Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Granulocyte Pro-Myeloperoxidase is Redundantly Processed by Proprotein Convertase Furin and PC7 in HL-60 cells
Biochem Cell Biol. 2024 Mar 14. doi: 10.1139/bcb-2023-0339. Online ahead of print.ABSTRACTNeutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precursor named promyeloperoxidase which arbor a propeptide that gets cleaved latter during secretory routing in post endoplasmic reticulum compartments. Although evidence suggested that this proc...
Source: Biochemistry and Cell Biology - March 14, 2024 Category: Biochemistry Authors: Vanessa Lapointe Fr édéric Couture Source Type: research
Chromatin and Nucleosome-Associated Features in Liquid Biopsy: Implications for Cancer Biomarker Discovery
Biochem Cell Biol. 2024 Mar 13. doi: 10.1139/bcb-2024-0004. Online ahead of print.ABSTRACTCell-free DNA (cfDNA) from the bloodstream has been studied for cancer biomarker discovery, and chromatin-derived epigenetic features have come into the spotlight for their potential to expand clinical applications. Methylation, fragmentation, and nucleosome positioning patterns of cfDNA have previously been shown to reveal epigenomic and inferred transcriptomic information. More recently, histone modifications have emerged as a tool to further identify tumor-specific chromatin variants in plasma. A number of sequencing methods have b...
Source: Biochemistry and Cell Biology - March 13, 2024 Category: Biochemistry Authors: Lucas Penny Sasha Main Steven De Michino Scott Bratman Source Type: research
Chromatin and Nucleosome-Associated Features in Liquid Biopsy: Implications for Cancer Biomarker Discovery
Biochem Cell Biol. 2024 Mar 13. doi: 10.1139/bcb-2024-0004. Online ahead of print.ABSTRACTCell-free DNA (cfDNA) from the bloodstream has been studied for cancer biomarker discovery, and chromatin-derived epigenetic features have come into the spotlight for their potential to expand clinical applications. Methylation, fragmentation, and nucleosome positioning patterns of cfDNA have previously been shown to reveal epigenomic and inferred transcriptomic information. More recently, histone modifications have emerged as a tool to further identify tumor-specific chromatin variants in plasma. A number of sequencing methods have b...
Source: Biochemistry and Cell Biology - March 13, 2024 Category: Biochemistry Authors: Lucas Penny Sasha Main Steven De Michino Scott Bratman Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
Exogenous Hydrogen Sulfide Prevents SOD2 Degradation to Safeguard Renal Function in Diabetic Kidney Disease
This study was undertaken to unveil the mechanisms by which H2S counteracts against DKD. Utilizing mice and human renal tubular epithelial (HK-2) cells, we demonstrated a reduction in cystathionine-γ-lyase (CSE)/H2S levels within renal tissues of db/db mice and in HK-2 cells subjected to hyperglycemic and hyperlipidemic environments. Notably, we observed that NaHS supplementation could serve as an exogenous source of H2S. Exogenous H2S exhibited the capacity to mitigate the accumulation of reactive oxygen species (ROS) and attenuate the degradation of superoxide dismutase 2 (SOD2) by Lon protease homolog 1 (LONP1) induced...
Source: Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Qian Yang Mengyi Wang Huan Wang Cheng Ren Yifu Li Source Type: research
