Neonatal nociceptive stimulation results in pain sensitization, reduction of hippocampal 5-HT < sub > 1A < /sub > receptor, and p-CREB expression in adult female rats
This study shows sex- and age-specific responses of signaling pathways within the hippocampus accompanied by altered behavioral repertoire, at long-term after neonatal painful stimulation.PMID:38552745 | DOI:10.1016/j.bbr.2024.114975 (Source: Brain Research)
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Jackeline Malheiros Cristiane Amaral Luiz Severino da Silva Ruth Guinsburg Luciene Covolan Source Type: research
Long-term table tennis training alters dynamic functional connectivity and white matter microstructure in large scale brain regions
In this study, we investigated functional and structural changes in large-scale brain regions between 20 table tennis players (TTPs) and 21 healthy controls (HCs) using 7-Tesla magnetic resonance imaging (MRI) techniques. Compared with those of HCs, TTPs exhibited significantly greater anisotropy fraction (FA) and axial diffusivity (AD) values in multiple fiber tracts. We used the locations with the most significant structural changes in white matter as the seed areas and then compared static and dynamic functional connectivity (sFC and dFC). Brodmann 11, located in the orbitofrontal cortex, showed altered dFC values to la...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Chanying Zheng Yuting Cao Yuyang Li Zhoucheng Ye Xize Jia Mengting Li Yang Yu Wenming Liu Source Type: research
The biological efficacy of Apelin against focal transient cerebral ischemia-reperfusion injury. A systematic review and meta-analysis of animal studies
CONCLUSION: The present meta-analysis was conducted to assess preclinical studies related to Apelin treatment in rodent ischemic stroke. Apelin can exert promising neuroprotective effects by reducing infarct volume, neurological deficit, caspase 3, apoptotic cell number, TNF- α and brain water content and increasing BCL2. The current evidence supports the anti-apoptotic and anti-inflammatory properties of Apelin, but its effectiveness in decreasing CHOP level in animal models of ischemic stroke needs further elucidation. This study was registered within the International Prospective Register of Systematic Reviews (PROSPER...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Sedigheh Behrouzifar Habibollah Esmaily Source Type: research
Upregulation of NADPH-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: Development of sporadic Alzheimer's disease
In conclusion, impairment in insulin function induces early changes in ROS/RNS contents through NOX and iNOS upregulation and neuronal apoptosis in the hippocampus. Our results could mechanistically explain the role of impaired insulin function in the development of sAD.PMID:38552936 | DOI:10.1016/j.brainres.2024.148890 (Source: Brain Research)
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Mubeen A Ansari Aishah Al-Jarallah Muddanna S Rao Ahmed Babiker Khaled Bensalamah Source Type: research
Effects of older age on visual and self-motion sensory cue integration in navigation
Exp Brain Res. 2024 Mar 28. doi: 10.1007/s00221-024-06818-7. Online ahead of print.ABSTRACTOlder adults demonstrate impairments in navigation that cannot be explained by general cognitive and motor declines. Previous work has shown that older adults may combine sensory cues during navigation differently than younger adults, though this work has largely been done in dark environments where sensory integration may differ from full-cue environments. Here, we test whether aging adults optimally combine cues from two sensory systems critical for navigation: vision (landmarks) and body-based self-motion cues. Participants comple...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Corey S Shayman Maggie K McCracken Hunter C Finney Andoni M Katsanevas Peter C Fino Jeanine K Stefanucci Sarah H Creem-Regehr Source Type: research
Brain waves and landscape settings: emotional responses to attractiveness
In this study, we investigated how changes in elements of attractiveness influence ones' emotional perception and present the related pattern of changes in brain activities. Therefore, we implied five elements of attractiveness including mystery, visual openness, landscape or greenness, walkability, and social interaction using the Delphi method. Then, we made changes in each element separately to make the landscape more attractive and assessed their effects on a group of young adults. We used the self-assessment manikin questionnaire to measure the participants' emotional perception while the participants' brain activitie...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Zahra Karami Seyed-Abbas Yazdanfar Maryam Kashefpour Reza Khosrowabadi Source Type: research
The expression of decision and learning variables in movement patterns related to decision actions
Exp Brain Res. 2024 Mar 29. doi: 10.1007/s00221-024-06805-y. Online ahead of print.ABSTRACTDecisions are not necessarily easy to separate into a planning and an execution phase and the decision-making process can often be reflected in the movement associated with the decision. Here, we used formalized definitions of concepts relevant in decision-making and learning to explore if and how these concepts correlate with decision-related movement paths, both during and after a choice is made. To this end, we let 120 participants (46 males, mean age = 24.5 years) undergo a repeated probabilistic two-choice task with changing pro...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Ida Selbing Joshua Skewes Source Type: research
Systematic review and meta-analysis of randomized controlled trials on the effects of exercise interventions on amyloid beta levels in humans
Exp Brain Res. 2024 Mar 29. doi: 10.1007/s00221-024-06821-y. Online ahead of print.ABSTRACTAlzheimer's disease (AD) represents the most common type of dementia. A crucial mechanism attributed to its development is amyloid beta (Aβ) dynamics dysregulation. The extent to which exercise can modulate this phenomenon is uncertain. The aim of this study was to summarize the existing literature evaluating this issue. A comprehensive systematic search was performed in Pubmed, Scopus, Embase, Web of Science, and SciELO databases and completed in August 2023, aiming to identify randomized controlled trials investigating the effect ...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Isabela Mayer Pucci Andreo F Aguiar Rodrigo M Pucci Juliano Casonatto Sergio Marques Borghi Source Type: research
Exercise-induced central and peripheral sympathetic activity in a community-based group of epilepsy patients differ from healthy controls
In this study, exercise-induced changes of the interrelation of central and peripheral autonomic activity in patients with epilepsy was assessed. 21 patients with epilepsy (16 seizure-free), and 21 healthy matched controls performed an exhaustive bicycle ergometer test. Immediately before and after the exercise test, resting state electroencephalography measurements (Brain Products GmbH, 128-channel actiCHamp) of 5 min were carried out to investigate functional connectivity assessed by phase locking value in source space for whole brain, central autonomic network and visual network. Additionally, 1-lead ECG (Brain products...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Franziska van den Bongard Julia Kristin Gowik Jessica Coenen Rasmus Jakobsmeyer Claus Reinsberger Source Type: research
GPS Tracking Technology and Re-visiting the Relationship between the Avian Visual Wulst and Homing Pigeon Navigation
Behav Brain Res. 2024 Mar 27:114971. doi: 10.1016/j.bbr.2024.114971. Online ahead of print.ABSTRACTWithin their familiar areas homing pigeons rely on familiar visual landscape features and landmarks for homing. However, the neural basis of visual landmark-based navigation has been so far investigated mainly in relation to the role of the hippocampal formation. The avian visual Wulst is the telencephalic projection field of the thalamofugal pathway that has been suggested to be involved in processing lateral visual inputs that originate from the far visual field. The Wulst is therefore a good candidate for a neural structur...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Sara Cioccarelli Dimitri Giunchi Enrica Pollonara Giovanni Casini Verner P Bingman Anna Gagliardo Source Type: research
The hippocampal Salt-Inducible Kinase 2-CREB-Regulated Transcription Co-activator 1 system mediates the antidepressant actions of paroxetine in mice
Behav Brain Res. 2024 Mar 27:114972. doi: 10.1016/j.bbr.2024.114972. Online ahead of print.ABSTRACTThe hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor (SSRI). Recent studies have indicated that paroxetine also modulates several pharmacological targets other than the 5-HT ...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Xiang-Ming Cai Xiao-Yu Sun Rui Li Pei-Juan Wang Jian-Cheng Qi Yu-Xin Ge Lei Yang Source Type: research
Neonatal nociceptive stimulation results in pain sensitization, reduction of hippocampal 5-HT < sub > 1A < /sub > receptor, and p-CREB expression in adult female rats
This study shows sex- and age-specific responses of signaling pathways within the hippocampus accompanied by altered behavioral repertoire, at long-term after neonatal painful stimulation.PMID:38552745 | DOI:10.1016/j.bbr.2024.114975 (Source: Brain Research)
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Jackeline Malheiros Cristiane Amaral Luiz Severino da Silva Ruth Guinsburg Luciene Covolan Source Type: research
Long-term table tennis training alters dynamic functional connectivity and white matter microstructure in large scale brain regions
In this study, we investigated functional and structural changes in large-scale brain regions between 20 table tennis players (TTPs) and 21 healthy controls (HCs) using 7-Tesla magnetic resonance imaging (MRI) techniques. Compared with those of HCs, TTPs exhibited significantly greater anisotropy fraction (FA) and axial diffusivity (AD) values in multiple fiber tracts. We used the locations with the most significant structural changes in white matter as the seed areas and then compared static and dynamic functional connectivity (sFC and dFC). Brodmann 11, located in the orbitofrontal cortex, showed altered dFC values to la...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Chanying Zheng Yuting Cao Yuyang Li Zhoucheng Ye Xize Jia Mengting Li Yang Yu Wenming Liu Source Type: research
The biological efficacy of Apelin against focal transient cerebral ischemia-reperfusion injury. A systematic review and meta-analysis of animal studies
CONCLUSION: The present meta-analysis was conducted to assess preclinical studies related to Apelin treatment in rodent ischemic stroke. Apelin can exert promising neuroprotective effects by reducing infarct volume, neurological deficit, caspase 3, apoptotic cell number, TNF- α and brain water content and increasing BCL2. The current evidence supports the anti-apoptotic and anti-inflammatory properties of Apelin, but its effectiveness in decreasing CHOP level in animal models of ischemic stroke needs further elucidation. This study was registered within the International Prospective Register of Systematic Reviews (PROSPER...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Sedigheh Behrouzifar Habibollah Esmaily Source Type: research
Upregulation of NADPH-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: Development of sporadic Alzheimer's disease
In conclusion, impairment in insulin function induces early changes in ROS/RNS contents through NOX and iNOS upregulation and neuronal apoptosis in the hippocampus. Our results could mechanistically explain the role of impaired insulin function in the development of sAD.PMID:38552936 | DOI:10.1016/j.brainres.2024.148890 (Source: Brain Research)
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Mubeen A Ansari Aishah Al-Jarallah Muddanna S Rao Ahmed Babiker Khaled Bensalamah Source Type: research
