Post-translational modifications: emerging directors of cell-fate decisions during endoplasmic reticulum stress in Arabidopsis thaliana
Biochem Soc Trans. 2024 Apr 11:BST20231025. doi: 10.1042/BST20231025. Online ahead of print.ABSTRACTHomeostasis of the endoplasmic reticulum (ER) is critical for growth, development, and stress responses. Perturbations causing an imbalance in ER proteostasis lead to a potentially lethal condition known as ER stress. In ER stress situations, cell-fate decisions either activate pro-life pathways that reestablish homeostasis or initiate pro-death pathways to prevent further damage to the organism. Understanding the mechanisms underpinning cell-fate decisions in ER stress is critical for crop development and has the potential ...
Source: Biochemical Society Transactions - April 10, 2024 Category: Biochemistry Authors: Ethan Thibault Federica Brandizzi Source Type: research
Atomic force microscopy 3D structural reconstruction of individual particles in the study of amyloid protein assemblies
Biochem Soc Trans. 2024 Apr 11:BST20230857. doi: 10.1042/BST20230857. Online ahead of print.ABSTRACTRecent developments in atomic force microscopy (AFM) image analysis have made three-dimensional (3D) structural reconstruction of individual particles observed on 2D AFM height images a reality. Here, we review the emerging contact point reconstruction AFM (CPR-AFM) methodology and its application in 3D reconstruction of individual helical amyloid filaments in the context of the challenges presented by the structural analysis of highly polymorphous and heterogeneous amyloid protein structures. How individual particle-level s...
Source: Biochemical Society Transactions - April 10, 2024 Category: Biochemistry Authors: Claudia Chitty Kinga Kuliga Wei-Feng Xue Source Type: research
Post-translational modifications: emerging directors of cell-fate decisions during endoplasmic reticulum stress in Arabidopsis thaliana
Biochem Soc Trans. 2024 Apr 11:BST20231025. doi: 10.1042/BST20231025. Online ahead of print.ABSTRACTHomeostasis of the endoplasmic reticulum (ER) is critical for growth, development, and stress responses. Perturbations causing an imbalance in ER proteostasis lead to a potentially lethal condition known as ER stress. In ER stress situations, cell-fate decisions either activate pro-life pathways that reestablish homeostasis or initiate pro-death pathways to prevent further damage to the organism. Understanding the mechanisms underpinning cell-fate decisions in ER stress is critical for crop development and has the potential ...
Source: Biochemical Society Transactions - April 10, 2024 Category: Biochemistry Authors: Ethan Thibault Federica Brandizzi Source Type: research
Atomic force microscopy 3D structural reconstruction of individual particles in the study of amyloid protein assemblies
Biochem Soc Trans. 2024 Apr 11:BST20230857. doi: 10.1042/BST20230857. Online ahead of print.ABSTRACTRecent developments in atomic force microscopy (AFM) image analysis have made three-dimensional (3D) structural reconstruction of individual particles observed on 2D AFM height images a reality. Here, we review the emerging contact point reconstruction AFM (CPR-AFM) methodology and its application in 3D reconstruction of individual helical amyloid filaments in the context of the challenges presented by the structural analysis of highly polymorphous and heterogeneous amyloid protein structures. How individual particle-level s...
Source: Biochemical Society Transactions - April 10, 2024 Category: Biochemistry Authors: Claudia Chitty Kinga Kuliga Wei-Feng Xue Source Type: research
Mechanically operated signalling scaffolds
Biochem Soc Trans. 2024 Apr 4:BST20221194. doi: 10.1042/BST20221194. Online ahead of print.ABSTRACTCellular signalling is a complex process and involves cascades of enzymes that, in response to a specific signal, give rise to exact cellular responses. Signalling scaffold proteins organise components of these signalling pathways in space and time to co-ordinate signalling outputs. In this review we introduce a new class of mechanically operated signalling scaffolds that are built into the cytoskeletal architecture of the cell. These proteins contain force-dependent binary switch domains that integrate chemical and mechanica...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Neil J Ball Samuel F H Barnett Benjamin T Goult Source Type: research
The SWI/SNF ATP-dependent chromatin remodeling complex in cell lineage priming and early development
Biochem Soc Trans. 2024 Apr 4:BST20230416. doi: 10.1042/BST20230416. Online ahead of print.ABSTRACTATP dependent chromatin remodelers have pivotal roles in transcription, DNA replication and repair, and maintaining genome integrity. SWI/SNF remodelers were first discovered in yeast genetic screens for factors involved in mating type switching or for using alternative energy sources therefore termed SWI/SNF complex (short for SWItch/Sucrose NonFermentable). The SWI/SNF complexes utilize energy from ATP hydrolysis to disrupt histone-DNA interactions and shift, eject, or reposition nucleosomes making the underlying DNA more a...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Dhurjhoti Saha Srinivas Animireddy Blaine Bartholomew Source Type: research
Decoding the ubiquitin landscape by cutting-edge ubiquitinomic approaches
Biochem Soc Trans. 2024 Apr 4:BST20230457. doi: 10.1042/BST20230457. Online ahead of print.ABSTRACTFunctional consequences of protein ubiquitination have gone far beyond the degradation regulation as was initially imagined during its discovery 40 years back. The state-of-the-art has revealed the plethora of signaling pathways that are largely regulated by ubiquitination process in eukaryotes. To no surprise, ubiquitination is often dysregulated in many human diseases, including cancer, neurodegeneration and infection. Hence it has become a major focus with high-gain research value for many investigators to unravel new prot...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Brindhavanam P T Indrajit Sahu Source Type: research
Mechanically operated signalling scaffolds
Biochem Soc Trans. 2024 Apr 4:BST20221194. doi: 10.1042/BST20221194. Online ahead of print.ABSTRACTCellular signalling is a complex process and involves cascades of enzymes that, in response to a specific signal, give rise to exact cellular responses. Signalling scaffold proteins organise components of these signalling pathways in space and time to co-ordinate signalling outputs. In this review we introduce a new class of mechanically operated signalling scaffolds that are built into the cytoskeletal architecture of the cell. These proteins contain force-dependent binary switch domains that integrate chemical and mechanica...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Neil J Ball Samuel F H Barnett Benjamin T Goult Source Type: research
The SWI/SNF ATP-dependent chromatin remodeling complex in cell lineage priming and early development
Biochem Soc Trans. 2024 Apr 4:BST20230416. doi: 10.1042/BST20230416. Online ahead of print.ABSTRACTATP dependent chromatin remodelers have pivotal roles in transcription, DNA replication and repair, and maintaining genome integrity. SWI/SNF remodelers were first discovered in yeast genetic screens for factors involved in mating type switching or for using alternative energy sources therefore termed SWI/SNF complex (short for SWItch/Sucrose NonFermentable). The SWI/SNF complexes utilize energy from ATP hydrolysis to disrupt histone-DNA interactions and shift, eject, or reposition nucleosomes making the underlying DNA more a...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Dhurjhoti Saha Srinivas Animireddy Blaine Bartholomew Source Type: research
Decoding the ubiquitin landscape by cutting-edge ubiquitinomic approaches
Biochem Soc Trans. 2024 Apr 4:BST20230457. doi: 10.1042/BST20230457. Online ahead of print.ABSTRACTFunctional consequences of protein ubiquitination have gone far beyond the degradation regulation as was initially imagined during its discovery 40 years back. The state-of-the-art has revealed the plethora of signaling pathways that are largely regulated by ubiquitination process in eukaryotes. To no surprise, ubiquitination is often dysregulated in many human diseases, including cancer, neurodegeneration and infection. Hence it has become a major focus with high-gain research value for many investigators to unravel new prot...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Brindhavanam P T Indrajit Sahu Source Type: research
Mechanically operated signalling scaffolds
Biochem Soc Trans. 2024 Apr 4:BST20221194. doi: 10.1042/BST20221194. Online ahead of print.ABSTRACTCellular signalling is a complex process and involves cascades of enzymes that, in response to a specific signal, give rise to exact cellular responses. Signalling scaffold proteins organise components of these signalling pathways in space and time to co-ordinate signalling outputs. In this review we introduce a new class of mechanically operated signalling scaffolds that are built into the cytoskeletal architecture of the cell. These proteins contain force-dependent binary switch domains that integrate chemical and mechanica...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Neil J Ball Samuel F H Barnett Benjamin T Goult Source Type: research
The SWI/SNF ATP-dependent chromatin remodeling complex in cell lineage priming and early development
Biochem Soc Trans. 2024 Apr 4:BST20230416. doi: 10.1042/BST20230416. Online ahead of print.ABSTRACTATP dependent chromatin remodelers have pivotal roles in transcription, DNA replication and repair, and maintaining genome integrity. SWI/SNF remodelers were first discovered in yeast genetic screens for factors involved in mating type switching or for using alternative energy sources therefore termed SWI/SNF complex (short for SWItch/Sucrose NonFermentable). The SWI/SNF complexes utilize energy from ATP hydrolysis to disrupt histone-DNA interactions and shift, eject, or reposition nucleosomes making the underlying DNA more a...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Dhurjhoti Saha Srinivas Animireddy Blaine Bartholomew Source Type: research
Decoding the ubiquitin landscape by cutting-edge ubiquitinomic approaches
Biochem Soc Trans. 2024 Apr 4:BST20230457. doi: 10.1042/BST20230457. Online ahead of print.ABSTRACTFunctional consequences of protein ubiquitination have gone far beyond the degradation regulation as was initially imagined during its discovery 40 years back. The state-of-the-art has revealed the plethora of signaling pathways that are largely regulated by ubiquitination process in eukaryotes. To no surprise, ubiquitination is often dysregulated in many human diseases, including cancer, neurodegeneration and infection. Hence it has become a major focus with high-gain research value for many investigators to unravel new prot...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Brindhavanam P T Indrajit Sahu Source Type: research
Mechanically operated signalling scaffolds
Biochem Soc Trans. 2024 Apr 4:BST20221194. doi: 10.1042/BST20221194. Online ahead of print.ABSTRACTCellular signalling is a complex process and involves cascades of enzymes that, in response to a specific signal, give rise to exact cellular responses. Signalling scaffold proteins organise components of these signalling pathways in space and time to co-ordinate signalling outputs. In this review we introduce a new class of mechanically operated signalling scaffolds that are built into the cytoskeletal architecture of the cell. These proteins contain force-dependent binary switch domains that integrate chemical and mechanica...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Neil J Ball Samuel F H Barnett Benjamin T Goult Source Type: research
The SWI/SNF ATP-dependent chromatin remodeling complex in cell lineage priming and early development
Biochem Soc Trans. 2024 Apr 4:BST20230416. doi: 10.1042/BST20230416. Online ahead of print.ABSTRACTATP dependent chromatin remodelers have pivotal roles in transcription, DNA replication and repair, and maintaining genome integrity. SWI/SNF remodelers were first discovered in yeast genetic screens for factors involved in mating type switching or for using alternative energy sources therefore termed SWI/SNF complex (short for SWItch/Sucrose NonFermentable). The SWI/SNF complexes utilize energy from ATP hydrolysis to disrupt histone-DNA interactions and shift, eject, or reposition nucleosomes making the underlying DNA more a...
Source: Biochemical Society Transactions - April 4, 2024 Category: Biochemistry Authors: Dhurjhoti Saha Srinivas Animireddy Blaine Bartholomew Source Type: research
