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Inorganic polyphosphate and the regulation of mitochondrial physiology
Biochem Soc Trans. 2023 Nov 13:BST20230735. doi: 10.1042/BST20230735. Online ahead of print.ABSTRACTInorganic polyphosphate (polyP) is an ancient polymer that is well-conserved throughout evolution. It is formed by multiple subunits of orthophosphates linked together by phosphoanhydride bonds. The presence of these bonds, which are structurally similar to those found in ATP, and the high abundance of polyP in mammalian mitochondria, suggest that polyP could be involved in the regulation of the physiology of the organelle, especially in the energy metabolism. In fact, the scientific literature shows an unequivocal role for ...
Source: Biochemical Society Transactions - November 13, 2023 Category: Biochemistry Authors: Renata T Da Costa Lindsey M Riggs Maria E Solesio Source Type: research

Engineering CRISPR guide RNAs for programmable RNA sensors
Biochem Soc Trans. 2023 Nov 13:BST20221486. doi: 10.1042/BST20221486. Online ahead of print.ABSTRACTAs the most valuable feature of the CRISPR system, the programmability based on Watson-Crick base pairing has been widely exploited in engineering RNA sensors. The base pairing in these systems offers a connection between the RNA of interest and the CRISPR effector, providing a highly specific mechanism for RNA detection both in vivo and in vitro. In the last decade, despite the many successful RNA sensing approaches developed during the era of CRISPR explosion, a deeper understanding of the characteristics of CRISPR systems...
Source: Biochemical Society Transactions - November 13, 2023 Category: Biochemistry Authors: Yang Liu Wei Liu Baojun Wang Source Type: research

Correction: Current Working Models of SMC-driven DNA-loop extrusion
Biochem Soc Trans. 2023 Nov 2:BST20220898_COR. doi: 10.1042/BST-2022-0898C_COR. Online ahead of print.NO ABSTRACTPMID:37916827 | DOI:10.1042/BST-2022-0898C_COR (Source: Biochemical Society Transactions)
Source: Biochemical Society Transactions - November 2, 2023 Category: Biochemistry Authors: Kyoung-Wook Moon Je-Kyung Ryu Source Type: research

Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology
Biochem Soc Trans. 2023 Oct 31;51(5):1947-1956. doi: 10.1042/BST20230483.ABSTRACTInorganic polyphosphate (polyP), the polymeric form of phosphate, is attracting ever-growing attention due to the many functions it appears to perform within mammalian cells. This essay does not aim to systematically review the copious mammalian polyP literature. Instead, we examined polyP synthesis and functions in various microorganisms and used an evolutionary perspective to theorise key issues of this field and propose solutions. By highlighting the presence of VTC4 in distinct species of very divergent eucaryote clades (Opisthokonta, Viri...
Source: Biochemical Society Transactions - October 16, 2023 Category: Biochemistry Authors: Filipy Borghi Adolfo Saiardi Source Type: research