Cost-Effectiveness Analysis of Pembrolizumab as an Adjuvant Treatment of Resected Stage IIB or IIC Melanoma in the United States
ConclusionAs an adjuvant treatment of stage IIB or IIC melanoma, pembrolizumab was estimated to reduce recurrence, extend patients ’ life and QALYs, and be cost-effective versus observation at a US willingness-to-pay threshold. (Source: Advances in Therapy)
Source: Advances in Therapy - May 16, 2023 Category: Drugs & Pharmacology Source Type: research

Real-World Apremilast Use for Treatment of Plaque Psoriasis in Italy: Patient Perspective, Characteristics, and Clinical Outcomes from the DARWIN Study
ConclusionsPatients treated with apremilast for 6  months in Italian clinical practice reported improved QoL, clinically relevant improvements in symptoms, high treatment satisfaction, and high treatment persistence. Our data indicate apremilast is a valuable treatment option for moderate plaque psoriasis.Study RegistrationClinicalTrials.gov identifier, NCT04031027. (Source: Advances in Therapy)
Source: Advances in Therapy - May 12, 2023 Category: Drugs & Pharmacology Source Type: research

An Economic Analysis of Transjugular Intrahepatic Portosystemic Covered Stent Shunt for Variceal Bleeding and Refractory Ascites in a Spanish Setting
ConclusionsTIPSS is likely to be a cost-effective and a cost-saving treatment in patients with cirrhosis in indications 1 and 2, compared with standard treatments. The analyses estimate clinical benefits along with reduced healthcare costs from avoided downstream resource consumption. (Source: Advances in Therapy)
Source: Advances in Therapy - May 9, 2023 Category: Drugs & Pharmacology Source Type: research

Eliciting Patient Insights on the Burden of Nontuberculous Mycobacterial Lung Disease (NTM-LD) and Healthcare Gaps in Germany Through Qualitative Semi-structured Interviews
ConclusionsNTM-LD can considerably impair the lives of patients and their families and/or caregivers. A multidisciplinary approach and establishment of more widespread regional expert centers for NTM-LD management in Germany with well-structured referral and communication pathways accompanied by peer-to-peer support of patient advocacy groups are urgently needed. (Source: Advances in Therapy)
Source: Advances in Therapy - May 8, 2023 Category: Drugs & Pharmacology Source Type: research

Safety and Effectiveness of Vedolizumab in Patients with Moderate-to-Severe Ulcerative Colitis: An Interim Analysis of a Japanese Post-Marketing Surveillance Study
ConclusionThe results confirm a safety and effectiveness profile of vedolizumab consistent with that observed in previous trials.Clinical Trial RegistrationJapicCTI-194603, NCT03824561. (Source: Advances in Therapy)
Source: Advances in Therapy - May 4, 2023 Category: Drugs & Pharmacology Source Type: research