DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
DYRK1B haploinsufficiency in a Holstein cattle with epilepsy
In this study, epilepsy with focal seizures progressing to generalized seizures was diagnosed in a 6-month-old Holstein heifer. The seizures were characterized by a brief pre-ictal phase with depression and vocalization. During the ictal phase eyelid spasms, tongue contractions, nodding and abundant salivation were observed, rapidly followed by a convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Finally, during the postictal phase the heifer was obtunded and disorientated, unable to perceive obstacles and hypermetric, and pressed its head against objects. In the inter-seizure...
Source: Animal Genetics - August 15, 2023 Category: Genetics & Stem Cells Authors: Joana G P Jacinto Marilena Bolcato Irene M H äfliger Anna Oevermann Arcangelo Gentile Cord Dr ögemüller Source Type: research
Development and validation of SNP markers for giant panda using a kompetitive allele specific PCR approach
Anim Genet. 2023 Aug 14. doi: 10.1111/age.13350. Online ahead of print.NO ABSTRACTPMID:37580020 | DOI:10.1111/age.13350 (Source: Animal Genetics)
Source: Animal Genetics - August 14, 2023 Category: Genetics & Stem Cells Authors: Shujuan Ma Ying Zhu Honglin Wu Source Type: research
Degree of leukochimerism with calf age in Angus-crossbred twin sets
This study examined the degree to which this leukochimerism changes with age. DNA was extracted from hair bulbs containing mesenchymal dermal papilla to determine the individual's true genotype and blood samples were obtained at six time points from 1 week to 8 months of age to assess leukochimerism. Samples were genotyped using a medium density SNP chip, and quantitative estimates of allele frequency were determined using SNPs for which members of a twin set had alternative homozygous genotypes. The results indicate statistically significant changes in the proportion of self and co-twin with age and suggest that by 2-4 mo...
Source: Animal Genetics - August 9, 2023 Category: Genetics & Stem Cells Authors: Heather L Hunt Brian W Kirkpatrick Source Type: research
Degree of leukochimerism with calf age in Angus-crossbred twin sets
This study examined the degree to which this leukochimerism changes with age. DNA was extracted from hair bulbs containing mesenchymal dermal papilla to determine the individual's true genotype and blood samples were obtained at six time points from 1 week to 8 months of age to assess leukochimerism. Samples were genotyped using a medium density SNP chip, and quantitative estimates of allele frequency were determined using SNPs for which members of a twin set had alternative homozygous genotypes. The results indicate statistically significant changes in the proportion of self and co-twin with age and suggest that by 2-4 mo...
Source: Animal Genetics - August 9, 2023 Category: Genetics & Stem Cells Authors: Heather L Hunt Brian W Kirkpatrick Source Type: research
