Disposition of levobupivacaine during intraoperative continuous caudal epidural analgesia in a preterm neonate

CONCLUSION: The results confirm our hypothesis of altered pharmacokinetics in the preterm neonate. Therefore, levobupivacaine therapy in these patients should be carefully monitored. Since therapeutic drug monitoring of levobupivacaine is not established in clinical routines, we suggest monitoring the intraoperative pain profile using validated scores.TRIAL REGISTRATION: EudraCT number: 2020-000595-37.PMID:37997373 | DOI:10.5507/bp.2023.047
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Authors: Source Type: research