Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis.
CONCLUSION: The clinical disease activity under EPO treatment correlates with the individual increase in plasma GLA levels. Thus, the results of this pilot study indicate that an increase in plasma GLA might be used as predictive parameter for responsiveness of AD to EPO therapy. PMID: 24435467 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - January 17, 2014 Category: Drugs & Pharmacology Authors: Simon D, Eng PA, Borelli S, Kägi R, Zimmermann C, Zahner C, Drewe J, Hess L, Ferrari G, Lautenschlager S, Wüthrich B, Schmid-Grendelmeier P Tags: Adv Ther Source Type: research

Effect of β-Glucan on Drain Fluid and Amount of Drainage Following Modified Radical Mastectomy.
Effect of β-Glucan on Drain Fluid and Amount of Drainage Following Modified Radical Mastectomy. Adv Ther. 2014 Jan 14; Authors: Yenidogan E, Akgul GG, Gulcelik MA, Dinc S, Colakoglu MK, Kayaoglu HA Abstract INTRODUCTION: To reduce the seroma formation following mastectomy and axillary dissection, many different techniques and drugs have been investigated. The aim of this study is to evaluate the effects of oral β-glucan on drain fluid and efficacy of daily drainage and drain removal day in mastectomy patients. METHODS: One hundred and thirty breast cancer patients of Ankara Oncology Training...
Source: Advances in Therapy - January 14, 2014 Category: Drugs & Pharmacology Authors: Yenidogan E, Akgul GG, Gulcelik MA, Dinc S, Colakoglu MK, Kayaoglu HA Tags: Adv Ther Source Type: research

Zofenopril Plus Hydrochlorothiazide and Irbesartan Plus Hydrochlorothiazide in Previously Treated and Uncontrolled Diabetic and Non-diabetic Essential Hypertensive Patients.
CONCLUSION: In previously monotherapy-treated, uncontrolled patients with hypertension, zofenopril 30-60 mg + HCTZ 12.5 mg is as effective as irbesartan 150-300 mg plus HCTZ 12.5 mg, with the added value of a potential protective effect against vascular inflammation. PMID: 24415271 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - January 11, 2014 Category: Drugs & Pharmacology Authors: Agabiti-Rosei E, Manolis A, Zava D, Omboni S Tags: Adv Ther Source Type: research

Pharmacoeconomic Outcomes for Pregabalin: A Systematic Review in Neuropathic Pain, Generalized Anxiety Disorder, and Epilepsy from a Spanish Perspective.
CONCLUSION: The majority of published evidence supports the possibility that pregabalin could be a cost-effective and/or cost-saving alternative for the treatment of refractory epilepsy, GAD, and neuropathic pain, in both treatment-naïve patients and in those who have demonstrated inadequate response or intolerance to previous therapy. PMID: 24390901 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - January 4, 2014 Category: Drugs & Pharmacology Authors: Darbà J, Kaskens L, Pérez C, Alvarez E, Navarro-Artieda R, Sicras-Mainar A Tags: Adv Ther Source Type: research

Effect of Metformin on Ballooning Degeneration in Nonalcoholic Steatohepatitis (NASH): When to Use Metformin in Nonalcoholic Fatty Liver Disease (NAFLD).
Abstract The key histologic feature of nonalcoholic steatohepatitis (NASH) is hepatocellular ballooning (HB). It plays an important role in NASH progression and is an independent predictor of liver mortality. In this review, we identified all studies using metformin in the treatment of nonalcoholic fatty liver disease (NAFLD) that included pre- and post-treatment liver biopsies. We specifically reviewed the effects of metformin on HB. Improved HB was noted in pediatric populations and in those adult patients who were able to lose weight and improve or normalize transaminases during therapy. Previous studies have s...
Source: Advances in Therapy - January 3, 2014 Category: Drugs & Pharmacology Authors: Doycheva I, Loomba R Tags: Adv Ther Source Type: research

Efficacy of Sublingual Fentanyl vs. Oral Morphine for Cancer-Related Breakthrough Pain.
iso I, Velázquez Clavarana L Abstract INTRODUCTION: Breakthrough cancer pain (BTcP) is recognized as a clinically significant complication of chronic cancer pain with most BTcP episodes peaking in intensity within a few minutes and lasting for approximately 30 min. Although a number of rapid-onset fentanyl preparations have been developed in the last decade, BTcP is still typically managed through the use of rescue doses of oral morphine but a comparative study of sublingual fentanyl and oral morphine is still lacking. The aim of this study was to determine the efficacy, tolerability, and patient satis...
Source: Advances in Therapy - January 3, 2014 Category: Drugs & Pharmacology Authors: Velázquez Rivera I, Muñoz Garrido JC, García Velasco P, España Ximénez de Enciso I, Velázquez Clavarana L Tags: Adv Ther Source Type: research

Enteric-Coated Aspirin Versus Other Antiplatelet Drugs in Acute Non-Cardioembolic Ischemic Stroke: Post-marketing Study in Japan.
CONCLUSION: It seems that these results showed the safety and efficacy of the enteric-coated aspirin in acute stroke care in Japanese patients. Incidence of hemorrhagic events was comparable between the enteric-coated aspirin group and the other antiplatelet drugs group. PMID: 24385407 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - January 3, 2014 Category: Drugs & Pharmacology Authors: Takahashi S, Mizuno O, Sakaguchi T, Yamada T, Inuyama L Tags: Adv Ther Source Type: research

Methylphenidate Hydrochloride Modified-Release in Adults with Attention Deficit Hyperactivity Disorder: A Randomized Double-Blind Placebo-Controlled Trial.
Abstract INTRODUCTION: Treatment options for adults with attention deficit hyperactivity disorder (ADHD) are limited. The study was conducted to confirm the clinically effective and safe dose of methylphenidate hydrochloride modified-release (MPH-LA) in adults with ADHD and evaluate the maintenance of effect of MPH-LA. METHODS: The study consisted of three treatment phases. The double-blind dose-confirmation phase: 9-week double-blind period (3-week titration period, 6-week fixed dose) with randomization to MPH-LA 40, 60, or 80 mg/day or placebo. The real-life dose-optimization phase: a 5-week re-titrati...
Source: Advances in Therapy - December 27, 2013 Category: Drugs & Pharmacology Authors: Huss M, Ginsberg Y, Tvedten T, Arngrim T, Philipsen A, Carter K, Chen CW, Kumar V Tags: Adv Ther Source Type: research

Erratum to: Additive Postprandial Glucose-Lowering Effects of Mitiglinide and Sitagliptin in Patients with Type 2 Diabetes Mellitus.
PMID: 24353067 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - December 19, 2013 Category: Drugs & Pharmacology Authors: Jung JA, Kaku K, Kim JH, Kim JR, Ko JW, Lee SY, Huh W Tags: Adv Ther Source Type: research

Use of Plasma in the Management of Central Nervous System Bleeding: Evidence-Based Consensus Recommendations.
CONCLUSION: The Panel considered plasma to be reasonable therapy for CNS hemorrhage requiring urgent correction of coagulopathy, although physicians should be prepared for potential cardiopulmonary complications, and evidence suggests that alternative therapies have superior risk-benefit profiles. Plasma could not be recommended in the absence of hemorrhage or coagulopathy. Consideration of the absolute risks and benefits of plasma therapy before transfusion is imperative. PMID: 24338742 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - December 14, 2013 Category: Drugs & Pharmacology Authors: Shander A, Michelson EA, Sarani B, Flaherty ML, Shulman IA Tags: Adv Ther Source Type: research

Correlation of the Coronary Severity Scores and Mean Platelet Volume in Diabetes Mellitus.
This study aimed to assess relationship between MVP and the severity of coronary atherosclerosis in patients with diabetes mellitus (DM), stable CAD and normal left ventricular ejection fractions. METHODS: Thirty-three DM and 46 nonDM patients with stable CAD diagnosed by selective coronary angiography were included in the study. All angiographic variables pertinent to Gensini score (GS) and Syntax score (SS) calculation were computed by two experienced interventional cardiologists. All patients underwent echocardiographic examination. MPV and other biochemical markers were measured on admission. RESULTS: All pat...
Source: Advances in Therapy - December 7, 2013 Category: Drugs & Pharmacology Authors: Abalı G, Akpınar O, Söylemez N Tags: Adv Ther Source Type: research

Retrospective Analysis of First-Line Anti-Vascular Endothelial Growth Factor Treatment Patterns in Wet Age-Related Macular Degeneration.
CONCLUSION: Aflibercept and ranibizumab were used at a similar frequency resulting in similar intravitreal anti-VEGF injection healthcare expenditures among wet AMD patients initiating first-line intravitreal anti-VEGF treatment. PMID: 24310208 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - December 6, 2013 Category: Drugs & Pharmacology Authors: Johnston SS, Wilson K, Huang A, Smith D, Varker H, Turpcu A Tags: Adv Ther Source Type: research

The Real-World Dose-Relativity of Sevelamer Hydrochloride and Lanthanum Carbonate Monotherapy in Patients with End-Stage Renal Disease.
CONCLUSION: In this post hoc analysis of real-world dose-relativity, the overall SH:LC dose-relativity ratio was 2.8 (median individual patient ratio 2.6 (95% CI 2.6-2.8). These findings are consistent with the World Health Organization-defined daily dose and previous studies of the relative phosphate binding capacity of the two drugs. Patients requiring SH doses>7,200 mg/day had higher SH:LC dose-relativities of 3.1-4.2 (median individual patient ratios 3.1-4.0). These findings have implications for the tablet burden and cost-effectiveness of SH and LC in the treatment of hyperphosphatemia. PMID: 24307220 [Pu...
Source: Advances in Therapy - December 5, 2013 Category: Drugs & Pharmacology Authors: Wilson RJ, Keith MS, Preston P, Copley JB Tags: Adv Ther Source Type: research

Comparative Short-Term Effect of Once-Daily Molsidomine on Chronic Angina in General Practitioners' versus Cardiologists' Coronary Patient Populations.
CONCLUSION: Despite significant demographic and clinical differences between patients in care of GPs and cardiologists, molsidomine was equally efficient in these two patient cohorts, with a trend towards less anginal attacks in the elderly when treated with the 16 mg compared with the 8 mg formulation. Compliance and tolerability to the drug were excellent in both patient cohorts. PMID: 24307221 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - December 4, 2013 Category: Drugs & Pharmacology Authors: Messin R Tags: Adv Ther Source Type: research

The INITIATOR Study: Pilot Data on Real-World Clinical and Economic Outcomes in US Patients with Type 2 Diabetes Initiating Injectable Therapy.
Abstract INTRODUCTION: Type 2 diabetes mellitus (T2DM) progression often results in treatment intensification with injectable therapy to maintain glycemic control. Using pilot data from the Initiation of New Injectable Treatment Introduced after Anti-diabetic Therapy with Oral-only Regimens study, real-world treatment patterns among T2DM patients initiating injectable therapy with insulin glargine or liraglutide were assessed. METHODS: This was a retrospective analysis of claims from the OptumInsight™ (OI; January 1, 2010 to July 30, 2010) and HealthCore(®) (HC; January 1, 2010 to June 1, 2010) heal...
Source: Advances in Therapy - November 30, 2013 Category: Drugs & Pharmacology Authors: Thayer S, Wei W, Buysman E, Brekke L, Crown W, Grabner M, Raparla S, Quimbo R, Cziraky MJ, Hu W, Cuddihy R Tags: Adv Ther Source Type: research

The Fixed-Dose Combination of Olmesartan/Amlodipine Was Superior in Central Aortic Blood Pressure Reduction Compared with Perindopril/Amlodipine: A Randomized, Double-Blind Trial in Patients with Hypertension.
Abstract INTRODUCTION: Central blood pressure (BP), an important measure of cardiovascular risk, has been shown to be effectively reduced by calcium channel blockade with amlodipine (AML) plus renin-angiotensin system blockade by the angiotensin-converting enzyme inhibitor, perindopril (PER). The aim of the SEVITENSION study was to compare the central effects of PER/AML against renin-angiotensin system blockade with the angiotensin II receptor blocker olmesartan (OLM) plus AML. METHODS: In this multicenter, parallel group, non-inferiority study, patients received AML 10 mg during a 2- to 4-week run-in be...
Source: Advances in Therapy - November 30, 2013 Category: Drugs & Pharmacology Authors: Ruilope L, Schaefer A Tags: Adv Ther Source Type: research

The Dipeptidyl Peptidase (DPP)-4 Inhibitors for Type 2 Diabetes Mellitus in Challenging Patient Groups.
Abstract Treating hyperglycemia is a critical aspect of managing type 2 diabetes mellitus (T2DM), but can be especially challenging in patients from vulnerable groups such as those with chronic kidney disease, African Americans, and older people. The dipeptidyl peptidase (DPP)-4 inhibitors are relatively new oral antidiabetes drugs that have been incorporated into treatment algorithms over the past few years and have also been studied in these vulnerable patients. Clinical trials with DPP-4 inhibitors have now been reported for all these patient groups and have demonstrated significant improvements in measures of ...
Source: Advances in Therapy - November 28, 2013 Category: Drugs & Pharmacology Authors: Kountz D Tags: Adv Ther Source Type: research

Evolution of the Treatment Paradigm for Patients with Metastatic Castration-Resistant Prostate Cancer.
Abstract As recently as 2004, treatment options for men with metastatic castration-resistant prostate cancer (mCRPC) were limited, with docetaxel the only approved agent conferring a survival benefit. The therapeutic landscape is now very different, with several agents demonstrating prolonged survival since 2010. New agents for the treatment of mCRPC include sipuleucel-T, cabazitaxel, abiraterone acetate, enzalutamide and radium-223. All are now approved for use in this patient group, although the specific licensing terms vary between agents. In addition, denosumab may have utility in patients with bone metastases...
Source: Advances in Therapy - November 26, 2013 Category: Drugs & Pharmacology Authors: Malik Z, Payne H, Ansari J, Chowdhury S, Butt M, Birtle A, Sundar S, Eswar CV, Hughes S, Bahl A Tags: Adv Ther Source Type: research

"All I want for Christmas is Two": The Advent of Novel Fixed-Combination Inhalers for COPD and Outlook for 2014.
"All I want for Christmas is Two": The Advent of Novel Fixed-Combination Inhalers for COPD and Outlook for 2014. Adv Ther. 2013 Nov 26; Authors: Beeh KM PMID: 24276854 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - November 26, 2013 Category: Drugs & Pharmacology Authors: Beeh KM Tags: Adv Ther Source Type: research

Diabetes Treatment: Recent Developments.
PMID: 24263555 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - November 22, 2013 Category: Drugs & Pharmacology Authors: Veves A, Baltzis D, Eleftheriadou I Tags: Adv Ther Source Type: research

Vandetanib in Advanced Medullary Thyroid Cancer: Review of Adverse Event Management Strategies.
CONCLUSIONS: Good patient and team communication is necessary for the prevention, early detection, and management of AEs of vandetanib. Physicians, nurses, and other healthcare providers play a critical role in providing AE management and patient support to optimize outcomes with vandetanib in MTC. PMID: 24249433 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - November 19, 2013 Category: Drugs & Pharmacology Authors: Grande E, Kreissl MC, Filetti S, Newbold K, Reinisch W, Robert C, Schlumberger M, Tolstrup LK, Zamorano JL, Capdevila J Tags: Adv Ther Source Type: research

Additive Postprandial Glucose-Lowering Effects of Mitiglinide and Sitagliptin in Patients with Type 2 Diabetes Mellitus.
Abstract INTRODUCTION: The aim of this research was to compare the pharmacodynamics of the combination of mitiglinide and sitagliptin to that of each agent alone in Korean patients with type 2 diabetes mellitus (T2DM). METHODS: Patients with T2DM received mitiglinide alone, sitagliptin alone, or both drugs together in randomized sequence. A meal tolerance test (MTT) was conducted for each group, and plasma concentrations of glucose, insulin, C-peptide, glucagon, and intact glucagon-like peptide-1, and dipeptidyl peptidase-4 activity were measured from 2 h before breakfast through 4 h after breakfast...
Source: Advances in Therapy - November 19, 2013 Category: Drugs & Pharmacology Authors: Jung JA, Kaku K, Kim JH, Kim JR, Ko JW, Lee SY, Huh W Tags: Adv Ther Source Type: research

Viscosupplementation for Osteoarthritis: a Primer for Primary Care Physicians.
CONCLUSION: For primary care physicians who treat and care for patients with OA of the knee, IA injection with HAs constitutes a safe and effective treatment that can be routinely administered in the office setting. PMID: 24203348 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - November 8, 2013 Category: Drugs & Pharmacology Authors: Reid MC Tags: Adv Ther Source Type: research

Budget Impact Analysis of a Fixed-Dose Combination of Fluticasone Propionate and Formoterol Fumarate (FP/FORM) in a Pressurized Metered-Dose Inhaler (pMDI) for Asthma.
CONCLUSIONS: The comparable efficacy and lower acquisition costs of FP/FORM compared with FP/SAL make it a cost-saving option for the UK NHS for the treatment of asthma patients requiring combination maintenance therapy using a pMDI. PMID: 24194361 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - November 6, 2013 Category: Drugs & Pharmacology Authors: Dunlop W, Heron L, Fox G, Greaney M Tags: Adv Ther Source Type: research

Obesity and Bipolar Disorder: Synergistic Neurotoxic Effects?
Abstract Bipolar disorder (BD) is a disabling and chronic neuropsychiatric disorder that is typified by a complex illness presentation, episode recurrence and by its frequent association with psychiatric and medical comorbidities. Over the past decade, obesity has emerged as one of many comorbidities generating substantial concern in the BD population due to important prognostic implications. This comprehensive review details the bidirectional relationship between obesity and BD as evidenced by alterations in the structure and function of the central nervous system, in addition to greater depressive recurrence, co...
Source: Advances in Therapy - November 6, 2013 Category: Drugs & Pharmacology Authors: Liu CS, Carvalho AF, Mansur RB, McIntyre RS Tags: Adv Ther Source Type: research

Dose Conversion Ratio in Hemodialysis Patients Switched from Darbepoetin Alfa to PEG-Epoetin Beta: AFFIRM Study.
CONCLUSION: In these hemodialysis patients switched from DA to PEG-Epo the DCR was 1.17 and 1.21 after accounting for the effect of transfusions. The number of transfusions and units transfused increased approximately threefold from the pre-switch to the post-switch period. PMID: 24173670 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - October 31, 2013 Category: Drugs & Pharmacology Authors: Choi P, Farouk M, Manamley N, Addison J Tags: Adv Ther Source Type: research

Recent Therapeutic Advances in Gastroenterology and Hepatology.
PMID: 24170588 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - October 30, 2013 Category: Drugs & Pharmacology Authors: Freedberg DE, Abrams JA Tags: Adv Ther Source Type: research

An Overview of Corneal Collagen Cross-Linking (CXL).
Abstract Corneal collagen cross-linking (CXL) was first described over a decade ago and is now considered to be one of the most important surgical innovations of modern ophthalmology. Prior to its introduction, no interventions were available to arrest, or slow down ectatic disease progression, with corneal transplantation required in the majority of cases. Unlike earlier treatments of corneal ectasias that attempted to only improve the consequences of the disease, CXL aims to address the corneal biomechanical weakening itself. The long-term safety and efficacy of CXL have been established in several studies that ...
Source: Advances in Therapy - October 30, 2013 Category: Drugs & Pharmacology Authors: Kymionis GD, Mikropoulos DG, Portaliou DM, Voudouragkaki IC, Kozobolis VP, Konstas AG Tags: Adv Ther Source Type: research

Improvement of Glycemic Control by Re-education in Insulin Injection Technique in Patients with Diabetes Mellitus.
Abstract INTRODUCTION: The aim of this study was to evaluate the effectiveness of re-education in the insulin injection technique for glycemic control. METHODS: A preliminary experimental study was performed with 87 insulin-treated diabetic outpatients (11 with type 1 diabetes, 76 with type 2 diabetes; 43 men, 44 women). All patients had been treated with insulin for more than 3 years. After answering questions about the insulin injection technique, the patients' knowledge levels were scored. Correct answers and explanation sheets were subsequently given to all patients. The physicians in charge gave a s...
Source: Advances in Therapy - October 30, 2013 Category: Drugs & Pharmacology Authors: Nakatani Y, Matsumura M, Monden T, Aso Y, Nakamoto T Tags: Adv Ther Source Type: research

Everolimus Plus Exemestane in Postmenopausal Patients with HR(+) Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis.
Abstract INTRODUCTION: Effective treatments for hormone-receptor-positive (HR(+)) breast cancer (BC) following relapse/progression on nonsteroidal aromatase inhibitor (NSAI) therapy are needed. Initial Breast Cancer Trials of OraL EveROlimus-2 (BOLERO-2) trial data demonstrated that everolimus and exemestane significantly prolonged progression-free survival (PFS) versus placebo plus exemestane alone in this patient population. METHODS: BOLERO-2 is a phase 3, double-blind, randomized, international trial comparing everolimus (10 mg/day) plus exemestane (25 mg/day) versus placebo plus exemestane in po...
Source: Advances in Therapy - October 25, 2013 Category: Drugs & Pharmacology Authors: Yardley DA, Noguchi S, Pritchard KI, Burris HA, Baselga J, Gnant M, Hortobagyi GN, Campone M, Pistilli B, Piccart M, Melichar B, Petrakova K, Arena FP, Erdkamp F, Harb WA, Feng W, Cahana A, Taran T, Lebwohl D, Rugo HS Tags: Adv Ther Source Type: research

Age Distribution for Partial and Radical Nephrectomy: Whose Nephrons are Being Spared?
Abstract INTRODUCTION: Nephron sparing surgery (NSS) is recommended for patients with T1 renal cell carcinoma (RCC) whenever surgically feasible. By analyzing data from all urological clinics in the whole state of Lower Saxony, Germany, regardless of clinic size or level of expertise, we investigated whether current practice reflects the need for NSS in older patients on a broader scale. METHODS: From 2005 to 2010, more than 100 medical facilities and urological clinics in Lower Saxony, Germany were evaluated for their individual rates of partial nephrectomy (PN) and radical nephrectomy (RN) based on patient'...
Source: Advances in Therapy - October 24, 2013 Category: Drugs & Pharmacology Authors: von Klot C, Herrmann TR, Wegener G, Kuczyk MA, Hupe MC, Akkoyun M, Peters I, Kramer MW, Merseburger AS Tags: Adv Ther Source Type: research

Loteprednol Etabonate Ophthalmic Gel 0.5% Following Cataract Surgery: Integrated Analysis of Two Clinical Studies.
Abstract INTRODUCTION: We aimed to evaluate the safety and efficacy of loteprednol etabonate (LE) gel 0.5% compared with vehicle in the treatment of postoperative inflammation and pain following cataract surgery, using the integrated analysis of data from two identical, prospective, multicenter, randomized, double-masked, parallel-group, vehicle-controlled trials. METHODS: Patients with anterior chamber cell (ACC) inflammation ≥ grade 2 (6-15 cells) 1 day post-surgery were randomized to receive 1 or 2 drops of LE gel 0.5% or vehicle 4 times per day instilled in the study eye for 14 days. Pri...
Source: Advances in Therapy - October 18, 2013 Category: Drugs & Pharmacology Authors: Rajpal RK, Fong R, Comstock TL Tags: Adv Ther Source Type: research

A Phase 2 Study of Naproxen Submicron Particle Capsules in Patients with Post-Surgical Dental Pain.
Abstract BACKGROUND: Naproxen is an NSAID with documented efficacy in pain management; however, it is associated with serious dose-related adverse events. A lower-dose naproxen drug product with comparable efficacy to commercially available naproxen could address these concerns. We studied the efficacy and safety of naproxen submicron particle capsules in patients with acute post-surgical dental pain. METHODS: A phase 2, multicenter, randomized, single-dose study (NCT01229228) enrolled 254 patients (18-34 years old) undergoing third molar extraction. Patients who experienced moderate-to-severe pain ≤6...
Source: Advances in Therapy - October 15, 2013 Category: Drugs & Pharmacology Authors: Young CL, Strand V, Altman R, Daniels S Tags: Adv Ther Source Type: research

Comparison of Carotid Artery Stenting and Carotid Endarterectomy in Patients with Symptomatic Carotid Artery Stenosis: A Single Center Study.
CONCLUSION: In our trial of patients with symptomatic carotid artery stenosis, no significant difference could be shown in periprocedural outcomes, postprocedural outcomes except TIA, and in composite endpoints between the CEA and CAS groups. CAS is a safe and efficacious alternative for the treatment of symptomatic carotid artery stenosis. PMID: 24105435 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - October 9, 2013 Category: Drugs & Pharmacology Authors: Taş MH, Simşek Z, Colak A, Koza Y, Demir P, Demir R, Kaya U, Tanboga IH, Gundogdu F, Sevimli S Tags: Adv Ther Source Type: research

Drug-Induced Long QT Syndrome in Women.
Abstract Congenital long QT syndromes (LQTS) are inherited heart diseases that can present as palpitations, syncope (fainting), seizures, cardiac arrest, and sudden death. Acquired LQTS mostly occurs as a result of exposure to an environmental stressor that is responsible for the excessive prolongation of the QT interval. The most common environmental stressor is adverse drug reactions, which can lead to drug-induced LQTS (di-LQTS). Female gender has been increasingly recognized as an independent risk factor for di-LQTS, which in females is influenced by other factors, including age, menstrual cycle, and hormone r...
Source: Advances in Therapy - October 2, 2013 Category: Drugs & Pharmacology Authors: Li G, Cheng G, Wu J, Zhou X, Liu P, Sun C Tags: Adv Ther Source Type: research

OnabotulinumtoxinA is Effective in Patients with Urinary Incontinence due to Neurogenic Detrusor Activity Regardless of Concomitant Anticholinergic Use or Neurologic Etiology.
CONCLUSION: Regardless of concomitant anticholinergic use or etiology, onabotulinumtoxinA significantly improved UI symptoms, urodynamics, and QOL in patients with UI due to NDO. OnabotulinumtoxinA was well tolerated in all groups. PMID: 24072665 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - September 27, 2013 Category: Drugs & Pharmacology Authors: Ginsberg D, Cruz F, Herschorn S, Gousse A, Keppenne V, Aliotta P, Sievert KD, Brin MF, Jenkins B, Thompson C, Lam W, Heesakkers J, Haag-Molkenteller C Tags: Adv Ther Source Type: research

Dose-Finding Study of Landiolol Hydrochloride: A Short-Acting β1-Blocker for Controlling Heart Rate During Coronary Computed-Tomography Angiography in Japan.
CONCLUSION: Landiolol hydrochloride showed a rapid onset and short β-blocking effect, and was most effective at a dose of 0.5 mg/kg. However, the diagnosable proportion had no significant differences among the three groups in CCTA. Therefore, the clinically recommended dose was 0.125 mg/kg or less, considering the heart rate of patients with suspected coronary stenosis during CCTA. PMID: 24062147 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - September 24, 2013 Category: Drugs & Pharmacology Authors: Hirano M, Hara K, Ikari Y, Jinzaki M, Iino M, Hamada C, Kuribayashi S Tags: Adv Ther Source Type: research

Effects of Tirofiban Maintenance Duration on Myocardial Perfusion Defect Severity in Anterior Myocardial Infarction.
CONCLUSION: The use of tirofiban, when administered at a high bolus dose and maintained for 48 h, was safe and significantly reduced perfusion defect severity in patients with anterior STEMI presenting early after symptom onset and undergoing primary PCI. PMID: 24057341 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - September 21, 2013 Category: Drugs & Pharmacology Authors: Tas MH, Simsek Z, Ayan A, Aksu U, Demirelli S, Koza Y, Lazoglu Z, Seven B, Senocak H Tags: Adv Ther Source Type: research

Systematic Review of Contracture Reduction in the Lower Extremity with Dynamic Splinting.
DISCUSSION: Dynamic splinting is a safe and efficacious treatment for lower extremity joint contractures. Joint specific stretching protocols accomplished greater durations of end-range stretching which may be considered to be responsible for connective tissue elongation. PMID: 24018464 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - September 10, 2013 Category: Drugs & Pharmacology Authors: Furia JP, Willis FB, Shanmugam R, Curran SA Tags: Adv Ther Source Type: research

A Review of the Impact of Pneumococcal Polysaccharide Conjugate Vaccine (7-valent) on Pneumococcal Meningitis.
CONCLUSIONS: The results from this review demonstrate that PCV7 has had a significant impact on pneumococcal meningitis across all ages through its use in pediatric immunization programs. With the introduction of 13-valent PCV (PCV13) we can expect to see a reduction in the incidence of pneumococcal meningitis due to the six additional serotypes included, as well as continued protection against pneumococcal meningitis due to PCV7 serotypes. Robust surveillance systems are essential for the evaluation of the impact of PCV13 on all-type pneumococcal meningitis and for monitoring the evolution of non-vaccine serotype pneumoco...
Source: Advances in Therapy - September 3, 2013 Category: Drugs & Pharmacology Authors: Tin Tin Htar M, Madhava H, Balmer P, Christopoulou D, Menegas D, Bonnet E Tags: Adv Ther Source Type: research

Abiraterone Acetate: Targeting Persistent Androgen Dependence in Castration-Resistant Prostate Cancer.
Abstract Abiraterone acetate is the first second-line hormonal agent proven to improve survival in metastatic castration-resistant prostate cancer. It selectively inhibits cytochrome P450 17 (CYP17) α-hydroxylase and cytochrome17,20 (C17,20)-lyase, which are enzymes critical for androgen synthesis. Abiraterone acetate was initially approved in the United States in 2011 after demonstrating a 4-month survival benefit in docetaxel-refractory metastatic prostate cancer. The FDA recently expanded its indication for use in the pre-chemotherapy setting after it elicited significant delays in disease progression and...
Source: Advances in Therapy - August 27, 2013 Category: Drugs & Pharmacology Authors: Harshman LC, Taplin ME Tags: Adv Ther Source Type: research

Valsartan/Amlodipine Compared to Nifedipine GITS in Patients with Hypertension Inadequately Controlled by Monotherapy.
This study compared the efficacy and safety of valsartan/amlodipine single-pill combination with nifedipine gastrointestinal therapeutic system (GITS) in Chinese patients with hypertension who were inadequately controlled with monotherapy. METHODS: In this multicenter, open-label, active-controlled, parallel-group study, 564 patients with hypertension not adequately controlled by prior monotherapy were randomized to receive valsartan/amlodipine 80/5 mg or nifedipine GITS 30 mg once daily for 12 weeks. RESULTS: In the intention-to-treat analysis (n = 540), valsartan/amlodipine (n =&nb...
Source: Advances in Therapy - August 21, 2013 Category: Drugs & Pharmacology Authors: Wang JG, Zeng WF, He YS, Chen LL, Wei M, Li ZP, Zhang BW, Li Y, for the EXAM Investigators Tags: Adv Ther Source Type: research

Cytomegalovirus DNAemia Detected with Real-Time Polymerase Chain Reaction in Hematopoietic Stem Cell Transplant Patients.
Abstract INTRODUCTION: Cytomegalovirus (CMV) infections continue to cause significant morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients. Successful pre-emptive therapy in transplant patients depends on the availability of reliable diagnostic tests for CMV infections. The purpose of this retrospective study was to evaluate CMV DNA viral load, incidence of CMV disease and CMV seropositivity, risk factors and correlation between CMV DNA positivity and clinical course in HSCT patients. METHODS: Two hundred and twenty-five patients who underwent peripheral blood stem cell or bone marr...
Source: Advances in Therapy - August 20, 2013 Category: Drugs & Pharmacology Authors: Sahin DG, Gunduz E, Kasifoglu N, Akay OM, Us T, Gulbas Z Tags: Adv Ther Source Type: research

Tofacitinib for Treatment of Rheumatoid Arthritis.
Abstract The management of rheumatoid arthritis has seen a dramatic improvement with the introduction of a range of biological disease modifying anti-rheumatic drugs (DMARDs) in recent years. Nonetheless, a proportion of patients remain resistant or intolerant to multiple conventional and biological DMARDs, so innovative strategies are needed to offer patients new therapeutic options. Tofacitinib is the first of a new class of orally active DMARDs, with immunomodulating effects through inhibition of intracellular Janus kinase (JAK) pathways. It has been recently licensed for treatment of adults with moderate to se...
Source: Advances in Therapy - August 14, 2013 Category: Drugs & Pharmacology Authors: Rakieh C, Conaghan PG Tags: Adv Ther Source Type: research

C-QUALITY: Cost and Quality-of-Life Pharmacoeconomic Analysis of Antidepressants in Major Depressive Disorder in Italy.
CONCLUSION: The results indicate that escitalopram is the most cost-effective pharmacological treatment strategy for the Italian health service compared with other SSRIs and all SNRIs used in the first-line treatment of MDD. PMID: 23929174 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - August 9, 2013 Category: Drugs & Pharmacology Authors: Mencacci C, Aguglia E, Biggio G, Cappellari L, Di Sciascio G, Fagiolini A, Maina G, Tortorella A, Katz P, Ripellino C Tags: Adv Ther Source Type: research

Reduction in Framingham Risk of Cardiovascular Disease in Obese Patients Undergoing Laparoscopic Adjustable Gastric Banding.
Abstract BACKGROUND: Obesity is a major risk factor for cardiovascular disease (CVD), with weight loss offering improvement in CVD risk factors. AIMS: To examine whether weight loss in laparoscopic adjustable gastric band (LAGB)-treated obese patients is associated with meaningful reductions in estimated 10- and 30- year Framingham CVD risk 12-15 months post-LAGB. METHODS: Obese adult patients [body mass index (BMI) ≥30 kg/m(2)] treated with LAGB were identified in a large US healthcare database. Patients without CVD at baseline and with measures of BMI, systolic blood pressure, diabetes, an...
Source: Advances in Therapy - July 30, 2013 Category: Drugs & Pharmacology Authors: Largent JA, Vasey J, Bessonova L, Okerson T, Wong ND Tags: Adv Ther Source Type: research

Use of Pertuzumab for the Treatment of HER2-Positive Metastatic Breast Cancer.
CONCLUSION: Pertuzumab provided a more comprehensive inhibition of HER2-driven signalling pathways. When administered together with trastuzumab, pertuzumab represent a significant advancement for the treatment of HER2-positive metastatic breast cancer patients. PMID: 23881722 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - July 24, 2013 Category: Drugs & Pharmacology Authors: De Mattos-Arruda L, Cortes J Tags: Adv Ther Source Type: research

Targeting the Gut-Liver Axis in Cirrhosis: Antibiotics and Non-Selective β-Blockers.
Targeting the Gut-Liver Axis in Cirrhosis: Antibiotics and Non-Selective β-Blockers. Adv Ther. 2013 Jul 24; Authors: Madsen BS, Havelund T, Krag A Abstract The gut-liver axis in cirrhosis and portal hypertension is gaining increasing attention as a key pathophysiological mechanism responsible for progression of liver failure and development of complications such as spontaneous infections and hepatocellular carcinoma. Antibiotics and non-selective β-blockers (NSBB) intercept this axis and each drug has proven efficacy in clinical trials. A synergistic effect is a hitherto unproven possibility. The...
Source: Advances in Therapy - July 24, 2013 Category: Drugs & Pharmacology Authors: Madsen BS, Havelund T, Krag A Tags: Adv Ther Source Type: research

The Effect of Personality Dimensions on Functional Outcomes in Mood Disorders.
CONCLUSION: The results suggest that discrete personality dimensions may exert direct and indirect effects on functional outcomes in individuals with mood disorders. Personalizing disease management approaches in mood disorders with emphasis on vocational rehabilitation may benefit from measurement and intervention targeting personality. PMID: 23839119 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - July 10, 2013 Category: Drugs & Pharmacology Authors: Leen J, Soczynska JK, Gallaugher LA, Woldeyohannes HO, Alsuwaidan MT, Cha DS, Dale RM, Muzina DJ, Kennedy SH, McIntyre RS Tags: Adv Ther Source Type: research

Insulin Degludec Once-Daily in Type 2 Diabetes: Simple or Step-Wise Titration (BEGIN: Once Simple Use).
CONCLUSION: IDeg was effective and well tolerated using either the Simple or Step-wise titration algorithm. While selection of an algorithm must be based on individual patient characteristics and goals, the ability to attain good glycemic control using a simplified titration algorithm may enable patient empowerment through self-titration, improved convenience, and reduced costs. PMID: 23812875 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - June 29, 2013 Category: Drugs & Pharmacology Authors: Philis-Tsimikas A, Brod M, Niemeyer M, Ocampo Francisco AM, Rothman J Tags: Adv Ther Source Type: research