Association of the combined parameters including the frequency of primary cilia, PD-L1, Smoothened protein, membranous β-catenin and cytoplasmic β-catenin expression with the outcome of patients with clear cell renal cell carcinoma
CONCLUSION: The present study provides the first data on the potential association and combined prognostic significance of frequency of primary cilia, PD-L1, Smoothened protein and β-catenin expression with the outcome in clear cell renal cell carcinoma.PMID:38420990 | DOI:10.5507/bp.2024.005 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - February 29, 2024 Category: Biomedical Science Authors: Aneta Rozsypalova Blanka Rosova Alzbeta Filipova Dimitar Hadzi Nikolov Renata Chloupkova Igor Richter Roman Zachoval Radoslav Matej Bohuslav Melichar Tomas Buchler Josef Dvorak Source Type: research

Experimental model of primary intraocular lymphoma based on BALB/CaNn strain and A20 cells is optimal for investigational research
CONCLUSION: Slower progression of the disease in BALB/CaNn mice, greater possibility to examine the retina due to mild vitreous involvement, and later occurrence of exophthalmos makes this strain more suitable for further investigational research.PMID:38410917 | DOI:10.5507/bp.2024.003 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - February 27, 2024 Category: Biomedical Science Authors: Eva Skrlova Eva Uherkova Aneta Klimova Diana Malarikova Petra Svozilkova Petr Matous Vit Herynek Tomas Kucera Pavel Klener Jarmila Heissigerova Source Type: research

Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression
CONCLUSIONS: Elevated markers of oxidative stress, inflammatory and endothelial activation were independent of the virologic and immunologic status of people with HIV. These results support the hypothesis that residual viremia in cellular reservoirs of various tissues is a key factor related to the premature aging of the immune system and predisposition to the premature development of diseases associated with aging.PMID:38390755 | DOI:10.5507/bp.2024.002 (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - February 23, 2024 Category: Biomedical Science Authors: Katerina Havlickova Svatava Snopkova Miroslav Pohanka Radek Svacinka David Vydrar Petr Husa Jirina Zavrelova Filip Zlamal Lenka Fabianova Miroslav Penka Petr Husa Source Type: research

Peripapillary retinal nerve fiber layer following vessel density correction at different IOP values
CONCLUSION: The greatest changes in RNFLc (RNFL minus VD) were in eyes with pathological IOP in segments 5 and 8, the location of the retinal ganglion cell magnocellular fibers. That is, when the thickness of the nerve fiber layer was reduced by correcting for vessel density, there was a significant correlation in segments 5 (r =-0.32, p<0.05) and 8 (r =-0.21, P<0.05) with intraocular pressure. The results suggest use of a corrected RNFL from VD value as more appropriate for detecting early changes in glaucoma.PMID:38230508 | DOI:10.5507/bp.2024.001 (Source: Biomedical Papers of the Medical Faculty of the Univ Palack...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - January 17, 2024 Category: Biomedical Science Authors: Jan Lestak Martin Fus Sarka Pitrova Source Type: research

Catheter ablation for non-paroxysmal atrial fibrillation. A review
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024 Jan 15. doi: 10.5507/bp.2023.053. Online ahead of print.ABSTRACTAtrial fibrillation (AF), the most common cardiac arrhythmia is associated with increased morbidity and mortality. The higher mortality is due to the risk of heart failure and cardioembolic events. This in-depth review focuses on the strategies and efficacy of catheter ablation for non-paroxysmal atrial fibrillation. The main medical databases were searched for contemporary studies on catheter ablation for non-paroxysmal AF. Catheter ablation is currently proven to be the most effective treatment for AF...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - January 17, 2024 Category: Biomedical Science Authors: Sabri Hassouna Pavel Osmancik Source Type: research

Peripapillary retinal nerve fiber layer following vessel density correction at different IOP values
CONCLUSION: The greatest changes in RNFLc (RNFL minus VD) were in eyes with pathological IOP in segments 5 and 8, the location of the retinal ganglion cell magnocellular fibers. That is, when the thickness of the nerve fiber layer was reduced by correcting for vessel density, there was a significant correlation in segments 5 (r =-0.32, p<0.05) and 8 (r =-0.21, P<0.05) with intraocular pressure. The results suggest use of a corrected RNFL from VD value as more appropriate for detecting early changes in glaucoma.PMID:38230508 | DOI:10.5507/bp.2024.001 (Source: Biomedical Papers of the Medical Faculty of the Univ Palack...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - January 17, 2024 Category: Biomedical Science Authors: Jan Lestak Martin Fus Sarka Pitrova Source Type: research

Catheter ablation for non-paroxysmal atrial fibrillation. A review
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024 Jan 15. doi: 10.5507/bp.2023.053. Online ahead of print.ABSTRACTAtrial fibrillation (AF), the most common cardiac arrhythmia is associated with increased morbidity and mortality. The higher mortality is due to the risk of heart failure and cardioembolic events. This in-depth review focuses on the strategies and efficacy of catheter ablation for non-paroxysmal atrial fibrillation. The main medical databases were searched for contemporary studies on catheter ablation for non-paroxysmal AF. Catheter ablation is currently proven to be the most effective treatment for AF...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - January 17, 2024 Category: Biomedical Science Authors: Sabri Hassouna Pavel Osmancik Source Type: research

Peripapillary retinal nerve fiber layer following vessel density correction at different IOP values
CONCLUSION: The greatest changes in RNFLc (RNFL minus VD) were in eyes with pathological IOP in segments 5 and 8, the location of the retinal ganglion cell magnocellular fibers. That is, when the thickness of the nerve fiber layer was reduced by correcting for vessel density, there was a significant correlation in segments 5 (r =-0.32, p<0.05) and 8 (r =-0.21, P<0.05) with intraocular pressure. The results suggest use of a corrected RNFL from VD value as more appropriate for detecting early changes in glaucoma.PMID:38230508 | DOI:10.5507/bp.2024.001 (Source: Biomedical Papers of the Medical Faculty of the Univ Palack...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - January 17, 2024 Category: Biomedical Science Authors: Jan Lestak Martin Fus Sarka Pitrova Source Type: research