Prevalence of Co-existing Autoimmune Disease in Rheumatoid Arthritis: A Cross-Sectional Study
ConclusionPatients with RA have more concurrent autoimmune diseases than patients with OA. These data suggest that the interrelationship between RA and other autoimmune diseases, and outcomes associated with the occurrence of multiple autoimmune diseases, may play an important role in disease understanding, management, and treatment decisions.FundingBristol-Myers Squibb. (Source: Advances in Therapy)
Source: Advances in Therapy - October 24, 2017 Category: Drugs & Pharmacology Source Type: research

Treatment Persistence and Healthcare Costs Among Patients with Rheumatoid Arthritis Changing Biologics in the USA
This study examined treatment persistence, cost, and cost per persistent patient among MOA switchers versus TNFi cyclers.MethodsThis study of Commercial and Medicare Advantage claims data from the Optum Research Database included patients with RA and at least one claim for a TNFi (adalimumab, certolizumab pegol, etanercept, golimumab, or infliximab) between January 2012 and September 2015 who changed to another TNFi or a different MOA therapy (abatacept, tocilizumab, or tofacitinib) within 1  year. The index date was the date of the change in therapy. Treatment persistence was defined as no subsequent switch or 60-day...
Source: Advances in Therapy - October 16, 2017 Category: Drugs & Pharmacology Source Type: research

Treatment Patterns, Complications, and Health Care Utilization Among Endometriosis Patients Undergoing a Laparoscopy or a Hysterectomy: A Retrospective Claims Analysis
ConclusionThis study indicated significantly different 1-year post-surgical outcomes for patients who underwent an endometriosis-related hysterectomy relative to a laparoscopy. Furthermore, the endometriosis patients in this analysis had a considerable risk of surgical complications, subsequent surgeries, and hospital admissions, both during and after their initial therapeutic laparoscopy or hysterectomy.FundingAbbVie. (Source: Advances in Therapy)
Source: Advances in Therapy - October 16, 2017 Category: Drugs & Pharmacology Source Type: research

Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men
ConclusionSystemic exposure to mifepristone increased following multiple doses of mifepristone 600  mg daily plus ketoconazole 200 mg twice daily. Little to no increase in AEs occurred. Dose adjustment of mifepristone may be needed when given with ketoconazole.FundingCorcept Therapeutics. (Source: Advances in Therapy)
Source: Advances in Therapy - October 11, 2017 Category: Drugs & Pharmacology Source Type: research

Sepsis: A Review of Advances in Management
This article reviews key elements of sepsis management, focusing on diagnosis, biomarkers and therapy. The main recent advance in therapy is the strategy of personalized medicine, based on a precise approach using biomarkers to identify specific individuals who are likely to benefit from more personalized attention. (Source: Advances in Therapy)
Source: Advances in Therapy - October 11, 2017 Category: Drugs & Pharmacology Source Type: research

Assessing the Role of Reversible Contraceptives in the Health Care of Women as it Pertains to Cancer Prevention
We present here the current understanding of the role of effective and reversible contraceptives in the prevention and development of female genital cancers along with breast and colon cancers. Despite ongoing but unsubstantiated concerns regarding the use of hormonal and intrauterine contraceptives for a variety of clinical outcomes including cancer, contraceptive use in high- and low-risk reproductive-aged women remains an important part of cancer risk reduction for many malignancies. (Source: Advances in Therapy)
Source: Advances in Therapy - October 11, 2017 Category: Drugs & Pharmacology Source Type: research

Challenges Associated with Estimating Utility in Wet Age-Related Macular Degeneration: A Novel Regression Analysis to Capture the Bilateral Nature of the Disease
AbstractIntroductionThe estimation of utility values for the economic evaluation of therapies for wet age-related macular degeneration (AMD) is a particular challenge. Previous economic models in wet AMD have been criticized for failing to capture the bilateral nature of wet AMD by modelling visual acuity (VA) and utility values associated with the better-seeing eye only.MethodsHere we present a de novo regression analysis using generalized estimating equations (GEE) applied to a previous dataset of time trade-off (TTO)-derived utility values from a sample of the UK population that wore contact lenses to simulate visual de...
Source: Advances in Therapy - October 10, 2017 Category: Drugs & Pharmacology Source Type: research

Pharmacotherapy Choice Is Associated with 2-Year Mortality for Patients with Heart Failure and Reduced Ejection Fraction
ConclusionIPT was associated with decreased 2-year mortality risk. Timely consideration of triple IPT therapies may be warranted once HFrEF diagnosis is confirmed.FundingNovartis Pharmaceuticals Corp. located in East Hanover, NJ, USA. (Source: Advances in Therapy)
Source: Advances in Therapy - October 10, 2017 Category: Drugs & Pharmacology Source Type: research

Subcutaneous Rituximab for the Treatment of B-Cell Hematologic Malignancies: A Review of the Scientific Rationale and Clinical Development
This article is a companion paper to G. Salles, et al., which is also published in this issue.FundingF. Hoffmann-La Roche Ltd. (Source: Advances in Therapy)
Source: Advances in Therapy - October 5, 2017 Category: Drugs & Pharmacology Source Type: research

Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience
This article is a companion paper to A. Davies, et al., which is also published in this issue.FundingF. Hoffmann-La Roche Ltd., Basel, Switzerland. (Source: Advances in Therapy)
Source: Advances in Therapy - October 5, 2017 Category: Drugs & Pharmacology Source Type: research

Mechanical Ventilation During Resuscitation: How Manual Chest Compressions Affect a Ventilator ’s Function
AbstractIntroductionGuidelines for resuscitation recommend positive-pressure ventilation with a fixed ventilation rate as provided by an automated transport ventilator during cardiopulmonary resuscitation (CPR) with a secured airway. We investigated the influence of manual chest compressions (CC) on the accuracy of ventilator presets and the quality of CC with intermittent positive-pressure ventilation (IPPV), bilevel ventilation (BiLevel), and the novel ventilation mode chest compression synchronized ventilation (CCSV) in a simulation model.MethodsNinety paramedics performed continuous CC for 2 min on a modified advanced ...
Source: Advances in Therapy - October 5, 2017 Category: Drugs & Pharmacology Source Type: research

Modeled Health Economic Impact of a Hypothetical Certolizumab Pegol Risk-Sharing Scheme for Patients with Moderate-to-Severe Rheumatoid Arthritis in Finland
ConclusionThe present analysis estimated that CZP, with or without the risk-sharing scheme, is a cost-effective alternative treatment for RA patients in Finland. The surplus provided by the CZP risk-sharing scheme could fund treatment for 6% more Finnish RA patients.FundingUCB Pharma. (Source: Advances in Therapy)
Source: Advances in Therapy - October 3, 2017 Category: Drugs & Pharmacology Source Type: research

Pharmacological and Non-pharmacological Treatments for Stroke Prevention in Patients with Atrial Fibrillation
AbstractAtrial fibrillation (AF) is associated with significant risk of stroke and other thromboembolic events, which can be effectively prevented using oral anticoagulation (OAC) with either vitamin K antagonists (VKAs) or non-VKA oral anticoagulants (NOACs) dabigatran, rivaroxaban, apixaban, or edoxaban. Until recently, VKAs were the only available means for OAC treatment. NOACs had similar efficacy and were safer than or as safe as warfarin with respect to reduced rates of hemorrhagic stroke or other intracranial bleeding in the respective pivotal randomized clinical trials (RCTs) of stroke prevention in non-valvular AF...
Source: Advances in Therapy - September 27, 2017 Category: Drugs & Pharmacology Source Type: research

Content Validity of a Willingness to Quit Tool for Use with Current Smokers in Clinical Practice
ConclusionThe WTQ tool is a brief tool to assess willingness to quit and to engage communication between patients and physicians. All smokers should be offered smoking cessation support and facilitating a discussion on willingness to quit further supports a personalized quit plan.FundingPfizer Inc. (Source: Advances in Therapy)
Source: Advances in Therapy - September 22, 2017 Category: Drugs & Pharmacology Source Type: research

Concurrent Improvement in Both Binge Eating and Depressive Symptoms with Naltrexone/Bupropion Therapy in Overweight or Obese Subjects with Major Depressive Disorder in an Open-Label, Uncontrolled Study
ConclusionNB may be effective in reducing binge eating symptoms associated with MDD and overweight/obesity. Evaluation of NB in BED appears warranted.FundingOrexigen Therapeutics, Inc. (Source: Advances in Therapy)
Source: Advances in Therapy - September 16, 2017 Category: Drugs & Pharmacology Source Type: research

Methodological Aspects in Studies Based on Clinical Routine Data
AbstractAbstractRandomized controlled clinical trials are regarded as the gold standard for comparing different clinical interventions, but generally their conduct is operationally cumbersome, time-consuming, and expensive. Studies and investigations based on clinical routine data on the contrary utilize existing data acquired under real-life conditions and are increasingly popular among practitioners. In this paper, methodological aspects of studies based on clinical routine data are discussed. Important limitations and considerations as well as unique strengths of these types of studies are indicated and exemplarily demo...
Source: Advances in Therapy - September 12, 2017 Category: Drugs & Pharmacology Source Type: research

Insulin Resistance and Hunger in Childhood Obesity: A Patient and Physician ’s Perspective
This article is co-authored by the mother of a child with obesity and insulin resistance, who gives her perspective. It is also co-authored by the treating Obesity Medicine clinician and an investigator in obesity clinical research (both certified in Obesity Medicine), who give their perspectives. The discussion focuses upon the potential clinical use of metformin in managing young patients with obesity and insulin resistance. The article integrates what is scientifically known about the mechanisms of actions of metformin and how these mechanisms are reflected in the clinical response of young patients. (Source: Advances in Therapy)
Source: Advances in Therapy - September 7, 2017 Category: Drugs & Pharmacology Source Type: research

Once-Daily Triple Therapy in Patients with Advanced COPD: Healthcare Resource Utilization Data and Associated Costs from the FULFIL Trial
ConclusionsThis healthcare resource utilization evidence suggests that, in a clinical trial setting over a 24- or 52-week timeframe, non-drug costs associated with management of a single inhaler fluticasone furoate/umeclidinium/vilanterol are lower compared with twice-daily budesonide/formoterol.Trial RegistrationClinicalTrials.gov number: NCT02345161.FundingGSK (Source: Advances in Therapy)
Source: Advances in Therapy - September 5, 2017 Category: Drugs & Pharmacology Source Type: research

The Impact of Histologic Phenotype in the Treatment of Sinonasal Cancer
AbstractThe management of sinonasal cancer is a challenge due to its low occurrence and anatomical and significant diversity of histological types. The therapeutic modality used should be tailored individually according to the histology, tumour stage, molecular profile and previous treatments. The clinical management of sinonasal cancer has improved greatly owing to developments in endoscopic surgery and precision radiotherapy. Complete surgical resection is the mainstay of sinonasal malignancies' management but multimodality therapy is associated with improved outcomes in certain histologies. The recognition of various hi...
Source: Advances in Therapy - September 4, 2017 Category: Drugs & Pharmacology Source Type: research

Erratum to: Multicenter, Randomized, Investigator-Masked Study Comparing Brimonidine Tartrate 0.1% and Timolol Maleate 0.5% as Adjunctive Therapies to Prostaglandin Analogues in Normal-Tension Glaucoma
(Source: Advances in Therapy)
Source: Advances in Therapy - August 30, 2017 Category: Drugs & Pharmacology Source Type: research

Erratum to: Gluten and Aluminum Content in Synthroid ® (Levothyroxine Sodium Tablets)
(Source: Advances in Therapy)
Source: Advances in Therapy - August 30, 2017 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of Linagliptin in 2681 Asian Patients Stratified by Age, Obesity, and Renal Function: A Pooled Analysis of Randomized Clinical Trials
AbstractIntroductionAsian patients with type 2 diabetes (T2D) are younger, leaner, and more likely to develop renal dysfunction than White populations. In this multiethnic analysis of data from phase 3 trials, we investigated the efficacy and safety of the dipeptidyl peptidase-4 inhibitor linagliptin in Asians stratified by these subphenotypes.MethodsData from randomized, double-blind, placebo-controlled trials evaluating linagliptin (as monotherapy, add-on therapy to metformin  ± sulfonylurea, combined with pioglitazone or added to insulin) were pooled with efficacy data from 11 randomized trials of at le...
Source: Advances in Therapy - August 17, 2017 Category: Drugs & Pharmacology Source Type: research

The Challenge of Assessing Adherence to Subcutaneous Biological Drugs in Immune-Mediated Inflammatory Diseases. Letter to the Editor Regarding Michetti P, Weinman J, Mrowietz U, et al. Adv Ther (2017);34:91 –108. doi:10.1007/s12325-016-0441-3
(Source: Advances in Therapy)
Source: Advances in Therapy - August 17, 2017 Category: Drugs & Pharmacology Source Type: research

A Pharmacokinetic Bioequivalence Study Comparing Pirfenidone Tablet and Capsule Dosage Forms in Healthy Adult Volunteers
ConclusionsThe pirfenidone 801-mg tablet met bioequivalence criteria when compared with three 267-mg capsules in the fasted state. The tabletCmax was slightly higher relative to capsules in the fed state, but this is not expected to have a clinically meaningful impact on the benefit –risk profile of pirfenidone.FundingThis work was supported by F. Hoffmann-La Roche Ltd. (Source: Advances in Therapy)
Source: Advances in Therapy - August 14, 2017 Category: Drugs & Pharmacology Source Type: research

Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects
ConclusionIn these studies, OCA showed weak to no suppression/inhibition of metabolic enzymes and drug transporters at the highest recommended therapeutic dose in patients with PBC. On the basis on these analyses, monitoring and maintenance of target INR range are required during coadministration of OCA with drugs that are metabolized by CYP1A2 (R-warfarin).FundingIntercept Pharmaceuticals, Inc. (Source: Advances in Therapy)
Source: Advances in Therapy - August 14, 2017 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness of Posaconazole Tablets for Invasive Fungal Infections Prevention in Acute Myelogenous Leukemia or Myelodysplastic Syndrome Patients in Spain
ConclusionFrom the Spanish NHS perspective, posaconazole tablets are cost-effective compared to FLU or ITRA in AML or MSD patients with chemotherapy-induced neutropenia and at high risk for IFDs.FundingMSD Sharp& Dohme. (Source: Advances in Therapy)
Source: Advances in Therapy - August 14, 2017 Category: Drugs & Pharmacology Source Type: research

Foveal Microstructure Analysis in Eyes with Diabetic Macular Edema Treated with Vitrectomy
AbstractIntroductionThe purpose of this study was to evaluate baseline and postoperative factors affecting outcomes after vitrectomy for diabetic macular edema (DME) using optical coherence tomography (OCT).MethodsVitrectomy combined with inner limiting membrane (ILM) peeling and additional laser photocoagulation therapy was performed on 36 eyes of 30 DME patients. Evaluations included the logarithm of the minimal angle of resolution (logMAR), best-corrected visual acuity (BCVA) and OCT parameters at baseline and 1, 3, 6, and 12  months postoperatively. Correlations between OCT parameters and BCVA were assessed at eac...
Source: Advances in Therapy - August 14, 2017 Category: Drugs & Pharmacology Source Type: research

Health-Related Quality of Life in Individuals with Down Syndrome: Results from a Non-Interventional Longitudinal Multi-National Study
ConclusionThe findings of this study underline that further research is needed to better understand the nature of HRQoL in DS. Further research using a shorter time interval between assessment time points to examine test-retest reliability is also required.FundingF. Hoffmann-La Roche Ltd. (Source: Advances in Therapy)
Source: Advances in Therapy - August 9, 2017 Category: Drugs & Pharmacology Source Type: research

The Patterns of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) Use in Patients with Atrial Fibrillation in Seven Balkan Countries: a Report from the BALKAN-AF Survey
AbstractIntroductionData on management of atrial fibrillation (AF) in the Balkan Region are scarce. To capture the patterns in AF management in contemporary clinical practice in the Balkan countries a prospective survey was conducted between December 2014 and February 2015, and we report results pertinent to the use of non-vitamin K antagonist oral anticoagulants (NOACs).MethodsA 14-week prospective, multicenter survey of consecutive AF patients seen by cardiologists or internal medicine specialists was conducted in Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Montenegro, Romania, and Serbia (a total of about 50 mil...
Source: Advances in Therapy - August 9, 2017 Category: Drugs & Pharmacology Source Type: research

Hypoglycemia After Initiation of Basal Insulin in Patients with Type 2 Diabetes in the United States: Implications for Treatment Discontinuation and Healthcare Costs and Utilization
This study aimed to determine the impact of hypoglycemia soon after basal insulin initiation on treatment discontinuation and economic outcomes in patients with T2D.MethodsHypoglycemic events within 6  months of basal insulin initiation were identified using retrospective cohort data from patients with T2D, at least 18 years of age, initiated on basal insulin therapy in the Clinformatics™ Data Mart for Multiplan claims database from January 1, 2008, through August 31, 2012. Data were adjusted for baseline characteristics. Discontinuation was established for patients with 12-month follow-up data, while disco...
Source: Advances in Therapy - August 4, 2017 Category: Drugs & Pharmacology Source Type: research

Changes in Healthcare Utilization After Etanercept Initiation in Patients with Rheumatoid Arthritis: A Retrospective Claims Analysis
ConclusionOverall healthcare utilization decreased after etanercept initiation. Patients who were most compliant with etanercept had significantly lower utilization than less compliant patients.FundingAmgen, Inc (Source: Advances in Therapy)
Source: Advances in Therapy - August 2, 2017 Category: Drugs & Pharmacology Source Type: research

Erratum to: Patient Perspectives on Gene Transfer Therapy for Sickle Cell Disease
(Source: Advances in Therapy)
Source: Advances in Therapy - August 2, 2017 Category: Drugs & Pharmacology Source Type: research

Catheter Ablation of Atrial Fibrillation: An Overview for Clinicians
AbstractCatheter ablation (CA) of atrial fibrillation (AF) is currently one of the most commonly performed electrophysiology procedures. Ablation of paroxysmal AF is based on the elimination of triggers by pulmonary vein isolation (PVI), while different strategies for additional AF substrate modification on top of PVI have been proposed for ablation of persistent AF. Nowadays, various technologies for AF ablation are available. The radiofrequency point-by-point ablation navigated by electro-anatomical mapping system and cryo-balloon technology are comparable in terms of the efficacy and safety of the PVI procedure. Long-te...
Source: Advances in Therapy - July 21, 2017 Category: Drugs & Pharmacology Source Type: research

Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial
ConclusionClonidine MBT is well tolerated and exhibits proportional saliva and plasma PK over the 50 –100-µg dose level. The MBT results in higher saliva concentrations and lower systemic exposure than OT, which was associated with a trend towards fewer adverse events and less dry mouth, fatigue and hypotensive effect.FundingOnxeo SA.Trial RegistrationClinicalTrials.gov identifier, NCT02548806. (Source: Advances in Therapy)
Source: Advances in Therapy - July 19, 2017 Category: Drugs & Pharmacology Source Type: research

Prescribing Trends in a Glaucoma Clinic and Adherence to EGS Guidelines: A Retrospective, Non-Interventional, Single-Center UK Study
DiscussionThere was a clear hierarchy of PGA as first-line, BB as second-line, while CAI and AA were considered third-line choices. First-line choices were generally in line with EGS guidelines. There was a tendency to breach guidelines by escalating treatment in dual steps rather than single steps (especially in third-line treatment). Combination drops were popular. In third-line treatment there was an increased incidence of prescribing errors. This data is important in terms of informing patients of the expected treatment course, to remind clinicians about best practice, and also to guide comparisons of cost-effectivenes...
Source: Advances in Therapy - July 19, 2017 Category: Drugs & Pharmacology Source Type: research

Patient Perspectives on Gene Transfer Therapy for Sickle Cell Disease
ConclusionOlder adults had more desire to participate in human clinical GTT trials than younger participants. When recruiting for trials, researchers should develop GTT educational materials that address participant lack of trust in the healthcare system, cultural beliefs, fears related to side effects, and include visual illustrations. Use of such materials will provide adults with SCD the information they need to fully evaluate GTT. (Source: Advances in Therapy)
Source: Advances in Therapy - July 17, 2017 Category: Drugs & Pharmacology Source Type: research

Practical Considerations for the Use of Subcutaneous Treatment in the Management of Dyslipidaemia
AbstractSuboptimal drug adherence represents a major challenge to effective primary and secondary prevention of cardiovascular disease. While adherence is influenced by multiple considerations, polypharmacy and dosing frequency appear to be rate-limiting factors in patient satisfaction and subsequent adherence. The cardiovascular and metabolic therapeutic areas have recently benefited from a number of advances in drug therapy, in particular protease proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and incretin-based therapies, respectively. These drugs are administered subcutaneously and offer efficacious t...
Source: Advances in Therapy - July 17, 2017 Category: Drugs & Pharmacology Source Type: research

Fixed-Dose Versus Off-Label Combination of Isosorbide Dinitrate Plus Hydralazine Hydrochloride: Retrospective Propensity-Matched Analysis in Black Medicare Patients with Heart Failure
ConclusionThe 1-year survival advantage for FDC-ISDN/HYD compared with off-label combinations in adherent black Medicare beneficiaries with HF suggests a genuine difference between these medications and warrants prospective investigation. (Source: Advances in Therapy)
Source: Advances in Therapy - July 13, 2017 Category: Drugs & Pharmacology Source Type: research

Intragastric Balloon Treatment for Obesity: Review of Recent Studies
ConclusionBased on the available evidence, it is unlikely that IGB use will supplant other forms of obesity treatment. The estimated cost of endoscopic balloon implantation and retrieval is US $8,150. Collectively, a relatively small control-subtracted %TBWL and the potential for serious complications makes IGB unlikely to become widely adopted. Given the recent FDA warning, IGB longevity on the market is questionable. (Source: Advances in Therapy)
Source: Advances in Therapy - July 13, 2017 Category: Drugs & Pharmacology Source Type: research

Burden of Atopic Dermatitis in the United States: Analysis of Healthcare Claims Data in the Commercial, Medicare, and Medi-Cal Databases
AbstractIntroductionComparative data on the burden of atopic dermatitis (AD) in adults relative to the general population are limited. We performed a large-scale evaluation of the burden of disease among US adults with AD relative to matched non-AD controls, encompassing comorbidities, healthcare resource utilization (HCRU), and costs, using healthcare claims data. The impact of AD disease severity on these outcomes was also evaluated.MethodsAdult AD patients in the Commercial (n = 83,106), Medicare (n = 31,060), and Medi-Cal (n = 5550) databases were matched (1:1) to non-AD controls by demogr...
Source: Advances in Therapy - July 13, 2017 Category: Drugs & Pharmacology Source Type: research

Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays
AbstractNasal blockage is the most bothersome symptom of acute rhinitis. Nasal decongestant sprays containing alpha-sympathomimetics, such as oxymetazoline and xylometazoline, have a rapid onset of action. However, this effect decreases with repeated application and, furthermore, the ciliary function of the nasal mucosa is practically paralyzed. Dexpanthenol promotes cell proliferation and protects the epithelium. Combining these two agents has demonstrated beneficial synergetic effects on the symptoms of acute rhinitis. In a post hoc analysis of a large-scale double-blind, active-controlled study including 152 patients, w...
Source: Advances in Therapy - July 10, 2017 Category: Drugs & Pharmacology Source Type: research

Prevalence of Lower Urinary Tract Symptoms in China, Taiwan, and South Korea: Results from a Cross-Sectional, Population-Based Study
ConclusionsLUTS are highly prevalent in men and women aged at least 40  years who participated in this study in China, Taiwan, and South Korea and increases with increasing age. A minority of individuals with LUTS seek healthcare and our results suggest an increased patient awareness of LUTS is required.FundingAstellas Pharma Singapore Pte. Ltd.Trial registrationClinicalTrials.gov identifier, NCT02618421. (Source: Advances in Therapy)
Source: Advances in Therapy - July 7, 2017 Category: Drugs & Pharmacology Source Type: research

Short-Term Effects of a Combined Nutraceutical on Lipid Level, Fatty Liver Biomarkers, Hemodynamic Parameters, and Estimated Cardiovascular Disease Risk: A Double-Blind, Placebo-Controlled Randomized Clinical Trial
AbstractIntroductionThere is a growing interest in nutraceuticals improving cardiovascular risk factor levels and related organ damage.MethodsThis double-blind, placebo-controlled randomized clinical trial aims to compare the effect of a combined nutraceutical containing red yeast rice (10  mg), phytosterols (800 mg), andl-tyrosol (5  mg) on lipid profile, blood pressure, endothelial function, and arterial stiffness in a group of 60 patients with polygenic hypercholesterolemia resistant to Mediterranean diet.ResultsAfter 8 weeks of treatment, when compared to the placebo group, the active treated patients ex...
Source: Advances in Therapy - July 7, 2017 Category: Drugs & Pharmacology Source Type: research

Update of Ablative Fractionated Lasers to Enhance Cutaneous Topical Drug Delivery
AbstractAblative fractional lasers (AFXL) enhance uptake of therapeutics and this newly emerging field is called laser-assisted drug delivery (LAD). This new science has emerged over the past decade and is finding its way into clinical practice. LAD is poised to change how medicine delivers drugs. Topical and systemic application of pharmaceutical agents for therapeutic effect is an integral part of medicine. With topical therapy, the stratum corneum barrier of the skin impairs the ability of drugs to enter the body. The purpose of LAD is to alter the stratum corneum, epidermis, and dermis to facilitate increased penetrati...
Source: Advances in Therapy - July 7, 2017 Category: Drugs & Pharmacology Source Type: research

Treatment Persistence and Clinical Outcomes of Tumor Necrosis Factor Inhibitor Cycling or Switching to a New Mechanism of Action Therapy: Real-world Observational Study of Rheumatoid Arthritis Patients in the United States with Prior Tumor Necrosis Factor Inhibitor Therapy
ConclusionIn this study, TNFi cycling was common in clinical practice, but switching to a new MOA DMARD was associated with significantly better treatment persistence and a trend toward greater CDAI reduction that was not significant after adjustment for baseline disease activity.FundingSanofi and Regeneron Pharmaceuticals. (Source: Advances in Therapy)
Source: Advances in Therapy - July 3, 2017 Category: Drugs & Pharmacology Source Type: research

A Review of the Long-Term Efficacy, Tolerability, and Safety of Exenatide Once Weekly for Type 2 Diabetes
ConclusionExeOW is a well-tolerated and convenient option for long-term treatment of T2D allowing significant and persistent glycemic control with moderate weight loss and low risk of hypoglycemia unless associated with sulfonylureas. (Source: Advances in Therapy)
Source: Advances in Therapy - July 3, 2017 Category: Drugs & Pharmacology Source Type: research

Monovision Versus Multifocality for Presbyopia: Systematic Review and Meta-Analysis of Randomized Controlled Trials
ConclusionsRandomized comparisons of monovision to multifocality are scarce. Existing estimates regarding spectacle independence (imprecision, indirectness) and particularly regarding unaided VA and CS (assessment/reporting heterogeneity, bias, imprecision, indirectness) are burdened with uncertainty. Dysphotopsia is less common with monovision, but estimate uncertainty is high (bias, imprecision). (Source: Advances in Therapy)
Source: Advances in Therapy - July 3, 2017 Category: Drugs & Pharmacology Source Type: research

Resource Utilization Among Glaucoma Patients in the UK Treated with Beta-Blocker and Non-Beta-Blocker Adjunctive Therapy: A Retrospective Cohort Analysis
This study examined resource usage (number of GP visits and hospitalizations) and diagnoses of respiratory or cardiovascular conditions among glaucoma patients prescribed beta-blockers compared to patients not prescribed beta-blockers.MethodsA retrospective cohort analysis was conducted using data from the UK Clinical Practice Research Datalink (CPRD) database over the period January 1, 2006 to March 31, 2014. Adult patients with at least one diagnosis of glaucoma were categorized into beta-blocker users and non-beta-blocker users. Beta-blocker users were further separated into patients that maintained beta-blocker therapy...
Source: Advances in Therapy - July 1, 2017 Category: Drugs & Pharmacology Source Type: research

Intracameral Dexamethasone Injection as Adjuvant Therapy in Endothelial Immune Reaction After Penetrating and Posterior Lamellar Keratoplasty: A Retrospective Clinical Observation
ConclusionThe ICI seems to be a safe adjuvant approach, which improves therapeutic efficacy of SEIR after keratoplasty. (Source: Advances in Therapy)
Source: Advances in Therapy - June 30, 2017 Category: Drugs & Pharmacology Source Type: research

Assessing the Therapeutic Utility of Professional Continuous Glucose Monitoring in Type 2 Diabetes Across Various Therapies: A Retrospective Evaluation
AbstractBackgroundThere have been few large studies that have analyzed the effect of professional (masked) continuous glucose monitoring (P-CGM) on glycemic control in patients with type 2 diabetes (T2DM) who were on a broad spectrum of baseline therapies.MethodsWe performed a retrospective, blinded evaluation of glycemic control in 296 T2DM adults for 6  months following a 6- to 7-day study of their glycemic profile using masked P-CGM. At baseline, 91% of the patients were on some form of insulin treatment with oral hypoglycemic agents (OHA), while 7% were on one or more OHAs without insulin, and the remaining 2% wer...
Source: Advances in Therapy - June 30, 2017 Category: Drugs & Pharmacology Source Type: research