Evaluating three strategies of genome-wide association analysis for integrating data from multiple populations
Anim Genet. 2024 Jan 7. doi: 10.1111/age.13394. Online ahead of print.ABSTRACTIn livestock, genome-wide association studies (GWAS) are usually conducted in a single population (single-GWAS) with limited sample size and detection power. To enhance the detection power of GWAS, meta-analysis of GWAS (meta-GWAS) and mega-analysis of GWAS (mega-GWAS) have been proposed to integrate data from multiple populations at the level of summary statistics or individual data, respectively. However, there is a lack of comparison for these different strategies, which makes it difficult to guide the best practice of GWAS integrating data fr...
Source: Animal Genetics - January 8, 2024 Category: Genetics & Stem Cells Authors: Zhanming Zhong Guangzhen Li Zhiting Xu Haonan Zeng Jinyan Teng Xueyan Feng Shuqi Diao Yahui Gao Jiaqi Li Zhe Zhang Source Type: research
Integrated analysis of differently expressed microRNAs and mRNAs at different postnatal stages reveals intramuscular fat deposition regulation in goats (Capra hircus)
Anim Genet. 2024 Jan 4. doi: 10.1111/age.13384. Online ahead of print.ABSTRACTIntramuscular fat refers to the adipose tissue distributed in the muscle. It is an important indicator that affects the quality of goat meat, and can directly affect the tenderness and flavor of goat meat. Our previous study revealed the mRNA that may be crucial for intramuscular fat deposition during goat growth; however, how the microRNAs (miRNAs) are involved in the process is largely unclear. In the present study, a total of 401 known miRNAs and 120 goat novel miRNAs, including 110 differentially expressed (DE) miRNAs, were identified among l...
Source: Animal Genetics - January 4, 2024 Category: Genetics & Stem Cells Authors: Wenyang Zhang Yu Liao Peng Shao Yuling Yang Lian Huang Zhanyu Du Changhui Zhang Yong Wang Yaqiu Lin Jiangjiang Zhu Source Type: research
Integrated analysis of differently expressed microRNAs and mRNAs at different postnatal stages reveals intramuscular fat deposition regulation in goats (Capra hircus)
Anim Genet. 2024 Jan 4. doi: 10.1111/age.13384. Online ahead of print.ABSTRACTIntramuscular fat refers to the adipose tissue distributed in the muscle. It is an important indicator that affects the quality of goat meat, and can directly affect the tenderness and flavor of goat meat. Our previous study revealed the mRNA that may be crucial for intramuscular fat deposition during goat growth; however, how the microRNAs (miRNAs) are involved in the process is largely unclear. In the present study, a total of 401 known miRNAs and 120 goat novel miRNAs, including 110 differentially expressed (DE) miRNAs, were identified among l...
Source: Animal Genetics - January 4, 2024 Category: Genetics & Stem Cells Authors: Wenyang Zhang Yu Liao Peng Shao Yuling Yang Lian Huang Zhanyu Du Changhui Zhang Yong Wang Yaqiu Lin Jiangjiang Zhu Source Type: research
Integrated analysis of differently expressed microRNAs and mRNAs at different postnatal stages reveals intramuscular fat deposition regulation in goats (Capra hircus)
Anim Genet. 2024 Jan 4. doi: 10.1111/age.13384. Online ahead of print.ABSTRACTIntramuscular fat refers to the adipose tissue distributed in the muscle. It is an important indicator that affects the quality of goat meat, and can directly affect the tenderness and flavor of goat meat. Our previous study revealed the mRNA that may be crucial for intramuscular fat deposition during goat growth; however, how the microRNAs (miRNAs) are involved in the process is largely unclear. In the present study, a total of 401 known miRNAs and 120 goat novel miRNAs, including 110 differentially expressed (DE) miRNAs, were identified among l...
Source: Animal Genetics - January 4, 2024 Category: Genetics & Stem Cells Authors: Wenyang Zhang Yu Liao Peng Shao Yuling Yang Lian Huang Zhanyu Du Changhui Zhang Yong Wang Yaqiu Lin Jiangjiang Zhu Source Type: research
Genome-wide association studies for the number of piglets born alive and dead in Dongliao black pigs
Anim Genet. 2023 Dec 26. doi: 10.1111/age.13385. Online ahead of print.ABSTRACTLitter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome-wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous ...
Source: Animal Genetics - December 26, 2023 Category: Genetics & Stem Cells Authors: Hao Sun Yu Cheng Yu He Chao Cheng Hongxia Zhao Sumei Yang Meng Wei Jingxiu Yang Shuang Liang Chunyan Bai Boxing Sun Source Type: research
Genome-wide association studies for the number of piglets born alive and dead in Dongliao black pigs
Anim Genet. 2023 Dec 26. doi: 10.1111/age.13385. Online ahead of print.ABSTRACTLitter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome-wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous ...
Source: Animal Genetics - December 26, 2023 Category: Genetics & Stem Cells Authors: Hao Sun Yu Cheng Yu He Chao Cheng Hongxia Zhao Sumei Yang Meng Wei Jingxiu Yang Shuang Liang Chunyan Bai Boxing Sun Source Type: research
Genome-wide association studies for the number of piglets born alive and dead in Dongliao black pigs
Anim Genet. 2023 Dec 26. doi: 10.1111/age.13385. Online ahead of print.ABSTRACTLitter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome-wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous ...
Source: Animal Genetics - December 26, 2023 Category: Genetics & Stem Cells Authors: Hao Sun Yu Cheng Yu He Chao Cheng Hongxia Zhao Sumei Yang Meng Wei Jingxiu Yang Shuang Liang Chunyan Bai Boxing Sun Source Type: research
Genome-wide association studies for the number of piglets born alive and dead in Dongliao black pigs
Anim Genet. 2023 Dec 26. doi: 10.1111/age.13385. Online ahead of print.ABSTRACTLitter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome-wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous ...
Source: Animal Genetics - December 26, 2023 Category: Genetics & Stem Cells Authors: Hao Sun Yu Cheng Yu He Chao Cheng Hongxia Zhao Sumei Yang Meng Wei Jingxiu Yang Shuang Liang Chunyan Bai Boxing Sun Source Type: research
Genome-wide association studies for the number of piglets born alive and dead in Dongliao black pigs
Anim Genet. 2023 Dec 26. doi: 10.1111/age.13385. Online ahead of print.ABSTRACTLitter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome-wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous ...
Source: Animal Genetics - December 26, 2023 Category: Genetics & Stem Cells Authors: Hao Sun Yu Cheng Yu He Chao Cheng Hongxia Zhao Sumei Yang Meng Wei Jingxiu Yang Shuang Liang Chunyan Bai Boxing Sun Source Type: research
Genome-wide association studies for the number of piglets born alive and dead in Dongliao black pigs
Anim Genet. 2023 Dec 26. doi: 10.1111/age.13385. Online ahead of print.ABSTRACTLitter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome-wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous ...
Source: Animal Genetics - December 26, 2023 Category: Genetics & Stem Cells Authors: Hao Sun Yu Cheng Yu He Chao Cheng Hongxia Zhao Sumei Yang Meng Wei Jingxiu Yang Shuang Liang Chunyan Bai Boxing Sun Source Type: research
Genome-wide association studies for the number of piglets born alive and dead in Dongliao black pigs
Anim Genet. 2023 Dec 26. doi: 10.1111/age.13385. Online ahead of print.ABSTRACTLitter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome-wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous ...
Source: Animal Genetics - December 26, 2023 Category: Genetics & Stem Cells Authors: Hao Sun Yu Cheng Yu He Chao Cheng Hongxia Zhao Sumei Yang Meng Wei Jingxiu Yang Shuang Liang Chunyan Bai Boxing Sun Source Type: research
Genome-wide association studies for the number of piglets born alive and dead in Dongliao black pigs
Anim Genet. 2023 Dec 26. doi: 10.1111/age.13385. Online ahead of print.ABSTRACTLitter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome-wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous ...
Source: Animal Genetics - December 26, 2023 Category: Genetics & Stem Cells Authors: Hao Sun Yu Cheng Yu He Chao Cheng Hongxia Zhao Sumei Yang Meng Wei Jingxiu Yang Shuang Liang Chunyan Bai Boxing Sun Source Type: research
Single and longitudinal genome-wide association studies for dairy traits available in goats with three recorded lactations
Anim Genet. 2023 Dec 22. doi: 10.1111/age.13391. Online ahead of print.ABSTRACTMilk yield and composition phenotypes are systematically recorded across several lactations in goats, but the majority of genome-wide association studies (GWAS) performed so far have rather ignored the longitudinal nature of such data. Here, we have used two different GWAS approaches to analyse data from three lactations recorded in Murciano-Granadina goats. In Analysis 1, independent GWAS have been carried out for each trait and lactation, while a single longitudinal GWAS, jointly considering all data, has been performed in Analysis 2. In both ...
Source: Animal Genetics - December 22, 2023 Category: Genetics & Stem Cells Authors: Maria Gracia Luigi-Sierra Amparo Mart ínez Martina Macri Juan Vicente Delgado Anna Castell ó Javier Fern ández Alvarez Xavier Such Jordi Jordana Marcel Amills Source Type: research
Single and longitudinal genome-wide association studies for dairy traits available in goats with three recorded lactations
Anim Genet. 2023 Dec 22. doi: 10.1111/age.13391. Online ahead of print.ABSTRACTMilk yield and composition phenotypes are systematically recorded across several lactations in goats, but the majority of genome-wide association studies (GWAS) performed so far have rather ignored the longitudinal nature of such data. Here, we have used two different GWAS approaches to analyse data from three lactations recorded in Murciano-Granadina goats. In Analysis 1, independent GWAS have been carried out for each trait and lactation, while a single longitudinal GWAS, jointly considering all data, has been performed in Analysis 2. In both ...
Source: Animal Genetics - December 22, 2023 Category: Genetics & Stem Cells Authors: Maria Gracia Luigi-Sierra Amparo Mart ínez Martina Macri Juan Vicente Delgado Anna Castell ó Javier Fern ández Alvarez Xavier Such Jordi Jordana Marcel Amills Source Type: research
Single and longitudinal genome-wide association studies for dairy traits available in goats with three recorded lactations
Anim Genet. 2023 Dec 22. doi: 10.1111/age.13391. Online ahead of print.ABSTRACTMilk yield and composition phenotypes are systematically recorded across several lactations in goats, but the majority of genome-wide association studies (GWAS) performed so far have rather ignored the longitudinal nature of such data. Here, we have used two different GWAS approaches to analyse data from three lactations recorded in Murciano-Granadina goats. In Analysis 1, independent GWAS have been carried out for each trait and lactation, while a single longitudinal GWAS, jointly considering all data, has been performed in Analysis 2. In both ...
Source: Animal Genetics - December 22, 2023 Category: Genetics & Stem Cells Authors: Maria Gracia Luigi-Sierra Amparo Mart ínez Martina Macri Juan Vicente Delgado Anna Castell ó Javier Fern ández Alvarez Xavier Such Jordi Jordana Marcel Amills Source Type: research
