Targeting PTGES/PGE2 axis enhances sensitivity of colorectal cancer cells to 5-fluorouracil
In this study, we identified prostaglandin E synthase (PTGES)/prostaglandin E2 (PGE2) axis as an important regulator for 5FU sensitivity in CRC cells. We found that PTGES expression and PGE2 production are elevated in CRC cells in comparison to normal colorectal epithelial cells. Depletion of PTGES significantly enhanced the inhibitory effect of 5FU on CRC cell viability that was fully reverted by exogenous supplement of PGE2. Inhibition of PTGES enzymatic function, by either inducing loss-of-function mutant or treatment with selective inhibitors, phenocopied the PTGES depletion in terms of 5FU sensitization. Mechanistical...
Source: Biochemistry and Cell Biology - June 26, 2023 Category: Biochemistry Authors: Song Geng Hao Zhan Lianmeng Cao Longlong Geng Xiang Ren Source Type: research
Targeting PTGES/PGE2 axis enhances sensitivity of colorectal cancer cells to 5-fluorouracil
In this study, we identified prostaglandin E synthase (PTGES)/prostaglandin E2 (PGE2) axis as an important regulator for 5FU sensitivity in CRC cells. We found that PTGES expression and PGE2 production are elevated in CRC cells in comparison to normal colorectal epithelial cells. Depletion of PTGES significantly enhanced the inhibitory effect of 5FU on CRC cell viability that was fully reverted by exogenous supplement of PGE2. Inhibition of PTGES enzymatic function, by either inducing loss-of-function mutant or treatment with selective inhibitors, phenocopied the PTGES depletion in terms of 5FU sensitization. Mechanistical...
Source: Biochemistry and Cell Biology - June 26, 2023 Category: Biochemistry Authors: Song Geng Hao Zhan Lianmeng Cao Longlong Geng Xiang Ren Source Type: research
HSPA4 regulated glioma progression via activation of AKT signaling pathway
Biochem Cell Biol. 2023 Jun 20. doi: 10.1139/bcb-2022-0321. Online ahead of print.ABSTRACTGlioma is still an incurable disease with high invasiveness. Heat shock 70 kDa protein 4 (HSPA4) is a member of the HSP110 family, and is associated with the development and progression of various cancers. In the current study, we assessed the expression of HSPA4 in clinical samples, and found that HSPA4 was up-regulated in glioma tissues and correlated with tumor recurrence and grade. Survival analyses demonstrated that glioma patients with high HSPA4 expression had lower overall survival and disease-free survival times. In vitro kno...
Source: Biochemistry and Cell Biology - June 20, 2023 Category: Biochemistry Authors: Xi Yuan Xiangdong Sun Bin Zhou Shuang Zhao Yikun Li Haolang Ming Source Type: research
HSPA4 regulated glioma progression via activation of AKT signaling pathway
Biochem Cell Biol. 2023 Jun 20. doi: 10.1139/bcb-2022-0321. Online ahead of print.ABSTRACTGlioma is still an incurable disease with high invasiveness. Heat shock 70 kDa protein 4 (HSPA4) is a member of the HSP110 family, and is associated with the development and progression of various cancers. In the current study, we assessed the expression of HSPA4 in clinical samples, and found that HSPA4 was up-regulated in glioma tissues and correlated with tumor recurrence and grade. Survival analyses demonstrated that glioma patients with high HSPA4 expression had lower overall survival and disease-free survival times. In vitro kno...
Source: Biochemistry and Cell Biology - June 20, 2023 Category: Biochemistry Authors: Xi Yuan Xiangdong Sun Bin Zhou Shuang Zhao Yikun Li Haolang Ming Source Type: research
HSPA4 regulated glioma progression via activation of AKT signaling pathway
Biochem Cell Biol. 2023 Jun 20. doi: 10.1139/bcb-2022-0321. Online ahead of print.ABSTRACTGlioma is still an incurable disease with high invasiveness. Heat shock 70 kDa protein 4 (HSPA4) is a member of the HSP110 family, and is associated with the development and progression of various cancers. In the current study, we assessed the expression of HSPA4 in clinical samples, and found that HSPA4 was up-regulated in glioma tissues and correlated with tumor recurrence and grade. Survival analyses demonstrated that glioma patients with high HSPA4 expression had lower overall survival and disease-free survival times. In vitro kno...
Source: Biochemistry and Cell Biology - June 20, 2023 Category: Biochemistry Authors: Xi Yuan Xiangdong Sun Bin Zhou Shuang Zhao Yikun Li Haolang Ming Source Type: research
HSPA4 regulated glioma progression via activation of AKT signaling pathway
Biochem Cell Biol. 2023 Jun 20. doi: 10.1139/bcb-2022-0321. Online ahead of print.ABSTRACTGlioma is still an incurable disease with high invasiveness. Heat shock 70 kDa protein 4 (HSPA4) is a member of the HSP110 family, and is associated with the development and progression of various cancers. In the current study, we assessed the expression of HSPA4 in clinical samples, and found that HSPA4 was up-regulated in glioma tissues and correlated with tumor recurrence and grade. Survival analyses demonstrated that glioma patients with high HSPA4 expression had lower overall survival and disease-free survival times. In vitro kno...
Source: Biochemistry and Cell Biology - June 20, 2023 Category: Biochemistry Authors: Xi Yuan Xiangdong Sun Bin Zhou Shuang Zhao Yikun Li Haolang Ming Source Type: research
HSPA4 regulated glioma progression via activation of AKT signaling pathway
Biochem Cell Biol. 2023 Jun 20. doi: 10.1139/bcb-2022-0321. Online ahead of print.ABSTRACTGlioma is still an incurable disease with high invasiveness. Heat shock 70 kDa protein 4 (HSPA4) is a member of the HSP110 family, and is associated with the development and progression of various cancers. In the current study, we assessed the expression of HSPA4 in clinical samples, and found that HSPA4 was up-regulated in glioma tissues and correlated with tumor recurrence and grade. Survival analyses demonstrated that glioma patients with high HSPA4 expression had lower overall survival and disease-free survival times. In vitro kno...
Source: Biochemistry and Cell Biology - June 20, 2023 Category: Biochemistry Authors: Xi Yuan Xiangdong Sun Bin Zhou Shuang Zhao Yikun Li Haolang Ming Source Type: research
Dysregulation of insulin-like growth factor-1 signaling in postnatal bone elongation
Biochem Cell Biol. 2023 May 29. doi: 10.1139/bcb-2023-0025. Online ahead of print.ABSTRACTInsulin-like growth factor-1 (IGF-1) is a critical modulator of cell growth and survival, making it a central part of maintaining essentially every biological system in the body. Knowledge of the intricate mechanisms involved in activating IGF-1 signaling is not only key to understanding basic processes of growth and development, but also for addressing diseases, such as cancer and diabetes. This brief review explores how dysregulation of normal IGF-1 signaling can impact growth by examining its role in postnatal bone elongation. IGF-...
Source: Biochemistry and Cell Biology - May 29, 2023 Category: Biochemistry Authors: Cassaundra A White Maria A Serrat Source Type: research
Remembering the legacy of Professor Mohammad Hashemi: a pioneer in molecular genetic studies in southeast Iran (1965-2019)
Biochem Cell Biol. 2023 May 29. doi: 10.1139/bcb-2023-0116. Online ahead of print.ABSTRACTProfessor Mohammad Hashemi was a clinical biochemist and cancer genetic scientist. He has been chair and head of Department of Clinical Biochemistry at Zahedan University of Medical Sciences, Zahedan, Iran. He has played an important role in the improvement of understanding of genetics of disease in southeast Iran. He was also a part of international team for the discovery of the role of calprotectin (S100A8/A9) in cancer biology via regulation of cell fate in tumor cells. He had over 300 peer-reviewed scientific publications and trai...
Source: Biochemistry and Cell Biology - May 29, 2023 Category: Biochemistry Authors: Farhad Tabasi Ebrahim Eskandari Saeid Ghavami Source Type: research
Dysregulation of insulin-like growth factor-1 signaling in postnatal bone elongation
Biochem Cell Biol. 2023 May 29. doi: 10.1139/bcb-2023-0025. Online ahead of print.ABSTRACTInsulin-like growth factor-1 (IGF-1) is a critical modulator of cell growth and survival, making it a central part of maintaining essentially every biological system in the body. Knowledge of the intricate mechanisms involved in activating IGF-1 signaling is not only key to understanding basic processes of growth and development, but also for addressing diseases, such as cancer and diabetes. This brief review explores how dysregulation of normal IGF-1 signaling can impact growth by examining its role in postnatal bone elongation. IGF-...
Source: Biochemistry and Cell Biology - May 29, 2023 Category: Biochemistry Authors: Cassaundra A White Maria A Serrat Source Type: research
Remembering the legacy of Professor Mohammad Hashemi: a pioneer in molecular genetic studies in southeast Iran (1965-2019)
Biochem Cell Biol. 2023 May 29. doi: 10.1139/bcb-2023-0116. Online ahead of print.ABSTRACTProfessor Mohammad Hashemi was a clinical biochemist and cancer genetic scientist. He has been chair and head of Department of Clinical Biochemistry at Zahedan University of Medical Sciences, Zahedan, Iran. He has played an important role in the improvement of understanding of genetics of disease in southeast Iran. He was also a part of international team for the discovery of the role of calprotectin (S100A8/A9) in cancer biology via regulation of cell fate in tumor cells. He had over 300 peer-reviewed scientific publications and trai...
Source: Biochemistry and Cell Biology - May 29, 2023 Category: Biochemistry Authors: Farhad Tabasi Ebrahim Eskandari Saeid Ghavami Source Type: research
Dysregulation of insulin-like growth factor-1 signaling in postnatal bone elongation
Biochem Cell Biol. 2023 May 29. doi: 10.1139/bcb-2023-0025. Online ahead of print.ABSTRACTInsulin-like growth factor-1 (IGF-1) is a critical modulator of cell growth and survival, making it a central part of maintaining essentially every biological system in the body. Knowledge of the intricate mechanisms involved in activating IGF-1 signaling is not only key to understanding basic processes of growth and development, but also for addressing diseases, such as cancer and diabetes. This brief review explores how dysregulation of normal IGF-1 signaling can impact growth by examining its role in postnatal bone elongation. IGF-...
Source: Biochemistry and Cell Biology - May 29, 2023 Category: Biochemistry Authors: Cassaundra A White Maria A Serrat Source Type: research
Remembering the legacy of Professor Mohammad Hashemi: a pioneer in molecular genetic studies in southeast Iran (1965-2019)
Biochem Cell Biol. 2023 May 29. doi: 10.1139/bcb-2023-0116. Online ahead of print.ABSTRACTProfessor Mohammad Hashemi was a clinical biochemist and cancer genetic scientist. He has been chair and head of Department of Clinical Biochemistry at Zahedan University of Medical Sciences, Zahedan, Iran. He has played an important role in the improvement of understanding of genetics of disease in southeast Iran. He was also a part of international team for the discovery of the role of calprotectin (S100A8/A9) in cancer biology via regulation of cell fate in tumor cells. He had over 300 peer-reviewed scientific publications and trai...
Source: Biochemistry and Cell Biology - May 29, 2023 Category: Biochemistry Authors: Farhad Tabasi Ebrahim Eskandari Saeid Ghavami Source Type: research
Dysregulation of insulin-like growth factor-1 signaling in postnatal bone elongation
Biochem Cell Biol. 2023 May 29. doi: 10.1139/bcb-2023-0025. Online ahead of print.ABSTRACTInsulin-like growth factor-1 (IGF-1) is a critical modulator of cell growth and survival, making it a central part of maintaining essentially every biological system in the body. Knowledge of the intricate mechanisms involved in activating IGF-1 signaling is not only key to understanding basic processes of growth and development, but also for addressing diseases, such as cancer and diabetes. This brief review explores how dysregulation of normal IGF-1 signaling can impact growth by examining its role in postnatal bone elongation. IGF-...
Source: Biochemistry and Cell Biology - May 29, 2023 Category: Biochemistry Authors: Cassaundra A White Maria A Serrat Source Type: research
Remembering the legacy of Professor Mohammad Hashemi: a pioneer in molecular genetic studies in southeast Iran (1965-2019)
Biochem Cell Biol. 2023 May 29. doi: 10.1139/bcb-2023-0116. Online ahead of print.ABSTRACTProfessor Mohammad Hashemi was a clinical biochemist and cancer genetic scientist. He has been chair and head of Department of Clinical Biochemistry at Zahedan University of Medical Sciences, Zahedan, Iran. He has played an important role in the improvement of understanding of genetics of disease in southeast Iran. He was also a part of international team for the discovery of the role of calprotectin (S100A8/A9) in cancer biology via regulation of cell fate in tumor cells. He had over 300 peer-reviewed scientific publications and trai...
Source: Biochemistry and Cell Biology - May 29, 2023 Category: Biochemistry Authors: Farhad Tabasi Ebrahim Eskandari Saeid Ghavami Source Type: research
