Oral application of magnesium-L-threonate alleviates radicular pain by inhibiting neuro-inflammation dependent central sensitization of rats
CONCLUSIONS: Oral application of L-TAMS alleviates radicular pain by inhibiting neuro-inflammation dependent central sensitization of rats.PMID:38604557 | DOI:10.1016/j.brainres.2024.148910 (Source: Brain Research)
Source: Brain Research - April 11, 2024 Category: Neurology Authors: Siyuan Li Hongjian Yi Fuli Yuan Xuejuan Zhang Yi Zhong Yangliang Huang Source Type: research
Implicit and explicit motor imagery ability after SCI: Moving the elbow makes the difference
Brain Res. 2024 Apr 9:148911. doi: 10.1016/j.brainres.2024.148911. Online ahead of print.ABSTRACTCervical spinal cord injury (SCI) causes dramatic sensorimotor deficits that restrict both activity and participation. Restoring activity and participation requires extensive upper limb rehabilitation focusing elbow and wrist movements, which can include motor imagery. Yet, it remains unclear whether MI ability is impaired or spared after SCI. We investigated implicit and explicit MI ability in individuals with C6 or C7 SCI (SCIC6 and SCIC7 groups), as well as in aged- and gender-matched controls without SCI. Inspired by previo...
Source: Brain Research - April 11, 2024 Category: Neurology Authors: S ébastien Mateo Aymeric Guillot Sonia Henkous Anthony Gelis S ébastien Daligault Gilles Rode Christian Collet Franck Di Rienzo Source Type: research
Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies
This study aims to explore the antidepressant-like effects of the major constituents found in C. asiatica, i.e., asiatic acid, asiaticoside, madecassic acid, and madecassoside at three doses (1.25, 2.5, and 5mg/kg, i.p), on the behavioural and cortisol level of unpredictable chronic stress (UCS) zebrafish model. Based on the findings from the behavioural study, the cortisol levels in the zebrafish body after treatment with the two most effective compounds were measured using enzyme-linked immunosorbent assay (ELISA). Furthermore, a molecular docking study was conducted to predict the inhibitory impact of the triterpenoid c...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Zaynab Mando Huda Mando Adlin Afzan Khozirah Shaari Zurina Hassan Mohamad Nurul Azmi Fauziahanim Zakaria Source Type: research
Structural Characteristics of Amygdala Subregions in Type 2 Diabetes Mellitus
This study aims to explore the microstructural alterations of the amygdala in T2DM and to investigate the relationship between the alterations and depressive symptoms. Fifty T2DM and 50 healthy controls were included. Firstly, the volumes of subcortical regions and subregions of amygdala were calculated by FreeSurfer. Covariance analysis (ANCOVA) was conducted between the two groups with covariates of age, sex, and estimated total intracranial volume to explore the differences in volume of subcortical regions and subregions of amygdala. Furthermore, the structural covariance within the amygdala subregions was performed. Mo...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Wenbin Qiu Xiaomei Yue Haoming Huang Limin Ge Weiye Lu Zidong Cao Yawen Rao Xin Tan Yan Wang Jinjian Wu Yuna Chen Shijun Qiu Gang Li Source Type: research
A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
Manipulation of α4βδ GABA < sub > A < /sub > receptors alters synaptic pruning in layer 3 prelimbic prefrontal cortex and impairs temporal order recognition: Implications for schizophrenia and autism
Brain Res. 2024 Apr 8:148929. doi: 10.1016/j.brainres.2024.148929. Online ahead of print.ABSTRACTTemporal order memory is impaired in autism spectrum disorder (ASD) and schizophrenia (SCZ). These disorders, more prevalent in males, result in abnormal dendritic spine pruning during adolescence in layer 3 (L3) medial prefrontal cortex (mPFC), yielding either too many (ASD) or too few (SCZ) spines. Here we tested whether altering spine density in neural circuits including the mPFC could be associated with impaired temporal order memory in male mice. We have shown that α4βδ GABAA receptors (GABARs) emerge at puberty on spin...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Sheryl S Smith Safae Benanni Quiana Jones Lindsay Kenney Matthew Evrard Source Type: research
Targeting VDAC: A potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease
This article aims to provide an overview of the role of VDAC in mitochondrial dysfunction, its association with Alzheimer's disease, and the potential of targeting VDAC for developing novel therapeutic interventions. Understanding the involvement of VDAC in Alzheimer's disease may pave the way for the development of effective treatments that can restore mitochondrial function and halt disease progression.PMID:38599511 | DOI:10.1016/j.brainres.2024.148920 (Source: Brain Research)
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Yaqian Yang Xiaotao Jia Xinmao Yang Jie Wang Yan Fang Xiaoping Ying Meiqian Zhang Jing Wei Yanfang Pan Source Type: research
Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies
This study aims to explore the antidepressant-like effects of the major constituents found in C. asiatica, i.e., asiatic acid, asiaticoside, madecassic acid, and madecassoside at three doses (1.25, 2.5, and 5mg/kg, i.p), on the behavioural and cortisol level of unpredictable chronic stress (UCS) zebrafish model. Based on the findings from the behavioural study, the cortisol levels in the zebrafish body after treatment with the two most effective compounds were measured using enzyme-linked immunosorbent assay (ELISA). Furthermore, a molecular docking study was conducted to predict the inhibitory impact of the triterpenoid c...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Zaynab Mando Huda Mando Adlin Afzan Khozirah Shaari Zurina Hassan Mohamad Nurul Azmi Fauziahanim Zakaria Source Type: research
Structural Characteristics of Amygdala Subregions in Type 2 Diabetes Mellitus
This study aims to explore the microstructural alterations of the amygdala in T2DM and to investigate the relationship between the alterations and depressive symptoms. Fifty T2DM and 50 healthy controls were included. Firstly, the volumes of subcortical regions and subregions of amygdala were calculated by FreeSurfer. Covariance analysis (ANCOVA) was conducted between the two groups with covariates of age, sex, and estimated total intracranial volume to explore the differences in volume of subcortical regions and subregions of amygdala. Furthermore, the structural covariance within the amygdala subregions was performed. Mo...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Wenbin Qiu Xiaomei Yue Haoming Huang Limin Ge Weiye Lu Zidong Cao Yawen Rao Xin Tan Yan Wang Jinjian Wu Yuna Chen Shijun Qiu Gang Li Source Type: research
A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
Manipulation of α4βδ GABA < sub > A < /sub > receptors alters synaptic pruning in layer 3 prelimbic prefrontal cortex and impairs temporal order recognition: Implications for schizophrenia and autism
Brain Res. 2024 Apr 8:148929. doi: 10.1016/j.brainres.2024.148929. Online ahead of print.ABSTRACTTemporal order memory is impaired in autism spectrum disorder (ASD) and schizophrenia (SCZ). These disorders, more prevalent in males, result in abnormal dendritic spine pruning during adolescence in layer 3 (L3) medial prefrontal cortex (mPFC), yielding either too many (ASD) or too few (SCZ) spines. Here we tested whether altering spine density in neural circuits including the mPFC could be associated with impaired temporal order memory in male mice. We have shown that α4βδ GABAA receptors (GABARs) emerge at puberty on spin...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Sheryl S Smith Safae Benanni Quiana Jones Lindsay Kenney Matthew Evrard Source Type: research
Targeting VDAC: A potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease
This article aims to provide an overview of the role of VDAC in mitochondrial dysfunction, its association with Alzheimer's disease, and the potential of targeting VDAC for developing novel therapeutic interventions. Understanding the involvement of VDAC in Alzheimer's disease may pave the way for the development of effective treatments that can restore mitochondrial function and halt disease progression.PMID:38599511 | DOI:10.1016/j.brainres.2024.148920 (Source: Brain Research)
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Yaqian Yang Xiaotao Jia Xinmao Yang Jie Wang Yan Fang Xiaoping Ying Meiqian Zhang Jing Wei Yanfang Pan Source Type: research
M1-type microglia-derived exosomes contribute to blood-brain barrier damage
CONCLUSION: M1-type microglia-derived exosomes contribute to the injury of BBB cell model, which has the involvement of miRNAs. Our findings provide new perspectives and potential mechanisms for future M1 microglia-derived exosomes as therapeutic targets in stroke.PMID:38588846 | DOI:10.1016/j.brainres.2024.148919 (Source: Brain Research)
Source: Brain Research - April 8, 2024 Category: Neurology Authors: Wen Jiang Yan Wu Ailan Pang Peiyao Li Song Mei Source Type: research
Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats
Brain Res. 2024 Apr 6:148918. doi: 10.1016/j.brainres.2024.148918. Online ahead of print.ABSTRACTThe lateral habenula (LHb) projects to the ventral tegmental area (VTA) and dorsal raphe nuclei (DRN) that deliver dopamine (DA) and serotonin (5-HT) to cortical and limbic regions such as the medial prefrontal cortex (mPFC), hippocampus and basolateral amygdala (BLA). Dysfunctions of VTA-related mesocorticolimbic dopaminergic and DRN-related serotonergic systems contribute to non-motor symptoms in Parkinson's disease (PD). However, how the LHb affects the VTA and DRN in PD remains unclear. Here, we used electrophysiological an...
Source: Brain Research - April 8, 2024 Category: Neurology Authors: Huihui Tan Chengxue Du Li Zhang Yuan Guo Yaxin Yang Qingfeng Sun Qiaojun Zhang Libo Li Source Type: research
M1-type microglia-derived exosomes contribute to blood-brain barrier damage
CONCLUSION: M1-type microglia-derived exosomes contribute to the injury of BBB cell model, which has the involvement of miRNAs. Our findings provide new perspectives and potential mechanisms for future M1 microglia-derived exosomes as therapeutic targets in stroke.PMID:38588846 | DOI:10.1016/j.brainres.2024.148919 (Source: Brain Research)
Source: Brain Research - April 8, 2024 Category: Neurology Authors: Wen Jiang Yan Wu Ailan Pang Peiyao Li Song Mei Source Type: research
