Genome-wide analyses based on a novel donkey 40K liquid chip reveal the gene responsible for coat color diversity in Chinese Dezhou donkey
In this study, genome-wide association analysis was performed for the differences in coat color traits between the Sanfen (n = 97) and Wutou (n = 108) strains using a novel donkey 40K liquid chip developed based on GenoBaits technology, to identify genomic regions and causal genes that could explain this variation. We also used FST and The cross-population composite likelihood ratio test (XPCLR) analyses to explore selected regions related to coat color differences. We identified one significant region on chromosome 15, with the most significant SNP located within the agouti signaling protein (ASIP) gene. At the same time,...
Source: Animal Genetics - November 23, 2023 Category: Genetics & Stem Cells Authors: Shuqin Liu Jiangtian Su Qiwen Yang Minhao Sun Zhaofei Wang Jie Yu Halima Jafari Chuzhao Lei Yujiang Sun Ruihua Dang Source Type: research
Relevance of pharmacogenetics and pharmacogenomics in veterinary clinical practice: A review
The objective of this review is to present an overview of historical landmarks, current developments in various animal species, challenges and future perspectives of genomics in drug development and dosage optimization for individualized medicine in veterinary subjects.PMID:37990577 | DOI:10.1111/age.13376 (Source: Animal Genetics)
Source: Animal Genetics - November 22, 2023 Category: Genetics & Stem Cells Authors: Ayushi Vaidhya Kanika Ghildiyal Divya Rajawat Sonali Sonejita Nayak Subhashree Parida Manjit Panigrahi Source Type: research
Relevance of pharmacogenetics and pharmacogenomics in veterinary clinical practice: A review
The objective of this review is to present an overview of historical landmarks, current developments in various animal species, challenges and future perspectives of genomics in drug development and dosage optimization for individualized medicine in veterinary subjects.PMID:37990577 | DOI:10.1111/age.13376 (Source: Animal Genetics)
Source: Animal Genetics - November 22, 2023 Category: Genetics & Stem Cells Authors: Ayushi Vaidhya Kanika Ghildiyal Divya Rajawat Sonali Sonejita Nayak Subhashree Parida Manjit Panigrahi Source Type: research
Identification of genomic regions associated with differences in fleece type in Huacaya and Suri alpacas (Vicugna pacos)
In this study, 91 alpacas (54 Huacayas and 37 Suris) from Germany and Switzerland were genotyped using the 76k alpaca SNP array. Only 59k chromosome-localised markers map to the alpaca reference assembly VicPac3.1, and after quality control 49 866 SNPs, were retained for population structure assessment and to conduct a genome-wide association study. Both principal component and neighbour-joining tree analysis showed that the two fleece-type cohorts overlapped rather than forming two distinct clusters. Genome-wide significantly associated markers were observed in the scaffold region of chromosome 16 (NW_021964192.1), which ...
Source: Animal Genetics - November 20, 2023 Category: Genetics & Stem Cells Authors: K Tan O O Adeniyi A Letko G RuddGarces E Manz H Wagner P Zanolari C Dr ögemüller G L ühken Source Type: research
Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle
This study compares the transcriptomic response of peripheral blood mononuclear cells to an in vitro Brucella abortus strain RB51 (RB51) bacterial challenge between contemporary Holsteins and Holsteins that have not been selected for milk production traits since the mid-1960s. Total RNA was extracted from peripheral blood mononuclear cells from four contemporary and four unselected lactating, primiparous cows following 24-h incubation with or without stimulation with RB51 bacteria. RNA was sequenced and reads analyzed using tools from galaxy.scinet.usda.gov. A total of 412 differentially expressed genes (false discovery ra...
Source: Animal Genetics - November 10, 2023 Category: Genetics & Stem Cells Authors: Kaitlyn M Sarlo Davila Paola Boggiatto Steven Olsen John D Lippolis Brian A Crooker Ellie J Putz Source Type: research
Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle
This study compares the transcriptomic response of peripheral blood mononuclear cells to an in vitro Brucella abortus strain RB51 (RB51) bacterial challenge between contemporary Holsteins and Holsteins that have not been selected for milk production traits since the mid-1960s. Total RNA was extracted from peripheral blood mononuclear cells from four contemporary and four unselected lactating, primiparous cows following 24-h incubation with or without stimulation with RB51 bacteria. RNA was sequenced and reads analyzed using tools from galaxy.scinet.usda.gov. A total of 412 differentially expressed genes (false discovery ra...
Source: Animal Genetics - November 10, 2023 Category: Genetics & Stem Cells Authors: Kaitlyn M Sarlo Davila Paola Boggiatto Steven Olsen John D Lippolis Brian A Crooker Ellie J Putz Source Type: research
Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle
This study compares the transcriptomic response of peripheral blood mononuclear cells to an in vitro Brucella abortus strain RB51 (RB51) bacterial challenge between contemporary Holsteins and Holsteins that have not been selected for milk production traits since the mid-1960s. Total RNA was extracted from peripheral blood mononuclear cells from four contemporary and four unselected lactating, primiparous cows following 24-h incubation with or without stimulation with RB51 bacteria. RNA was sequenced and reads analyzed using tools from galaxy.scinet.usda.gov. A total of 412 differentially expressed genes (false discovery ra...
Source: Animal Genetics - November 10, 2023 Category: Genetics & Stem Cells Authors: Kaitlyn M Sarlo Davila Paola Boggiatto Steven Olsen John D Lippolis Brian A Crooker Ellie J Putz Source Type: research
Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle
This study compares the transcriptomic response of peripheral blood mononuclear cells to an in vitro Brucella abortus strain RB51 (RB51) bacterial challenge between contemporary Holsteins and Holsteins that have not been selected for milk production traits since the mid-1960s. Total RNA was extracted from peripheral blood mononuclear cells from four contemporary and four unselected lactating, primiparous cows following 24-h incubation with or without stimulation with RB51 bacteria. RNA was sequenced and reads analyzed using tools from galaxy.scinet.usda.gov. A total of 412 differentially expressed genes (false discovery ra...
Source: Animal Genetics - November 10, 2023 Category: Genetics & Stem Cells Authors: Kaitlyn M Sarlo Davila Paola Boggiatto Steven Olsen John D Lippolis Brian A Crooker Ellie J Putz Source Type: research
Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle
This study compares the transcriptomic response of peripheral blood mononuclear cells to an in vitro Brucella abortus strain RB51 (RB51) bacterial challenge between contemporary Holsteins and Holsteins that have not been selected for milk production traits since the mid-1960s. Total RNA was extracted from peripheral blood mononuclear cells from four contemporary and four unselected lactating, primiparous cows following 24-h incubation with or without stimulation with RB51 bacteria. RNA was sequenced and reads analyzed using tools from galaxy.scinet.usda.gov. A total of 412 differentially expressed genes (false discovery ra...
Source: Animal Genetics - November 10, 2023 Category: Genetics & Stem Cells Authors: Kaitlyn M Sarlo Davila Paola Boggiatto Steven Olsen John D Lippolis Brian A Crooker Ellie J Putz Source Type: research
Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle
This study compares the transcriptomic response of peripheral blood mononuclear cells to an in vitro Brucella abortus strain RB51 (RB51) bacterial challenge between contemporary Holsteins and Holsteins that have not been selected for milk production traits since the mid-1960s. Total RNA was extracted from peripheral blood mononuclear cells from four contemporary and four unselected lactating, primiparous cows following 24-h incubation with or without stimulation with RB51 bacteria. RNA was sequenced and reads analyzed using tools from galaxy.scinet.usda.gov. A total of 412 differentially expressed genes (false discovery ra...
Source: Animal Genetics - November 10, 2023 Category: Genetics & Stem Cells Authors: Kaitlyn M Sarlo Davila Paola Boggiatto Steven Olsen John D Lippolis Brian A Crooker Ellie J Putz Source Type: research
Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle
This study compares the transcriptomic response of peripheral blood mononuclear cells to an in vitro Brucella abortus strain RB51 (RB51) bacterial challenge between contemporary Holsteins and Holsteins that have not been selected for milk production traits since the mid-1960s. Total RNA was extracted from peripheral blood mononuclear cells from four contemporary and four unselected lactating, primiparous cows following 24-h incubation with or without stimulation with RB51 bacteria. RNA was sequenced and reads analyzed using tools from galaxy.scinet.usda.gov. A total of 412 differentially expressed genes (false discovery ra...
Source: Animal Genetics - November 10, 2023 Category: Genetics & Stem Cells Authors: Kaitlyn M Sarlo Davila Paola Boggiatto Steven Olsen John D Lippolis Brian A Crooker Ellie J Putz Source Type: research
Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle
This study compares the transcriptomic response of peripheral blood mononuclear cells to an in vitro Brucella abortus strain RB51 (RB51) bacterial challenge between contemporary Holsteins and Holsteins that have not been selected for milk production traits since the mid-1960s. Total RNA was extracted from peripheral blood mononuclear cells from four contemporary and four unselected lactating, primiparous cows following 24-h incubation with or without stimulation with RB51 bacteria. RNA was sequenced and reads analyzed using tools from galaxy.scinet.usda.gov. A total of 412 differentially expressed genes (false discovery ra...
Source: Animal Genetics - November 10, 2023 Category: Genetics & Stem Cells Authors: Kaitlyn M Sarlo Davila Paola Boggiatto Steven Olsen John D Lippolis Brian A Crooker Ellie J Putz Source Type: research
Effect of selection genotype on immune response to Brucella abortus RB51 in Holstein cattle
This study compares the transcriptomic response of peripheral blood mononuclear cells to an in vitro Brucella abortus strain RB51 (RB51) bacterial challenge between contemporary Holsteins and Holsteins that have not been selected for milk production traits since the mid-1960s. Total RNA was extracted from peripheral blood mononuclear cells from four contemporary and four unselected lactating, primiparous cows following 24-h incubation with or without stimulation with RB51 bacteria. RNA was sequenced and reads analyzed using tools from galaxy.scinet.usda.gov. A total of 412 differentially expressed genes (false discovery ra...
Source: Animal Genetics - November 10, 2023 Category: Genetics & Stem Cells Authors: Kaitlyn M Sarlo Davila Paola Boggiatto Steven Olsen John D Lippolis Brian A Crooker Ellie J Putz Source Type: research
No trade-off between growth and OsHV-1 tolerance in Pacific oysters (Crassostrea gigas) farmed on the West Coast, USA
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13375. Online ahead of print.ABSTRACTAn important pathogen of concern for Pacific oyster growers in the USA is ostreid herpesvirus 1 (OsHV-1). Currently, oyster stocks exist that are tolerant to OsHV-1; however, it is uncertain if a trade-off exists between their tolerance to OsHV-1 and their growth in different environments. To investigate any potential trade-offs, Pacific oyster families with varying levels of OsHV-1 tolerance were grown in a bay where OsHV-1 is endemic (Tomales Bay, CA) and in a bay where OsHV-1 is absent (Willapa Bay, WA). In Tomales Bay, we found that oysters f...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Konstantin Divilov Blaine Schoolfield Noah Merz Chris Langdon Source Type: research
MFSD2A frameshift variant in Kerry Hill sheep with microcephaly
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13374. Online ahead of print.ABSTRACTMicrocephaly is a rare neurodevelopmental disorder characterized by reduced skull circumference and brain volume that occurs sporadically in farm animals. We investigated an early-onset neurodegenerative disorder observed in seven lambs of purebred Kerry Hill sheep. Clinical signs included inability to stand or severe ataxia, convulsions, and early death. Diagnostic imaging and brain necropsy confirmed microcephaly. The pedigree of the lambs suggested monogenic autosomal recessive inheritance. We sequenced the genome of one affected lamb, and com...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Gabriela Rudd Garces Anna Letko Irene M H äfliger Jana M üller Christiane Herden Anne Nesseler Henrik Wagner Martin J Schmidt Cord Dr ögemüller Gesine L ühken Source Type: research
