Retinal microvascular abnormalities in major depression
CONCLUSION: According to the literature, acute and chronic neuroinflammation is associated with changes in microvascular form and function. The endothelium becomes a major participant in the inflammatory response damaging the surrounding tissue and its function. Because the retina and brain tissue share a common embryonic origin, we suspect similar microvascular pathology in the retina and in the brain in major depression. Our results may contribute to a better understanding of depression etiopathogenesis and to its personalized treatment.PMID:37465892 | DOI:10.5507/bp.2023.026 (Source: Biomedical Papers of the Medical Fac...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - July 19, 2023 Category: Biomedical Science Authors: Evgenii Sadykov Ladislav Hosak Alexandr Stepanov Jana Zapletalova Jan Studnicka Source Type: research

Gamma-glutamyltransferase-associated glycoprotein patterns in human seminal plasma of normozoospermic men: a new aspect of biomarker heterogeneity
CONCLUSIONS: GGT contributes to several molecular patterns that differ between the soluble and extracellular vesicle fractions of hSP. Their glycobiochemical heterogeneity is due to difference in the presence of distinct sialylated and mannosylated glycans. Moreover, GGT-associated glycoprotein patterns differentiate between high molecular mass forms of GGT in the soluble fraction of hSP. They hold promise as possible targets for increasing biomarker potential of GGT.PMID:37465893 | DOI:10.5507/bp.2023.031 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - July 19, 2023 Category: Biomedical Science Authors: Tamara Jankovic Jelena Danilovic Lukovic Sanja Goc Ninoslav Mitic Ljiljana Hajdukovic Miroslava Jankovic Source Type: research

Retinal microvascular abnormalities in major depression
CONCLUSION: According to the literature, acute and chronic neuroinflammation is associated with changes in microvascular form and function. The endothelium becomes a major participant in the inflammatory response damaging the surrounding tissue and its function. Because the retina and brain tissue share a common embryonic origin, we suspect similar microvascular pathology in the retina and in the brain in major depression. Our results may contribute to a better understanding of depression etiopathogenesis and to its personalized treatment.PMID:37465892 | DOI:10.5507/bp.2023.026 (Source: Biomedical Papers of the Medical Fac...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - July 19, 2023 Category: Biomedical Science Authors: Evgenii Sadykov Ladislav Hosak Alexandr Stepanov Jana Zapletalova Jan Studnicka Source Type: research

Gamma-glutamyltransferase-associated glycoprotein patterns in human seminal plasma of normozoospermic men: a new aspect of biomarker heterogeneity
CONCLUSIONS: GGT contributes to several molecular patterns that differ between the soluble and extracellular vesicle fractions of hSP. Their glycobiochemical heterogeneity is due to difference in the presence of distinct sialylated and mannosylated glycans. Moreover, GGT-associated glycoprotein patterns differentiate between high molecular mass forms of GGT in the soluble fraction of hSP. They hold promise as possible targets for increasing biomarker potential of GGT.PMID:37465893 | DOI:10.5507/bp.2023.031 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - July 19, 2023 Category: Biomedical Science Authors: Tamara Jankovic Jelena Danilovic Lukovic Sanja Goc Ninoslav Mitic Ljiljana Hajdukovic Miroslava Jankovic Source Type: research

Retinal microvascular abnormalities in major depression
CONCLUSION: According to the literature, acute and chronic neuroinflammation is associated with changes in microvascular form and function. The endothelium becomes a major participant in the inflammatory response damaging the surrounding tissue and its function. Because the retina and brain tissue share a common embryonic origin, we suspect similar microvascular pathology in the retina and in the brain in major depression. Our results may contribute to a better understanding of depression etiopathogenesis and to its personalized treatment.PMID:37465892 | DOI:10.5507/bp.2023.026 (Source: Biomedical Papers of the Medical Fac...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - July 19, 2023 Category: Biomedical Science Authors: Evgenii Sadykov Ladislav Hosak Alexandr Stepanov Jana Zapletalova Jan Studnicka Source Type: research