Switching from Biphasic Human Insulin to Premix Insulin Analogs: A Review of the Evidence Regarding Quality of Life and Adherence to Medication in Type 2 Diabetes Mellitus
AbstractDiabetes is a growing public health concern. Effective use of therapies for this chronic disease is necessary to improve long-term prognosis, but treatment adherence can be difficult to promote in clinical practice, and insulin, in particular, can impact both positively and negatively on patients ’ quality of life (QoL). Currently, guidelines advocate for QoL as a treatment goal in its own right, with treatment decisions based on patient concerns regarding injection frequency and adverse events, as well as glycemic control. Successful insulin management ideally requires a regimen to replic ate normal endogeno...
Source: Advances in Therapy - October 13, 2016 Category: Drugs & Pharmacology Source Type: research

Outcomes Following Implantation of Two Second-Generation Trabecular Micro-Bypass Stents in Patients with Open-Angle Glaucoma on One Medication: 18-Month Follow-Up
ConclusionIn this prospective, open-label, single-arm study, the standalone implantation of two second-generation trabecular micro-bypass stents in OAG patients on 1 preoperative medication resulted in IOP reduction to ≤15 mmHg and elimination of medication through 18 months, with favorable safety.Trial RegistrationClinicalTrials.gov identifier, NCT02868190.FundingGlaukos Corporation, San Clemente, CA. (Source: Advances in Therapy)
Source: Advances in Therapy - October 13, 2016 Category: Drugs & Pharmacology Source Type: research

Reward-Induced Eating: Therapeutic Approaches to Addressing Food Cravings
AbstractThe homeostatic controls over eating are inextricably linked to the reward aspects of eating. The result is an integrated response that coordinates the internal milieu with the prevailing environment. Thus, appetite, which reflects a complex interaction among the external environment, behavioral profile, and subjective states as well as the storage and metabolism of energy, has an important role in the regulation of energy balance. In the prevailing food environment which offers an abundance of food choices it is likely that the motivation to consume from a wide range of delectable foods plays a greater role in con...
Source: Advances in Therapy - October 7, 2016 Category: Drugs & Pharmacology Source Type: research

Perceptions of Oncologists, Healthcare Policy Makers, Patients and the General Population on the Value of Pharmaceutical Treatments in Oncology
ConclusionsGains in QoL, survival, safety, cost and innovation are perceived differently by different groups of stakeholders. It is recommended to consider the perspective of different stakeholders in the assessment of a new cancer drugs to obtain more informed decisions when deciding on the most appropriate treatment to use.FundingEli Lilly& Co, Madrid (Spain). (Source: Advances in Therapy)
Source: Advances in Therapy - October 7, 2016 Category: Drugs & Pharmacology Source Type: research

The Role of Panobinostat Plus Bortezomib and Dexamethasone in Treating Relapsed or Relapsed and Refractory Multiple Myeloma: A European Perspective
AbstractPanobinostat is an oral pan-histone deacetylase inhibitor developed by Novartis. Panobinostat acts via epigenetic modification and inhibition of the aggresome pathway. In August 2015, the European Commission authorized panobinostat for use in combination with bortezomib and dexamethasone for the treatment of relapsed or relapsed and refractory multiple myeloma (MM) in patients who have received  ≥2 prior regimens including bortezomib and an immunomodulatory drug. In January 2016, the National Institute for Health and Care Excellence recommended panobinostat for use in the same combination and patient popula...
Source: Advances in Therapy - September 27, 2016 Category: Drugs & Pharmacology Source Type: research

Hip Osteoarthritis: Etiopathogenesis and Implications for Management
AbstractHighly prevalent among the elderly, hip osteoarthritis (OA) carries a heavy burden of disease. Guidelines for the management of hip OA are often extrapolated from knee OA research, despite clear differences in the etiopathogenesis and response to treatments of OA at these sites. We propose that hip OA requires specific attention separate from other OA phenotypes. Our understanding of the etiopathogenesis of hip OA has seen significant advance over the last 15 years, since Ganz and colleagues proposed femoroacetabular impingement (FAI) as an important etiological factor. This narrative review summarizes the current ...
Source: Advances in Therapy - September 26, 2016 Category: Drugs & Pharmacology Source Type: research

Clinical Implications of Switching Lipid Lowering Treatment from Rosuvastatin to Other Agents in Primary Care
ConclusionWe conclude that switching from rosuvastatin to another non-equipotent LLT may impart an increased risk of AMI and should be avoided.FundingAstraZeneca SpA. (Source: Advances in Therapy)
Source: Advances in Therapy - September 26, 2016 Category: Drugs & Pharmacology Source Type: research

Letter to the Editor Regarding: Diabetic Peripheral Neuropathy as a Predictor of Asymptomatic Myocardial Ischemia in Type 2 Diabetes Mellitus: A Cross-Sectional Study
(Source: Advances in Therapy)
Source: Advances in Therapy - September 26, 2016 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness of High Dose Hemodialysis in Comparison to Conventional In-Center Hemodialysis in the Netherlands
ConclusionTreating dialysis patients with conventional HD at home shows to be cost saving in comparison to conventional ICHD. However, the magnitude of clinical benefit of high dose HD at home is over two times greater than the clinical benefit of conventional HD at home. According to our analysis, from a payer ’s perspective, high dose HD should be offered as a home therapy to obtain its clinical benefits in a cost-effective manner. Future research should consider our findings alongside societal factors, such as patient preference, monitoring cost for the home patient, productivity loss and capacity.FundingBaxter BV...
Source: Advances in Therapy - September 23, 2016 Category: Drugs & Pharmacology Source Type: research

A Review of Daclatasvir Drug –Drug Interactions
This article presents an overview of the drug interaction studies conducted during the clinical development of DCV, the findings of these studies that led to the guidance on concomitant medication use and dosage along with any required DCV dose modifications, and th e use of the known metabolic pathway of DCV to guide concomitant dosing where direct drug–drug studies have not been conducted. The robust characterization of the DCV clinical pharmacology program has demonstrated that DCV has few or no clinically relevant DDIs with medications with which it is li kely to be co-administered, and the majority of DDIs that ...
Source: Advances in Therapy - September 23, 2016 Category: Drugs & Pharmacology Source Type: research

A Retrospective Claims Database Study on Drug Utilization in Japanese Patients with Crohn ’s Disease Treated with Adalimumab or Infliximab
ConclusionJapanese patients have a high primary response to anti-tumor necrosis factor therapy in the real-world setting, in line with the results of clinical trials. This initial therapeutic advantage can be lost during the maintenance phase, leading to dose escalation, treatment switch, or discontinuation. This study suggests that those events occurred in comparable proportions of patients treated with either ADA or IFX. However, these findings should be considered with caution given the retrospective nature and small size of the study.FundingAbbvie GK, Tokyo, Japan. (Source: Advances in Therapy)
Source: Advances in Therapy - September 23, 2016 Category: Drugs & Pharmacology Source Type: research

Clinical Evaluation of the Immune Colloidal Gold Method for Rapid Qualitative and Quantitative Measurement of Thyroid-Stimulating Hormone as an Assay for Hypothyroidism
ConclusionBoth ICG-based assays are easier and faster to perform than the third-generation, laboratory-based serum TSH assay method. The ICG-based methods showed acceptable performance in the simplified screening for hypothyroidism.Trial registrationClinicalTrials.gov identifier, NCT01921452.FundingMerck Serono Co., Ltd. (Source: Advances in Therapy)
Source: Advances in Therapy - September 7, 2016 Category: Drugs & Pharmacology Source Type: research

Nonclinical Evaluation of PF-06438179: A Potential Biosimilar to Remicade ® (Infliximab)
ConclusionsThe analytical and nonclinical studies have supported advancement of PF-06438179 into global comparative clinical trials.FundingPfizer Inc. (Source: Advances in Therapy)
Source: Advances in Therapy - September 1, 2016 Category: Drugs & Pharmacology Source Type: research

Methoxyflurane Analgesia in Adult Patients in the Emergency Department: A Subgroup Analysis of a Randomized, Double-blind, Placebo-controlled Study (STOP!)
AbstractIntroductionAcute pain remains highly prevalent in the Emergency Department (ED) setting. This double-blind, randomized, placebo-controlled UK study investigated the efficacy and safety of low-dose methoxyflurane analgesia for the treatment of acute pain in the ED in the adult population of the STOP! trial.MethodsPatients presenting to the ED requiring analgesia for acute pain (pain score of 4 –7 on the Numerical Rating Scale) due to minor trauma were randomized in a 1:1 ratio to receive methoxyflurane (up to 6 mL) or placebo (normal saline), both via a Penthrox® (Medical Developments International L...
Source: Advances in Therapy - August 27, 2016 Category: Drugs & Pharmacology Source Type: research

Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy
AbstractRosacea is a chronic inflammatory disease with transient and non-transient redness as key characteristics. Brimonidine is a selective α2-adrenergic receptor (AR) agonist approved for persistent facial erythema of rosacea based on significant efficacy and good safety data. The majority of patients treated with brimonidine report a benefit; however, there have been sporadic reports of worsening erythema after the initial response. A group of dermatologists, receptor physiology, and neuroimmunology scientists met to explore potential mechanisms contributing to side effects as well as differences in efficacy. We ...
Source: Advances in Therapy - August 25, 2016 Category: Drugs & Pharmacology Source Type: research

Erratum to: Comparative Analysis of Length of Stay and Inpatient Costs for Orthopedic Surgery Patients Treated with IV Acetaminophen and IV Opioids vs. IV Opioids Alone for Post-Operative Pain
(Source: Advances in Therapy)
Source: Advances in Therapy - August 25, 2016 Category: Drugs & Pharmacology Source Type: research

Management and Outcome of Periprocedural Cardiac Perforation and Tamponade with Radiofrequency Catheter Ablation of Cardiac Arrhythmias: A Single Medium-Volume Center Experience
ConclusionIncidence of RFA-related CT in our medium-volume center was low and significantly associated with AF ablation. The outcome of CT was mostly favorable after pericardiocentesis, but readily accessible cardiothoracic surgery back-up should be mandatory in RFA centers. (Source: Advances in Therapy)
Source: Advances in Therapy - August 23, 2016 Category: Drugs & Pharmacology Source Type: research

Diabetic Peripheral Neuropathy as a Predictor of Asymptomatic Myocardial Ischemia in Type 2 Diabetes Mellitus: A Cross-Sectional Study
AbstractIntroductionDiabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and has been associated with cardiovascular disease, the leading cause of mortality in diabetes. As asymptomatic myocardial ischemia (MI) is frequent in diabetes, we hypothesized that DPN may be associated with MI in patients with type 2 diabetes mellitus and no history of cardiovascular events.MethodsEighty-two patients with DPN (n = 41) or without DPN (n = 41) were included. Among the DPN group, 15 had active foot ulcers. All subjects underwent Technetium-99 m sestamibi single-photon emiss...
Source: Advances in Therapy - August 23, 2016 Category: Drugs & Pharmacology Source Type: research

Misoprostol Vaginal Insert in Labor Induction: A Cost –Consequences Model for 5 European Countries—An Economic Evaluation Supported with Literature Review and Retrospective Data Collection
ConclusionsIOL with the use of MVI generated savings from a hospital perspective in most countries and scenarios, in comparison to alternative technologies.FundingSponsorship, article processing charges, and the open access charge for this study were funded by Ferring Pharmaceuticals Poland. (Source: Advances in Therapy)
Source: Advances in Therapy - August 22, 2016 Category: Drugs & Pharmacology Source Type: research

A Systematic Review and Network Meta-Analysis to Evaluate the Comparative Efficacy of Interventions for Unfit Patients with Chronic Lymphocytic Leukemia
ConclusionG-Clb is likely to show superior efficacy to other treatment options selected in our NMA for unfit treatment-na ïve patients with CLL.FundingF. Hoffmann-La Roche Ltd. (Source: Advances in Therapy)
Source: Advances in Therapy - August 17, 2016 Category: Drugs & Pharmacology Source Type: research

Self-Care in the Twenty First Century: A Vital Role for the Pharmacist
This article was developed to describe global healthcare trends affecting self-care with a specific focus on the role of the pharmacist in facilitating over-the-counter (OTC) medication management. Potential healthcare-related economic benefits associated with the self-care model are outlined. The importance of the collaboration between healthcare providers (HCPs), including specialists, primary care providers, and pharmacists, is also discussed. The evolving role of the pharmacist is examined and recommendations are provided for ways to successfully engage with other HCPs and consumers to optimize the pharmacist ’s ...
Source: Advances in Therapy - August 17, 2016 Category: Drugs & Pharmacology Source Type: research

Systematic Review of Current Devices for 24-h Intraocular Pressure Monitoring
This article is a systematic review of current and future technologies for measuring IOP over a 24-h period. (Source: Advances in Therapy)
Source: Advances in Therapy - August 16, 2016 Category: Drugs & Pharmacology Source Type: research

Simple Predictive Model for Identifying Patients with Chronic Hepatitis C and Hepatitis C Virus Genotype 4 Infection with a High Probability of Sustained Virologic Response with Peginterferon Alfa-2a/Ribavirin: Pooled Analysis of Data from Two Large, International Cohort Studies
AbstractIntroductionWherever access to direct-acting antiviral agents is restricted, dual peginterferon/ribavirin (PegIFN/RBV) therapy remains an option for treatment of hepatitis C virus (HCV) genotype 4 (GT4) infection, which predominates in the Middle East and Sub-Saharan Africa. Our goal was to develop a baseline scoring system to identify GT4-infected patients with a low or high probability of achieving a sustained virologic response (SVR) with PegIFN alfa-2a/RBV using data from two large cohort studies.MethodsAssociations between baseline characteristics and SVR were explored by generalized additive models and multip...
Source: Advances in Therapy - August 12, 2016 Category: Drugs & Pharmacology Source Type: research

Gastroenterologists ’ Perceptions Regarding Ulcerative Colitis and Its Management: Results from a Large-Scale Survey
This study assessed physicians ’ perceptions of UC, concepts of disease severity and remission, and treatment goals.MethodsGastroenterologists who typically treated ≥10 adults with UC per month were recruited for a large-scale, web-based survey. Participants were asked about their perceptions of UC (often vs. Crohn’s disease [CD]), treatment goals, and medication use. Response data were evaluated via descriptive statistics and univariate and multivariable a nalyses.ResultsGastroenterologists (N = 500) with a mean of 16.5 years (standard deviation, 8.7 years) in practice participated. In c...
Source: Advances in Therapy - August 10, 2016 Category: Drugs & Pharmacology Source Type: research

Patients ’ Perspective of Medication Adherence in Chronic Conditions: A Qualitative Study
ConclusionOur results highlight how the patient –prescriber’s relationship and factors such as health beliefs, motivation and perception of illness control impact on medication adherence in chronic patients. Future interventions to optimize adherence to treatment should focus on shared decision-making and more extensive health education.FundingCelgene Corporation. (Source: Advances in Therapy)
Source: Advances in Therapy - August 9, 2016 Category: Drugs & Pharmacology Source Type: research

Impact of Treatment with Naloxegol for Opioid-Induced Constipation on Patients ’ Health State Utility
ConclusionThese analyses suggest that treatment with naloxegol improves patients ’ health state utility; driven predominantly by the relief of patients’ constipation.FundingAstraZeneca. (Source: Advances in Therapy)
Source: Advances in Therapy - August 1, 2016 Category: Drugs & Pharmacology Source Type: research

Factors and Regional Differences Associated with Endometriosis: A Multi-Country, Case –Control Study
ConclusionThe findings provide insight into potential risk factors for endometriosis and differences between regions in terms of endometriosis management and symptomatology. Further investigations are required to confirm the associations found in this study.Trial registrationClinicalTrials.gov identifier, NCT01351051.FundingIpsen. (Source: Advances in Therapy)
Source: Advances in Therapy - August 1, 2016 Category: Drugs & Pharmacology Source Type: research

Short-Term Cardioprotective Effects of the Original Perindopril/Amlodipine Fixed-Dose Combination in Patients with Stable Coronary Artery Disease: Results of the PAPA-CAD Study
Conclusion The fixed-dose combination of perindopril and amlodipine improved the CCS class and exercise capacity in patients with SCAD after 6  months of treatment. The fixed-dose combination of perindopril and amlodipine can have favorable effects on the cardiovascular system, not only by its BP-lowering effect and its effect on vascular resistance but also through its direct cardiovascular protective effects. Funding Egis Pharmaceuticals. Trial registration 21938-1/2011-EKU (698/PI/11.) (Source: Advances in Therapy)
Source: Advances in Therapy - July 30, 2016 Category: Drugs & Pharmacology Source Type: research

Reliability and Responsiveness of NutriQoL ® Questionnaire
Conclusion NutriQoL is a reliable and unique instrument to measure the HRQoL in HEN patients. NutriQoL detects changes in the health status of the patient. Nevertheless, further research is needed to determine the full extent of the questionnaire responsiveness. (Source: Advances in Therapy)
Source: Advances in Therapy - July 28, 2016 Category: Drugs & Pharmacology Source Type: research

Erratum to: Development and Evaluation of a New Technological Way of Engaging Patients and Enhancing Understanding of Drug Tolerability in Early Clinical Development: PROACT
(Source: Advances in Therapy)
Source: Advances in Therapy - July 27, 2016 Category: Drugs & Pharmacology Source Type: research

The Role of the Pharmacist in the Treatment of Patients with Infantile Hemangioma Using Propranolol
Conclusion It seems that pharmacist participation increases adherence to treatment and reduces the likelihood of adverse effects, allowing for safe and effective therapy in patients with IH. (Source: Advances in Therapy)
Source: Advances in Therapy - July 26, 2016 Category: Drugs & Pharmacology Source Type: research

Long-term Safety and Efficacy of Latanoprostene Bunod 0.024% in Japanese Subjects with Open-Angle Glaucoma or Ocular Hypertension: The JUPITER Study
Conclusion Once daily LBN ophthalmic solution 0.024% was safe and well-tolerated in Japanese subjects with OAG or OHT when used for up to 1  year. Long-term treatment with LBN ophthalmic solution 0.024% provided significant and sustained IOP reduction. Trial registration ClinicalTrials.gov identifier, NCT01895972. Funding Bausch & amp; Lomb, Inc. a division of Valeant Pharmaceuticals International Inc. (Source: Advances in Therapy)
Source: Advances in Therapy - July 25, 2016 Category: Drugs & Pharmacology Source Type: research

Impact of Warfarin on Atrial-Fibrillation Outcomes Related to Economic Consumption Patterns: Hospitalization, Cost, and Mortality may be Predictable and Modifiable at the Population Level
Conclusions These data signal that a nontrivial portion of acute events (hospitalization and mortality) are amenable to medical intervention (warfarin). When acute events are amenable to medical intervention and occur at a higher frequency because guidelines have not been applied evenly across affected populations, it is appropriate to define those occurrences as disparities associated with systemic failure in evidence-based medicine. Quality-improvement initiatives that reduce therapeutic disparities may result in lower cost and improved outcomes. Funding No funding or sponsorship was received for this study or public...
Source: Advances in Therapy - July 25, 2016 Category: Drugs & Pharmacology Source Type: research

The Cost-Effectiveness of Ranibizumab Treat and Extend Regimen Versus Aflibercept in the UK
Conclusion This evaluation suggests that treating patients with ranibizumab according to the T & amp;E regimen could be a better use of NHS resources than aflibercept, and could, therefore, be considered as a first-line regimen for patients with wet AMD in the UK. Funding Novartis Pharmaceuticals UK Limited. (Source: Advances in Therapy)
Source: Advances in Therapy - July 25, 2016 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic Properties of Oral Lafutidine Tablets and the Effect of Food on its Pharmacokinetics in Healthy Chinese Subjects
Conclusion The PK of lafutidine showed dose proportionality. There was no significant accumulation of lafutidine tablets with multiple dosing. Food did not affect the degree of lafutidine absorption, but it did reduce the rate of absorption. Further study is needed regarding the effect of gender on lafutidine. Lafutidine was well tolerated within the dose range 10 –40 mg, and no serious adverse events were observed. (Source: Advances in Therapy)
Source: Advances in Therapy - July 21, 2016 Category: Drugs & Pharmacology Source Type: research

Additive Intraocular Pressure Lowering Effects of the Rho Kinase Inhibitor, Ripasudil in Glaucoma Patients Not Able to Obtain Adequate Control After Other Maximal Tolerated Medical Therapy
Conclusions Use of ripasudil as an adjunctive therapy resulted in lowering of the IOP. Ripasudil was well tolerated. Funding Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (26462689). (Source: Advances in Therapy)
Source: Advances in Therapy - July 20, 2016 Category: Drugs & Pharmacology Source Type: research

Topical Ivermectin 10  mg/g and Oral Doxycycline 40 mg Modified-Release: Current Evidence on the Complementary Use of Anti-Inflammatory Rosacea Treatments
Abstract Rosacea is a common, chronic inflammatory skin disease that can present with a variety of signs and symptoms. The potentially simultaneous occurrence of different signs and symptoms is due to different underlying inflammatory pathways, emphasizing the need for complementary treatment approaches. Topical ivermectin cream (10  mg/g) and systemic, oral anti-inflammatory doxycycline (40 mg modified-release) are both approved for the treatment of papulopustular rosacea (PPR). Whether or not a combined therapeutic approach may be more beneficial than monotherapy for patients with PPR remains to be tested. Here, we...
Source: Advances in Therapy - July 18, 2016 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics and Safety of Triple Therapy with Vonoprazan, Amoxicillin, and Clarithromycin or Metronidazole: A Phase 1, Open-Label, Randomized, Crossover Study
Conclusion In healthy Japanese male subjects, triple therapy with vonoprazan–amoxicillin–clarithromycin increased vonoprazan and clarithromycin exposure. The safety and tolerability profile of triple therapy with vonoprazan–amoxicillin–clarithromycin or vonoprazan–amoxicillin–metronidazole was favorable in this population. Funding Takeda Pharmaceutical Company Ltd. Trial registration JapicCTI-153102. (Source: Advances in Therapy)
Source: Advances in Therapy - July 18, 2016 Category: Drugs & Pharmacology Source Type: research

Effectiveness and Tolerability of Ivabradine with or Without Concomitant Beta-Blocker Therapy in Patients with Chronic Stable Angina in Routine Clinical Practice
Abstract Introduction In the prospective, open-label, non-interventional, multicenter RESPONSIfVE study, the effectiveness, response rates and tolerability of ivabradine with or without beta blocker (BB) were evaluated in patients with chronic stable angina pectoris (AP) in daily clinical practice. Methods In patients with AP, ivabradine was given twice daily in flexible doses for 4 months. Resting heart rate (HR), number of angina attacks, short-acting nitrate use, severity of symptoms [by Canadian Cardiovascular Society (CCS) score] and tolerabili...
Source: Advances in Therapy - July 18, 2016 Category: Drugs & Pharmacology Source Type: research

Topical Ivermectin 10 mg/g and Oral Doxycycline 40 mg Modified-Release: Current Evidence on the Complementary Use of Anti-Inflammatory Rosacea Treatments
Abstract Rosacea is a common, chronic inflammatory skin disease that can present with a variety of signs and symptoms. The potentially simultaneous occurrence of different signs and symptoms is due to different underlying inflammatory pathways, emphasizing the need for complementary treatment approaches. Topical ivermectin cream (10 mg/g) and systemic, oral anti-inflammatory doxycycline (40 mg modified-release) are both approved for the treatment of papulopustular rosacea (PPR). Whether or not a combined therapeutic approach may be more beneficial than monotherapy for patients with PPR remains to be tested. H...
Source: Advances in Therapy - July 18, 2016 Category: Drugs & Pharmacology Source Type: research

Sodium-Glucose Cotransporter-2 Inhibition and the Glomerulus: A Review
Abstract Blood glucose-lowering treatment options generally target insulin action or beta-cell function. In diabetes, expression of the sodium-glucose cotransporter-2 (SGLT2) genes is up-regulated and renal threshold increased, resulting in increased glucose reabsorption from glomerular filtrate, reducing urinary glucose excretion and worsening the hyperglycemic condition. The SGLT2 inhibitors (SGLT2i) are a novel class of anti-diabetic drugs that lower blood glucose levels through the suppression of renal glucose reabsorption thereby promoting renal glucose excretion. The efficacy of SGLT2i is reduced in renal im...
Source: Advances in Therapy - July 16, 2016 Category: Drugs & Pharmacology Source Type: research

Fentanyl Iontophoretic Transdermal System (IONSYS ® ) can be Safely used in the Hospital Environment with X-Rays, Computerized Tomography and Radiofrequency Identification Devices
Conclusion The performance of the ITS system was unaffected by X-ray exposure levels well beyond those associated with diagnostic X-rays and CT scans, and by exposure to radiofrequency field strengths typically generated by RFID devices. These results provide added confidence to clinicians that the fentanyl ITS system does not need to be removed during diagnostic X-rays and CT scans and can also be utilized in close proximity to RFID devices. Funding The studies and writing of this manuscript were supported financially by The Medicines Company. (Source: Advances in Therapy)
Source: Advances in Therapy - July 16, 2016 Category: Drugs & Pharmacology Source Type: research

Comparative Analysis of Length of Stay and Inpatient Costs for Orthopedic Surgery Patients Treated with IV Acetaminophen and IV Opioids vs. IV Opioids Alone for Post-Operative Pain
Abstract Introduction Recovery from orthopedic surgery is oriented towards restoring functional health outcomes while reducing hospital length of stay (LOS) and medical expenditures. Optimal pain management is a key to reaching these objectives. We sought to compare orthopedic surgery patients who received combination intravenous (IV) acetaminophen and IV opioid analgesia to those who received IV opioids alone and compared the two groups on LOS and hospitalization costs. Methods We performed a retrospective analysis of the Premier Database (Premier, Inc....
Source: Advances in Therapy - July 16, 2016 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness of Pharmacogenomic and Pharmacogenetic Test-Guided Personalized Therapies: A Systematic Review of the Approved Active Substances for Personalized Medicine in Germany
Conclusion Pharmacogenetic testing constitutes an opportunity to improve the CE of pharmacotherapy. The CE of targeted therapies depends on various factors including costs, prevalence of biomarkers, and test sensitivity and specificity. To guarantee the CE comparability of stratified drug therapies, national and international standards for evaluation studies should be defined. (Source: Advances in Therapy)
Source: Advances in Therapy - July 12, 2016 Category: Drugs & Pharmacology Source Type: research

Assessment of Factors Related to the Understanding of Education and Knowledge of Self-Care among Patients with Diabetes Mellitus: A Cross-Sectional Prospective Study
Conclusion Education about diabetes can significantly improve knowledge of self-care management and can help in achieving glycemic control. Continuing education about self-care management and complications is crucial and this should be accompanied by a regular assessment of pateients’ diabetic knowledge. (Source: Advances in Therapy)
Source: Advances in Therapy - July 11, 2016 Category: Drugs & Pharmacology Source Type: research

Sulodexide in Patients with Chronic Venous Disease of the Lower Limbs: Clinical Efficacy and Impact on Quality of Life
Abstract Introduction Chronic venous disease (CVD) of the lower limbs is a common problem. It is more prevalent in women than in men and has a significant impact on patients’ quality of life (QoL) and on the healthcare system. The aim of this study was to evaluate the efficacy of sulodexide in adult patients with CVD of the lower limbs and its effect on patients’ QoL. Methods Patients with CVD were treated with sulodexide [250 LSU (lipasemic units) twice daily] for 3 months in a setting of real-life clinical practice. The endpoints ...
Source: Advances in Therapy - July 11, 2016 Category: Drugs & Pharmacology Source Type: research

A Cost-Effectiveness Analysis of Clopidogrel for Patients with Non-ST-Segment Elevation Acute Coronary Syndrome in China
Conclusion This analysis suggests that treatment with clopidogrel plus ASA for up to 1 year for patients with NSTEACS is cost effective in the local context of China from a public payers’ perspective. Funding Sanofi China. (Source: Advances in Therapy)
Source: Advances in Therapy - July 11, 2016 Category: Drugs & Pharmacology Source Type: research

Making Insulin Accessible: Does Inhaled Insulin Fill an Unmet Need?
Abstract Glycemic control is fundamental to the management of diabetes. However, studies suggest that a significant proportion of people with diabetes, particularly those using insulin, are not achieving glycemic targets. The reasons for this are likely to be multifactorial. The real and perceived risk of hypoglycemia and the need for multiple daily injections are widely recognized as key barriers to effective insulin therapy. Therefore, there is a clear unmet need for a treatment option which can help mitigate these barriers. Alternative methods of insulin administration have been under investigation for several ...
Source: Advances in Therapy - July 6, 2016 Category: Drugs & Pharmacology Source Type: research

Effects of Brinzolamide, a Topical Carbonic Anhydrase Inhibitor, on Corneal Endothelial Cells
Abstract Introduction This clinical study aimed to investigate the effect of brinzolamide, a topical carbonic anhydrase inhibitor, on corneal endothelial cells (CECs) in patients with glaucoma using a follow-up clinical study design. Methods Patients with primary open-angle glaucoma or ocular hypertension were administrated an ophthalmic solution of either latanoprost alone (LT) as a control (n = 18) or latanoprost plus brinzolamide (LT + BR; n = 16). CECs were examined at baseline and at 4, 12, 24, and 48 weeks in 18 a...
Source: Advances in Therapy - July 6, 2016 Category: Drugs & Pharmacology Source Type: research

Efficacy and Treatment Costs of Monotherapy with bDMARDs in the Treatment of Rheumatoid Arthritis in Patients Intolerant to or Inappropriate to Continue Treatment with Methotrexate
Conclusion TCZ is a cost-effective therapeutic option compared to other tumor necrosis factor-α inhibitors (ADA, ETA, CTZ) as first-line monotherapy for patients who are intolerant to MTX, or for whom it is inappropriate to continue treatment with MTX. Funding Roche SpA. (Source: Advances in Therapy)
Source: Advances in Therapy - July 4, 2016 Category: Drugs & Pharmacology Source Type: research