Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity
Biochem Soc Trans. 2023 Nov 30:BST20221083. doi: 10.1042/BST20221083. Online ahead of print.ABSTRACTAdvances in immunotherapy in the last decade have revolutionized treatment paradigms across multiple cancer diagnoses. However, only a minority of patients derive durable benefit and progress with traditional approaches, such as cancer vaccines, remains unsatisfactory. A key to overcoming these barriers resides with a deeper understanding of tumor antigen presentation and the complex and dynamic heterogeneity of tumor-infiltrating antigen-presenting cells (APCs). Reminiscent of the 'second touch' hypothesis proposed by Klaus...
Source: Biochemical Society Transactions - November 30, 2023 Category: Biochemistry Authors: Athanasios Papadas Yun Huang Alexander Cicala Yaling Dou Matteo Fields Alicia Gibbons Duncan Hong Daniel J Lagal Victoria Quintana Alejandro Rizo Brolyn Zomalan Fotis Asimakopoulos Source Type: research
Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity
Biochem Soc Trans. 2023 Nov 30:BST20221083. doi: 10.1042/BST20221083. Online ahead of print.ABSTRACTAdvances in immunotherapy in the last decade have revolutionized treatment paradigms across multiple cancer diagnoses. However, only a minority of patients derive durable benefit and progress with traditional approaches, such as cancer vaccines, remains unsatisfactory. A key to overcoming these barriers resides with a deeper understanding of tumor antigen presentation and the complex and dynamic heterogeneity of tumor-infiltrating antigen-presenting cells (APCs). Reminiscent of the 'second touch' hypothesis proposed by Klaus...
Source: Biochemical Society Transactions - November 30, 2023 Category: Biochemistry Authors: Athanasios Papadas Yun Huang Alexander Cicala Yaling Dou Matteo Fields Alicia Gibbons Duncan Hong Daniel J Lagal Victoria Quintana Alejandro Rizo Brolyn Zomalan Fotis Asimakopoulos Source Type: research
Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity
Biochem Soc Trans. 2023 Nov 30:BST20221083. doi: 10.1042/BST20221083. Online ahead of print.ABSTRACTAdvances in immunotherapy in the last decade have revolutionized treatment paradigms across multiple cancer diagnoses. However, only a minority of patients derive durable benefit and progress with traditional approaches, such as cancer vaccines, remains unsatisfactory. A key to overcoming these barriers resides with a deeper understanding of tumor antigen presentation and the complex and dynamic heterogeneity of tumor-infiltrating antigen-presenting cells (APCs). Reminiscent of the 'second touch' hypothesis proposed by Klaus...
Source: Biochemical Society Transactions - November 30, 2023 Category: Biochemistry Authors: Athanasios Papadas Yun Huang Alexander Cicala Yaling Dou Matteo Fields Alicia Gibbons Duncan Hong Daniel J Lagal Victoria Quintana Alejandro Rizo Brolyn Zomalan Fotis Asimakopoulos Source Type: research
Insights into protein structure using cryogenic light microscopy
Biochem Soc Trans. 2023 Nov 28:BST20221246. doi: 10.1042/BST20221246. Online ahead of print.ABSTRACTFluorescence microscopy has witnessed many clever innovations in the last two decades, leading to new methods such as structured illumination and super-resolution microscopies. The attainable resolution in biological samples is, however, ultimately limited by residual motion within the sample or in the microscope setup. Thus, such experiments are typically performed on chemically fixed samples. Cryogenic light microscopy (Cryo-LM) has been investigated as an alternative, drawing on various preservation techniques developed f...
Source: Biochemical Society Transactions - November 28, 2023 Category: Biochemistry Authors: Hisham Mazal Franz-Ferdinand Wieser Vahid Sandoghdar Source Type: research
The MYBL1/TCFL5 transcription network: two collaborative factors with central role in male meiosis
Biochem Soc Trans. 2023 Nov 28:BST20231007. doi: 10.1042/BST20231007. Online ahead of print.ABSTRACTMale gametogenesis, spermatogenesis, is a stepwise developmental process to generate mature sperm. The most intricate process of spermatogenesis is meiosis during which two successive cell divisions ensue with dramatic cellular and molecular changes to produce haploid cells. After entry into meiosis, several forms of regulatory events control the orderly progression of meiosis and the timely entry into post-meiotic sperm differentiation. Among other mechanisms, changes to gene expression are controlled by key transcription f...
Source: Biochemical Society Transactions - November 28, 2023 Category: Biochemistry Authors: Martin S äflund Deniz M Özata Source Type: research
Insights into protein structure using cryogenic light microscopy
Biochem Soc Trans. 2023 Nov 28:BST20221246. doi: 10.1042/BST20221246. Online ahead of print.ABSTRACTFluorescence microscopy has witnessed many clever innovations in the last two decades, leading to new methods such as structured illumination and super-resolution microscopies. The attainable resolution in biological samples is, however, ultimately limited by residual motion within the sample or in the microscope setup. Thus, such experiments are typically performed on chemically fixed samples. Cryogenic light microscopy (Cryo-LM) has been investigated as an alternative, drawing on various preservation techniques developed f...
Source: Biochemical Society Transactions - November 28, 2023 Category: Biochemistry Authors: Hisham Mazal Franz-Ferdinand Wieser Vahid Sandoghdar Source Type: research
The MYBL1/TCFL5 transcription network: two collaborative factors with central role in male meiosis
Biochem Soc Trans. 2023 Nov 28:BST20231007. doi: 10.1042/BST20231007. Online ahead of print.ABSTRACTMale gametogenesis, spermatogenesis, is a stepwise developmental process to generate mature sperm. The most intricate process of spermatogenesis is meiosis during which two successive cell divisions ensue with dramatic cellular and molecular changes to produce haploid cells. After entry into meiosis, several forms of regulatory events control the orderly progression of meiosis and the timely entry into post-meiotic sperm differentiation. Among other mechanisms, changes to gene expression are controlled by key transcription f...
Source: Biochemical Society Transactions - November 28, 2023 Category: Biochemistry Authors: Martin S äflund Deniz M Özata Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Visualizing the dynamics of plant energy organelles
Biochem Soc Trans. 2023 Nov 17:BST20221093. doi: 10.1042/BST20221093. Online ahead of print.ABSTRACTPlant organelles predominantly rely on the actin cytoskeleton and the myosin motors for long-distance trafficking, while using microtubules and the kinesin motors mostly for short-range movement. The distribution and motility of organelles in the plant cell are fundamentally important to robust plant growth and defense. Chloroplasts, mitochondria, and peroxisomes are essential organelles in plants that function independently and coordinately during energy metabolism and other key metabolic processes. In response to developme...
Source: Biochemical Society Transactions - November 17, 2023 Category: Biochemistry Authors: Amanda M Koenig Bo Liu Jianping Hu Source Type: research
Visualizing the dynamics of plant energy organelles
Biochem Soc Trans. 2023 Nov 17:BST20221093. doi: 10.1042/BST20221093. Online ahead of print.ABSTRACTPlant organelles predominantly rely on the actin cytoskeleton and the myosin motors for long-distance trafficking, while using microtubules and the kinesin motors mostly for short-range movement. The distribution and motility of organelles in the plant cell are fundamentally important to robust plant growth and defense. Chloroplasts, mitochondria, and peroxisomes are essential organelles in plants that function independently and coordinately during energy metabolism and other key metabolic processes. In response to developme...
Source: Biochemical Society Transactions - November 17, 2023 Category: Biochemistry Authors: Amanda M Koenig Bo Liu Jianping Hu Source Type: research
