Neurobehavioral and molecular changes in a rodent model of ACTH-induced HPA axis dysfunction

In conclusion, ACTH administration resulted in a sex-specific onset of depressive-like symptoms and changes in brain regional expression of neurotrophic factors. These results suggest sex-specific mechanisms underlying the development of depressive-like behavior in a model of ACTH-induced HPA axis dysregulation.PMID:38580046 | DOI:10.1016/j.brainres.2024.148913

Source: Brain Research - April 5, 2024 Category: Neurology Authors: Farhanah N Sallie Leandrie Pienaar Andrea Lubbe Sanelisiwe Xhakaza Srinivasa R Manne Beatriz G de la Torre Fernando Albericio William Mu Daniels Aletta Me Millen Sooraj Baijnath Source Type: research