Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Protamines and the sperm nuclear basic proteins Pandora's Box of Insects
Biochem Cell Biol. 2024 Feb 26. doi: 10.1139/bcb-2023-0363. Online ahead of print.ABSTRACTInsects are the largest group of animals when it comes to the number and diversity of species. Yet, with the exception of Drosophila, no information is currently available on the primary structure of their sperm nuclear basic proteins (SNBPs). This paper represents the first attempt in this regard and provides information about six species of Mecoptera: Poecillimon thessalicus, Graptosaltria nigrofuscata, Apis mellifera, Nasonia vitripennis, Parachauliodes continentalis, and Tribolium castaneum. The SNBPs of these species were charact...
Source: Biochemistry and Cell Biology - February 26, 2024 Category: Biochemistry Authors: Melissa R Leyden Brent Gowen Rodrigo Gonzalez-Romero Jose Maria Eirin-Lopez Bo-Hyun Kim Fumio Hayashi Jay McCartney Patrick C Zhang Miyoko Kubo-Irie Jeffrey Shabanowitz Donald F Hunt Patrick Michael Ferree Harold Kasinsky Juan Ausio Source Type: research
Protamines and the sperm nuclear basic proteins Pandora's Box of Insects
Biochem Cell Biol. 2024 Feb 26. doi: 10.1139/bcb-2023-0363. Online ahead of print.ABSTRACTInsects are the largest group of animals when it comes to the number and diversity of species. Yet, with the exception of Drosophila, no information is currently available on the primary structure of their sperm nuclear basic proteins (SNBPs). This paper represents the first attempt in this regard and provides information about six species of Mecoptera: Poecillimon thessalicus, Graptosaltria nigrofuscata, Apis mellifera, Nasonia vitripennis, Parachauliodes continentalis, and Tribolium castaneum. The SNBPs of these species were charact...
Source: Biochemistry and Cell Biology - February 26, 2024 Category: Biochemistry Authors: Melissa R Leyden Brent Gowen Rodrigo Gonzalez-Romero Jose Maria Eirin-Lopez Bo-Hyun Kim Fumio Hayashi Jay McCartney Patrick C Zhang Miyoko Kubo-Irie Jeffrey Shabanowitz Donald F Hunt Patrick Michael Ferree Harold Kasinsky Juan Ausio Source Type: research
Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cag α of Helicobacter pylori
Biochem Cell Biol. 2024 Feb 20. doi: 10.1139/bcb-2023-0331. Online ahead of print.ABSTRACTWe here describe the structure-based design of small molecule inhibitors of the type IV secretion system of Helicobacter pylori. The secretion system is encoded by the cag pathogenicity island, and we chose Cagα, a hexameric ATPase and member of the family of VirB11-like proteins, as target for inhibitor design. We first solved the crystal structure of Cagα in a complex with the previously identified small molecule inhibitor 1G2. The molecule binds at the interface between two Cagα subunits and mutagenesis of the binding site ident...
Source: Biochemistry and Cell Biology - February 20, 2024 Category: Biochemistry Authors: Claire Morin Vijay Tailor Verma Tarun Arya Bastien Casu Eric Jolicoeur R éjean Ruel Anne Marinier Jurgen Sygusch Christian Baron Source Type: research
Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cag α of Helicobacter pylori
Biochem Cell Biol. 2024 Feb 20. doi: 10.1139/bcb-2023-0331. Online ahead of print.ABSTRACTWe here describe the structure-based design of small molecule inhibitors of the type IV secretion system of Helicobacter pylori. The secretion system is encoded by the cag pathogenicity island, and we chose Cagα, a hexameric ATPase and member of the family of VirB11-like proteins, as target for inhibitor design. We first solved the crystal structure of Cagα in a complex with the previously identified small molecule inhibitor 1G2. The molecule binds at the interface between two Cagα subunits and mutagenesis of the binding site ident...
Source: Biochemistry and Cell Biology - February 20, 2024 Category: Biochemistry Authors: Claire Morin Vijay Tailor Verma Tarun Arya Bastien Casu Eric Jolicoeur R éjean Ruel Anne Marinier Jurgen Sygusch Christian Baron Source Type: research
Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cag α of Helicobacter pylori
Biochem Cell Biol. 2024 Feb 20. doi: 10.1139/bcb-2023-0331. Online ahead of print.ABSTRACTWe here describe the structure-based design of small molecule inhibitors of the type IV secretion system of Helicobacter pylori. The secretion system is encoded by the cag pathogenicity island, and we chose Cagα, a hexameric ATPase and member of the family of VirB11-like proteins, as target for inhibitor design. We first solved the crystal structure of Cagα in a complex with the previously identified small molecule inhibitor 1G2. The molecule binds at the interface between two Cagα subunits and mutagenesis of the binding site ident...
Source: Biochemistry and Cell Biology - February 20, 2024 Category: Biochemistry Authors: Claire Morin Vijay Tailor Verma Tarun Arya Bastien Casu Eric Jolicoeur R éjean Ruel Anne Marinier Jurgen Sygusch Christian Baron Source Type: research
