Revealing chromatin-specific functions of histone deacylases
Biochem Soc Trans. 2024 Jan 8:BST20230693. doi: 10.1042/BST20230693. Online ahead of print.ABSTRACTHistone deacylases are erasers of Nε-acyl-lysine post-translational modifications and have been targeted for decades for the treatment of cancer, neurodegeneration and other disorders. Due to their relatively promiscuous activity on peptide substrates in vitro, it has been challenging to determine the individual targets and substrate identification mechanisms of each isozyme, and they have been considered redundant regulators. In recent years, biochemical and biophysical studies have incorporated the use of reconstituted nuc...
Source: Biochemical Society Transactions - January 8, 2024 Category: Biochemistry Authors: Carlos Moreno-Yruela Beat Fierz Source Type: research
Revealing chromatin-specific functions of histone deacylases
Biochem Soc Trans. 2024 Jan 8:BST20230693. doi: 10.1042/BST20230693. Online ahead of print.ABSTRACTHistone deacylases are erasers of Nε-acyl-lysine post-translational modifications and have been targeted for decades for the treatment of cancer, neurodegeneration and other disorders. Due to their relatively promiscuous activity on peptide substrates in vitro, it has been challenging to determine the individual targets and substrate identification mechanisms of each isozyme, and they have been considered redundant regulators. In recent years, biochemical and biophysical studies have incorporated the use of reconstituted nuc...
Source: Biochemical Society Transactions - January 8, 2024 Category: Biochemistry Authors: Carlos Moreno-Yruela Beat Fierz Source Type: research
Revealing chromatin-specific functions of histone deacylases
Biochem Soc Trans. 2024 Jan 8:BST20230693. doi: 10.1042/BST20230693. Online ahead of print.ABSTRACTHistone deacylases are erasers of Nε-acyl-lysine post-translational modifications and have been targeted for decades for the treatment of cancer, neurodegeneration and other disorders. Due to their relatively promiscuous activity on peptide substrates in vitro, it has been challenging to determine the individual targets and substrate identification mechanisms of each isozyme, and they have been considered redundant regulators. In recent years, biochemical and biophysical studies have incorporated the use of reconstituted nuc...
Source: Biochemical Society Transactions - January 8, 2024 Category: Biochemistry Authors: Carlos Moreno-Yruela Beat Fierz Source Type: research
RNA-binding proteins that preferentially interact with 8-oxoG-modified RNAs: our current understanding
Biochem Soc Trans. 2024 Jan 4:BST20230254. doi: 10.1042/BST20230254. Online ahead of print.ABSTRACTCells encounter a variety of stresses throughout their lifetimes. Oxidative stress can occur via a myriad of factors, including exposure to chemical toxins or UV light. Importantly, these stressors induce chemical changes (e.g. chemical modifications) to biomolecules, such as RNA. Commonly, guanine is oxidized to form 8-oxo-7,8-hydroxyguanine (8-oxoG) and this modification can disrupt a plethora of cellular processes including messenger RNA translation and stability. Polynucleotide phosphorylase (PNPase), heterogeneous nuclea...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Kathleen E Taylor Lucas G Miller Lydia M Contreras Source Type: research
Intersectin - many facets of a scaffold protein
Biochem Soc Trans. 2024 Jan 4:BST20211241. doi: 10.1042/BST20211241. Online ahead of print.ABSTRACTIntersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions including regulation of endocytosis, vesicle transport, and activation of various signal transduction pathways. There are two ITSN genes located on chromosomes 21 and 2 encoding for proteins ITSN1 and ITSN2, respectively. Each ITSN gene encodes two major isoforms, ITSN-Long (ITSN-L) and ITSN-Short (ITSN-S), due to alternative splicing. ITSN1 and 2, collectively referred to as ITSN, are implicated in many physiological and pathological proc...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Mubashir Mintoo Vinodh Rajagopalan John P O'Bryan Source Type: research
Genetic regulation of enteric nervous system development in zebrafish
Biochem Soc Trans. 2024 Jan 4:BST20230343. doi: 10.1042/BST20230343. Online ahead of print.ABSTRACTThe enteric nervous system (ENS) is a complex series of interconnected neurons and glia that reside within and along the entire length of the gastrointestinal tract. ENS functions are vital to gut homeostasis and digestion, including local control of peristalsis, water balance, and intestinal cell barrier function. How the ENS develops during embryological development is a topic of great concern, as defects in ENS development can result in various diseases, the most common being Hirschsprung disease, in which variable regions...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Rosa A Uribe Source Type: research
Deubiquitylating enzymes in Arabidopsis thaliana endocytic protein degradation
Biochem Soc Trans. 2024 Jan 4:BST20230561. doi: 10.1042/BST20230561. Online ahead of print.ABSTRACTThe regulation of ubiquitylation is key for plant growth and development, in which the activities of ubiquitylating enzymes as well as deubiquitylating enzymes (DUBs) determine the stability or function of the modified proteins. In contrast with ubiquitylating enzymes, there are less numbers of DUBs. DUBs can be classified into seven protein families according to the amino acid sequence of their catalytic domains. The catalytic domains of animal and plant DUB families show high homology, whereas the regions outside of the cat...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Karin Vogel Erika Isono Source Type: research
RNA-binding proteins that preferentially interact with 8-oxoG-modified RNAs: our current understanding
Biochem Soc Trans. 2024 Jan 4:BST20230254. doi: 10.1042/BST20230254. Online ahead of print.ABSTRACTCells encounter a variety of stresses throughout their lifetimes. Oxidative stress can occur via a myriad of factors, including exposure to chemical toxins or UV light. Importantly, these stressors induce chemical changes (e.g. chemical modifications) to biomolecules, such as RNA. Commonly, guanine is oxidized to form 8-oxo-7,8-hydroxyguanine (8-oxoG) and this modification can disrupt a plethora of cellular processes including messenger RNA translation and stability. Polynucleotide phosphorylase (PNPase), heterogeneous nuclea...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Kathleen E Taylor Lucas G Miller Lydia M Contreras Source Type: research
Intersectin - many facets of a scaffold protein
Biochem Soc Trans. 2024 Jan 4:BST20211241. doi: 10.1042/BST20211241. Online ahead of print.ABSTRACTIntersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions including regulation of endocytosis, vesicle transport, and activation of various signal transduction pathways. There are two ITSN genes located on chromosomes 21 and 2 encoding for proteins ITSN1 and ITSN2, respectively. Each ITSN gene encodes two major isoforms, ITSN-Long (ITSN-L) and ITSN-Short (ITSN-S), due to alternative splicing. ITSN1 and 2, collectively referred to as ITSN, are implicated in many physiological and pathological proc...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Mubashir Mintoo Vinodh Rajagopalan John P O'Bryan Source Type: research
Genetic regulation of enteric nervous system development in zebrafish
Biochem Soc Trans. 2024 Jan 4:BST20230343. doi: 10.1042/BST20230343. Online ahead of print.ABSTRACTThe enteric nervous system (ENS) is a complex series of interconnected neurons and glia that reside within and along the entire length of the gastrointestinal tract. ENS functions are vital to gut homeostasis and digestion, including local control of peristalsis, water balance, and intestinal cell barrier function. How the ENS develops during embryological development is a topic of great concern, as defects in ENS development can result in various diseases, the most common being Hirschsprung disease, in which variable regions...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Rosa A Uribe Source Type: research
Deubiquitylating enzymes in Arabidopsis thaliana endocytic protein degradation
Biochem Soc Trans. 2024 Jan 4:BST20230561. doi: 10.1042/BST20230561. Online ahead of print.ABSTRACTThe regulation of ubiquitylation is key for plant growth and development, in which the activities of ubiquitylating enzymes as well as deubiquitylating enzymes (DUBs) determine the stability or function of the modified proteins. In contrast with ubiquitylating enzymes, there are less numbers of DUBs. DUBs can be classified into seven protein families according to the amino acid sequence of their catalytic domains. The catalytic domains of animal and plant DUB families show high homology, whereas the regions outside of the cat...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Karin Vogel Erika Isono Source Type: research
RNA-binding proteins that preferentially interact with 8-oxoG-modified RNAs: our current understanding
Biochem Soc Trans. 2024 Jan 4:BST20230254. doi: 10.1042/BST20230254. Online ahead of print.ABSTRACTCells encounter a variety of stresses throughout their lifetimes. Oxidative stress can occur via a myriad of factors, including exposure to chemical toxins or UV light. Importantly, these stressors induce chemical changes (e.g. chemical modifications) to biomolecules, such as RNA. Commonly, guanine is oxidized to form 8-oxo-7,8-hydroxyguanine (8-oxoG) and this modification can disrupt a plethora of cellular processes including messenger RNA translation and stability. Polynucleotide phosphorylase (PNPase), heterogeneous nuclea...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Kathleen E Taylor Lucas G Miller Lydia M Contreras Source Type: research
Intersectin - many facets of a scaffold protein
Biochem Soc Trans. 2024 Jan 4:BST20211241. doi: 10.1042/BST20211241. Online ahead of print.ABSTRACTIntersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions including regulation of endocytosis, vesicle transport, and activation of various signal transduction pathways. There are two ITSN genes located on chromosomes 21 and 2 encoding for proteins ITSN1 and ITSN2, respectively. Each ITSN gene encodes two major isoforms, ITSN-Long (ITSN-L) and ITSN-Short (ITSN-S), due to alternative splicing. ITSN1 and 2, collectively referred to as ITSN, are implicated in many physiological and pathological proc...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Mubashir Mintoo Vinodh Rajagopalan John P O'Bryan Source Type: research
Genetic regulation of enteric nervous system development in zebrafish
Biochem Soc Trans. 2024 Jan 4:BST20230343. doi: 10.1042/BST20230343. Online ahead of print.ABSTRACTThe enteric nervous system (ENS) is a complex series of interconnected neurons and glia that reside within and along the entire length of the gastrointestinal tract. ENS functions are vital to gut homeostasis and digestion, including local control of peristalsis, water balance, and intestinal cell barrier function. How the ENS develops during embryological development is a topic of great concern, as defects in ENS development can result in various diseases, the most common being Hirschsprung disease, in which variable regions...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Rosa A Uribe Source Type: research
Deubiquitylating enzymes in Arabidopsis thaliana endocytic protein degradation
Biochem Soc Trans. 2024 Jan 4:BST20230561. doi: 10.1042/BST20230561. Online ahead of print.ABSTRACTThe regulation of ubiquitylation is key for plant growth and development, in which the activities of ubiquitylating enzymes as well as deubiquitylating enzymes (DUBs) determine the stability or function of the modified proteins. In contrast with ubiquitylating enzymes, there are less numbers of DUBs. DUBs can be classified into seven protein families according to the amino acid sequence of their catalytic domains. The catalytic domains of animal and plant DUB families show high homology, whereas the regions outside of the cat...
Source: Biochemical Society Transactions - January 4, 2024 Category: Biochemistry Authors: Karin Vogel Erika Isono Source Type: research
