptoms and changes in brain regional expression of neurotrophic factors. These results suggest sex-specific mechanisms underlying the development of depressive-like behavior in a model of ACTH-induced HPA axis dysregulation.PMID:38580046 | DOI:10.1016/j.brainres.2024.148913 (Source: Brain Research)
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Farhanah N Sallie Leandrie Pienaar Andrea Lubbe Sanelisiwe Xhakaza Srinivasa R Manne Beatriz G de la Torre Fernando Albericio William Mu Daniels Aletta Me Millen Sooraj Baijnath Source Type: research
Role of electrophysiological activity and interactions of lateral habenula in the development of depression-like behavior in a chronic restraint stress model
Brain Res. 2024 Apr 3:148914. doi: 10.1016/j.brainres.2024.148914. Online ahead of print.ABSTRACTClosed-loop deep brain stimulation (DBS) system offers a promising approach for treatment-resistant depression, but identifying universally accepted electrophysiological biomarkers for closed-loop DBS systems targeting depression is challenging. There is growing evidence suggesting a strong association between the lateral habenula (LHb) and depression. Here, we took LHb as a key target, utilizing multi-site local field potentials (LFPs) to study the acute and chronic changes in electrophysiology, functional connectivity, and br...
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Chang Wang Yuting Sun Yanjie Xing Kezhou Liu Kedi Xu Source Type: research
Berberine and hesperidin prevent the memory consolidation impairment induced by pentylenotetrazole in zebrafish
This study verified the effects of the natural compounds berberine and hesperidin on seizure development and cognitive impairment triggered by pentylenetetrazole (PTZ) in zebrafish. Adult animals were submitted to a training session in the inhibitory avoidance test and, after 10minutes, they received an intraperitoneal injection of 25, 50, or 100mg/kg berberine or 100 or 200mg/kg hesperidin. After 30minutes, the animals were exposed to 7.5mM PTZ for 10minutes. Animals were submitted to the test session 24h after the training session to verify their cognitive performance. Zebrafish larvae were exposed to 100µM or 500µM be...
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Kanandra Taisa Bertoncello Gabriel Rodrigues Carla Denise Bonan Source Type: research
Vulnerable at rest? A resting-state EEG study and psycho-social factors of young adult offspring of alcohol-dependent parents
CONCLUSIONS: This study does not provide evidence suggesting vulnerability in offspring based on differences in spontaneous brain activity. Moreover, this investigation highlights the importance of interventions aimed at enhancing social connections in offspring. Such interventions can not only reduce the risk of developing AUD, given its strong association with increased feelings of loneliness but also improve the overall well-being of the offspring.PMID:38580199 | DOI:10.1016/j.bbr.2024.114980 (Source: Brain Research)
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Milagros Rubio Ana Sion Isabel Dom ínguez Centeno Daniel Maldonado S ánchez Gabriel Rubio Maartje Luijten Rosa Jurado Barba Source Type: research
Neurophysiological Analysis of Disadvantageous Social Inequity: Exploring Emotional Behavior Changes and c-Fos Expression in a Male Rat Model
In this study, we developed a rat model to determine the effects of socially equal or unequal reward and stress on emotional changes in male rats. During the training session, the rats were trained to escape when a sound cue was presented, and they were assigned to one of the following groups: all escaping rats [advantageous equity (AE)], freely moving rats alongside a restrained rat [advantageous inequity (AI)], all restrained rats [disadvantageous equity (DE)], and a rat restrained in the presence of freely moving companions [disadvantageous inequity (DI)]. During the test session, rats in the advantageous group (AE and ...
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Yujeong Jeong Jihyun Noh Source Type: research
Neurobehavioral and molecular changes in a rodent model of ACTH-induced HPA axis dysfunction
In conclusion, ACTH administration resulted in a sex-specific onset of depressive-like symptoms and changes in brain regional expression of neurotrophic factors. These results suggest sex-specific mechanisms underlying the development of depressive-like behavior in a model of ACTH-induced HPA axis dysregulation.PMID:38580046 | DOI:10.1016/j.brainres.2024.148913 (Source: Brain Research)
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Farhanah N Sallie Leandrie Pienaar Andrea Lubbe Sanelisiwe Xhakaza Srinivasa R Manne Beatriz G de la Torre Fernando Albericio William Mu Daniels Aletta Me Millen Sooraj Baijnath Source Type: research
Role of electrophysiological activity and interactions of lateral habenula in the development of depression-like behavior in a chronic restraint stress model
Brain Res. 2024 Apr 3:148914. doi: 10.1016/j.brainres.2024.148914. Online ahead of print.ABSTRACTClosed-loop deep brain stimulation (DBS) system offers a promising approach for treatment-resistant depression, but identifying universally accepted electrophysiological biomarkers for closed-loop DBS systems targeting depression is challenging. There is growing evidence suggesting a strong association between the lateral habenula (LHb) and depression. Here, we took LHb as a key target, utilizing multi-site local field potentials (LFPs) to study the acute and chronic changes in electrophysiology, functional connectivity, and br...
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Chang Wang Yuting Sun Yanjie Xing Kezhou Liu Kedi Xu Source Type: research
Berberine and hesperidin prevent the memory consolidation impairment induced by pentylenotetrazole in zebrafish
This study verified the effects of the natural compounds berberine and hesperidin on seizure development and cognitive impairment triggered by pentylenetetrazole (PTZ) in zebrafish. Adult animals were submitted to a training session in the inhibitory avoidance test and, after 10minutes, they received an intraperitoneal injection of 25, 50, or 100mg/kg berberine or 100 or 200mg/kg hesperidin. After 30minutes, the animals were exposed to 7.5mM PTZ for 10minutes. Animals were submitted to the test session 24h after the training session to verify their cognitive performance. Zebrafish larvae were exposed to 100µM or 500µM be...
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Kanandra Taisa Bertoncello Gabriel Rodrigues Carla Denise Bonan Source Type: research
Vulnerable at rest? A resting-state EEG study and psycho-social factors of young adult offspring of alcohol-dependent parents
CONCLUSIONS: This study does not provide evidence suggesting vulnerability in offspring based on differences in spontaneous brain activity. Moreover, this investigation highlights the importance of interventions aimed at enhancing social connections in offspring. Such interventions can not only reduce the risk of developing AUD, given its strong association with increased feelings of loneliness but also improve the overall well-being of the offspring.PMID:38580199 | DOI:10.1016/j.bbr.2024.114980 (Source: Brain Research)
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Milagros Rubio Ana Sion Isabel Dom ínguez Centeno Daniel Maldonado S ánchez Gabriel Rubio Maartje Luijten Rosa Jurado Barba Source Type: research
Neurophysiological Analysis of Disadvantageous Social Inequity: Exploring Emotional Behavior Changes and c-Fos Expression in a Male Rat Model
In this study, we developed a rat model to determine the effects of socially equal or unequal reward and stress on emotional changes in male rats. During the training session, the rats were trained to escape when a sound cue was presented, and they were assigned to one of the following groups: all escaping rats [advantageous equity (AE)], freely moving rats alongside a restrained rat [advantageous inequity (AI)], all restrained rats [disadvantageous equity (DE)], and a rat restrained in the presence of freely moving companions [disadvantageous inequity (DI)]. During the test session, rats in the advantageous group (AE and ...
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Yujeong Jeong Jihyun Noh Source Type: research
Triptolide alleviates cerebral ischemia/reperfusion injury via regulating the Fractalkine/CX3CR1 signaling pathway
CONCLUSION: TP inhibits not only microglia polarization towards the M1 phenotype by suppressing the CTSS/Fractalkine/CX3CR1 pathway activation, but also HT-22 apoptosis by crosstalk with BV-2 cells, thereby ameliorating CIRI. These findings reveal a novel mechanism of TP in improving CIRI, and offer potential implications for addressing the preventive and therapeutic strategies of CIRI.PMID:38574865 | DOI:10.1016/j.brainresbull.2024.110939 (Source: Brain Research)
Source: Brain Research - April 4, 2024 Category: Neurology Authors: Jiajun Zhou Wei Ye Ling Chen Junheng Li Yijun Zhou Chunfeng Bai Lian Luo Source Type: research
Transcriptomic insights into multiple system atrophy from a PLP- α-synuclein transgenic mouse model
In this study, we investigated differentially expressed genes (DEGs) via RNA-sequencing of brain samples from a validated PLP-α-synuclein transgenic mouse model, identifying a total of 40 DEGs in the PLP group compared to wild-type (WT), with top detected genes being Gm15446, Mcm6, Aldh7a1 and Gm3435. We observed a significant enrichment of immune pathways and endothelial cell genes among the upregulated genes, whereas downregulated genes were significantly enriched for oligodendrocyte and neuronal genes. We then calculated possible overlap of these DEGs with previously profiled human MSA RNA, resulting in the identificat...
Source: Brain Research - April 4, 2024 Category: Neurology Authors: L Nicholson I S Piras M D DeBoth A Siniard A Heras-Garvin N Stefanova M J Huentelman Source Type: research
Triptolide alleviates cerebral ischemia/reperfusion injury via regulating the Fractalkine/CX3CR1 signaling pathway
CONCLUSION: TP inhibits not only microglia polarization towards the M1 phenotype by suppressing the CTSS/Fractalkine/CX3CR1 pathway activation, but also HT-22 apoptosis by crosstalk with BV-2 cells, thereby ameliorating CIRI. These findings reveal a novel mechanism of TP in improving CIRI, and offer potential implications for addressing the preventive and therapeutic strategies of CIRI.PMID:38574865 | DOI:10.1016/j.brainresbull.2024.110939 (Source: Brain Research)
Source: Brain Research - April 4, 2024 Category: Neurology Authors: Jiajun Zhou Wei Ye Ling Chen Junheng Li Yijun Zhou Chunfeng Bai Lian Luo Source Type: research
