The MYBL1/TCFL5 transcription network: two collaborative factors with central role in male meiosis
Biochem Soc Trans. 2023 Nov 28:BST20231007. doi: 10.1042/BST20231007. Online ahead of print.ABSTRACTMale gametogenesis, spermatogenesis, is a stepwise developmental process to generate mature sperm. The most intricate process of spermatogenesis is meiosis during which two successive cell divisions ensue with dramatic cellular and molecular changes to produce haploid cells. After entry into meiosis, several forms of regulatory events control the orderly progression of meiosis and the timely entry into post-meiotic sperm differentiation. Among other mechanisms, changes to gene expression are controlled by key transcription f...
Source: Biochemical Society Transactions - November 28, 2023 Category: Biochemistry Authors: Martin S äflund Deniz M Özata Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Mechanisms of stress management in mitochondrial protein import
Biochem Soc Trans. 2023 Nov 21:BST20230377. doi: 10.1042/BST20230377. Online ahead of print.ABSTRACTMitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because the two diverse lipid membranes encase mitochondria. Efficient protein translocation across membranes and accurate sorting to specific sub-compartments require the cooperation of multiple factors. Any failure in mitochondrial protein import can disrupt organelle fitness. Proteins intended for mitoch...
Source: Biochemical Society Transactions - November 21, 2023 Category: Biochemistry Authors: Maryam Mukhtar Krutika Thakkur Agnieszka Chacinska Piotr Bragoszewski Source Type: research
Visualizing the dynamics of plant energy organelles
Biochem Soc Trans. 2023 Nov 17:BST20221093. doi: 10.1042/BST20221093. Online ahead of print.ABSTRACTPlant organelles predominantly rely on the actin cytoskeleton and the myosin motors for long-distance trafficking, while using microtubules and the kinesin motors mostly for short-range movement. The distribution and motility of organelles in the plant cell are fundamentally important to robust plant growth and defense. Chloroplasts, mitochondria, and peroxisomes are essential organelles in plants that function independently and coordinately during energy metabolism and other key metabolic processes. In response to developme...
Source: Biochemical Society Transactions - November 17, 2023 Category: Biochemistry Authors: Amanda M Koenig Bo Liu Jianping Hu Source Type: research
Visualizing the dynamics of plant energy organelles
Biochem Soc Trans. 2023 Nov 17:BST20221093. doi: 10.1042/BST20221093. Online ahead of print.ABSTRACTPlant organelles predominantly rely on the actin cytoskeleton and the myosin motors for long-distance trafficking, while using microtubules and the kinesin motors mostly for short-range movement. The distribution and motility of organelles in the plant cell are fundamentally important to robust plant growth and defense. Chloroplasts, mitochondria, and peroxisomes are essential organelles in plants that function independently and coordinately during energy metabolism and other key metabolic processes. In response to developme...
Source: Biochemical Society Transactions - November 17, 2023 Category: Biochemistry Authors: Amanda M Koenig Bo Liu Jianping Hu Source Type: research
Visualizing the dynamics of plant energy organelles
Biochem Soc Trans. 2023 Nov 17:BST20221093. doi: 10.1042/BST20221093. Online ahead of print.ABSTRACTPlant organelles predominantly rely on the actin cytoskeleton and the myosin motors for long-distance trafficking, while using microtubules and the kinesin motors mostly for short-range movement. The distribution and motility of organelles in the plant cell are fundamentally important to robust plant growth and defense. Chloroplasts, mitochondria, and peroxisomes are essential organelles in plants that function independently and coordinately during energy metabolism and other key metabolic processes. In response to developme...
Source: Biochemical Society Transactions - November 17, 2023 Category: Biochemistry Authors: Amanda M Koenig Bo Liu Jianping Hu Source Type: research
Structural basis of molecular recognition among classical cadherins mediating cell adhesion
Biochem Soc Trans. 2023 Nov 16:BST20230356. doi: 10.1042/BST20230356. Online ahead of print.ABSTRACTCadherins are type-I membrane glycoproteins that primarily participate in calcium-dependent cell adhesion and homotypic cell sorting in various stages of embryonic development. Besides their crucial role in cellular and physiological processes, increasing studies highlight their involvement in pathophysiological functions ranging from cancer progression and metastasis to being entry receptors for pathogens. Cadherins mediate these cellular processes through homophilic, as well as heterophilic interactions (within and outside...
Source: Biochemical Society Transactions - November 16, 2023 Category: Biochemistry Authors: Sarbartha Mukherjee Saumyadeep Goswami Sagarika Dash Dibyendu Samanta Source Type: research
The enzymes of the oxidative phase of the pentose phosphate pathway as targets of reactive species: consequences for NADPH production
Biochem Soc Trans. 2023 Nov 16:BST20231027. doi: 10.1042/BST20231027. Online ahead of print.ABSTRACTThe pentose phosphate pathway (PPP) is a key metabolic pathway. The oxidative phase of this process involves three reactions catalyzed by glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconolactonase (6PGL) and 6-phosphogluconate dehydrogenase (6PGDH) enzymes. The first and third steps (catalyzed by G6PDH and 6PGDH, respectively) are responsible for generating reduced nicotinamide adenine dinucleotide phosphate (NAPDH), a key cofactor for maintaining the reducing power of cells and detoxification of both endogenous an...
Source: Biochemical Society Transactions - November 16, 2023 Category: Biochemistry Authors: Eduardo Fuentes-Lemus Juan Sebasti án Reyes Juan David Figueroa Michael J Davies Camilo L ópez-Alarcón Source Type: research
Engineering CRISPR guide RNAs for programmable RNA sensors
Biochem Soc Trans. 2023 Nov 13:BST20221486. doi: 10.1042/BST20221486. Online ahead of print.ABSTRACTAs the most valuable feature of the CRISPR system, the programmability based on Watson-Crick base pairing has been widely exploited in engineering RNA sensors. The base pairing in these systems offers a connection between the RNA of interest and the CRISPR effector, providing a highly specific mechanism for RNA detection both in vivo and in vitro. In the last decade, despite the many successful RNA sensing approaches developed during the era of CRISPR explosion, a deeper understanding of the characteristics of CRISPR systems...
Source: Biochemical Society Transactions - November 13, 2023 Category: Biochemistry Authors: Yang Liu Wei Liu Baojun Wang Source Type: research
Inorganic polyphosphate and the regulation of mitochondrial physiology
Biochem Soc Trans. 2023 Nov 13:BST20230735. doi: 10.1042/BST20230735. Online ahead of print.ABSTRACTInorganic polyphosphate (polyP) is an ancient polymer that is well-conserved throughout evolution. It is formed by multiple subunits of orthophosphates linked together by phosphoanhydride bonds. The presence of these bonds, which are structurally similar to those found in ATP, and the high abundance of polyP in mammalian mitochondria, suggest that polyP could be involved in the regulation of the physiology of the organelle, especially in the energy metabolism. In fact, the scientific literature shows an unequivocal role for ...
Source: Biochemical Society Transactions - November 13, 2023 Category: Biochemistry Authors: Renata T Da Costa Lindsey M Riggs Maria E Solesio Source Type: research
Engineering CRISPR guide RNAs for programmable RNA sensors
Biochem Soc Trans. 2023 Nov 13:BST20221486. doi: 10.1042/BST20221486. Online ahead of print.ABSTRACTAs the most valuable feature of the CRISPR system, the programmability based on Watson-Crick base pairing has been widely exploited in engineering RNA sensors. The base pairing in these systems offers a connection between the RNA of interest and the CRISPR effector, providing a highly specific mechanism for RNA detection both in vivo and in vitro. In the last decade, despite the many successful RNA sensing approaches developed during the era of CRISPR explosion, a deeper understanding of the characteristics of CRISPR systems...
Source: Biochemical Society Transactions - November 13, 2023 Category: Biochemistry Authors: Yang Liu Wei Liu Baojun Wang Source Type: research
