No trade-off between growth and OsHV-1 tolerance in Pacific oysters (Crassostrea gigas) farmed on the West Coast, USA
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13375. Online ahead of print.ABSTRACTAn important pathogen of concern for Pacific oyster growers in the USA is ostreid herpesvirus 1 (OsHV-1). Currently, oyster stocks exist that are tolerant to OsHV-1; however, it is uncertain if a trade-off exists between their tolerance to OsHV-1 and their growth in different environments. To investigate any potential trade-offs, Pacific oyster families with varying levels of OsHV-1 tolerance were grown in a bay where OsHV-1 is endemic (Tomales Bay, CA) and in a bay where OsHV-1 is absent (Willapa Bay, WA). In Tomales Bay, we found that oysters f...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Konstantin Divilov Blaine Schoolfield Noah Merz Chris Langdon Source Type: research
MFSD2A frameshift variant in Kerry Hill sheep with microcephaly
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13374. Online ahead of print.ABSTRACTMicrocephaly is a rare neurodevelopmental disorder characterized by reduced skull circumference and brain volume that occurs sporadically in farm animals. We investigated an early-onset neurodegenerative disorder observed in seven lambs of purebred Kerry Hill sheep. Clinical signs included inability to stand or severe ataxia, convulsions, and early death. Diagnostic imaging and brain necropsy confirmed microcephaly. The pedigree of the lambs suggested monogenic autosomal recessive inheritance. We sequenced the genome of one affected lamb, and com...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Gabriela Rudd Garces Anna Letko Irene M H äfliger Jana M üller Christiane Herden Anne Nesseler Henrik Wagner Martin J Schmidt Cord Dr ögemüller Gesine L ühken Source Type: research
No trade-off between growth and OsHV-1 tolerance in Pacific oysters (Crassostrea gigas) farmed on the West Coast, USA
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13375. Online ahead of print.ABSTRACTAn important pathogen of concern for Pacific oyster growers in the USA is ostreid herpesvirus 1 (OsHV-1). Currently, oyster stocks exist that are tolerant to OsHV-1; however, it is uncertain if a trade-off exists between their tolerance to OsHV-1 and their growth in different environments. To investigate any potential trade-offs, Pacific oyster families with varying levels of OsHV-1 tolerance were grown in a bay where OsHV-1 is endemic (Tomales Bay, CA) and in a bay where OsHV-1 is absent (Willapa Bay, WA). In Tomales Bay, we found that oysters f...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Konstantin Divilov Blaine Schoolfield Noah Merz Chris Langdon Source Type: research
MFSD2A frameshift variant in Kerry Hill sheep with microcephaly
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13374. Online ahead of print.ABSTRACTMicrocephaly is a rare neurodevelopmental disorder characterized by reduced skull circumference and brain volume that occurs sporadically in farm animals. We investigated an early-onset neurodegenerative disorder observed in seven lambs of purebred Kerry Hill sheep. Clinical signs included inability to stand or severe ataxia, convulsions, and early death. Diagnostic imaging and brain necropsy confirmed microcephaly. The pedigree of the lambs suggested monogenic autosomal recessive inheritance. We sequenced the genome of one affected lamb, and com...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Gabriela Rudd Garces Anna Letko Irene M H äfliger Jana M üller Christiane Herden Anne Nesseler Henrik Wagner Martin J Schmidt Cord Dr ögemüller Gesine L ühken Source Type: research
No trade-off between growth and OsHV-1 tolerance in Pacific oysters (Crassostrea gigas) farmed on the West Coast, USA
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13375. Online ahead of print.ABSTRACTAn important pathogen of concern for Pacific oyster growers in the USA is ostreid herpesvirus 1 (OsHV-1). Currently, oyster stocks exist that are tolerant to OsHV-1; however, it is uncertain if a trade-off exists between their tolerance to OsHV-1 and their growth in different environments. To investigate any potential trade-offs, Pacific oyster families with varying levels of OsHV-1 tolerance were grown in a bay where OsHV-1 is endemic (Tomales Bay, CA) and in a bay where OsHV-1 is absent (Willapa Bay, WA). In Tomales Bay, we found that oysters f...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Konstantin Divilov Blaine Schoolfield Noah Merz Chris Langdon Source Type: research
MFSD2A frameshift variant in Kerry Hill sheep with microcephaly
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13374. Online ahead of print.ABSTRACTMicrocephaly is a rare neurodevelopmental disorder characterized by reduced skull circumference and brain volume that occurs sporadically in farm animals. We investigated an early-onset neurodegenerative disorder observed in seven lambs of purebred Kerry Hill sheep. Clinical signs included inability to stand or severe ataxia, convulsions, and early death. Diagnostic imaging and brain necropsy confirmed microcephaly. The pedigree of the lambs suggested monogenic autosomal recessive inheritance. We sequenced the genome of one affected lamb, and com...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Gabriela Rudd Garces Anna Letko Irene M H äfliger Jana M üller Christiane Herden Anne Nesseler Henrik Wagner Martin J Schmidt Cord Dr ögemüller Gesine L ühken Source Type: research
No trade-off between growth and OsHV-1 tolerance in Pacific oysters (Crassostrea gigas) farmed on the West Coast, USA
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13375. Online ahead of print.ABSTRACTAn important pathogen of concern for Pacific oyster growers in the USA is ostreid herpesvirus 1 (OsHV-1). Currently, oyster stocks exist that are tolerant to OsHV-1; however, it is uncertain if a trade-off exists between their tolerance to OsHV-1 and their growth in different environments. To investigate any potential trade-offs, Pacific oyster families with varying levels of OsHV-1 tolerance were grown in a bay where OsHV-1 is endemic (Tomales Bay, CA) and in a bay where OsHV-1 is absent (Willapa Bay, WA). In Tomales Bay, we found that oysters f...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Konstantin Divilov Blaine Schoolfield Noah Merz Chris Langdon Source Type: research
MFSD2A frameshift variant in Kerry Hill sheep with microcephaly
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13374. Online ahead of print.ABSTRACTMicrocephaly is a rare neurodevelopmental disorder characterized by reduced skull circumference and brain volume that occurs sporadically in farm animals. We investigated an early-onset neurodegenerative disorder observed in seven lambs of purebred Kerry Hill sheep. Clinical signs included inability to stand or severe ataxia, convulsions, and early death. Diagnostic imaging and brain necropsy confirmed microcephaly. The pedigree of the lambs suggested monogenic autosomal recessive inheritance. We sequenced the genome of one affected lamb, and com...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Gabriela Rudd Garces Anna Letko Irene M H äfliger Jana M üller Christiane Herden Anne Nesseler Henrik Wagner Martin J Schmidt Cord Dr ögemüller Gesine L ühken Source Type: research
No trade-off between growth and OsHV-1 tolerance in Pacific oysters (Crassostrea gigas) farmed on the West Coast, USA
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13375. Online ahead of print.ABSTRACTAn important pathogen of concern for Pacific oyster growers in the USA is ostreid herpesvirus 1 (OsHV-1). Currently, oyster stocks exist that are tolerant to OsHV-1; however, it is uncertain if a trade-off exists between their tolerance to OsHV-1 and their growth in different environments. To investigate any potential trade-offs, Pacific oyster families with varying levels of OsHV-1 tolerance were grown in a bay where OsHV-1 is endemic (Tomales Bay, CA) and in a bay where OsHV-1 is absent (Willapa Bay, WA). In Tomales Bay, we found that oysters f...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Konstantin Divilov Blaine Schoolfield Noah Merz Chris Langdon Source Type: research
MFSD2A frameshift variant in Kerry Hill sheep with microcephaly
Anim Genet. 2023 Nov 3. doi: 10.1111/age.13374. Online ahead of print.ABSTRACTMicrocephaly is a rare neurodevelopmental disorder characterized by reduced skull circumference and brain volume that occurs sporadically in farm animals. We investigated an early-onset neurodegenerative disorder observed in seven lambs of purebred Kerry Hill sheep. Clinical signs included inability to stand or severe ataxia, convulsions, and early death. Diagnostic imaging and brain necropsy confirmed microcephaly. The pedigree of the lambs suggested monogenic autosomal recessive inheritance. We sequenced the genome of one affected lamb, and com...
Source: Animal Genetics - November 3, 2023 Category: Genetics & Stem Cells Authors: Gabriela Rudd Garces Anna Letko Irene M H äfliger Jana M üller Christiane Herden Anne Nesseler Henrik Wagner Martin J Schmidt Cord Dr ögemüller Gesine L ühken Source Type: research
RNA sequencing analysis reveals that missense mutation in SOX10 is associated with iris color phenotype in quail
Anim Genet. 2023 Oct 31. doi: 10.1111/age.13371. Online ahead of print.ABSTRACTTo investigate the molecular mechanisms underlying the differences in iris color in quail, the transcriptome of iris tissue from black quail and Korean quail at day 10 of hatching was RNA sequenced in this study. The differentially expressed genes (DEGs) were screened, functionally annotated and enriched after the quality control and mapping of the raw data. RT-qPCR validation was performed using EIF2S3 as an internal reference gene. The screened SNPs were studied by bioinformatics analysis and iris color correlation analysis. The results showed...
Source: Animal Genetics - October 31, 2023 Category: Genetics & Stem Cells Authors: Shiwei Ren Xiaohui Zhang Youzhi Pang Yanxia Qi Linke Huo Fanghu Wu Yuanyuan Shang Jinquan Xi Source Type: research
RNA sequencing analysis reveals that missense mutation in SOX10 is associated with iris color phenotype in quail
Anim Genet. 2023 Oct 31. doi: 10.1111/age.13371. Online ahead of print.ABSTRACTTo investigate the molecular mechanisms underlying the differences in iris color in quail, the transcriptome of iris tissue from black quail and Korean quail at day 10 of hatching was RNA sequenced in this study. The differentially expressed genes (DEGs) were screened, functionally annotated and enriched after the quality control and mapping of the raw data. RT-qPCR validation was performed using EIF2S3 as an internal reference gene. The screened SNPs were studied by bioinformatics analysis and iris color correlation analysis. The results showed...
Source: Animal Genetics - October 31, 2023 Category: Genetics & Stem Cells Authors: Shiwei Ren Xiaohui Zhang Youzhi Pang Yanxia Qi Linke Huo Fanghu Wu Yuanyuan Shang Jinquan Xi Source Type: research
RNA sequencing analysis reveals that missense mutation in SOX10 is associated with iris color phenotype in quail
Anim Genet. 2023 Oct 31. doi: 10.1111/age.13371. Online ahead of print.ABSTRACTTo investigate the molecular mechanisms underlying the differences in iris color in quail, the transcriptome of iris tissue from black quail and Korean quail at day 10 of hatching was RNA sequenced in this study. The differentially expressed genes (DEGs) were screened, functionally annotated and enriched after the quality control and mapping of the raw data. RT-qPCR validation was performed using EIF2S3 as an internal reference gene. The screened SNPs were studied by bioinformatics analysis and iris color correlation analysis. The results showed...
Source: Animal Genetics - October 31, 2023 Category: Genetics & Stem Cells Authors: Shiwei Ren Xiaohui Zhang Youzhi Pang Yanxia Qi Linke Huo Fanghu Wu Yuanyuan Shang Jinquan Xi Source Type: research
Functional SNPs in SYISL promoter significantly affect muscle fiber density and muscle traits in pigs
In this study, three SNPs in exons and six SNPs within the promoter of pSYISL were identified. Association analysis showed that the two SNPs in exons are significantly associated with loin muscle area (p < 0.05); the six SNPs in the promoter that show complete linkage are significantly associated with live backfat thickness and live loin muscle area in American Large White pigs. Bioinformatics and luciferase reporter assays as well as in vitro binding experiments indicated that the mutation of SNP rs702045770 (g.539G>A) leads to the loss of YY1 binding to the promoter, thus affecting the expression level of pSYISL, a...
Source: Animal Genetics - October 26, 2023 Category: Genetics & Stem Cells Authors: Wei Lv Yaxin Peng Jingjing Hu Mingfei Zhu Yangcang Mao Litong Wang Guoshui Wang Zaiyan Xu Wangjun Wu Bo Zuo Source Type: research
Functional SNPs in SYISL promoter significantly affect muscle fiber density and muscle traits in pigs
In this study, three SNPs in exons and six SNPs within the promoter of pSYISL were identified. Association analysis showed that the two SNPs in exons are significantly associated with loin muscle area (p < 0.05); the six SNPs in the promoter that show complete linkage are significantly associated with live backfat thickness and live loin muscle area in American Large White pigs. Bioinformatics and luciferase reporter assays as well as in vitro binding experiments indicated that the mutation of SNP rs702045770 (g.539G>A) leads to the loss of YY1 binding to the promoter, thus affecting the expression level of pSYISL, a...
Source: Animal Genetics - October 26, 2023 Category: Genetics & Stem Cells Authors: Wei Lv Yaxin Peng Jingjing Hu Mingfei Zhu Yangcang Mao Litong Wang Guoshui Wang Zaiyan Xu Wangjun Wu Bo Zuo Source Type: research
