Effectiveness and Tolerability of Bisoprolol/Perindopril Single-Pill Combination in Patients with Arterial Hypertension and a History of Myocardial Infarction: The PRIDE Observational Study
ConclusionTreatment of symptomatic patients with CAD, hypertension, and a history of MI with a bisoprolol/perindopril SPC was associated with significant decreases in SBP/DBP and a high proportion of patients achieving BP treatment goals. This was accompanied by improvements in angina symptoms and reductions in HR in a broad patient population representative of those seen in everyday clinical practice.Trial RegistrationClinicalTrials.gov Identifier NCT04656847. (Source: Advances in Therapy)
Source: Advances in Therapy - April 8, 2023 Category: Drugs & Pharmacology Source Type: research

A Charter to Fundamentally Change the Role of Oral Corticosteroids in the Management of Asthma
AbstractAsthma affects 339 million people worldwide, with an estimated 5 –10% experiencing severe asthma. In emergency settings, oral corticosteroids (OCS) can be lifesaving, but acute and long-term treatment can produce clinically important adverse outcomes and increase the risk of mortality. Therefore, global guidelines recommend limiting the use of OCS. Despite the risks, research indicates that 40–60% of people with severe asthma are receiving or have received long-term OCS treatment. Although often perceived as a low-cost option, long-term OCS use can result in significant health impairments and costs owing to adv...
Source: Advances in Therapy - April 7, 2023 Category: Drugs & Pharmacology Source Type: research

Predicting Risk of 1-Year Hospitalization Among Patients with Pulmonary Arterial Hypertension
ConclusionsThe US claims-based predictive models showed acceptable performance to predict 1-year hospitalization among patients with PAH. (Source: Advances in Therapy)
Source: Advances in Therapy - April 6, 2023 Category: Drugs & Pharmacology Source Type: research

Safety Surveillance During Drug Development: Comparative Evaluation of Existing Regulations
AbstractDrug safety monitoring is essential for developing efficient and safe treatments. It starts with preclinical toxicology studies and continues with the observation and analysis of potentially harmful effects in humans throughout the whole drug life cycle. Safety surveillance during the clinical phase is of paramount importance for protecting the health of clinical trial (CT) participants at a period when relatively little is known about the drug safety profile, and for reassuring that detected risks are minimized when the product obtains marketing approval. This review aimed to investigate current safety surveillanc...
Source: Advances in Therapy - April 5, 2023 Category: Drugs & Pharmacology Source Type: research

Type  2 Myocardial Infarction and Long-Term Mortality Risk Factors: A Retrospective Cohort Study
ConclusionsThere is significant underdiagnosis of type  2 MI (1.98% out of all MIs). If the patient is prescribed a preventive medication like ACEi or statins, the mortality risk is lower. Increased awareness of elevation of laboratory results could help to improve the treatment of these patients and identify the most vulnerable groups. (Source: Advances in Therapy)
Source: Advances in Therapy - April 5, 2023 Category: Drugs & Pharmacology Source Type: research

Parents ’ Experience of Administering Vosoritide: A Daily Injectable for Children with Achondroplasia
ConclusionsParents and children are resilient to challenges posed by a daily injectable treatment and highly motivated to improve their quality of life. Parents are prepared to overcome short-term treatment challenges for future gains in terms of health and functional independence for their children. Greater support could ensure they have the right information to initiate treatment and manage treatment at home, which will improve parents ’ and children’s experience. (Source: Advances in Therapy)
Source: Advances in Therapy - April 5, 2023 Category: Drugs & Pharmacology Source Type: research

A Response to: Letter to the Editor Regarding “Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Triple Therapy Compared with Other Therapies for the Treatment of COPD: A Network Meta-analysis”
(Source: Advances in Therapy)
Source: Advances in Therapy - April 1, 2023 Category: Drugs & Pharmacology Source Type: research

Letter to the Editor Regarding “Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Triple Therapy Compared with Other Therapies for the Treatment of COPD: A Network Meta-Analysis”
(Source: Advances in Therapy)
Source: Advances in Therapy - April 1, 2023 Category: Drugs & Pharmacology Source Type: research

A Systematic Review of the Economic and Health-Related Quality of Life Impact of Advanced Therapies Used to Treat Moderate-to-Severe Ulcerative Colitis
ConclusionThese findings highlight a high unmet need for therapies for moderate-to-severe UC that can reduce the healthcare burden and impact on society. Further research is warranted, as the reported evidence was limited by the small sample sizes of some treatment groups within a study. (Source: Advances in Therapy)
Source: Advances in Therapy - March 31, 2023 Category: Drugs & Pharmacology Source Type: research

Characteristics and Outcomes in Cases of US Male Patients with Metastatic Breast Cancer Receiving Abemaciclib in Routine Clinical Practice
ConclusionPrevalence of male MBC in this dataset was consistent with expected prevalence in the broader population. Most  male patients received an abemaciclib-containing regimen in ≥ 3L, with anti-cancer activity observed despite heavy metastatic burden and prior treatments in a metastatic setting. (Source: Advances in Therapy)
Source: Advances in Therapy - March 30, 2023 Category: Drugs & Pharmacology Source Type: research

Genetic and Molecular Distinctions Between Axial Psoriatic Arthritis and Radiographic Axial Spondyloarthritis: Post Hoc Analyses from Four Phase  3 Clinical Trials
ConclusionThe differences in HLA genetic associations, serum cytokines, and enrichment scores support the concept that axPsA and r-axSpA may be distinct disorders. The comparable pharmacodynamic effects of guselkumab on cytokine levels and pathway-associated genes observed in patients with axPsA and non-axPsA are consistent with demonstrated clinical improvements across PsA cohorts. These findings contribute to the understanding of potential genetic and molecular distinctions between axPsA and r-axSpA.Trial RegistrationClinicalTrials.gov identifiers, NCT03162796, NCT0315828, NCT02437162, and NCT02438787. (Source: Advances in Therapy)
Source: Advances in Therapy - March 30, 2023 Category: Drugs & Pharmacology Source Type: research

Human Uterine Lavage: First Live Births from In Vivo Conceived Genetically Screened Blastocysts
ConclusionsThis is the first report of live births from genetically screened human euploid blastocysts obtained by uterine lavage. The nonsurgical uterine lavage office procedure represents the only current approach to obtain in vivo conceived embryos and can provide a benchmark for comparison to standard in vitro cultured blastocysts. Live births of in vivo conceived blastocysts represent the validation that the nonsurgical uterine lavage procedure allows simplified access to naturally conceived embryos without performing the surgical procedure of an oocyte aspiration. Owing to its simplicity, uterine lavage may be useful...
Source: Advances in Therapy - March 29, 2023 Category: Drugs & Pharmacology Source Type: research

Correction to: Measuring Self-management Among People with Diabetes Mellitus: A Systematic Review of Patient-Reported Diabetes-Specific Instruments in English and Chinese
(Source: Advances in Therapy)
Source: Advances in Therapy - March 27, 2023 Category: Drugs & Pharmacology Source Type: research

Significance of Dynamic Changes of VCA-IgA Levels in Pre- and Post-treatment Plasma of Patients with Nasopharyngeal Carcinoma: Development of a Clinically-Oriented Model
ConclusionThe proposed VCA-IgA-based nomogram demonstrated a promising ability to predict the DFS of patients with NPC after antitumor therapy. It could be used as a clinical guidance to improve the therapeutic/surveillance strategies of these patients. (Source: Advances in Therapy)
Source: Advances in Therapy - March 25, 2023 Category: Drugs & Pharmacology Source Type: research

Temperature Control After Cardiac Arrest: A Narrative Review
AbstractCardiac arrest (CA) is a critical public health issue affecting more than half a million Americans annually. The main determinant of outcome post-CA is hypoxic –ischemic brain injury (HIBI), and temperature control is currently the only evidence-based, guideline-recommended intervention targeting secondary brain injury. Temperature control is a key component of a post-CA care bundle; however, conflicting evidence challenges its wide implementation across the vastly heterogeneous population of CA survivors. Here, we critically appraise the available literature on temperature control in HIBI, detail how the evidenc...
Source: Advances in Therapy - March 25, 2023 Category: Drugs & Pharmacology Source Type: research