Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol
Brain Res Bull. 2024 Apr 1;211:110935. doi: 10.1016/j.brainresbull.2024.110935. Online ahead of print.ABSTRACTChronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mPFC) and nucleus accumbens (NAc), and consequently leading to oxidative stress and neuroinflammation. Previous studies from our lab tested β-lactam antibiotics and novel beta-lactam non-antibiotic, MC-100093, and showed these β-lactam upregulated the major astrocytic glutamate transporter, GLT-1, and consequently reduced ethanol intake and normalized glutamate ho...
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Shelby Travaglianti Ahmed Alotaibi Woonyen Wong Magid Abou-Gharbia Wayne Childers Youssef Sari Source Type: research
Concurrent brain structural and functional alterations in the thalamus of adult survivors of childhood brain tumors: a multimodal MRI study
This study analyzed voxel-based morphometry (VBM) derived from T1-weighted MRI and the amplitude of low-frequency fluctuation (ALFF) from resting-state functional magnetic resonance imaging (rs-fMRI) to examine the structural and functional alterations in 35 brain tumor survivors using 35 matching healthy individuals as controls. Compared with healthy controls, brain tumor survivors had decreased gray matter volumes (GMV) in the thalamus and increased GMV in the superior frontal gyrus. Functionally, brain tumor survivors had lower ALFF values in the inferior temporal gyrus and medial prefrontal area and higher ALFF values ...
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Jinfeng Hou Tricia Z King Hongbo Chen Qian Wang You Xie Hui Mao Liya Wang Luqi Cheng Source Type: research
Aurothioglucose encapsulated nanoparticles fostered neuroprotection in streptozotocin-induced Alzheimer's disease
This study was planned to prepare the PLGA nanoparticles of aurothioglucose (ATG) and check the neuroprotective potential against STZ-induced AD in rats. The nanoparticles were prepared using the double emulsion solvent evaporation method and characterized for various parameters such as drug-excipient interaction, particle size, zeta potential, and morphology. Then, rats were injected STZ (3 mg/kg/i.c.v., days 1 and 3) and ATG (5 and 10 mg/kg/s.c.), ATG NPs (2.5 and 5 mg/kg/s.c.) and donepezil (2 mg/kg/p.o) from 15th to 29th day. Behavior parameters were performed using an actophotometer, MWM, and ORT. On the 30th day, all...
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Shiv Kumar Kushawaha Mahendra Singh Ashawat Divya Soni Puneet Kumar None Rimpi Ashish Baldi Source Type: research
Inhibition of TREM-1 alleviates neuroinflammation by modulating microglial polarization via SYK/p38MAPK signaling pathway after traumatic brain injury
CONCLUSIONS: These findings suggest that TREM-1 can be a potential clinical therapeutic target for alleviating neuroinflammation after TBI.PMID:38570153 | DOI:10.1016/j.brainres.2024.148907 (Source: Brain Research)
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Tianqi Zhao Yuxin Zhou Dabing Zhang Dong Han Jingyuan Ma Shanshan Li Ting Li Shuqun Hu Zhouru Li Source Type: research
Neuritin promotes autophagic flux by inhibiting the cGAS-STING pathway to alleviate brain injury after subarachnoid haemorrhage
CONCLUSION: Neuritin alleviated EBI by restoring impaired autophagic flux after SAH through the regulation of the cGAS-STING pathway.PMID:38570154 | DOI:10.1016/j.brainres.2024.148909 (Source: Brain Research)
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Hao Zhang Kunhao Ren Youjie Hu Bin Liu Yaowen He Hui Xu Ketao Ma Weidong Tian Linzhi Dai Dong Zhao Source Type: research
Unpleasant emotion inhibits attentional focus toward a peripheral target in a visual search: an ERP study
Exp Brain Res. 2024 Apr 3. doi: 10.1007/s00221-024-06796-w. Online ahead of print.ABSTRACTPrevious studies have found that emotional states affect the extent of attention, and the effect has been explained by adaptive views. If the adaptive explanations are true, emotion should modulate attentional focus toward a peripheral stimulus. The present study investigated if emotion affects the focus of attention toward a peripheral target in a visual search paradigm with event-related brain potential (ERP) measurement. In each trial of the experiment, participants performed a visual search task after an emotion (unpleasant, neutr...
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Motoyuki Sanada Jun'ichi Katayama Source Type: research
Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol
Brain Res Bull. 2024 Apr 1:110935. doi: 10.1016/j.brainresbull.2024.110935. Online ahead of print.ABSTRACTChronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mPFC) and nucleus accumbens (NAc), and consequently leading to oxidative stress and neuroinflammation. Previous studies from our lab tested β-lactam antibiotics and novel β-lactam non-antibiotic, MC-100093, and showed these β-lactam upregulated the major astrocytic glutamate transporter, GLT-1, and consequently reduced ethanol intake and normalized glutamate homeosta...
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Shelby Travaglianti Ahmed Alotaibi Woonyen Wong Magid Abou-Gharbia Wayne Childers Youssef Sari Source Type: research
Concurrent brain structural and functional alterations in the thalamus of adult survivors of childhood brain tumors: a multimodal MRI study
This study analyzed voxel-based morphometry (VBM) derived from T1-weighted MRI and the amplitude of low-frequency fluctuation (ALFF) from resting-state functional magnetic resonance imaging (rs-fMRI) to examine the structural and functional alterations in 35 brain tumor survivors using 35 matching healthy individuals as controls. Compared with healthy controls, brain tumor survivors had decreased gray matter volumes (GMV) in the thalamus and increased GMV in the superior frontal gyrus. Functionally, brain tumor survivors had lower ALFF values in the inferior temporal gyrus and medial prefrontal area and higher ALFF values ...
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Jinfeng Hou Tricia Z King Hongbo Chen Qian Wang You Xie Hui Mao Liya Wang Luqi Cheng Source Type: research
Inhibition of TREM-1 alleviates neuroinflammation by modulating microglial polarization via SYK/p38MAPK signaling pathway after traumatic brain injury
CONCLUSIONS: These findings suggest that TREM-1 can be a potential clinical therapeutic target for alleviating neuroinflammation after TBI.PMID:38570153 | DOI:10.1016/j.brainres.2024.148907 (Source: Brain Research)
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Tianqi Zhao Yuxin Zhou Dabing Zhang Dong Han Jingyuan Ma Shanshan Li Ting Li Shuqun Hu Zhouru Li Source Type: research
Neuritin promotes autophagic flux by inhibiting the cGAS-STING pathway to alleviate brain injury after subarachnoid haemorrhage
CONCLUSION: Neuritin alleviated EBI by restoring impaired autophagic flux after SAH through the regulation of the cGAS-STING pathway.PMID:38570154 | DOI:10.1016/j.brainres.2024.148909 (Source: Brain Research)
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Hao Zhang Kunhao Ren Youjie Hu Bin Liu Yaowen He Hui Xu Ketao Ma Weidong Tian Linzhi Dai Dong Zhao Source Type: research
Characterisation of behaviours relevant to apathy syndrome in the aged male rat
Behav Brain Res. 2024 Apr 1:114977. doi: 10.1016/j.bbr.2024.114977. Online ahead of print.ABSTRACTApathy is a complex psychiatric syndrome characterised by motivational deficit, emotional blunting and cognitive changes. It occurs alongside a broad range of neurological disorders, but also occurs in otherwise healthy ageing. Despite its clinical prevalence, apathy does not yet have a designated treatment strategy. Generation of a translational animal model of apathy syndrome would facilitate the development of novel treatments. Given the multidimensional nature of apathy, a model cannot be achieved with a single behavioural...
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Megan G Jackson Stafford L Lightman Emma S J Robinson Source Type: research
Aurothioglucose encapsulated nanoparticles fostered neuroprotection in streptozotocin-induced Alzheimer's disease
This study was planned to prepare the PLGA nanoparticles of aurothioglucose (ATG) and check the neuroprotective potential against STZ-induced AD in rats. The nanoparticles were prepared using the double emulsion solvent evaporation method and characterized for various parameters such as drug-excipient interaction, particle size, zeta potential, and morphology. Then, rats were injected STZ (3 mg/kg/i.c.v., days 1 and 3) and ATG (5 and 10 mg/kg/s.c.), ATG NPs (2.5 and 5 mg/kg/s.c.) and donepezil (2 mg/kg/p.o) from 15th to 29th day. Behavior parameters were performed using an actophotometer, MWM, and ORT. On the 30th day, all...
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Shiv Kumar Kushawaha Mahendra Singh Ashawat Divya Soni Puneet Kumar None Rimpi Ashish Baldi Source Type: research
Healthy adults favor stable left/right hand choices over performance at an unconstrained reach-to-grasp task
Exp Brain Res. 2024 Apr 2. doi: 10.1007/s00221-024-06828-5. Online ahead of print.ABSTRACTReach-to-grasp actions are fundamental to the daily activities of human life, but few methods exist to assess individuals' reaching and grasping actions in unconstrained environments. The Block Building Task (BBT) provides an opportunity to directly observe and quantify these actions, including left/right hand choices. Here we sought to investigate the motor and non-motor causes of left/right hand choices, and optimize the design of the BBT, by manipulating motor and non-motor difficulty in the BBT's unconstrained reach-to-grasp task....
Source: Brain Research - April 2, 2024 Category: Neurology Authors: Taewon Kim Ruiwen Zhou Samah Gassass T éa Soberano Lei Liu Benjamin A Philip Source Type: research
Total sleep deprivation effects on the attentional blink
Exp Brain Res. 2024 Apr 2. doi: 10.1007/s00221-024-06826-7. Online ahead of print.ABSTRACTThe Attentional Blink (AB) is a phenomenon that reflects difficulty in detecting or identifying the second of two successive targets (T1 and T2) that are presented in rapid succession, between 200-500ms apart. The AB involves indicators of attentional and temporal integration mechanisms related to the early stages of visual processing. The aim of this study was to identify the effects of 24-h of sleep deprivation (total sleep deprivation, TSD) on the attentional and temporal integration mechanisms of the AB. Twenty-two undergraduate s...
Source: Brain Research - April 2, 2024 Category: Neurology Authors: Carlos Gallegos Candelaria Ram írez A ída García Jorge Borrani Pablo Valdez Source Type: research
Activation of NLRP3 inflammasome in a rat model of cerebral small vessel disease
Exp Brain Res. 2024 Apr 2. doi: 10.1007/s00221-024-06824-9. Online ahead of print.ABSTRACTCerebral small vessel disease (CSVD) is increasingly being recognized as a leading contributor to cognitive impairment in the elderly. However, there is a lack of effective preventative or therapeutic options for CSVD. In this exploratory study, we investigated the interplay between neuroinflammation and CSVD pathogenesis as well as the cognitive performance, focusing on NLRP3 signaling as a new therapeutic target. Spontaneously hypertensive stroke-prone (SHRSP) rats served as a CSVD model. We found that SHRSP rats showed decline in l...
Source: Brain Research - April 2, 2024 Category: Neurology Authors: Meiyan Zhang Xiaoyan Lan Yue Gao Yu Zou Shen Li Yajie Liang Miroslaw Janowski Piotr Walczak Chengyan Chu Source Type: research
