Central Neuropathic Mechanisms in Pain Signaling Pathways: Current Evidence and Recommendations
AbstractPurposeThis is a comprehensive review of the current literature on central neuropathic pain mechanisms that is secondary to spinal cord injury. It reviews recent and seminal findings on the pathophysiology, diagnosis, and treatment and compares treatment options and recommendations.Recent FindingsNeuropathic pain (NP) is a common complication of spinal cord injury (SCI). Chronicity of NP is attributed to increased abundance of inflammatory mediators and ion channel dysfunction leading to afferent nerve sensitization; nerve damage and nerve –glia cross talk have also been implicated. Conventional treatment is ...
Source: Advances in Therapy - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Influence of Microbiota on NSAID Enteropathy: A Systematic Review of Current Knowledge and the Role of Probiotics
AbstractMicrobiota are increasingly studied, providing more precise information on their important role in physiologic processes. They also influence some pathologic processes, such as NSAID-induced enteropathy. This side effect is much more diffuse than it  has been described in the past. It derives mainly from the local action of the medicines and is caused by the local binding of gram-negative bacterial lipopolysaccharides and infiltration of neutrophils into the intestinal mucosa. The initial interest in the interaction between these damages and m icrobiota is very old, but new and interesting data are available. ...
Source: Advances in Therapy - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Comparable Effect of Two-Step Versus Extended Infusions on the Pharmacokinetics of Imipenem in Patients with Sepsis and Septic Shock
ConclusionThe two-step and extended regimens of imipenem are comparable to the PK/PD target in the treatment of sepsis and septic shock. A higher dose (1.0  gq8h) should be considered for target achievement at an MIC of  >  8 μg/ml.Trial RegistrationClinicalTrials.gov identifier, NCT02616354. (Source: Advances in Therapy)
Source: Advances in Therapy - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Comparison of Two Different Treat-and-Extend Protocols with Aflibercept in Wet Age-Related Macular Degeneration: Two-Year Results
ConclusionsAt 2  years, the anatomical and functional responses between the two treatment groups were similar. However, the number of given aflibercept injections was smaller in the rapid extensions protocol.Trial RegistrationEU Clinical Trials Register Number, 2015-001394-41/FI (Source: Advances in Therapy)
Source: Advances in Therapy - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

A Map of Racial and Ethnic Disparities in Influenza Vaccine Uptake in the Medicare Fee-for-Service Program
ConclusionUrgent and targeted efforts are needed to equitably increase IIV rates, thus protecting the most vulnerable populations from the negative health impact of influenza as well as the tax-paying public from the Medicare costs from failing to do so. (Source: Advances in Therapy)
Source: Advances in Therapy - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Survival of Patients with First and Metachronous Second Primary Breast Cancer or Lung Cancer Malignancy: Comparisons Using the SEER Database
AbstractIntroductionBreast cancer (BC) and lung cancer (LuC) are common malignancies. The survival of patients with metachronous second primary malignancy (MSPM) of BC and LuC after a first primary of BC and LuC remains unclear.MethodsData of patients with BC and LuC, with or without MSPM of BC and LuC, who were diagnosed from 2000 to 2014, were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The baseline characteristics of the different groups were compared using chi-square tests. The survival curves were compared using the log-rank test. Survival analysis was also performed in other malign...
Source: Advances in Therapy - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Emergence Delirium in Perioperative Pediatric Care: A Review of Current Evidence and New Directions
The objective of this manuscript is to provide a comprehensive review of anesthetic considerations for pediatric ED and to provide an update on techniques that have been found to be effective in reducing the overall risk of developing post operative ED in pediatric patients. (Source: Advances in Therapy)
Source: Advances in Therapy - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Distinct Serum and Vitreous Inflammation-Related Factor Profiles in Patients with Proliferative Vitreoretinopathy
ConclusionOur study found that none of the circulating inflammation-related factors were changed in PVR or RRD patients, indicating the absence of a system inflammatory biomarkers to predict the development of proliferative vitreoretinopathy. As a supplement to previous research, the concentrations of PDGF-AA, TGF- α, VEGF, IL-6, IL-8, and TNFβ were significantly upregulated in the vitreous of PVR patients. These factors should be considered for preventing PVR. (Source: Advances in Therapy)
Source: Advances in Therapy - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Systematic Scoring Balloon Lesion Preparation for Drug-Coated Balloon Angioplasty in Clinical Routine: Results of the PASSWORD Observational Study
ConclusionsThe routine use of a non-slip element scoring balloon catheter to prepare lesions suitable for drug-coated balloon angioplasty is associated with high procedural success rates and low TLF rates in de novo lesions. (Source: Advances in Therapy)
Source: Advances in Therapy - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Intracranial Atherosclerotic Stenoses: Pathophysiology, Epidemiology, Risk Factors and Current Therapy Options
AbstractIntracranial atherosclerotic stenoses (ICAS) are one of the most common causes of first and recurrent cerebrovascular ischaemic events worldwide, with highest prevalence in Asian, Hispanic and African populations. Clinical trials have improved the understanding of epidemiology, risk factors and imaging characteristics of patients with ICAS. Current therapeutic approaches concerning these patients include management of risk factors, best medical therapy, potentially endovascular and rarely surgical therapy. In our review, we elucidate the current epidemiology and evidence in evaluation of risk factors and therapeuti...
Source: Advances in Therapy - April 8, 2020 Category: Drugs & Pharmacology Source Type: research

Post-transplantation Outcomes in Patients with PA or MMA: A Review of the Literature
ConclusionsLiver transplantation and combined liver –kidney transplantation appears to benefit some patients with PA or MMA, respectively, but this approach does not provide complete correction of the metabolic defect and some patients remain at risk from disease-related and transplantation-related complications, including death. Thus, all treatmen t avenues should be exhausted before consideration of organ transplantation and the benefits of this approach must be weighed against the risk of perioperative complications on an individual basis. (Source: Advances in Therapy)
Source: Advances in Therapy - April 8, 2020 Category: Drugs & Pharmacology Source Type: research

Inhalation Therapy for Stable COPD: 20 Years of GOLD Reports
AbstractThe Global Initiative for Chronic Lung Disease (GOLD) was formed in the late 1990s to spread awareness of chronic obstructive pulmonary disease (COPD) as a major public health problem and facilitate its prevention and treatment. GOLD has since become internationally recognized for the development of evidence-based strategy documents, most notably the annual GOLD Reports, for COPD diagnosis, management, and prevention. The GOLD Reports incorporate the latest evidence and expert consensus to guide the management and prevention of COPD on a global level. Since the first GOLD Report in 2001, profound innovations have t...
Source: Advances in Therapy - April 3, 2020 Category: Drugs & Pharmacology Source Type: research

Serum High-Density Lipoprotein Cholesterol is Significantly Associated with the Presence and Severity of Pulmonary Arterial Hypertension: A Retrospective Cross-Sectional Study
AbstractIntroductionTo explore the relationship between serum high-density lipoprotein cholesterol (HDL-C) levels and the presence and severity of pulmonary arterial hypertension (PAH).MethodsA total of 177 patients with PAH and 103 patients without pulmonary hypertension (PH) were enrolled in this study. All patients underwent right heart catheterization (RHC) for diagnosing and assessing the severity of PAH. Demographics, comorbidities, and laboratory data including serum HDL-C levels were collected.ResultsPlasma HDL-C levels in patients with PAH were significantly lower compared with patients without PH (1.08  &p...
Source: Advances in Therapy - April 1, 2020 Category: Drugs & Pharmacology Source Type: research

Warning Against the Use of Anti-Inflammatory Medicines to Cure COVID-19: Building Castles in the Air
(Source: Advances in Therapy)
Source: Advances in Therapy - April 1, 2020 Category: Drugs & Pharmacology Source Type: research

Genetic Diagnosis of Rare Diseases: Past and Present
AbstractRare diseases are heterogeneous life-threatening or seriously debilitating conditions that affect
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Albuminuria Downregulation of the Anti-Aging Factor Klotho: The Missing Link Potentially Explaining the Association of Pathological Albuminuria with Premature Death
AbstractTen percent of the adult population has chronic kidney disease (CKD), which is diagnosed when the glomerular filtration rate (GFR) is below 60  mL/min per 1.73 m2 or when albuminuria is above 30  mg/day. The numerical thresholds were chosen because they are associated with an increased risk of CKD progression or premature death within a wider scenario of accelerated aging. Indeed, CKD is one of the fastest growing causes of death worldwide. A decreased GFR is associated with the accumulati on of uraemic toxins that may promote tissue and organ damage. However, CKD may be diagnosed when the GFR is com...
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Complications of Phosphate and Vitamin D Treatment in X-Linked Hypophosphataemia
AbstractConventional treatment of X-linked hypophosphataemia (XLH) consists in the oral administration of phosphate plus calcitriol supplements. Although this therapy has reduced bone deformities and even achieved adequate patient growth, overtreatment or low adherence could lead to subsequent consequences that may compromise the efficacy of the therapy. Some of the complications associated with phosphate and vitamin  D treatment are abdominal discomfort, diarrhoea, hypokalaemia, hyperparathyroidism, hypercalcaemia or hypercalciuria, nephrocalcinosis or nephrolithiasis, and ectopic calcifications. Therefore, constant ...
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Hypophosphataemic Rickets: Similar Phenotype of Different Diseases
AbstractHypophosphataemic rickets (HR) is a group of rare disorders caused by excessive renal phosphate wasting in which the participation of fibroblast growth factor  23 (FGF23) can be prominent. These diseases pose therapeutic challenges with important consequences for growth and bone development in childhood, with higher risk of fractures and poorer bone healing, dental problems, and nephrolithiasis or nephrocalcinosis. In some cases, the diagnostic delay can be very long; laboratory findings and an exhaustive anamnesis could help distinguish between various pathologies, and FGF23 values—although currently no...
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Panel Discussion: Some Aspects of the Management of Patients with X-Linked Hypophosphataemic Rickets
The objective of this paper is to answer some of the more frequent questions related to the management of patients with XLH by a group of experts participating in a scientific conference on XLH held in Madrid. (Source: Advances in Therapy)
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Surgical Indications in Hypophosphataemic Rickets
This article briefly reviews the indications for surgery procedures to be performed in these patients, highlighting when to use aggressive and non-aggressive approaches. (Source: Advances in Therapy)
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Paediatric Metabolic Bone Disease: A Lifetime Ahead
AbstractBeyond its functions in locomotion, support and protection of vital organs, bone also interacts with other organs to adjust mineral balance in response to physiological requirements. Bone remodelling is a continuous process of bone resorption and formation for the purpose of maintaining healthy bone mass and growth. Any derangement in this process can cause bone disorders with important clinical consequences. The most prominent features of bone diseases in children include early bone fractures, deformities and pain, which can persist and worsen later in life if an accurate and timely diagnosis is not achieved. Bioc...
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Usefulness of X-rays in the Differential Diagnosis of Hypophosphataemic Rickets
AbstractRickets and osteomalacia are two related conditions linked by the lack of mineralization of bone tissue due to a disturbance of calcium and phosphate homeostasis. Some of the most characteristic features of rickets are skeletal deformities, fractures, linear and continuous periosteal reaction, and enlargement of the metaphyseal space in an irregular and frayed form. However, these radiological findings are not exclusive to these diseases, but may also originate in children who were born prematurely or in those who have suffered physical abuse or an accident. Hence, it is important to establish a differential diagno...
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

X-Linked Hypophosphataemic Rickets and Growth
This article briefly describes the relation ship between XLH and growth retardation, and how to address this alteration in patients with XLH. (Source: Advances in Therapy)
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Microindentation: A New Technique for Bone Quality Assessment
AbstractFractures are the result of the application of a greater force on bone than its strength. Therefore, to understand fracture physiopathology, it is essential to know bone strength determinants. These include bone mineral density (BMD), bone spatial structure (bone geometry and microarchitecture) and bone mechanical and tissue properties. While BMD and bone spatial structure can be easily evaluated through imaging technology, assessment of bone tissue and mechanical properties is complex and typically requires invasive techniques that are not suitable in clinical practice. Microindentation is a relatively recently de...
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Hypophosphataemic Rickets: Diagnosis Algorithm —How Not to Make a Mistake
AbstractHypophosphataemic rickets is a heterogeneous group of entities characterized by rickets or osteomalacia due to a phosphate deficit caused mainly by decreased renal reabsorption. They are also characterized by defective intestinal absorption of calcium and rickets or osteomalacia unresponsive to cholecalciferol. These metabolic alterations lead to growth retardation, bone pain and deformities, and short stature. For a correct diagnosis and treatment of all forms of rickets, the basic aspects of pathophysiology of the calcium-phosphorus metabolism and the relevance of the bone-kidney axis modulated by the presence of...
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

FGF23: Is It Another Biomarker for Phosphate –Calcium Metabolism?
This article will review the role of FGF23 in phosphate homeostasis, its relationship to mortality, fractures and chronic renal failure, and how the levels of this factor can be reduced. (Source: Advances in Therapy)
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

FGF23-Related Hypophosphataemic Bone Disease
This article is based on previously conducted studies and does not contain any new st udies with human participants or animals performed by the author. (Source: Advances in Therapy)
Source: Advances in Therapy - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Service Evaluation of Methoxyflurane Versus Standard Care for Overall Management of Patients with Pain Due to Injury
ConclusionUse of methoxyflurane in adult patients with trauma pain significantly reduced the ED LOS and may potentially improve patient flow through the ED. (Source: Advances in Therapy)
Source: Advances in Therapy - March 30, 2020 Category: Drugs & Pharmacology Source Type: research

Barriers to the Wider Use of Pre-exposure Prophylaxis in the United States: A Narrative Review
AbstractAntiretroviral pre-exposure prophylaxis (PrEP) to prevent HIV transmission was first approved by the US Food and Drug Administration in 2012. Despite correlations of decreases in new HIV infections being greatest where PrEP has been deployed, the uptake of PrEP is lagging, particularly among populations with disproportionate HIV burden. This narrative review seeks to identify individual and systemic barriers to PrEP usage in the USA. A comprehensive search of recent literature uncovered a complex array of structural, social, clinical, and behavioral barriers, including knowledge/awareness of PrEP, perception of HIV...
Source: Advances in Therapy - March 30, 2020 Category: Drugs & Pharmacology Source Type: research

A Narrative Review and Expert Panel Recommendations on Dyslipidaemia Management After Acute Coronary Syndrome in Countries Outside Western Europe and North America
AbstractPatients who have experienced an acute coronary syndrome (ACS) are at very high risk of recurrent atherosclerotic cardiovascular disease (CVD) events. Dyslipidaemia, a major risk factor for CVD, is poorly controlled post ACS in countries outside Western Europe and North America, despite the availability of effective lipid-modifying therapies (LMTs) and guidelines governing their use. Recent guideline updates recommend that low-density lipoprotein cholesterol (LDL-C), the primary target for dyslipidaemia therapy, be reduced by ≥ 50% and to
Source: Advances in Therapy - March 29, 2020 Category: Drugs & Pharmacology Source Type: research

Efficacy and Treatment Burden of Intravitreal Aflibercept Versus Intravitreal Ranibizumab Treat-and-Extend Regimens at 2  Years: Network Meta-Analysis Incorporating Individual Patient Data Meta-Regression and Matching-Adjusted Indirect Comparison
ConclusionPatients with wAMD receiving an IVT-AFL T&E regimen achieved and maintained improvement in visual acuity with fewer injections over 2  years compared with RBZ T&E. IVT-AFL T&E may therefore serve as the optimal therapy for wAMD, as it was associated with clinical efficacy and minimized treatment burden. (Source: Advances in Therapy)
Source: Advances in Therapy - March 28, 2020 Category: Drugs & Pharmacology Source Type: research

Management of Patients with Coronary Artery Disease in Lithuania: a Comparison with Other Central Eastern European Countries Based on Data From the International CLARIFY Registry
AbstractIntroductionLithuania has one of the highest mortality rates from coronary heart disease (CHD) among European countries. Most CHD are preventable, but when they occur, the management of these patients is important in secondary prevention. The purpose of the present analysis was to describe the demographics, clinical profile, and contemporary management of patients with stable CHD in the Lithuanian population and to compare data with other Central Eastern European countries.MethodsCLARIFY (prospective observational longitudinal registry of patients with stable CHD) is an international cohort study in outpatients wit...
Source: Advances in Therapy - March 27, 2020 Category: Drugs & Pharmacology Source Type: research

XEN Gel Stent Open Conjunctiva Technique: A Practical Approach Paper
AbstractThe Xen Gel Stent lowers intraocular pressure by shunting aqueous humor to the subconjunctival space. While published studies include both open conjunctiva and closed conjunctiva approaches, most publications feature a closed conjunctiva, ab interno approach. While this approach is widely used, other approaches may be preferred for some patients. This paper provides details on surgical steps and tips for enhancing outcomes for an open conjunctiva technique for the implantation of the Xen Gel Stent, as well as reasoning as to when this approach should be used. (Source: Advances in Therapy)
Source: Advances in Therapy - March 21, 2020 Category: Drugs & Pharmacology Source Type: research

Fertility Outcomes After Laparoscopic Cystectomy in Infertile Patients with Stage  III–IV Endometriosis: a Cohort with 6–10 years of Follow-up
AbstractIntroductionOvarian endometriosis is the most common type of endometriosis (EM), affecting more than 40% of women with EM. Currently, surgical intervention is still controversial in infertile patients with ovarian endometriosis, especially in those with stage  III–IV EM. Very few studies have been done to analyze long-term pregnancy results in patients with endometrioma more than 5 years after surgery. Therefore, the aim of this study was to explore the pregnancy outcomes and the related factors in patients with endometrioma and stage III–IV endom etriosis during a long-term follow-up pos...
Source: Advances in Therapy - March 21, 2020 Category: Drugs & Pharmacology Source Type: research

Discrepancy Between Fasting Flow-Mediated Dilation and Parameter of Lipids in Blood: A Randomized Exploratory Study of the Effect of Omega-3 Fatty Acid Ethyl Esters on Vascular Endothelial Function in Patients With Hyperlipidemia
AbstractIntroductionOmega-3 fatty acid ethyl esters (omega-3), an eicosapentaenoic acid and docosahexaenoic acid preparation (Lotriga®, Takeda Pharmaceutical Company Limited), are approved in Japan to treat triglyceridemia. We investigated the effects of omega-3 on vascular endothelial function, measured by flow-mediated dilation (FMD).MethodsPatients with dyslipidemia receiving 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors were randomized 1:1 to receive omega-3 at 2  g (QD) or 4 g (2 g BID) for 8 weeks. The primary end point was the change from baseline of fasting  %FMD...
Source: Advances in Therapy - March 21, 2020 Category: Drugs & Pharmacology Source Type: research

New Perspectives for Mucolytic, Anti-inflammatory and Adjunctive Therapy with 1,8-Cineole in COPD and Asthma: Review on the New Therapeutic Approach
AbstractThe mucolytic monoterpene 1,8-cineole (eucalyptol), the major constituent of eucalyptus species, is well known for its anti-inflammatory, antioxidant, bronchodilatory, antiviral and antimicrobial effects. The main protective antiviral, anti-inflammatory and mucolytic mechanisms of 1,8-cineole are the induction of interferon regulatory factor  3 (IRF3), the control of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) along with decreasing mucin genes (MUC2, MUC19). In normal human monocytes direct inhibition was shown of reactive oxygen species (ROS)-mediated mucus hypersecretion...
Source: Advances in Therapy - March 21, 2020 Category: Drugs & Pharmacology Source Type: research

Proportion of High-Risk/Very High-Risk Patients in Europe with Low-Density Lipoprotein Cholesterol at Target According to European Guidelines: A Systematic Review
AbstractObjectiveAssess achievement of low-density lipoprotein cholesterol (LDL-C) targets in European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines.DesignSystematic literature review.Data SourcesMedline, EMBASE, Cumulated Index to Nursing and Allied Health Literature.Eligibility CriteriaObservational studies reporting LDL-C levels/target attainment, measured between 1  August 2006 to 31 August 2017, in European adults with established cardiovascular disease (CVD), diabetes with target organ damage, familial hypercholesterolaemia (FH) or 10-year risk of fatal CVD ≥&thinsp...
Source: Advances in Therapy - March 21, 2020 Category: Drugs & Pharmacology Source Type: research

A Longitudinal Assessment of the Impact of Endometriosis on Patients ’ Salary Growth and Risk of Leaving the Workforce
AbstractIntroductionThis retrospective cohort study evaluated the impact of endometriosis on the risks of work loss events and salary/growth over a 5-year period.MethodsWomen aged 18 –49 years with ≥ 1 endometriosis diagnosis were identified in a claims database and matched 1:1 to women without endometriosis (controls). The index date was the first endometriosis diagnosis date (endometriosis cohort) or a random date during the period of continuous eligibility (controls) . Baseline characteristics were compared between cohorts descriptively. Average annual salaries were compared over the 5 y...
Source: Advances in Therapy - March 20, 2020 Category: Drugs & Pharmacology Source Type: research

Methemoglobinemia in the Operating Room and Intensive Care Unit: Early Recognition, Pathophysiology, and Management
The objectives of this review are to describe the acquired and hereditary causes of methemoglobinemia, to recommend the most sensitive diagnostic tests, and to enable critical care clinicians to rapidly detect and treat methemoglobinemia. To meet these objectives, Internet search engines were queried with the keywords to select articles for review that included case reports, case series, observational, longitudinal, and surveillance studies. The most common causes of methemoglobinemia include oxidizing reactions to cocaine-derived anesthetics, such as benzocaine and lidocaine, to antibiotics, such as dapsone and other sulf...
Source: Advances in Therapy - March 19, 2020 Category: Drugs & Pharmacology Source Type: research

Persistence, Dose Titration, and Health Care Resource Utilization Among Crohn ’s Disease Patients Treated With Ustekinumab: A Real-World Analysis in the United States
ConclusionsThe majority of CD patients prescribed UST were biologic experienced, and persistence was high over the 1-year follow-up. UST treatment initiation was associated with reductions in ER visits, inpatient stays, and steroid and other medication use. (Source: Advances in Therapy)
Source: Advances in Therapy - March 19, 2020 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness Analysis of Atezolizumab Plus Chemotherapy in the First-Line Treatment of Metastatic Non-Squamous Non-Small Cell Lung Cancer
ConclusionFirst-line treatment with atezolizumab in combination with carboplatin plus nab-paclitaxel is not a cost-effective option in patients with metastatic non-squamous NSCLC. (Source: Advances in Therapy)
Source: Advances in Therapy - March 19, 2020 Category: Drugs & Pharmacology Source Type: research

Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
AbstractLife expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence is a state of cell cycle arrest with suppressed apoptosis and concomitant secretion of multiple bioactive factors (the senescence-associated secretory phenotype —SASP) that plays a physiological role in embryonic development and healing processes. However, DNA damage and oxidative stress that occur during aging caus...
Source: Advances in Therapy - March 17, 2020 Category: Drugs & Pharmacology Source Type: research

New Therapeutic Strategy and Innovative Lubricating Ophthalmic Solution in Minimizing Dry Eye Disease Associated with Cataract Surgery: A Randomized, Prospective Study
AbstractIntroductionTo evaluate the effects of a new lubricating, antioxidant solution (VisuEvo®) on dry eye disease (DED) in patients undergoing cataract surgery.MethodsPatients requiring cataract surgery with either healthy ocular surface or mild DED (tear break-up time, TBUT>  7, SchirmerI test>  15 mm/5 min) were enrolled in this multicenter, open-label, randomized, prospective study. Scheduled visits were 2 weeks before surgery (screening), day of surgery (V0), week 1 (V1), and 2 (V2) after surgery. VisuEvo® was self-administered three times daily for the whole study duration...
Source: Advances in Therapy - March 17, 2020 Category: Drugs & Pharmacology Source Type: research

Citicoline and Vitamin  B 12 Eye Drops in Type 1 Diabetes: Results of a 3-year Pilot Study Evaluating Morpho-Functional Retinal Changes
ConclusionsThis pilot study indicated that patients with DM1 with mild signs of diabetic retinopathy (DR) who underwent treatment with citicoline and vitamin  B12 eye drops for a 3-year duration achieved stabilization or decreased rate of functional impairment, neuroretinal degeneration, and microvascular damage.Trial RegistrationClinicalTrials.gov identifier, NCT04009980. (Source: Advances in Therapy)
Source: Advances in Therapy - March 16, 2020 Category: Drugs & Pharmacology Source Type: research

Comment on: “Retrospective Claims Analysis Indirectly Comparing Medication Adherence and Persistence Between Intravenous Biologics and Oral Small-Molecule Therapies in Inflammatory Bowel Diseases”
(Source: Advances in Therapy)
Source: Advances in Therapy - March 15, 2020 Category: Drugs & Pharmacology Source Type: research

Response to “Comment on Retrospective Claims Analysis Indirectly Comparing Medication Adherence and Persistence Between Intravenous Biologics and Oral Small-Molecule Therapies in Inflammatory Bowel Diseases”
(Source: Advances in Therapy)
Source: Advances in Therapy - March 15, 2020 Category: Drugs & Pharmacology Source Type: research

HER2-Positive Metastatic Breast Cancer: A Retrospective Cohort Study of Healthcare Costs in the Targeted-Therapy Age
ConclusionsHER2+ MBC is associated with high short-term and medium-term direct healthcare costs. These could be alleviated with early diagnosis and optimal standard-of-care treatment for early breast cancer, which can significantly reduce the risk of recurrence. (Source: Advances in Therapy)
Source: Advances in Therapy - March 14, 2020 Category: Drugs & Pharmacology Source Type: research

Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase  3 MERCURY-1 and -2
AbstractIntroductionNew open-angle glaucoma (OAG) and ocular hypertension (OHT) therapies that reduce treatment burden and improve outcomes relative to currently available agents are needed. Netarsudil, a novel Rho kinase inhibitor approved by the US Food and Drug Administration, reduces intraocular pressure (IOP) by increasing trabecular outflow. Two phase  3 superiority studies compared a fixed-dose combination (FDC) of netarsudil and the prostaglandin latanoprost with each active component for IOP-lowering efficacy.MethodsPooled efficacy and safety data were analyzed from MERCURY-1 and -2 studies in patients with O...
Source: Advances in Therapy - March 12, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of Nurse Preferences Between the Lanreotide Autogel New Syringe and the Octreotide Long-Acting Release Syringe: An International Simulated-Use Study (PRESTO)
AbstractIntroductionSomatostatin analogues are used to treat symptoms and slow tumour progression in patients with neuroendocrine tumours (NETs) and carcinoid syndrome and to reduce hormone secretion and pituitary tumour volume in patients with acromegaly. A new syringe for lanreotide autogel/depot (LAN) was developed following feedback from a human factors study to improve ease of injection compared with previous syringes. PRESTO aimed to assess preferences of nurses between the LAN new syringe and the octreotide long-acting release (LAR) syringe.MethodsPRESTO, a multinational, multicentre, prospective, noninterventional,...
Source: Advances in Therapy - March 11, 2020 Category: Drugs & Pharmacology Source Type: research

Managing NAFLD in Type  2 Diabetes: The Effect of Lifestyle Interventions, a Narrative Review
In conclusion, it is clear that lifestyle interventions are an effective treatment strategy in patients with both NAFLD and T2D, although further research is required to optimise these interventions and determine their scalability. (Source: Advances in Therapy)
Source: Advances in Therapy - March 7, 2020 Category: Drugs & Pharmacology Source Type: research