Degree of leukochimerism with calf age in Angus-crossbred twin sets
This study examined the degree to which this leukochimerism changes with age. DNA was extracted from hair bulbs containing mesenchymal dermal papilla to determine the individual's true genotype and blood samples were obtained at six time points from 1 week to 8 months of age to assess leukochimerism. Samples were genotyped using a medium density SNP chip, and quantitative estimates of allele frequency were determined using SNPs for which members of a twin set had alternative homozygous genotypes. The results indicate statistically significant changes in the proportion of self and co-twin with age and suggest that by 2-4 mo...
Source: Animal Genetics - August 9, 2023 Category: Genetics & Stem Cells Authors: Heather L Hunt Brian W Kirkpatrick Source Type: research
Degree of leukochimerism with calf age in Angus-crossbred twin sets
This study examined the degree to which this leukochimerism changes with age. DNA was extracted from hair bulbs containing mesenchymal dermal papilla to determine the individual's true genotype and blood samples were obtained at six time points from 1 week to 8 months of age to assess leukochimerism. Samples were genotyped using a medium density SNP chip, and quantitative estimates of allele frequency were determined using SNPs for which members of a twin set had alternative homozygous genotypes. The results indicate statistically significant changes in the proportion of self and co-twin with age and suggest that by 2-4 mo...
Source: Animal Genetics - August 9, 2023 Category: Genetics & Stem Cells Authors: Heather L Hunt Brian W Kirkpatrick Source Type: research
Degree of leukochimerism with calf age in Angus-crossbred twin sets
This study examined the degree to which this leukochimerism changes with age. DNA was extracted from hair bulbs containing mesenchymal dermal papilla to determine the individual's true genotype and blood samples were obtained at six time points from 1 week to 8 months of age to assess leukochimerism. Samples were genotyped using a medium density SNP chip, and quantitative estimates of allele frequency were determined using SNPs for which members of a twin set had alternative homozygous genotypes. The results indicate statistically significant changes in the proportion of self and co-twin with age and suggest that by 2-4 mo...
Source: Animal Genetics - August 9, 2023 Category: Genetics & Stem Cells Authors: Heather L Hunt Brian W Kirkpatrick Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346 (Source: Animal Genetics)
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346 (Source: Animal Genetics)
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346 (Source: Animal Genetics)
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346 (Source: Animal Genetics)
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346 (Source: Animal Genetics)
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346 (Source: Animal Genetics)
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346 (Source: Animal Genetics)
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346 (Source: Animal Genetics)
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346 (Source: Animal Genetics)
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346 (Source: Animal Genetics)
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
A frameshift deletion in F8 associated with hemophilia A in Labrador Retriever dogs
In this study, we performed careful clinical phenotyping to confirm hemophilia A in two distinct Labrador Retriever (LR) pedigrees. Whole-genome sequencing on an affected dog from litter 1 identified a case-specific frameshift deletion variant in F8 predicted to cause a premature stop codon (c.2923_2924del, p.(E975Kfs*8)). This variant was hemizygous in all the affected males from litter 1 (n = 3), while all the unaffected LRs in the pedigree were heterozygous or wild-type (n = 22). Additionally, screened samples from 199 LRs were all found to be wild-type. As a result of this study, a gene test can now be developed to scr...
Source: Animal Genetics - July 13, 2023 Category: Genetics & Stem Cells Authors: Marjo K Hyt önen Sanna Viitanen Sruthi Hundi Jonas Donner Hannes Lohi Maria Kaukonen Source Type: research
A frameshift deletion in F8 associated with hemophilia A in Labrador Retriever dogs
In this study, we performed careful clinical phenotyping to confirm hemophilia A in two distinct Labrador Retriever (LR) pedigrees. Whole-genome sequencing on an affected dog from litter 1 identified a case-specific frameshift deletion variant in F8 predicted to cause a premature stop codon (c.2923_2924del, p.(E975Kfs*8)). This variant was hemizygous in all the affected males from litter 1 (n = 3), while all the unaffected LRs in the pedigree were heterozygous or wild-type (n = 22). Additionally, screened samples from 199 LRs were all found to be wild-type. As a result of this study, a gene test can now be developed to scr...
Source: Animal Genetics - July 13, 2023 Category: Genetics & Stem Cells Authors: Marjo K Hyt önen Sanna Viitanen Sruthi Hundi Jonas Donner Hannes Lohi Maria Kaukonen Source Type: research
