Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemia
This study aims to identify factors possibly contributing to complications in children with acute leukaemia. Despite diverse etiological causes, similar processes trigger the process of cell malignancy. Genomic instability has received considerable attention in this context.METHOD: We conducted chromosomal analysis of bone marrow cells and measured the micronuclei (Mn) level in buccal cells over time. Statistical reliability assessment was performed using Analysis of variance (ANOVA), and the data were analyzed and visualized using the SPSS 12 statistical analysis software package.RESULTS: On the 15th day of treatment, our...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Sopiko Jashiashvili Alla Zedginidze Giorgi Ormotsadze Asmat Shengelaia Source Type: research

Disposition of levobupivacaine during intraoperative continuous caudal epidural analgesia in a preterm neonate
CONCLUSION: The results confirm our hypothesis of altered pharmacokinetics in the preterm neonate. Therefore, levobupivacaine therapy in these patients should be carefully monitored. Since therapeutic drug monitoring of levobupivacaine is not established in clinical routines, we suggest monitoring the intraoperative pain profile using validated scores.TRIAL REGISTRATION: EudraCT number: 2020-000595-37.PMID:37997373 | DOI:10.5507/bp.2023.047 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Jan Sipek Pavla Pokorna Martin Sima Jitka Styblova Vladimir Mixa Source Type: research

Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemia
This study aims to identify factors possibly contributing to complications in children with acute leukaemia. Despite diverse etiological causes, similar processes trigger the process of cell malignancy. Genomic instability has received considerable attention in this context.METHOD: We conducted chromosomal analysis of bone marrow cells and measured the micronuclei (Mn) level in buccal cells over time. Statistical reliability assessment was performed using Analysis of variance (ANOVA), and the data were analyzed and visualized using the SPSS 12 statistical analysis software package.RESULTS: On the 15th day of treatment, our...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Sopiko Jashiashvili Alla Zedginidze Giorgi Ormotsadze Asmat Shengelaia Source Type: research

Disposition of levobupivacaine during intraoperative continuous caudal epidural analgesia in a preterm neonate
CONCLUSION: The results confirm our hypothesis of altered pharmacokinetics in the preterm neonate. Therefore, levobupivacaine therapy in these patients should be carefully monitored. Since therapeutic drug monitoring of levobupivacaine is not established in clinical routines, we suggest monitoring the intraoperative pain profile using validated scores.TRIAL REGISTRATION: EudraCT number: 2020-000595-37.PMID:37997373 | DOI:10.5507/bp.2023.047 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Jan Sipek Pavla Pokorna Martin Sima Jitka Styblova Vladimir Mixa Source Type: research

Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemia
This study aims to identify factors possibly contributing to complications in children with acute leukaemia. Despite diverse etiological causes, similar processes trigger the process of cell malignancy. Genomic instability has received considerable attention in this context.METHOD: We conducted chromosomal analysis of bone marrow cells and measured the micronuclei (Mn) level in buccal cells over time. Statistical reliability assessment was performed using Analysis of variance (ANOVA), and the data were analyzed and visualized using the SPSS 12 statistical analysis software package.RESULTS: On the 15th day of treatment, our...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Sopiko Jashiashvili Alla Zedginidze Giorgi Ormotsadze Asmat Shengelaia Source Type: research

Disposition of levobupivacaine during intraoperative continuous caudal epidural analgesia in a preterm neonate
CONCLUSION: The results confirm our hypothesis of altered pharmacokinetics in the preterm neonate. Therefore, levobupivacaine therapy in these patients should be carefully monitored. Since therapeutic drug monitoring of levobupivacaine is not established in clinical routines, we suggest monitoring the intraoperative pain profile using validated scores.TRIAL REGISTRATION: EudraCT number: 2020-000595-37.PMID:37997373 | DOI:10.5507/bp.2023.047 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Jan Sipek Pavla Pokorna Martin Sima Jitka Styblova Vladimir Mixa Source Type: research

Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemia
This study aims to identify factors possibly contributing to complications in children with acute leukaemia. Despite diverse etiological causes, similar processes trigger the process of cell malignancy. Genomic instability has received considerable attention in this context.METHOD: We conducted chromosomal analysis of bone marrow cells and measured the micronuclei (Mn) level in buccal cells over time. Statistical reliability assessment was performed using Analysis of variance (ANOVA), and the data were analyzed and visualized using the SPSS 12 statistical analysis software package.RESULTS: On the 15th day of treatment, our...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Sopiko Jashiashvili Alla Zedginidze Giorgi Ormotsadze Asmat Shengelaia Source Type: research

Disposition of levobupivacaine during intraoperative continuous caudal epidural analgesia in a preterm neonate
CONCLUSION: The results confirm our hypothesis of altered pharmacokinetics in the preterm neonate. Therefore, levobupivacaine therapy in these patients should be carefully monitored. Since therapeutic drug monitoring of levobupivacaine is not established in clinical routines, we suggest monitoring the intraoperative pain profile using validated scores.TRIAL REGISTRATION: EudraCT number: 2020-000595-37.PMID:37997373 | DOI:10.5507/bp.2023.047 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Jan Sipek Pavla Pokorna Martin Sima Jitka Styblova Vladimir Mixa Source Type: research

Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemia
This study aims to identify factors possibly contributing to complications in children with acute leukaemia. Despite diverse etiological causes, similar processes trigger the process of cell malignancy. Genomic instability has received considerable attention in this context.METHOD: We conducted chromosomal analysis of bone marrow cells and measured the micronuclei (Mn) level in buccal cells over time. Statistical reliability assessment was performed using Analysis of variance (ANOVA), and the data were analyzed and visualized using the SPSS 12 statistical analysis software package.RESULTS: On the 15th day of treatment, our...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Sopiko Jashiashvili Alla Zedginidze Giorgi Ormotsadze Asmat Shengelaia Source Type: research

Disposition of levobupivacaine during intraoperative continuous caudal epidural analgesia in a preterm neonate
CONCLUSION: The results confirm our hypothesis of altered pharmacokinetics in the preterm neonate. Therefore, levobupivacaine therapy in these patients should be carefully monitored. Since therapeutic drug monitoring of levobupivacaine is not established in clinical routines, we suggest monitoring the intraoperative pain profile using validated scores.TRIAL REGISTRATION: EudraCT number: 2020-000595-37.PMID:37997373 | DOI:10.5507/bp.2023.047 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Jan Sipek Pavla Pokorna Martin Sima Jitka Styblova Vladimir Mixa Source Type: research

Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemia
This study aims to identify factors possibly contributing to complications in children with acute leukaemia. Despite diverse etiological causes, similar processes trigger the process of cell malignancy. Genomic instability has received considerable attention in this context.METHOD: We conducted chromosomal analysis of bone marrow cells and measured the micronuclei (Mn) level in buccal cells over time. Statistical reliability assessment was performed using Analysis of variance (ANOVA), and the data were analyzed and visualized using the SPSS 12 statistical analysis software package.RESULTS: On the 15th day of treatment, our...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Sopiko Jashiashvili Alla Zedginidze Giorgi Ormotsadze Asmat Shengelaia Source Type: research

Disposition of levobupivacaine during intraoperative continuous caudal epidural analgesia in a preterm neonate
CONCLUSION: The results confirm our hypothesis of altered pharmacokinetics in the preterm neonate. Therefore, levobupivacaine therapy in these patients should be carefully monitored. Since therapeutic drug monitoring of levobupivacaine is not established in clinical routines, we suggest monitoring the intraoperative pain profile using validated scores.TRIAL REGISTRATION: EudraCT number: 2020-000595-37.PMID:37997373 | DOI:10.5507/bp.2023.047 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Jan Sipek Pavla Pokorna Martin Sima Jitka Styblova Vladimir Mixa Source Type: research

Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemia
This study aims to identify factors possibly contributing to complications in children with acute leukaemia. Despite diverse etiological causes, similar processes trigger the process of cell malignancy. Genomic instability has received considerable attention in this context.METHOD: We conducted chromosomal analysis of bone marrow cells and measured the micronuclei (Mn) level in buccal cells over time. Statistical reliability assessment was performed using Analysis of variance (ANOVA), and the data were analyzed and visualized using the SPSS 12 statistical analysis software package.RESULTS: On the 15th day of treatment, our...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Sopiko Jashiashvili Alla Zedginidze Giorgi Ormotsadze Asmat Shengelaia Source Type: research

Disposition of levobupivacaine during intraoperative continuous caudal epidural analgesia in a preterm neonate
CONCLUSION: The results confirm our hypothesis of altered pharmacokinetics in the preterm neonate. Therefore, levobupivacaine therapy in these patients should be carefully monitored. Since therapeutic drug monitoring of levobupivacaine is not established in clinical routines, we suggest monitoring the intraoperative pain profile using validated scores.TRIAL REGISTRATION: EudraCT number: 2020-000595-37.PMID:37997373 | DOI:10.5507/bp.2023.047 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Jan Sipek Pavla Pokorna Martin Sima Jitka Styblova Vladimir Mixa Source Type: research

Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemia
This study aims to identify factors possibly contributing to complications in children with acute leukaemia. Despite diverse etiological causes, similar processes trigger the process of cell malignancy. Genomic instability has received considerable attention in this context.METHOD: We conducted chromosomal analysis of bone marrow cells and measured the micronuclei (Mn) level in buccal cells over time. Statistical reliability assessment was performed using Analysis of variance (ANOVA), and the data were analyzed and visualized using the SPSS 12 statistical analysis software package.RESULTS: On the 15th day of treatment, our...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 24, 2023 Category: Biomedical Science Authors: Sopiko Jashiashvili Alla Zedginidze Giorgi Ormotsadze Asmat Shengelaia Source Type: research