Cuscuta chinensis Lam. Flavonoids (CCLF) alleviate the symptoms of sepsis-associated encephalopathy via PI3K/Nrf2 pathway
Behav Brain Res. 2024 Mar 16:114887. doi: 10.1016/j.bbr.2024.114887. Online ahead of print.ABSTRACTSepsis-associated encephalopathy (SAE) frequently encounters patients who are in intensive care units and ~70% of patients with severe systemic infection. However, due to the unclear pathological mechanisms of SAE, the desease-modifying drug is still lack. Here, we aimed to explore whether the flavonoid components extracted from CCL (CCLF) seeds possess protective effects on SAE animals, and systematically evaluate the transcriptomic alteration (in the hippocampus) after CCLF treatment on SAE animals employing RNA sequencing....
Source: Brain Research - March 18, 2024 Category: Neurology Authors: Qi Boxiang Sheng Liping Qian Tong Source Type: research

MKP1 may be involved in the occurrence of depression by regulating hippocampal autophagy in rats
CONCLUSION: Enhanced hippocampal autophagy via MKP1-mediated ERK dephosphorylation may contribute to the development of depression.PMID:38499157 | DOI:10.1016/j.bbr.2024.114962 (Source: Brain Research)
Source: Brain Research - March 18, 2024 Category: Neurology Authors: Laipeng Feng Huiying Wang Chen Chen Jiacheng Fu Liqin Zhao Xia Zhao Mengjun Geng Mengdi Ren Lidan Tong Yan Li Jingyang Gu Chonghong Wang Source Type: research

Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study
Behav Brain Res. 2024 Mar 16:114963. doi: 10.1016/j.bbr.2024.114963. Online ahead of print.ABSTRACTLisdexamfetamine (LDX) is one of the drugs commonly used to treat attention deficit hyperactivity disorder (ADHD). However, its neurological side effects, particularly on cognition, are not fully understood. The present study focused on memory in rats treated with four weeks of LDX injection. We compared LDX-treated rats with control ones, using several methods to evaluate the behavioral responses and electrophysiological, molecular, and histological properties in the hippocampus. Our findings demonstrated that subchronic adm...
Source: Brain Research - March 18, 2024 Category: Neurology Authors: Seyedeh Naghmeh Nourirad Amhr-Hossein Bayat Moitaba Sani Amirreza Beirami Maral Hasanzadeh Susan Roustaee Mobina Fathi Kimia Vakili Siavash Parvardeh Gholam Hossein Meftahi Nahid Sarahian Fariba Khodagholi Abbas Aliaghaei Hojjat-Allah Abbaszadeh Meysam Ha Source Type: research

Variants in 3p24.3 predicts the risk of early neurological deterioration in large artery atherosclerotic stroke
The objective of this research is to examine the efficacy that PLCL2 may have on the risk of END in large artery atherosclerotic (LAA) stroke. Tagged single nucleotide polymorphisms (SNPs) were identified by a strategy of fine-mapping. The genotyping of the selected SNPs was performed by SNPscan. The impact of PLCL2 on indicating the susceptibility of END in LAA patients was evaluated by binary logistic regression. The SNP-SNP interactions of PLCL2 for END was assessed by generalized multifactor dimensionality reduction (GMDR). A total of 1527 LAA stroke patients were recruited, 582 patients (38 %) experienced END. Compare...
Source: Brain Research - March 18, 2024 Category: Neurology Authors: Xiaoya Huang Qiang Ye Zhenguo Zhu Yanyan Chen Niange Xia Rongrong Chen Wujun Geng Zusen Ye Source Type: research

Mu-ERD reflects action understanding, but the effect is small
Brain Res. 2024 Mar 16;1832:148854. doi: 10.1016/j.brainres.2024.148854. Online ahead of print.ABSTRACTSince the mid-2000's, many researchers have provided evidence that mu-ERD measured at the motor cortex may reflect the collective activation of upstream brain regions associated with the human mirror system during action observation paradigms; however, several recent papers have called these findings into question. Our study represents an effort to address these criticisms. In our study, participants watched videos in which the type of grip an actor used to grasp a coffee mug either conveyed the goal with 100 % certainty ...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Lawrence Paul Behmer Source Type: research

Sleep deprivation changes frequency-specific functional organization of the resting human brain
In this study, thirty-seven healthy male subjects underwent resting-state fMRI during rested wakefulness (RW) and after 36hours of SD, and we examined frequency-specific spectral connection changes (0.01-0.08Hz, interval = 0.01Hz) caused by SD. First, we conducted a multivariate pattern analysis combining linear SVM classifiers with a robust feature selection algorithm, and the results revealed that accuracies of 74.29%-84.29% could be achieved in the classification between RW and SD states in leave-one-out cross-validation at different frequency bands, moreover, the spectral connection at the lowest and highest frequency ...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Zhiguo Luo Erwei Yin Ye Yan Shaokai Zhao Liang Xie Hui Shen Ling-Li Zeng Lubin Wang Dewen Hu Source Type: research

Inhibition of lysyl oxidase by pharmacological intervention and genetic manipulation alleviates epilepsy-associated cognitive disorder
Brain Res Bull. 2024 Mar 15:110928. doi: 10.1016/j.brainresbull.2024.110928. Online ahead of print.ABSTRACTEpilepsy-associated cognitive disorder (ECD), a prevalent comorbidity in epilepsy patients, has so far uncharacterized etiological origins. Our prior work revealed that lysyl oxidase (Lox) acted as a novel contributor of ferroptosis, a recently discovered cell death mode in the regulation of brain function. However, the role of Lox-mediated ferroptosis in ECD remains unknown. ECD mouse model was established 2 months later following a single injection of kainic acid (KA) for. After chronic treatment with KA, mice were ...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Kang-Ni Chen Qi-Lin Peng Dan-Feng Cao Zhao-Jun Wang Kai Zhang Xin-Yu Zhou Dong-Yu Min Bo-Ting Zhou Xiao-Yuan Mao Source Type: research

Adora2A downregulation promotes caffeine neuroprotective effect against LPS-induced neuroinflammation in the hippocampus
Brain Res. 2024 Mar 15:148866. doi: 10.1016/j.brainres.2024.148866. Online ahead of print.ABSTRACTCaffeine has been extensively studied in the context of CNS pathologies as many researchers have shown that consuming it reduces pro-inflammatory biomarkers, potentially delaying the progression of neurodegenerative pathologies. Several lines of evidence suggest that adenosine receptors, especially A1 and A2A receptors, are the main targets of its neuroprotective action. We found that caffeine pretreatment 15 min before LPS administration reduced the expression of Il1b in the hippocampus and striatum. The harmful modulation of...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Paula Lemes Dos Santos Sanna Liebert Bernardes Carvalho Camila Cristina Dos Santos Afonso Kassia de Carvalho Rog ério Aires Jennyffer Souza Marcel Rodrigues Ferreira Alexander Birbrair Maria Martha Bernardi Alexandra Latini Rodrigo A Foganholi da Silva Source Type: research

The relationship between oxidative stress markers and 1H-Magnetic resonance spectroscopy findings in Obsessive compulsive disorder
CONCLUSIONS: Our study is the first to assess CN and OFC together in OCD patients using 3 T MR, investigating the relationship between neurometabolite concentrations and oxidative stress parameters. The negative correlation we observed between NAA/Cr levels and SOD and GPx in the caudate nucleus suggests that increased oxidative stress in this brain region in OCD patients may contribute to impaired neuronal integration and functionality.PMID:38494099 | DOI:10.1016/j.brainres.2024.148852 (Source: Brain Research)
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Fatma Suba şı Turgut Mahmut Bulut Salih Hattapo ğlu Mehmet G üneş Mehmet Cemal Kaya Faysal Ekici Mehmet Guli Çetinçakmak İbrahim Kaplan Murad Atmaca Source Type: research

Insular and prelimbic cortices control behavioral accuracy and precision in a temporal decision-making task in rats
Behav Brain Res. 2024 Mar 15:114961. doi: 10.1016/j.bbr.2024.114961. Online ahead of print.ABSTRACTThe anterior insular cortex (AIC) comprises a region of sensory integration. It appears to detect salient events in order to guide goal-directed behavior, code tracking errors, and estimate the passage of time. Temporal processing in the AIC may be instantiated by the integration of representations of interoception. Projections between the AIC and the medial prefrontal cortex (mPFC) - found both in rats and humans - also suggest a possible role for these structures in the integration of autonomic responses during ongoing beha...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Estela B Nepomoceno Samanta Rodrigues Katia S de Melo Tatiana L Ferreira David Freestone Marcelo S Caetano Source Type: research

Assessment of rTMS treatment effects for methamphetamine use disorder based on EEG microstates
This study included a comprehensive subject population to investigate the effect of rTMS on MUD microstates. 34 patients with MUD underwent a 4-week randomized, double-blind rTMS intervention (active=17, sham=17). Two resting-state EEG recordings and VAS evaluations were conducted before and after the intervention period. Additionally, 17 healthy individuals were included as baseline controls. The modified k-means clustering method was used to calculate four microstates (MS-A~MS-D) of EEG, and the FC network was also analyzed. The differences in microstate indicators between groups and within groups were compared. The dura...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Yongcong Li Banghua Yang Jun Ma Shouwei Gao Hui Zeng Wen Wang Source Type: research

CK2 negatively regulates the extinction of remote fear memory
In this study, we adopted a classical Pavlovian fear conditioning model to investigate the involvement of CK2 in remote fear memory extinction and its underlying mechanisms. The results indicated that the activity of CK2 in the medial prefrontal cortex (mPFC) of mice was significantly upregulated after extinction training of remote cued fear memory. Notably, administration of the CK2 inhibitor CX-4945 prior to extinction training facilitated the extinction of remote fear memory. In addition, CX-4945 significantly upregulated the expression of p-ERK1/2 and p-CREB in the mPFC. Our results suggest that CK2 negatively regulate...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Jie Yang Lin Lin Guang-Jing Zou Lai-Fa Wang Fang Li Chang-Qi Li Yan-Hui Cui Fu-Lian Huang Source Type: research

Mu-ERD reflects action understanding, but the effect is small
Brain Res. 2024 Mar 16;1832:148854. doi: 10.1016/j.brainres.2024.148854. Online ahead of print.ABSTRACTSince the mid-2000's, many researchers have provided evidence that mu-ERD measured at the motor cortex may reflect the collective activation of upstream brain regions associated with the human mirror system during action observation paradigms; however, several recent papers have called these findings into question. Our study represents an effort to address these criticisms. In our study, participants watched videos in which the type of grip an actor used to grasp a coffee mug either conveyed the goal with 100 % certainty ...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Lawrence Paul Behmer Source Type: research

Sleep deprivation changes frequency-specific functional organization of the resting human brain
In this study, thirty-seven healthy male subjects underwent resting-state fMRI during rested wakefulness (RW) and after 36hours of SD, and we examined frequency-specific spectral connection changes (0.01-0.08Hz, interval = 0.01Hz) caused by SD. First, we conducted a multivariate pattern analysis combining linear SVM classifiers with a robust feature selection algorithm, and the results revealed that accuracies of 74.29%-84.29% could be achieved in the classification between RW and SD states in leave-one-out cross-validation at different frequency bands, moreover, the spectral connection at the lowest and highest frequency ...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Zhiguo Luo Erwei Yin Ye Yan Shaokai Zhao Liang Xie Hui Shen Ling-Li Zeng Lubin Wang Dewen Hu Source Type: research

Inhibition of lysyl oxidase by pharmacological intervention and genetic manipulation alleviates epilepsy-associated cognitive disorder
Brain Res Bull. 2024 Mar 15:110928. doi: 10.1016/j.brainresbull.2024.110928. Online ahead of print.ABSTRACTEpilepsy-associated cognitive disorder (ECD), a prevalent comorbidity in epilepsy patients, has so far uncharacterized etiological origins. Our prior work revealed that lysyl oxidase (Lox) acted as a novel contributor of ferroptosis, a recently discovered cell death mode in the regulation of brain function. However, the role of Lox-mediated ferroptosis in ECD remains unknown. ECD mouse model was established 2 months later following a single injection of kainic acid (KA) for. After chronic treatment with KA, mice were ...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Kang-Ni Chen Qi-Lin Peng Dan-Feng Cao Zhao-Jun Wang Kai Zhang Xin-Yu Zhou Dong-Yu Min Bo-Ting Zhou Xiao-Yuan Mao Source Type: research